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Cited by 152Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Regulation of adiponectin multimerization, signaling and function

Open access
Liu, Meilian, Liu, Feng·2014·Best Practice & Research Clinical Endocrinology & Metabolism
DOI 10.1016/j.beem.2013.06.003PMC PMC3893790
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Abstract

Adiponectin, which exists in serum in three major complexes including trimer, hexamer, and the high molecular weight (HMW) form, has strong insulin sensitizing, anti-inflammatory and anti-diabetic functions. Different adiponectin complexes exert tissue-specific biological functions and activate distinct signaling pathways. In this review, we summarize our current understanding on the mechanisms regulating adiponectin multimerization. We also describe the major target tissues in which distinct adiponectin multimers exert their functional roles. Finally, we discuss the potential involvement of endoplasmic reticulum stress and mitochondrial stress in diet-induced adiponectin downregulation and highlight the roles of Disulfide bond A oxidoreductase-like protein (DsbA-L) in the prevention of endoplasmic reticulum stress and promotion of adiponectin multimerization, stability, and function.

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Crossref · 10.1016/j.beem.2013.06.003

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  • White adipose tissue (WAT) as a critical endocrine organ discharges bioactive molecules including adipokines that regulate lipid metabolism, energy balance, insulin sensitivity, angiogenesis immunity, and inflammation.

    “White adipose tissue (WAT) as a critical endocrine organ discharges bioactive molecules including the adipokines regulate lipid metabolism, energy balance, insulin sensitivity, angiogenesis immunity, and inflammation. 7,8”

    From Melatonin supplementation improves glycemic hemostasis, lipid profile, and adipokine concentrations of obese women: A double-blind randomized clinical trial (2024) · cites this paper as [7]

    The Summary (page unavailable) says adiponectin promotes fatty-acid oxidation, improves insulin sensitivity, and regulates appetite and energy expenditure; the Introduction identifies it as an adipokine whose secretion is regulated. The paper does not establish the full, broader claim that WAT-secreted adipokines regulate angiogenesis, immunity, and inflammation. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • The underlying mechanism of melatonin action on adiponectin includes the effects of indoleamine function on adiponectin signaling pathways, the antioxidant and anti-inflammatory features of melatonin, progression in mitochondrial action, and effects on other adipokine concentrations.

    “The underlying mechanism of melatonin action on adiponectin includes the effects of indoleamine function on adiponectin signaling pathways, the antioxidant and anti-inflammatory features of melatonin, progression in mitochondrial action, and effects on other adipokine concentrations. 7”

    From Melatonin supplementation improves glycemic hemostasis, lipid profile, and adipokine concentrations of obese women: A double-blind randomized clinical trial (2024) · cites this paper as [7]

    The sections on adiponectin signaling and mitochondrial function discuss adiponectin without linking either to melatonin. Searches for melatonin and indoleamine found no passage addressing melatonin’s proposed effects on adiponectin, inflammation, or other adipokines; the claim cannot be verified from our copy. (LLM, conf=0.76)

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Authors
Liu, M., & Liu, F.
Affiliations
Central South University (CN)
Corresponding author
  • Liu, Meilian
  • Liu, Feng
ORCID
Venue
Best Practice & Research Clinical Endocrinology & Metabolism
Publisher
Elsevier BV
Published
2014-01
Volume
28
Issue
1
Pages
25-31
ISSN
1521-690X (ISSN-L)
DOI
10.1016/j.beem.2013.06.003
PMC
PMC3893790
OpenAlex
W2025528312
Cited by
152
References
4
Citations by year
2026: 8 · 2025: 6 · 2024: 11 · 2023: 11 · 2022: 14 · 2021: 14 · 2020: 19 · 2019: 18 · 2018: 20 · 2017: 12 · 2016: 8 · 2015: 6 · 2014: 5
FWCI
0.75
Type
journal article
Language
en
Open access
Licence
Locations
  • Best Practice & Research Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK076902)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords
adiponectin, insulin sensitization, anti-inflammatory activity, anti-diabetic effects, endoplasmic reticulum stress, mitochondrial stress, DsbA-L, tissue-specific signaling
MeSH terms
Animals, Central Nervous System, Glutathione Transferase, Humans, Liver, Signal Transduction, Muscle, Skeletal, Mice, Adiponectin, AMP-Activated Protein Kinases, Protein Multimerization, Protein Stability, Endoplasmic Reticulum Stress

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