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Cited by 287Hydrogels: synthesis, properties, applicationsHemostasis and retained surgical itemsWound Healing and Treatments

Multi-crosslinking hydrogels with robust bio-adhesion and pro-coagulant activity for first-aid hemostasis and infected wound healing

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Zou, Chen-Yu, Lei, Xiong-Xin, Hu, Juan-Juan, Jiang, Yan-Lin, Li, Qian-Jin, Song, Yu-Ting, Zhang, Qing-Yi, Li-Ling, Jesse +1 more·2022·Bioactive Materials
DOI 10.1016/j.bioactmat.2022.02.034PMC PMC8965776
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Abstract

Bio-adhesive polysaccharide-based hydrogels have attracted much attention in first-aid hemostasis and wound healing for excellent biocompatibility, antibacterial property and pro-healing bioactivity. Yet, the inadequate mechanical properties and bio-adhesion limit their applications. Herein, based on dynamic covalent bonds, photo-triggered covalent bonds and hydrogen bonds, multifunctional bio-adhesive hydrogels comprising modified carboxymethyl chitosan, modified sodium alginate and tannic acid are developed. Multi-crosslinking strategy endows hydrogels with improved strength and flexibility simultaneously. Owing to cohesion enhancement strategy and self-healing ability, considerable bio-adhesion is presented by the hydrogel with a maximal adhesion strength of 162.6 kPa, 12.3-fold that of commercial fibrin glue. Based on bio-adhesion and pro-coagulant activity (e.g., the stimulative aggregation and adhesion of erythrocytes and platelets), the hydrogel reveals superior hemostatic performance in rabbit liver injury model with blood loss of 0.32 g, only 54.2% of that in fibrin glue. The healing efficiency of hydrogel for infected wounds is markedly better than commercial EGF Gel and Ag + Gel due to the enhanced antibacterial and antioxidant properties. Through the multi-crosslinking strategy, the hydrogels show enhanced mechanical properties, fabulous bio-adhesion, superior hemostatic performance and promoting healing ability, thereby have an appealing application value for the first-aid hemostasis and infected wound healing.

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Cited by

Sorted by citations

Authors
Zou, C.-Y., Lei, X.-X., Hu, J.-J., Jiang, Y.-L., Li, Q.-J., Song, Y.-T., Zhang, Q.-Y., Li-Ling, J., & Xie, H.-Q.
Affiliations
Sichuan University (CN)
ORCID
Venue
Bioactive Materials
Publisher
Elsevier BV
Published
2022-10
Volume
16
Pages
388-402
ISSN
  • 2097-1192 (ISSN-L)
  • 2452-199X
DOI
10.1016/j.bioactmat.2022.02.034
PMC
PMC8965776
OpenAlex
W4220858338
Cited by
287
References
1
Citations by year
2026: 27 · 2025: 74 · 2024: 96 · 2023: 71 · 2022: 19
FWCI
21.30
Type
journal article
Language
en
Open access
Licence
Locations
  • Bioactive Materials (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • West China Hospital, Sichuan University
  • National Natural Science Foundation of China (32171351)
  • Sichuan University
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Health Sciences › Medicine › Hematology › Hemostasis and retained surgical items
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
Keywords
infected wound healing, carboxymethyl chitosan, sodium alginate, tannic acid, dynamic covalent bonds, hydrogen bonding, self-healing hydrogels, procoagulant activity, platelet aggregation, erythrocyte aggregation, antibacterial activity, antioxidant activity, liver injury model

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