Exosomes: Small vesicles participating in intercellular communication

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834

Novel Proteinaceous Infectious Particles Cause Scrapie

Prusiner, S. B. (1982) · Science · doi:10.1126/science.6801762 · Cited by 5,118

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930

B lymphocytes secrete antigen-presenting vesicles.

Raposo, G., Nijman, H. W., Stoorvogel, W., Liejendekker, R., Harding, C. V., Melief, C. J., & Geuze, H. J. (1996) · The Journal of experimental medicine · doi:10.1084/jem.183.3.1161 · Cited by 3,546

Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes)

Johnstone, R. M., Adam, M., Hammond, J. R., Orr, L., & Turbide, C. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48095-7 · Cited by 2,931

Rab27a and Rab27b control different steps of the exosome secretion pathway

Ostrowski, M., Carmo, N. B., Krumeich, S., Fanget, I., Raposo, G., Savina, A., Moita, C. F., Schauer, K., Hume, A. N., Freitas, R. P., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2000 · Cited by 2,750

Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell derived exosomes

Zitvogel, L., Regnault, A., Lozier, A., Wolfers, J., Flament, C., Tenza, D., Ricciardi-Castagnoli, P., Raposo, G., & Amigorena, S. (1998) · Nature Medicine · doi:10.1038/nm0598-594 · Cited by 2,266

Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury

Lai, R. C., Arslan, F., Lee, M. M., Sze, N. S. K., Choo, A., Chen, T. S., Salto-Tellez, M., Timmers, L., Lee, C. N., El Oakley, R. M., et al. (2010) · Stem Cell Research · doi:10.1016/j.scr.2009.12.003 · Cited by 2,215

Intravenous hMSCs Improve Myocardial Infarction in Mice because Cells Embolized in Lung Are Activated to Secrete the Anti-inflammatory Protein TSG-6

Lee, R. H., Pulin, A. A., Seo, M. J., Kota, D. J., Ylostalo, J., Larson, B. L., Semprun-Prieto, L., Delafontaine, P., & Prockop, D. J. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.05.003 · Cited by 1,898

Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes

Harding, C., Heuser, J., & Stahl, P. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.97.2.329 · Cited by 1,775

Shedding microvesicles: artefacts no more

Cocucci, E., Racchetti, G., & Meldolesi, J. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.11.003 · Cited by 1,742

Functional delivery of viral miRNAs via exosomes

Pegtel, D. M., Cosmopoulos, K., Thorley-Lawson, D. A., van Eijndhoven, M. A. J., Hopmans, E. S., Lindenberg, J. L., de Gruijl, T. D., Würdinger, T., & Middeldorp, J. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914843107 · Cited by 1,641

A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

Sun, D., Zhuang, X., Xiang, X., Liu, Y., Zhang, S., Liu, C., Barnes, S., Grizzle, W., Miller, D., & Zhang, H.-G. (2010) · Molecular Therapy · doi:10.1038/mt.2010.105 · Cited by 1,572

Proteomic Analysis of Dendritic Cell-Derived Exosomes: A Secreted Subcellular Compartment Distinct from Apoptotic Vesicles

Théry, C., Boussac, M., Véron, P., Ricciardi-Castagnoli, P., Raposo, G., Garin, J., & Amigorena, S. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.12.7309 · Cited by 1,563

Sizing and phenotyping of cellular vesicles using Nanoparticle Tracking Analysis

Dragovic, R. A., Gardiner, C., Brooks, A. S., Tannetta, D. S., Ferguson, D. J. P., Hole, P., Carr, B., Redman, C. W. G., Harris, A. L., Dobson, P. J., et al. (2011) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2011.04.003 · Cited by 1,362

Alzheimer’s disease β-amyloid peptides are released in association with exosomes

Rajendran, L., Honsho, M., Zahn, T. R., Keller, P., Geiger, K. D., Verkade, P., & Simons, K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603838103 · Cited by 1,343

Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes.

Pan, B. T., Teng, K., Wu, C., Adam, M., & Johnstone, R. M. (1985) · The Journal of cell biology · doi:10.1083/jcb.101.3.942 · Cited by 1,241

High Levels of Exosomes Expressing CD63 and Caveolin-1 in Plasma of Melanoma Patients

Logozzi, M., De Milito, A., Lugini, L., Borghi, M., Calabrò, L., Spada, M., Perdicchio, M., Marino, M. L., Federici, C., Iessi, E., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005219 · Cited by 960

Proteomic and Biochemical Analyses of Human B Cell-derived Exosomes

Wubbolts, R., Leckie, R. S., Veenhuizen, P. T. M., Schwarzmann, G., Möbius, W., Hoernschemeyer, J., Slot, J.-W., Geuze, H. J., & Stoorvogel, W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207550200 · Cited by 884

ExoCarta: A compendium of exosomal proteins and RNA

Mathivanan, S., & Simpson, R. J. (2009) · PROTEOMICS · doi:10.1002/pmic.200900351 · Cited by 873

Cancer Exosomes Trigger Fibroblast to Myofibroblast Differentiation

Webber, J., Steadman, R., Mason, M. D., Tabi, Z., & Clayton, A. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1722 · Cited by 852

Characterisation of exosomes derived from human cells by nanoparticle tracking analysis and scanning electron microscopy

Sokolova, V., Ludwig, A.-K., Hornung, S., Rotan, O., Horn, P. A., Epple, M., & Giebel, B. (2011) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2011.05.013 · Cited by 851

Molecular mechanism of multivesicular body biogenesis by ESCRT complexes

Wollert, T., & Hurley, J. H. (2010) · Nature · doi:10.1038/nature08849 · Cited by 804

Large-scale proteomics and phosphoproteomics of urinary exosomes

Gonzales, P. A., Pisitkun, T., Hoffert, J. D., Tchapyjnikov, D., Star, R. A., Kleta, R., Wang, N. S., & Knepper, M. A. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008040406 · Cited by 727

Production and characterization of clinical grade exosomes derived from dendritic cells

Lamparski, H. G., Metha-Damani, A., Yao, J.-Y., Patel, S., Hsu, D.-H., Ruegg, C., & Le Pecq, J.-B. (2002) · Journal of Immunological Methods · doi:10.1016/s0022-1759(02)00330-7 · Cited by 700

Human Tumor-Derived Exosomes Down-Modulate NKG2D Expression

Clayton, A., Mitchell, J. P., Court, J., Linnane, S., Mason, M. D., & Tabi, Z. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.11.7249 · Cited by 574

Nonclassical IL-1β Secretion Stimulated by P2X7 Receptors Is Dependent on Inflammasome Activation and Correlated with Exosome Release in Murine Macrophages

Qu, Y., Franchi, L., Nunez, G., & Dubyak, G. R. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.3.1913 · Cited by 563

Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling

Chairoungdua, A., Smith, D. L., Pochard, P., Hull, M., & Caplan, M. J. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201002049 · Cited by 562

Analysis of antigen presenting cell derived exosomes, based on immuno-magnetic isolation and flow cytometry

Clayton, A., Court, J., Navabi, H., Adams, M., Mason, M. D., Hobot, J. A., Newman, G. R., & Jasani, B. (2001) · Journal of Immunological Methods · doi:10.1016/s0022-1759(00)00321-5 · Cited by 554

Human Tumor-Derived Exosomes Selectively Impair Lymphocyte Responses to Interleukin-2

Clayton, A., Mitchell, J. P., Court, J., Mason, M. D., & Tabi, Z. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3456 · Cited by 520

Fas Ligand–Positive Membranous Vesicles Isolated from Sera of Patients with Oral Cancer Induce Apoptosis of Activated T Lymphocytes

Kim, J. W., Wieckowski, E., Taylor, D. D., Reichert, T. E., Watkins, S., & Whiteside, T. L. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.1010.11.3 · Cited by 497

The endocytic matrix

Scita, G., & Di Fiore, P. P. (2010) · Nature · doi:10.1038/nature08910 · Cited by 447

Packaging of prions into exosomes is associated with a novel pathway of PrP processing

Vella, L., Sharples, R., Lawson, V., Masters, C., Cappai, R., & Hill, A. (2007) · The Journal of Pathology · doi:10.1002/path.2145 · Cited by 425

GM1 structure determines SV40-induced membrane invagination and infection

Ewers, H., Römer, W., Smith, A. E., Bacia, K., Dmitrieff, S., Chai, W., Mancini, R., Kartenbeck, J., Chambon, V., Berland, L., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb1999 · Cited by 417

New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes

Sheldon, H., Heikamp, E., Turley, H., Dragovic, R., Thomas, P., Oon, C. E., Leek, R., Edelmann, M., Kessler, B., Sainson, R. C. A., et al. (2010) · Blood · doi:10.1182/blood-2009-08-239228 · Cited by 410

Human Placenta Expresses and Secretes NKG2D Ligands via Exosomes that Down-Modulate the Cognate Receptor Expression: Evidence for Immunosuppressive Function

Hedlund, M., Stenqvist, A.-C., Nagaeva, O., Kjellberg, L., Wulff, M., Baranov, V., & Mincheva-Nilsson, L. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803477 · Cited by 332

A Membrane Form of TNF-α Presented by Exosomes Delays T Cell Activation-Induced Cell Death

Zhang, H.-G., Liu, C., Su, K., Yu, S., Zhang, L., Zhang, S., Wang, J., Cao, X., Grizzle, W., & Kimberly, R. P. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.12.7385 · Cited by 271

Updated Technology to Produce Highly Immunogenic Dendritic Cell-derived Exosomes of Clinical Grade: A Critical Role of Interferon-γ

Viaud, S., Ploix, S., Lapierre, V., Théry, C., Commere, P.-H., Tramalloni, D., Gorrichon, K., Virault-Rocroy, P., Tursz, T., Lantz, O., et al. (2011) · Journal of Immunotherapy · doi:10.1097/cji.0b013e3181fe535b · Cited by 201

More Efficient Induction of HLA-A*0201-Restricted and Carcinoembryonic Antigen (CEA)–Specific CTL Response by Immunization with Exosomes Prepared from Heat-Stressed CEA-Positive Tumor Cells

Dai, S., Wan, T., Wang, B., Zhou, X., Xiu, F., Chen, T., Wu, Y., & Cao, X. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-0810 · Cited by 199

Induction of Tolerance by Exosomes and Short-Term Immunosuppression in a Fully MHC-Mismatched Rat Cardiac Allograft Model

Pêche, H., Renaudin, K., Bériou, G., Mérieau, E., Amigorena, S., & Cuturi, M. C. (2006) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2006.01344.x · Cited by 130

Tolerosome‐induced oral tolerance is MHC dependent

Östman, S., Taube, M. B. P., & Telemo, E. (2005) · Immunology · doi:10.1111/j.1365-2567.2005.02245.x · Cited by 101

Exosome Theranostics: Biology and Translational Medicine

He, C., Zheng, S., Luo, Y., & Wang, B. (2018) · Theranostics · doi:10.7150/thno.21945 · Cited by 1,249

MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease

Kordelas, L., Rebmann, V, Ludwig, A.-K., Radtke, S., Ruesing, J., Doeppner, T. R., Epple, M., Horn, P. A., Beelen, D. W., & Giebel, B. (2014) · Leukemia · doi:10.1038/leu.2014.41 · Cited by 1,084

Extracellular Vesicles Improve Post-Stroke Neuroregeneration and Prevent Postischemic Immunosuppression

Doeppner, T. R., Herz, J., Görgens, A., Schlechter, J., Ludwig, A.-K., Radtke, S., de Miroschedji, K., Horn, P. A., Giebel, B., & Hermann, D. M. (2015) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0078 · Cited by 772

Molecular lipidomics of exosomes released by PC-3 prostate cancer cells

Llorente, A., Skotland, T., Sylvänne, T., Kauhanen, D., Róg, T., Orłowski, A., Vattulainen, I., Ekroos, K., & Sandvig, K. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.04.011 · Cited by 768

Isolation of exosomes by differential centrifugation: Theoretical analysis of a commonly used protocol

Livshits, M. A., Khomyakova, E., Evtushenko, E. G., Lazarev, V. N., Kulemin, N. A., Semina, S. E., Generozov, E. V., & Govorun, V. M. (2015) · Scientific Reports · doi:10.1038/srep17319 · Cited by 686