The DOI matches its Crossref record; 39 of the 40 references it cites were found in a registry or an index.
Protein interactions with subcutaneously implanted biosensors
Abstract
Biofouling of in vivo glucose sensors has been indicated as the primary reason for sensitivity losses observed during the first 24 h after implant [Wisniewski N, Moussy F, Reichert WM. Characterization of implantable biosensor membrane biofouling. Fresen J Anal Chem 2000; 366(6-7): 611-621]. Identification of the biomolecules that contribute to these sensitivity perturbations is the primary objective of the research presented. Active needle-type glucose sensors were implanted in Sprague-Dawley rats for 24h, and then a proteomics approach was used to identify the substances absorbed to the sensors. MALDI-TOF mass spectrometry was the primary tool utilized to identify the biomolecules in sensor leachate samples and species absorbed directly on sensor membranes excised from explanted in vivo sensors. Not surprisingly serum albumin was identified as the primary biomolecule present, however, predominantly as endogenous fragments of the protein. In addition, several other biomolecule fragments, mainly less than 15 kD, were identified. Based on these findings, it is concluded that fragments of larger biomolecules infiltrate the sensor membranes causing diminished glucose diffusivity, thus decreasing in vivo sensitivity.
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“A layer of inflammatory tissue forms around each CSII cannula that contains plasma proteins, platelets, red blood cells, white blood cells, and cellular debris.”
From Detailed Analysis of Insulin Absorption Variability and the Tissue Response to Continuous Subcutaneous Insulin Infusion Catheter Implantation in Swine (2017) · cites this paper as [15]
In the citing paper
“the majority of the biofouling proteins on the sensor membrane were fragments <15 kDa.102–103”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [102]
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Metadata
- Authors
- Gifford, R., Kehoe, J. J., Barnes, S. L., Kornilayev, B. A., Alterman, M. A., & Wilson, G. S.
- Affiliations
- University of Kansas (US)
- Corresponding author
- Wilson, George S.
- ORCID
- Alterman, Michail A.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2006-04
- Volume
- 27
- Issue
- 12
- Pages
- 2587-2598
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2026455723
- Cited by
- 117
- References
- 40
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 5 · 2018: 7 · 2017: 9 · 2016: 9 · 2015: 9 · 2014: 7 · 2013: 7 · 2012: 13
- FWCI
- 5.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01dk055297-03)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK55297)
- Topics
- Physical Sciences › Chemistry › Analytical Chemistry › Electrochemical sensors and biosensors
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Keywords
- subcutaneous glucose sensor, implantable biosensors, biofouling, protein adsorption, serum albumin, sensor membranes, proteomics, MALDI-TOF mass spectrometry
- MeSH terms
- Adsorption, Animals, Biocompatible Materials, Glucose, Male, Monitoring, Physiologic, Proteins, Biosensing Techniques, Rats, Sprague-Dawley, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Prostheses and Implants, Proteomics, Rats
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