Angiogenesis induced by controlled release of neuropeptide substance P
Abstract
The in vivo recruitment of circulating host cells to the site to be regenerated is one of the promising strategies for therapeutic angiogenesis. Substance P (SP), a member of neuropeptides, mediates pain perception and regulates wound healing, inflammation, tumor cell proliferation, and angiogenesis. This SP enhanced the migration, adhesion, and angiogenic gene expression of granulocytes in vitro. A biodegradable hydrogel was prepared from an anionic derivative of gelatin to achieve the controlled release of SP in vivo. When the anionic gelatin hydrogels incorporating SP were subcutaneously implanted into the mouse back, significant angiogenesis was induced around the site implanted, in contrast to the injection of SP solution. In vivo accumulation of granulocytes around the implanted sites was observed. It is concluded that the controlled release of SP efficiently induced the recruitment and the subsequent activation of granulocytes, one of the circulating cells with angiogenic activities, from the blood circulation into the site implanted, resulting in enhanced angiogenesis.
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SP can indirectly promote hemangiogenesis in tissues by recruiting granulocytes with angiogenic potential from blood circulation.
“SP can indirectly promote hemangiogenesis in tissues by recruiting granulocytes with angiogenic potential from the blood circulation61.”
From Neuropeptides Substance P and Calcitonin Gene Related Peptide Accelerate the Development and Fibrogenesis of Endometriosis (2019) · cites this paper as [61]
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- Authors
- Kohara, H., Tajima, S., Yamamoto, M., & Tabata, Y.
- Affiliations
- Kyoto University (JP)
- ORCID
- Yamamoto, Masaya
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2010-11
- Volume
- 31
- Issue
- 33
- Pages
- 8617-8625
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2040055558
- Cited by
- 99
- References
- 61
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 7 · 2023: 6 · 2022: 4 · 2021: 6 · 2020: 5 · 2019: 7 · 2018: 14 · 2017: 8 · 2016: 10 · 2015: 8 · 2014: 6 · 2013: 3 · 2012: 7
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- Kyoto University Research Information Repository (Kyoto University) (submittedVersion)
- Funders
- Japan Society for the Promotion of Science
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- substance P, neuropeptides, therapeutic angiogenesis, controlled release, biodegradable hydrogels, granulocytes, cell recruitment, wound healing, inflammation, angiogenic gene expression
- MeSH terms
- Animals, Cattle, Cell Adhesion, Cell Movement, Delayed-Action Preparations, Fluorescent Antibody Technique, Gelatin, Gene Expression Regulation, Granulocytes, Humans, Substance P, Neovascularization, Physiologic, Prosthesis Implantation, Hydrogel, Polyethylene Glycol Dimethacrylate, Sus scrofa, Mice
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