Polymeric micelles from poly (ethylene glycol)–poly (amino acid) block copolymer for drug and gene delivery
Open accessAbstract
Dramatic advances in biological research have revealed the mechanisms underlying many diseases at the molecular level. However, conventional techniques may be inadequate for direct application of this new knowledge to medical treatments. Nanobiotechnology, which integrates biology with the rapidly growing field of nanotechnology, has great potential to overcome many technical problems and lead to the development of effective therapies. The use of nanobiotechnology in drug delivery systems (DDS) is attractive for advanced treatment of conditions such as cancer and genetic diseases. In this review paper for a special issue on biomaterial research in Japan, we discuss the development of DDS based on polymeric micelles mainly in our group for anti-cancer drug and gene delivery, and also address our challenges associated with developing polymeric micelles as super-functionalized nanodevices with intelligent performance.
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PEG-b-P(Asp) and PEG-b-P(Glu) can form coordination complexes with platinum drugs such as cisplatin, DACHPt, and oxaliplatin.
“In subsequent studies, a different type of “conjugates” was developed using PEG-b-P(Asp) and PEG-b-P(Glu) – which can form a coordination complex with drugs containing transition metal complexes such as cis-dichlorodiammineplatinum(II) (cisplatin, CDDP), dichloro(1,2-diaminocyclohexane)platinum(II) (DACHPt) and cis-oxalato-(trans-l)-1,2-diaminocyclohexane-platinum(II) (oxaliplatin) [151].”
From Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval. (2020) · cites this paper as [151]
The micelle-delivery sections and Figure 4 describe coordination complexes of PEG-PAsp or PEG-PGlu with cisplatin and DACHPt. The paper mentions oxaliplatin as a free-drug comparator, not as a drug shown to form one of these polymer complexes. Page numbers are unavailable in our copy. (LLM, conf=0.89)
Experimental — accuracy not yet measuredPEG-b-P(Asp) and PEG-b-P(Glu) can create a stable complex with transition metal complexes-based drugs such as cisplatin, DACHPt, and oxaliplatin.
“A different class of “conjugate” was established in later studies using PEG-b-P(Asp) and PEG-b-P(Glu), which can create a stable complex with transition metal complexes-based drugs such as cis-dichlorodiammine platinum(II) (cisplatin), dichloro(1,2-diaminocyclohexane)platinum(II) (DACHPt) and cis-oxalato-(trans-l)-12-diaminocyclohexane-platinum(II) (oxaliplatin) [110].”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [110]
The micelle passages and Figure 4 caption describe PEG-PAsp and PEG-PGlu forming platinum coordination complexes with cisplatin (CDDP) or DACHPt. Section 4.1 mentions oxaliplatin only as a related free drug used for comparison, not as a drug complexed with either polymer. No page numbers are provided in our copy. (LLM, conf=0.88)
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Block copolymer micelles in nanomedicine applications
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“In subsequent studies, a different type of “conjugate”was developed using PEG-b-P(Asp) and PEG-b-P(Glu) –which can form a coordination complex with drugs containing transition metal complexes such as cisdichlorodiammineplatinum(II) (cisplatin, CDDP), dichloro(1,2diaminocyclohexane)platinum(II) (DACHPt) and cis-oxalato…”
BackgroundRecent Advances in Nanomicelles Delivery Systems.
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Preparation of protein-loaded PEG-PLA micelles and the effects of ultrasonication on particle size
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- Authors
- Osada, K., Christie, R. J., & Kataoka, K.
- Affiliations
- The University of Tokyo (JP)
- Center for Disease Biology and Integrative Medicine, The University of Tokyo (JP)
- Corresponding author
- Kataoka, Kazunori
- Venue
- Journal of The Royal Society Interface
- Publisher
- The Royal Society
- Published
- 2009-04
- Volume
- 6
- Issue
- suppl_3
- Pages
- S325-39
- ISSN
- 1742-5662 (ISSN-L)
- 1742-5689
- PMC
- PMC2690088
- OpenAlex
- W2120258853
- Cited by
- 218
- References
- 132
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 5 · 2023: 5 · 2022: 4 · 2021: 3 · 2020: 13 · 2019: 16 · 2018: 10 · 2017: 16 · 2016: 18 · 2015: 14 · 2014: 23 · 2013: 30 · 2012: 13
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of The Royal Society Interface (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Keywords
- polymeric micelles, drug delivery, gene delivery, nanobiotechnology, anticancer agents, polymeric nanoparticles
- MeSH terms
- Amino Acids, Antineoplastic Agents, DNA, Drug Stability, Humans, Micelles, Plasmids, Polyethylene Glycols, Gene Expression, Drug Delivery Systems, Gene Transfer Techniques, Nanotechnology
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