Cited by 218Nanoparticle-Based Drug DeliveryRNA Interference and Gene DeliveryDendrimers and Hyperbranched Polymers

Polymeric micelles from poly (ethylene glycol)–poly (amino acid) block copolymer for drug and gene delivery

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Osada, Kensuke, Christie, R. James, Kataoka, Kazunori·2009·Journal of The Royal Society Interface

Abstract

Dramatic advances in biological research have revealed the mechanisms underlying many diseases at the molecular level. However, conventional techniques may be inadequate for direct application of this new knowledge to medical treatments. Nanobiotechnology, which integrates biology with the rapidly growing field of nanotechnology, has great potential to overcome many technical problems and lead to the development of effective therapies. The use of nanobiotechnology in drug delivery systems (DDS) is attractive for advanced treatment of conditions such as cancer and genetic diseases. In this review paper for a special issue on biomaterial research in Japan, we discuss the development of DDS based on polymeric micelles mainly in our group for anti-cancer drug and gene delivery, and also address our challenges associated with developing polymeric micelles as super-functionalized nanodevices with intelligent performance.

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Crossref · 10.1098/rsif.2008.0547.focus

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  • PEG-b-P(Asp) and PEG-b-P(Glu) can form coordination complexes with platinum drugs such as cisplatin, DACHPt, and oxaliplatin.

    “In subsequent studies, a different type of “conjugates” was developed using PEG-b-P(Asp) and PEG-b-P(Glu) – which can form a coordination complex with drugs containing transition metal complexes such as cis-dichlorodiammineplatinum(II) (cisplatin, CDDP), dichloro(1,2-diaminocyclohexane)platinum(II) (DACHPt) and cis-oxalato-(trans-l)-1,2-diaminocyclohexane-platinum(II) (oxaliplatin) [151].”

    From Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval. (2020) · cites this paper as [151]

    The micelle-delivery sections and Figure 4 describe coordination complexes of PEG-PAsp or PEG-PGlu with cisplatin and DACHPt. The paper mentions oxaliplatin as a free-drug comparator, not as a drug shown to form one of these polymer complexes. Page numbers are unavailable in our copy. (LLM, conf=0.89)

    Experimental — accuracy not yet measured
  • PEG-b-P(Asp) and PEG-b-P(Glu) can create a stable complex with transition metal complexes-based drugs such as cisplatin, DACHPt, and oxaliplatin.

    “A different class of “conjugate” was established in later studies using PEG-b-P(Asp) and PEG-b-P(Glu), which can create a stable complex with transition metal complexes-based drugs such as cis-dichlorodiammine platinum(II) (cisplatin), dichloro(1,2-diaminocyclohexane)platinum(II) (DACHPt) and cis-oxalato-(trans-l)-12-diaminocyclohexane-platinum(II) (oxaliplatin) [110].”

    From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [110]

    The micelle passages and Figure 4 caption describe PEG-PAsp and PEG-PGlu forming platinum coordination complexes with cisplatin (CDDP) or DACHPt. Section 4.1 mentions oxaliplatin only as a related free drug used for comparison, not as a drug complexed with either polymer. No page numbers are provided in our copy. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

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Authors
Osada, K., Christie, R. J., & Kataoka, K.
Affiliations
  • The University of Tokyo (JP)
  • Center for Disease Biology and Integrative Medicine, The University of Tokyo (JP)
Corresponding author
Kataoka, Kazunori
Venue
Journal of The Royal Society Interface
Published
2009-04
Volume
6
Issue
suppl_3
Pages
S325-39
ISSN
  • 1742-5662 (ISSN-L)
  • 1742-5689
OpenAlex
W2120258853
Cited by
218
References
132
Citations by year
2026: 3 · 2025: 9 · 2024: 5 · 2023: 5 · 2022: 4 · 2021: 3 · 2020: 13 · 2019: 16 · 2018: 10 · 2017: 16 · 2016: 18 · 2015: 14 · 2014: 23 · 2013: 30 · 2012: 13
FWCI
0.79
Type
journal article
Language
en
Open access
Locations
  • Journal of The Royal Society Interface (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
  • Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
Keywords
polymeric micelles, drug delivery, gene delivery, nanobiotechnology, anticancer agents, polymeric nanoparticles
MeSH terms
Amino Acids, Antineoplastic Agents, DNA, Drug Stability, Humans, Micelles, Plasmids, Polyethylene Glycols, Gene Expression, Drug Delivery Systems, Gene Transfer Techniques, Nanotechnology

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