The DOI matches its Crossref record; 280 of the 280 references it cites were found in a registry or an index.
Neural tissue engineering options for peripheral nerve regeneration
Abstract
Tissue engineered nerve grafts (TENGs) have emerged as a potential alternative to autologous nerve grafts, the gold standard for peripheral nerve repair. Typically, TENGs are composed of a biomaterial-based template that incorporates biochemical cues. A number of TENGs have been used experimentally to bridge long peripheral nerve gaps in various animal models, where the desired outcome is nerve tissue regeneration and functional recovery. So far, the translation of TENGs to the clinic for use in humans has met with a certain degree of success. In order to optimize the TENG design and further approach the matching of TENGs with autologous nerve grafts, many new cues, beyond the traditional ones, will have to be integrated into TENGs. Furthermore, there is a strong requirement for monitoring the real-time dynamic information related to the construction of TENGs. The aim of this opinion paper is to specifically and critically describe the latest advances in the field of neural tissue engineering for peripheral nerve regeneration. Here we delineate new attempts in the design of template (or scaffold) materials, especially in the context of biocompatibility, the choice and handling of support cells, and growth factor release systems. We further discuss the significance of RNAi for peripheral nerve regeneration, anticipate the potential application of RNAi reagents for TENGs, and speculate on the possible contributions of additional elements, including angiogenesis, electrical stimulation, molecular inflammatory mediators, bioactive peptides, antioxidant reagents, and cultured biological constructs, to TENGs. Finally, we consider that a diverse array of physicochemical and biological cues must be orchestrated within a TENG to create a self-consistent coordinated system with a close proximity to the regenerative microenvironment of the peripheral nervous system.
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“First, the degradation rate of PLCL must be carefully matched to the regeneration rate of peripheral nerves. Excessively rapid degradation will lead to the loss of mechanical support of scaffolds, and the acidic products generated by the degradation of PLCL will also adversely affect nerve growth. Too long degradation time may also interfere with the growth of new nerve tissue [179].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [179]
In the citing paper
“For peripheral nerve regeneration, these scaffolds must first provide a suitable external environment for nerve fiber growth, using biomaterials to bridge the gap between interrupted nerve fibers. They should also possess sufficient mechanical strength to protect the damaged nerve tissue from secondary compression and invasion by surrounding tissues [179].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [179]
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Metadata
- Authors
- Gu, X., Ding, F., & Williams, D. F.
- Affiliations
- Nantong University (CN)
- Wake Forest University Health Sciences (US)
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 35
- Issue
- 24
- Pages
- 6143-6156
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W1985525878
- Cited by
- 630
- References
- 280
- Citations by year
- 2026: 23 · 2025: 44 · 2024: 42 · 2023: 57 · 2022: 72 · 2021: 57 · 2020: 70 · 2019: 73 · 2018: 73 · 2017: 46 · 2016: 40 · 2015: 24 · 2014: 9
- FWCI
- 4.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Key Basic Research Program of China (2014CB542202)
- Hi-Tech Research and Development Program of China (2012AA020502)
- National Natural Science Foundation of China (81130080, 81171180)
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Keywords
- peripheral nerve regeneration, tissue-engineered nerve grafts, neural scaffolds, biocompatibility, supporting cells, growth factor release, RNA interference, angiogenesis, electrical stimulation, inflammatory mediators, bioactive peptides, autologous nerve graft, functional recovery
- MeSH terms
- Animals, Biocompatible Materials, Humans, Nerve Regeneration, Peripheral Nerves, Tissue Engineering, RNA Interference, Tissue Scaffolds
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