Cited by 630Nerve injury and regenerationTissue Engineering and Regenerative MedicineNeuroscience and Neural Engineering

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Neural tissue engineering options for peripheral nerve regeneration

Gu, Xiaosong, Ding, Fei, Williams, David F.·2014·Biomaterials

DOI 10.1016/j.biomaterials.2014.04.064

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Abstract

Tissue engineered nerve grafts (TENGs) have emerged as a potential alternative to autologous nerve grafts, the gold standard for peripheral nerve repair. Typically, TENGs are composed of a biomaterial-based template that incorporates biochemical cues. A number of TENGs have been used experimentally to bridge long peripheral nerve gaps in various animal models, where the desired outcome is nerve tissue regeneration and functional recovery. So far, the translation of TENGs to the clinic for use in humans has met with a certain degree of success. In order to optimize the TENG design and further approach the matching of TENGs with autologous nerve grafts, many new cues, beyond the traditional ones, will have to be integrated into TENGs. Furthermore, there is a strong requirement for monitoring the real-time dynamic information related to the construction of TENGs. The aim of this opinion paper is to specifically and critically describe the latest advances in the field of neural tissue engineering for peripheral nerve regeneration. Here we delineate new attempts in the design of template (or scaffold) materials, especially in the context of biocompatibility, the choice and handling of support cells, and growth factor release systems. We further discuss the significance of RNAi for peripheral nerve regeneration, anticipate the potential application of RNAi reagents for TENGs, and speculate on the possible contributions of additional elements, including angiogenesis, electrical stimulation, molecular inflammatory mediators, bioactive peptides, antioxidant reagents, and cultured biological constructs, to TENGs. Finally, we consider that a diverse array of physicochemical and biological cues must be orchestrated within a TENG to create a self-consistent coordinated system with a close proximity to the regenerative microenvironment of the peripheral nervous system.

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Enhancement of regeneration with glia cell line–derived neurotrophic factor–transduced human amniotic fluid mesenchymal stem cells after sciatic nerve crush injury [RETRACTED]
Cheng, F., Tai, M., Sheu, M., Chen, C., Yang, D., Su, H., Ho, S.-P., Lai, S.-Z., & Pan, H.-C. (2009) · Journal of neurosurgery · doi:10.3171/2009.8.jns09850 · Cited by 70
Retracted
MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., & Mello, C. C. (1998) · Nature · doi:10.1038/35888 · Cited by 15,429
Most mammalian mRNAs are conserved targets of microRNAs
Friedman, R. C., Farh, K. K.-H., Burge, C. B., & Bartel, D. P. (2009) · Genome Research · doi:10.1101/gr.082701.108 · Cited by 8,462
Knocking down barriers: advances in siRNA delivery
Whitehead, K. A., Langer, R., & Anderson, D. G. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2742 · Cited by 3,115
On the mechanisms of biocompatibility
Williams, D. F. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.04.023 · Cited by 2,772
Self-citation
Long noncoding RNAs: functional surprises from the RNA worldPreprint
Wilusz, J. E., Sunwoo, H., & Spector, D. L. (2009) · Genes & Development · doi:10.1101/gad.1800909 · Cited by 2,322
Bone Marrow Stromal Stem Cells: Nature, Biology, and Potential Applications
Bianco, P., Riminucci, M., Gronthos, S., & Robey, P. G. (2001) · Stem Cells · doi:10.1634/stemcells.19-3-180 · Cited by 1,944
Long noncoding RNAs and human disease
Wapinski, O. L., & Chang, H. Y. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.04.001 · Cited by 1,925
Concise Review: Mesenchymal Stem/Multipotent Stromal Cells: The State of Transdifferentiation and Modes of Tissue Repair—Current Views
Phinney, D. G., & Prockop, D. J. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0637 · Cited by 1,910

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A Silk Sericin/Silicone Nerve Guidance Conduit Promotes Regeneration of a Transected Sciatic Nerve
Xie, H., Yang, W., Chen, J., Zhang, J., Lu, X., Zhao, X., Huang, K., Li, H., Chang, P., Wang, Z., et al. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201500355 · Cited by 97
Surface-anchored Graphene Oxide Nanosheets on Cell-scale Micropatterned Poly(D,L-lactide-co-caprolactone) Conduits Promote Peripheral Nerve Regeneration.
Zhang, D., Yao, Y., Duan, Y.-Y., Yu, X., Shi, H.-F., Nakkala, J. R., Zuo, X., Hong, L., Mao, Z.-W., & Gao, C.-Y. (2020) · ACS Applied Materials and Interfaces · doi:10.1021/acsami.9b20321 · Cited by 89
Neural tissue engineering: From bioactive scaffolds and in situ monitoring to regeneration
Gong, B., Zhang, X., Zahrani, A. A., Gao, W., Ma, G., Zhang, L., & Xue, J. (2022) · Exploration · doi:10.1002/exp.20210035 · Cited by 96
Silencing of circRNA.2837 Plays a Protective Role in Sciatic Nerve Injury by Sponging the miR-34 Family via Regulating Neuronal Autophagy
Zhou, Z., Niu, Y., Huang, G.-X., Lu, J., Chen, A., & Zhu, L. (2018) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2018.07.011 · Cited by 94
Aligned microchannel polymer-nanotube composites for peripheral nerve regeneration: Small molecule drug delivery
Manoukian, O. S., Arul, M. R., Rudraiah, S., Kalajzić, I., & Kumbar, S. G. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.01.013 · Cited by 93
3D printing scaffold coupled with low level light therapy for neural tissue regeneration
Zhu, W., George, J., Sorger, V. J., & Zhang, L. G. (2017) · Biofabrication · doi:10.1088/1758-5090/aa6999 · Cited by 92
Polymer Scaffolds with Preferential Parallel Grooves Enhance Nerve Regeneration
Mobasseri, S. A., Faroni, A., Minogue, B. M., Downes, S., Terenghi, G., & Reid, A. J. (2014) · Tissue Engineering Part A · doi:10.1089/ten.tea.2014.0266 · Cited by 92
Constructing conductive conduit with conductive fibrous infilling for peripheral nerve regeneration
Wei, J., Ao, Q., Wang, L., Huang, Z., Cai, Q., Chen, G., Yang, X., & Zhong, W. (2018) · Chemical Engineering Journal · doi:10.1016/j.cej.2018.04.044 · Cited by 91
Freeze-Drying Process for the Fabrication of Collagen-Based Sponges as Medical Devices in Biomedical Engineering
Katrilaka, C., Karipidou, N., Petrou, N., Manglaris, C., Katrilakas, G., Tzavellas, A.-N., Pitou, M., Tsiridis, E. E., Choli‐Papadopoulou, T., & Aggeli, A. (2023) · Materials · doi:10.3390/ma16124425 · Cited by 93
Development of Nanofiber Sponges-Containing Nerve Guidance Conduit for Peripheral Nerve Regeneration in Vivo
Sun, B., Zhou, Z., Wu, T. S., Chen, W., Li, D., Zheng, H., El‐Hamshary, H., Al‐Deyab, S. S., Mo, X., & Yu, Y. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b06707 · Cited by 90
Conductive micropatterned polyurethane films as tissue engineering scaffolds for Schwann cells and PC12 cells
Wu, Y., Wang, L., Hu, T., Ma, P. X., & Guo, B. (2018) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2018.02.036 · Cited by 90
Aligned fibrin/functionalized self-assembling peptide interpenetrating nanofiber hydrogel presenting multi-cues promotes peripheral nerve functional recovery
Yang, S., Zhu, J., Lu, C., Chai, Y., Cao, Z., Lü, J., Zhang, Z., Zhao, H., Huang, Y.-Y., Yao, S., et al. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.05.056 · Cited by 90
3D Bioprinting Technologies for Tissue Engineering Applications
Gu, B. K., Choi, D. J., Park, S. J., Kim, Y., & Kim, C. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-0950-2_2 · Cited by 95
Biomimetic and hierarchical nerve conduits from multifunctional nanofibers for guided peripheral nerve regeneration
Wang, J., Cheng, Y. G., Wang, H., Wang, Y., Zhang, K., Fan, C., Wang, H., & Mo, X. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.09.037 · Cited by 89
The electrostimulation and scar inhibition effect of chitosan/oxidized hydroxyethyl cellulose/reduced graphene oxide/asiaticoside liposome based hydrogel on peripheral nerve regeneration in vitro
Zheng, F., Li, R., He, Q., Koral, K., Tao, J., Fan, L., Xiang, R., Ma, J., Wang, N., Yin, Y., et al. (2020) · Materials Science and Engineering: C · doi:10.1016/j.msec.2019.110560 · Cited by 88
Cell therapies for spinal cord injury: a review of the clinical trials and cell-type therapeutic potential
Ribeiro, B. F., Cruz, B. D., de Sousa, B. M., Correia, P. D., David, N., Rocha, C., Almeida, R. D., Cunha, M., Baptista, A. M., & Vieira, S. I. (2023) · Brain · doi:10.1093/brain/awad047 · Cited by 88
The regulatory roles of non-coding RNAs in nerve injury and regeneration
Yu, B., Zhou, S., Yi, S., & Gu, X. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.09.006 · Cited by 87
Self-citation
Decellularized nerve matrix hydrogel scaffolds with longitudinally oriented and size-tunable microchannels for peripheral nerve regeneration
Rao, Z., Lin, T., Qiu, S., Zhou, J., Liu, S., Chen, S., Wang, T., Liu, X., Zhu, Q., Bai, Y., et al. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.111791 · Cited by 87
OUP accepted manuscript
Yi, S., Zhang, Y., Gu, X., Huang, L., Zhang, K., Qian, T., & Gu, X. (2020) · Burns & Trauma · doi:10.1093/burnst/tkaa002 · Cited by 87
Self-citation
Augmented peripheral nerve regeneration through elastic nerve guidance conduits prepared using a porous PLCL membrane with a 3D printed collagen hydrogel
Yoo, J., Park, J. H., Kwon, Y. W., Chung, J. J., Choi, I. C., Nam, J. J., Lee, H. S., Jeon, E. Y., Lee, K., Kim, S. H., et al. (2020) · Biomaterials Science · doi:10.1039/d0bm00847h · Cited by 86
The transcriptional landscape of dorsal root ganglia after sciatic nerve transection
Li, S., Xue, C., Yuan, Y., Zhang, R., Wang, Y., Wang, Y., Yu, B., Liu, J., Ding, F., Yang, Y., et al. (2015) · Scientific Reports · doi:10.1038/srep16888 · Cited by 85
Self-citation
Nanotechnology in peripheral nerve repair and reconstruction
Carvalho, C. R., Silva‐Correia, J., Oliveira, J. M., & Reis, R. L. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.006 · Cited by 86
An update–tissue engineered nerve grafts for the repair of peripheral nerve injuries
Huang, J. H., Patel, N. P., & Lyon, K. A. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.232458 · Cited by 84
Polydopamine‐Decorated PLCL Conduit to Induce Synergetic Effect of Electrical Stimulation and Topological Morphology for Peripheral Nerve Regeneration
Lu, S., Chen, W., Wang, J., Guo, Z., Xiao, L., Wei, L., Yu, J., Yuan, Y., Chen, W., Bian, M., et al. (2023) · Small Methods · doi:10.1002/smtd.202200883 · Cited by 82

Authors: Gu, X., Ding, F., & Williams, D. F.
Affiliations: Nantong University (CN)
Wake Forest University Health Sciences (US)
ORCID: Gu, Xiaosong
Ding, Fei
Williams, David F.
Venue: Biomaterials
Publisher: Elsevier BV
Published: 2014-08
Volume: 35
Issue: 24
Pages: 6143-6156
ISSN: 0142-9612 (ISSN-L)
DOI: 10.1016/j.biomaterials.2014.04.064
OpenAlex: W1985525878
Cited by: 630
References: 280
Citations by year: 2026: 23 · 2025: 44 · 2024: 42 · 2023: 57 · 2022: 72 · 2021: 57 · 2020: 70 · 2019: 73 · 2018: 73 · 2017: 46 · 2016: 40 · 2015: 24 · 2014: 9
FWCI: 4.52
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biomaterials (publishedVersion)
PubMed (publishedVersion)
Funders: National Key Basic Research Program of China (2014CB542202)
Hi-Tech Research and Development Program of China (2012AA020502)
National Natural Science Foundation of China (81130080, 81171180)
Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
Keywords: peripheral nerve regeneration, tissue-engineered nerve grafts, neural scaffolds, biocompatibility, supporting cells, growth factor release, RNA interference, angiogenesis, electrical stimulation, inflammatory mediators, bioactive peptides, autologous nerve graft, functional recovery
MeSH terms: Animals, Biocompatible Materials, Humans, Nerve Regeneration, Peripheral Nerves, Tissue Engineering, RNA Interference, Tissue Scaffolds

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Neural tissue engineering options for peripheral nerve regeneration

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