Cited by 124Photodynamic Therapy Research StudiesNanoplatforms for cancer theranosticsCancer Immunotherapy and Biomarkers

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Light-controlled oxygen production and collection for sustainable photodynamic therapy in tumor hypoxia

Wang, Haoran, Guo, Yunfei, Wang, Chao, Jiang, Xing, Liu, Honghui, Yuan, Ahu, Yan, Jing, Hu, Yiqiao, Wu, Jinhui·2021·Biomaterials

DOI 10.1016/j.biomaterials.2020.120621

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Abstract

Hypoxia exists in most malignant tumors and often contributes to therapy resistance, especially for aerobic treatments such as photodynamic therapy (PDT) and radiotherapy. Here, we developed a novel light-controlled sustainable PDT in which light was used to help photosynthetic microorganisms (Chlorella) produce oxygen, and perfluorocarbon was used to enrich oxygen around the photosensitizer for sustained oxygen supply. After light stops, Chlorella further acts as an adjuvant to promote dendritic cell (DC) activation, promoting the antitumor immune response. We showed that sustainable PDT could continuously provide oxygen for photosensitizers and avoid PDT-induced local hypoxia. More importantly, sustainable PDT also promoted the activation of DCs and amplified the antitumor immune effects. Therefore, this novel strategy provides an effective but simple method for improving PDT in both tumor hypoxia and normoxia, and enhancing the antitumor immunity may be a new anti-resistance strategy for treating patients with advanced-stage cancer.

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Authors: Wang, H., Guo, Y., Wang, C., Jiang, X., Liu, H., Yuan, A., Yan, J., Hu, Y., & Wu, J.
Affiliations: State Key Laboratory of Pharmaceutical Biotechnology (CN)
Nanjing University of Chinese Medicine (CN)
Nanjing Drum Tower Hospital (CN)
Corresponding author: Wu, Jinhui
ORCID: Wang, Haoran
Guo, Yunfei
Wang, Chao
Jiang, Xing
Yuan, Ahu
Yan, Jing
Hu, Yiqiao
Wu, Jinhui
Venue: Biomaterials
Publisher: Elsevier BV
Published: 2021-02
Volume: 269
Pages: 120621
ISSN: 0142-9612 (ISSN-L)
DOI: 10.1016/j.biomaterials.2020.120621
OpenAlex: W3114005745
Cited by: 124
References: 69
Citations by year: 2026: 13 · 2025: 22 · 2024: 25 · 2023: 25 · 2022: 25 · 2021: 14
FWCI: 9.01
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Biomaterials (publishedVersion)
PubMed (publishedVersion)
Funders: Outstanding Youth Foundation of Jiangsu Province of China
Fundamental Research Funds for the Central Universities
National Natural Science Foundation of China
National Key Research and Development Program of China
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Keywords: photodynamic therapy, tumor hypoxia, Chlorella, photosynthetic microorganisms, perfluorocarbon oxygen carriers, photosensitizers, dendritic cell activation, antitumor immunity, cancer immunotherapy, treatment resistance
MeSH terms: Tumor Hypoxia, Hypoxia, Chlorella, Humans, Oxygen, Photochemotherapy, Photosensitizing Agents, Cell Line, Tumor

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Light-controlled oxygen production and collection for sustainable photodynamic therapy in tumor hypoxia

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