Cited by 179Advancements in Transdermal Drug DeliveryAdvanced Drug Delivery SystemsTissue Engineering and Regenerative Medicine

The DOI matches its Crossref record; 271 of the 274 references it cites were found in a registry or an index.

Wearable and implantable devices for drug delivery: Applications and challenges

Kar, Abhinanda, Ahamad, Nadim, Dewani, Mahima, Awasthi, Lisha, Patil, Runali, Banerjee, Rinti·2022·Biomaterials

DOI 10.1016/j.biomaterials.2022.121435

Open this paper in CoChat — free account

Abstract

Poor adherence to drug dosing schedule is responsible for ∼50% of hospitalization cases. Most patients fail to adhere to a strict dosing schedule due to invasive drug administration, off-target toxicities, or medical conditions like dementia. The emerging concept of wearable devices (WDs), implantable devices (IDs) and combined wearable and implantable devices (WIDs) for drug delivery has created new opportunities for treating patients with chronic diseases needing repeated and long-term medical attention like diabetes, ocular disorders, cancer, wound healing, cardiovascular diseases, and contraception. WDs, worn on the body surface have created appealing non-invasive, self-administrable drug delivery platforms which receive huge patient compliance. Microneedle-skin patches, wound healing patches, drug-eluting contact lenses, mouth guards, intra-vaginal rings, pharmaceutical jewelry, and drug-loaded self-care textiles are popular WDs explored in drug delivery. In contrast, IDs are surgically placed inside body tissue allowing higher payload and enhanced localized effect for an extended duration. Hormone micropumps, hydrogel/nanofibrous depot, coronary stents, intravitreal devices, and intrauterine devices are some representative examples of IDs. In this review, we have described the past 10 years of research progress on drug-delivering WDs and IDs in the context of treating diseases that demand repeated and long-term medication, especially those affecting soft tissues. We highlighted several technical challenges that need to be addressed before considering the translation of such technologies to clinics.

Integrity signals

Registry

Crossref · 10.1016/j.biomaterials.2022.121435

Cites

271 of 271 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Adherence to medication.
Osterberg, L., & Blaschke, T. (2005) · New England Journal of Medicine · doi:10.1056/nejmra050100 · Cited by 7,974
Wearable biosensors for healthcare monitoring
Kim, J., Campbell, A. S., de Ávila, B. E.-F., & Wang, J. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0045-y · Cited by 3,373
On the mechanisms of biocompatibility
Williams, D. F. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.04.023 · Cited by 2,772
A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy
Lee, H., Choi, T. K., Lee, Y. B., Cho, H. R., Ghaffari, R., Wang, L., Choi, H. J., Chung, T. D., Lu, N., Hyeon, T., et al. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2016.38 · Cited by 1,802
Multifunctional wearable devices for diagnosis and therapy of movement disorders
Son, D., Lee, J., Qiao, S., Ghaffari, R., Kim, J., Lee, J. E., Song, C., Kim, S. J., Lee, D. J., Jun, S. W., et al. (2014) · Nature Nanotechnology · doi:10.1038/nnano.2014.38 · Cited by 1,462
Immune responses to implants – a review of the implications for the design of immunomodulatory biomaterials
Franz, S., Rammelt, S., Scharnweber, D., & Simon, J. C. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.05.078 · Cited by 1,391
Microneedles: A smart approach and increasing potential for transdermal drug delivery system
Waghule, T., Singhvi, G., Dubey, S. K., Pandey, M. M., Gupta, G., Singh, M., & Dua, K. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.10.078 · Cited by 1,277
Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module
Lee, H., Song, C., Hong, Y. S., Kim, M., Cho, H. R., Kang, T., Shin, K., Choi, S. H., Hyeon, T., & Kim, D.-H. (2017) · Science Advances · doi:10.1126/sciadv.1601314 · Cited by 1,118
Advanced materials and processing for drug delivery: The past and the future
Zhang, Y., Chan, H. F., & Leong, K. W. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.10.003 · Cited by 1,008
Smart wearable systems: Current status and future challenges
Chan, M., Estève, D., Fourniols, J.-Y., Escriba, C., & Campo, E. (2012) · Artificial Intelligence in Medicine · doi:10.1016/j.artmed.2012.09.003 · Cited by 953

Show all 274 references

Research works printed but not linked: 7

2011, vol. 86, 304
Bonadies, 2017, vol. 72
Qiao, 2017, vol. 28, 149
Pons-Faudoa, 2019, Advanced implantable drug delivery technologies: transforming the clinical landscape of therapeutics for chronic diseases, Biomed. Microdevices, 21, 1, 10.1007/s10544-019-0389-6 · DOI
Yang, 2020, E-jet 3D printed drug delivery implants to inhibit growth and metastasis of orthotopic breast cancer, Biomaterials, 230
Gao, 2014, vol. 853, 101
Iqbal, 2013, Coronary stents: historical development, current status and future directions, Br. Med. Bull., 106, 193, 10.1093/bmb/ldt009 · DOI

Sorted by citations

Artificial intelligence enhanced sensors - enabling technologies to next-generation healthcare and biomedical platform
Wang, C., He, T., Zhou, H., Zhang, Z., & Lee, C. (2023) · Bioelectronic Medicine · doi:10.1186/s42234-023-00118-1 · Cited by 295
Flexible and Stretchable Light-Emitting Diodes and Photodetectors for Human-Centric Optoelectronics
Chang, S., Koo, J. H., Yoo, J., Kim, M. S., Choi, M. K., Kim, D., & Song, Y. M. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00548 · Cited by 218
Ultrasound-triggered interfacial engineering-based microneedle for bacterial infection acne treatment
Xiang, Y., Lu, J., Mao, C., Zhu, Y., Wang, C., Wu, J., Liu, X., Wu, S., Kwan, K. Y.-H., Cheung, K., et al. (2023) · Science Advances · doi:10.1126/sciadv.adf0854 · Cited by 192
Digital health: trends, opportunities and challenges in medical devices, pharma and bio-technology
Kasoju, N., Remya, N. S., Sasi, R., Sreedharan, S., Soman, B., Kesavadas, C., Muraleedharan, C. V., Varma, P. R. H., & Behari, S. (2023) · CSI Transactions on ICT · doi:10.1007/s40012-023-00380-3 · Cited by 197
Clinical applications and therapeutic potentials of advanced nanoparticles: a comprehensive review on completed human clinical trials
Kumarasamy, R. V., Natarajan, P. M., Umapathy, V. R., Roy, J. R., Mironescu, M., & Palanisamy, C. P. (2024) · Frontiers in Nanotechnology · doi:10.3389/fnano.2024.1479993 · Cited by 154
Smart Dual‐Sensor Wound Dressing for Monitoring Cutaneous Wounds
Mirani, B., Hadisi, Z., Pagan, E., Dabiri, S. M. H., van Rijt, A., Almutairi, L., Noshadi, I., Armstrong, D. G., & Akbari, M. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202203233 · Cited by 132
Material and structural considerations for high-performance electrodes for wearable skin devices
Lim, K., Seo, H., Chung, W. G., Song, H., Oh, M., Ryu, S. Y., Kim, Y., & Park, J. (2024) · Communications Materials · doi:10.1038/s43246-024-00490-8 · Cited by 142
Review of Flexible Wearable Sensor Devices for Biomedical Application
Nan, X., Wang, X., Kang, T., Zhang, J., Dong, L., Dong, J., Xia, P., & Wei, D. (2022) · Micromachines · doi:10.3390/mi13091395 · Cited by 109
Composite microneedles loaded with Astragalus membranaceus polysaccharide nanoparticles promote wound healing by curbing the ROS/NF-κB pathway to regulate macrophage polarization
Liu, X., Guo, C., Yang, W., Wang, W., Diao, N., Cao, M., Cao, Y., Wang, X., Wang, X., Pei, H., et al. (2024) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2024.122574 · Cited by 105
Innovative Robotic Technologies and Artificial Intelligence in Pharmacy and Medicine: Paving the Way for the Future of Health Care—A Review
Stasevych, M., & Zvarych, V. I. (2023) · Big Data and Cognitive Computing · doi:10.3390/bdcc7030147 · Cited by 120
Advancements in Wearable and Implantable BioMEMS Devices: Transforming Healthcare Through Technology
Abhinav, V., Basu, P., Verma, S. S., Verma, J., Das, A., Kumari, S., Yadav, P. R., & Kumar, V. (2025) · Micromachines · doi:10.3390/mi16050522 · Cited by 106
Materials and device design for advanced phototherapy systems
Lee, J. S., Kim, J., Ye, Y., & Kim, T. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114339 · Cited by 83
Materials design and integration strategies for soft bioelectronics in digital healthcare
Kim, H. J., Koo, J. H., Lee, S., Hyeon, T., & Kim, D. (2025) · Nature Reviews Materials · doi:10.1038/s41578-025-00819-w · Cited by 88
Dual drug-loaded hydrogels with pH-responsive and antibacterial activity for skin wound dressing
Du, M., Jin, J., Zhou, F., Chen, J., & Jiang, W. (2022) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2022.113063 · Cited by 78
Soft Bioelectronics for Therapeutics
Zhang, Z., Zhu, Z., Zhou, P., Zou, Y., Yang, J., Haick, H., & Wang, Y. (2023) · ACS Nano · doi:10.1021/acsnano.3c02513 · Cited by 79
Remote‐Controlled Sensing and Drug Delivery via 3D‐Printed Hollow Microneedles
Razzaghi, M., Ninan, J. A., Azimzadeh, M., Askari, E., Najafabadi, A. H., Khademhosseini, A., & Akbari, M. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400881 · Cited by 78
Electroactive Polymers for On‐Demand Drug Release
Alkahtani, M. E., Elbadawi, M., Chapman, C. A. R., Green, R. A., Gaisford, S., Orlu, M., & Basit, A. W. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202301759 · Cited by 76
Emerging Wearable Chemical Sensors Enabling Advanced Integrated Systems toward Personalized and Preventive Medicine
He, T., Wen, F., Yang, Y., Le, X., Liu, W., & Lee, C. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.2c04527 · Cited by 75
Therapeutic applications of contact lens-based drug delivery systems in ophthalmic diseases
Zhao, L., Song, J., Du, Y., Ren, C., Guo, B., & Bi, H. (2023) · Drug Delivery · doi:10.1080/10717544.2023.2219419 · Cited by 77
Biomedical Metal–Organic framework materials on antimicrobial therapy: Perspectives and challenges
Hu, W., Ouyang, Q., Jiang, C., Huang, S., Nezamzadeh‐Ejhieh, A., Guo, D., Liu, J., & Peng, Y. (2024) · Materials Today Chemistry · doi:10.1016/j.mtchem.2024.102300 · Cited by 71
Recent advances of smart materials for ocular drug delivery
Wang, X., Luan, F., Yue, H., Song, C., Wang, S., Feng, J., Zhang, X., Yang, W. H., Li, Y., Wei, W., et al. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.115006 · Cited by 70
Artificial intelligence in smart drug delivery systems: a step toward personalized medicine
Panchpuri, M., Painuli, R., & Kumar, C. (2025) · RSC Pharmaceutics · doi:10.1039/d5pm00089k · Cited by 66
Hydrogel-Coated SERS Microneedles for Drug Monitoring in Dermal Interstitial Fluid
Yan, L., Wang, Y., Mei, R., Lv, B., Zhao, X., Bi, L., Xu, H. Z., & Chen, L. (2024) · ACS Sensors · doi:10.1021/acssensors.4c00276 · Cited by 58
Microfluidic technologies for wearable and implantable biomedical devices
Wang, Z., Shah, A., Lee, H., & Lee, C. H. (2025) · Lab on a Chip · doi:10.1039/d5lc00499c · Cited by 62
Gallic Acid-Loaded Sodium Alginate-Based (Polyvinyl Alcohol-Co-Acrylic Acid) Hydrogel Membranes for Cutaneous Wound Healing: Synthesis and Characterization
Naeem, A., Yu, C., Zhu, W., Chen, X., Wu, X., Chen, L., Zang, Z., & Guan, Y. (2022) · Molecules · doi:10.3390/molecules27238397 · Cited by 56
Solar-Powered Supercapacitors: A Review and Outlook on Next-Generation Sustainable Energy Storage Solutions
Yadav, A. A., Hunge, Y. M., Majumder, S., Islam, M. M., & Sakurai, T. (2025) · Energy & Fuels · doi:10.1021/acs.energyfuels.5c01661 · Cited by 54
Recent advances in the material design for intelligent wearable devices
Wu, Y., Li, Y., Tao, Y., Sun, L., & Yu, C. (2023) · Materials Chemistry Frontiers · doi:10.1039/d3qm00076a · Cited by 54
Degradable and Recyclable Hydrogels for Sustainable Bioelectronics
Jia, L., Li, Y., Ren, A., Xiang, T., & Zhou, S. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c05663 · Cited by 51
Drug Delivery Systems for Personal Healthcare by Smart Wearable Patch System
Khadka, B., Lee, B., & Kim, K.-T. (2023) · Biomolecules · doi:10.3390/biom13060929 · Cited by 50
Glycyrrhetinic Acid Liposomes Encapsulated Microcapsules from Microfluidic Electrospray for Inflammatory Wound Healing
Zhi, Y., Che, J., Zhu, H., Liu, R., & Zhao, Y. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202304353 · Cited by 46
A Hemoglobin Bionics‐Based System for Combating Antibiotic Resistance in Chronic Diabetic Wounds via Iron Homeostasis Regulation
Sun, Y., Liu, M., Sun, W., Tang, X., Zhou, Y., Zhang, J., & Yang, B. J. (2024) · Advanced Materials · doi:10.1002/adma.202405002 · Cited by 47
A battery-free nanofluidic intracellular delivery patch for internal organs
Yin, D., Wang, P., Hao, Y., Yue, W. W., Jiang, X., Yao, K., Wang, Y., Hang, X., Xiao, A., Zhou, J., et al. (2025) · Nature · doi:10.1038/s41586-025-08943-x · Cited by 48
Bonding states of gold/silver plasmonic nanostructures and sulfur-containing active biological ingredients in biomedical applications: a review
Esmailzadeh, F., Taheri‐Ledari, R., Salehi, M. M., Zarei-Shokat, S., Ganjali, F., Mohammadi, A., Zare, I., Kashtiaray, A., Jalali, F., & Maleki, A. R. (2024) · Physical Chemistry Chemical Physics · doi:10.1039/d3cp04131j · Cited by 43
Smart biomaterials in healthcare: Breakthroughs in tissue engineering, immunomodulation, patient-specific therapies, and biosensor applications
Raheem, A., Mandal, K., Biswas, S., Ahari, A. F., Najafabadi, A. H., Farhadi, N., Zehtabi, F., Gangrade, A., Mecwan, M. M., Maity, S., et al. (2025) · Applied Physics Reviews · doi:10.1063/5.0238817 · Cited by 42
Recent Advances in Hydrogels for the Diagnosis and Treatment of Dry Eye Disease
Li, Q., Cao, Y., & Wang, P. (2022) · Gels · doi:10.3390/gels8120816 · Cited by 39
Rise of implantable drugs: A chronicle of breakthroughs in drug delivery systems
Huanbutta, K., Puri, V., Sharma, A., Singh, I., Sriamornsak, P., & Sangnim, T. (2024) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2024.102193 · Cited by 38
Biomimetic zwitterionic copolymerized chitosan as an articular lubricant
Deng, J., Wei, R., Qiu, H., Wu, X., Yang, Y., Huang, Z., Miao, J., Liu, A., Chai, H., Cen, X. B., et al. (2024) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2024.121821 · Cited by 33
Self‐Powered Electrically Controlled Drug Release Systems Based on Nanogenerator
Luo, W., Luo, R., Liu, J., Li, Z., & Wang, Y. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202311938 · Cited by 29
Recent Advances in Bioelectronics for Localized Drug Delivery
Jiang, X., Wu, H., Xiao, A., Huang, Y., Yu, X., & Chang, L. (2023) · Small Methods · doi:10.1002/smtd.202301068 · Cited by 28
Ultrasound Mediated Polymerization for Cell Delivery, Drug Delivery, and 3D Printing
Debbi, L., Machour, M., Dahis, D., Shoyhet, H., Shuhmaher, M., Potter, R., Tabory, Y., Goldfracht, I., Dennis, I., Blechman, T., et al. (2024) · Small Methods · doi:10.1002/smtd.202301197 · Cited by 28
Programmable intratumoral drug delivery to breast cancer using wireless bioelectronic device with electrochemical actuation
Souri, M., Elahi, S., & Soltani, M. (2024) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2024.2323211 · Cited by 28
Implantable polypyrrole bioelectrodes inducing anti-inflammatory macrophage polarization for long-term in vivo signal recording
Lee, S., Park, J., Park, J., & Lee, J. Y. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.06.042 · Cited by 25
A reversible implantable memristor for health monitoring applications
Cao, Z., Xiang, L., Sun, B. T., Gao, K., Yu, J., Zhou, G., Duan, X., Yan, W., Lin, F., Li, Z., et al. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101096 · Cited by 24
Recent advances in materials and manufacturing of implantable devices for continuous health monitoring
Khan, A. A., & Kim, J. (2024) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2024.116461 · Cited by 28
Multiphysics modelling enhanced by imaging and artificial intelligence for personalised cancer nanomedicine: Foundations for clinical digital twins
Kashkooli, F. M., Bhandari, A., Gu, B., Kolios, M. C., Kohandel, M., & Zhan, W. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114138 · Cited by 28
Biochips on the Move: Emerging Trends in Wearable and Implantable Lab-on-Chip Health Monitors
Kazanskiy, N. L., Khorin, P. A., & Khonina, S. N. (2025) · Electronics · doi:10.3390/electronics14163224 · Cited by 29
An Implantable Magnetic Vascular Scaffold for Circulating Tumor Cell Removal In Vivo
Yin, Z., Shi, R., Xia, X., Li, L., Yang, Y., Li, S., Xu, J., Xu, Y., Cai, X., Wang, S., et al. (2022) · Advanced Materials · doi:10.1002/adma.202207870 · Cited by 25
Double-layered microneedle patch loaded with bioinspired nano-vaccine for melanoma treatment and wound healing
Chen, Z., Guo, Z., Hu, T., Huang, B., Zheng, Q., Du, X., Huang, L., & Hu, W. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.129961 · Cited by 25
Recent advances in harnessing biological macromolecules for wound management: A review
Yuan, J., Wang, S., Yang, J., Schneider, K. H., Xie, M., Chen, Y., Zheng, Z., Wang, X., Zhao, Z., Yu, J., et al. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.130989 · Cited by 25
Antibubbles Enable Tunable Payload Release with Low‐Intensity Ultrasound
Moreno-Gómez, N., Athanassiadis, A. G., Poortinga, A. T., & Fischer, P. (2023) · Advanced Materials · doi:10.1002/adma.202305296 · Cited by 24
Cancer Immunotherapy Using Bioengineered Micro/Nano Structured Hydrogels
Askari, E., Barough, M. S., Rahmanian, M., Mojtabavi, N., Sarrami‐Forooshani, R., Seyfoori, A., & Akbari, M. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202301174 · Cited by 22
Current status and challenges of shape memory scaffolds in biomedical applications
Wu, H., Yang, S., Li, J., Ma, T., Yang, K., Liao, T., Feng, W., Zhou, B., Yong, X., Zhou, K., et al. (2024) · MedComm – Biomaterials and Applications · doi:10.1002/mba2.95 · Cited by 22
Wirelessly controlled drug delivery systems for translational medicine
Wei, X., Wang, Y., Hu, H., Sheng, T., Yao, Y., Chen, C., Xu, G., Li, K., Su, Y., Nan, K., et al. (2025) · Nature Reviews Electrical Engineering · doi:10.1038/s44287-025-00151-z · Cited by 25
Ionic Diode‐Based Drug Delivery System
Yoo, H., Kang, S., Kim, J., Cho, W., Ha, H., Oh, S., Jeong, S., Lee, S., Lee, H., Park, C. S., et al. (2024) · Advanced Materials · doi:10.1002/adma.202412377 · Cited by 21
Novel synergistic approaches of protein delivery through physical enhancement for transdermal microneedle drug delivery: A review
Chakraborty, R., Afrose, N., & Kuotsu, K. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104467 · Cited by 20
Insights into the innovative approaches in fiber technology for drug delivery and pharmaceuticals
Wal, P., Wal, A., Saxena, B., Mishra, S., Elossaily, G. M., Arora, R., Singh, C., Sachdeva, M., Anwer, M. K., Gulati, M., et al. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104877 · Cited by 20
Exosomes from umbilical cord-derived mesenchymal stem cells combined with gelatin methacryloyl inhibit vein graft restenosis by enhancing endothelial functions
Deng, Y., Li, Y., Chu, Z., Dai, C., & Ge, J. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02145-1 · Cited by 20
Injectable miniaturized shape-memory electronic device for continuous glucose monitoring
Jiang, K., Wang, H., Long, Y., Han, Y., Zhang, H., & Weng, Q. (2023) · Device · doi:10.1016/j.device.2023.100117 · Cited by 19
Epidermal secretion-purified biosensing patch with hydrogel sebum filtering membrane and unidirectional flow microfluidic channels
Wang, Y., Zhang, Z., Shi, Y., Yu, X., Zhang, X., Ma, X., Su, J., Ding, R., & Lin, Y. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122810 · Cited by 19
The hidden power of glycine: A small amino acid with huge potential for piezoelectric and piezo-triboelectric nanogenerators
Nascimento, L., Richardson, G., Melo, P., & Barroca, N. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.161514 · Cited by 19
Ultrasoft, sensitive fiber-like sensor by assembly of bacterial cellulose (BC) nanofibrils and BC molecules for biocompatible strain sensing
Meng, S., Zhang, Y., Wu, N., Peng, C., Huang, Z., Lin, Z., Cheng, Q., Liu, Z., & Kong, T. (2022) · Nano Research · doi:10.1007/s12274-022-5040-9 · Cited by 19
Biofunctional coatings and drug-coated stents for restenosis therapy
Wen, Y., Li, Y., Yang, R. X., Chen, Y., Shen, Y., Liu, Y., Liu, X., Zhang, B., & Li, H. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101259 · Cited by 18
A Wireless Implantable Closed-Loop Electrochemical Drug Delivery System
Wang, M. L., Yeon, P., Mofidfar, M., Chamberlayne, C. F., Xu, H., Annes, J. P., Zare, R. N., & Arbabian, A. (2024) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2024.3507022 · Cited by 18
Conductive, Injectable, and Spinnable Aniline Tetramer-Modified Polysaccharide Hydrogels for Self-Powered Electrically Responsive Drug Release
Zhang, Y., Qi, J., Han, F., Chen, P., Li, B., Zhao, L., Bai, Z., Zhang, R., & Tao, Y. (2022) · ACS Applied Polymer Materials · doi:10.1021/acsapm.2c01506 · Cited by 17
Development of poly (lactic-co-glycolic acid) (PLGA) based implants using hot melt extrusion (HME) for sustained release of drugs: The impacts of PLGA’s material characteristics
Yang, F., Stahnke, R., Lawal, K., Mahnen, C. J., Duffy, P., Xu, S., & Dürig, T. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124556 · Cited by 18
Superlow Power Consumption Memristor Based on Borphyrin–Deoxyribonucleic Acid Composite Films as Artificial Synapse for Neuromorphic Computing
Wang, Z., Zhu, W., Li, J., Shao, Y., Li, X., Shi, H., Zhao, J., Zhou, Z., Wang, Y., & Yan, X. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c09300 · Cited by 18
Involvement of Human Volunteers in the Development and Evaluation of Wearable Devices Designed to Improve Medication Adherence: A Scoping Review
Marengo, L. L., & Barberato-Filho, S. (2023) · Sensors · doi:10.3390/s23073597 · Cited by 20
Drug-eluting contact lenses: Progress, challenges, and prospects
Gao, D., Yan, C., Wang, Y., Yang, H., Liu, M., Wang, Y., Li, C., Li, C., Cheng, G., & Zhang, L. (2024) · Biointerphases · doi:10.1116/6.0003612 · Cited by 16
A system for bioelectronic delivery of treatment directed toward wound healing
Baniya, P., Tebyani, M., Asefifeyzabadi, N., Nguyen, T., Hernandez, C., Zhu, K., Li, H., Selberg, J. A., Hsieh, H., Pansodtee, P., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-41572-w · Cited by 14
Interlacing biology and engineering: An introduction to textiles and their application in tissue engineering
Scholpp, S., Hoffmann, L. A., Schätzlein, E., Gries, T., Emonts, C., & Blaeser, A. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101617 · Cited by 16
Self-healing hydrogel based on oxidized pectin with grafted dopamine as gallic acid carrier for burn wound treatment
Wang, J., Song, N., Yin, L., Cui, Z., Wang, Y., Zhou, C., Li, J., & Qin, J. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.141826 · Cited by 13
External stimuli-responsive drug delivery to the posterior segment of the eye
Xu, S., Zhang, Y., Li, J., Zhang, X., & Wang, W. (2025) · Drug Delivery · doi:10.1080/10717544.2025.2476140 · Cited by 13
Study and Application of PZT in the Field of Wearable Devices
Xiang, W., Yin, Z., & Xue, Y. (2025) · Advanced Materials Technologies · doi:10.1002/admt.202401692 · Cited by 13
Responsive Microneedles for Diagnostic and Therapeutic Applications of Ocular Diseases
Mi, B., Mu, J., Ding, X., Guo, S., & Hua, X. (2025) · Small Methods · doi:10.1002/smtd.202402048 · Cited by 12
Recent Progress on the Application of Microneedles for In Situ Sampling in Surface-Enhanced Raman Scattering Detection
Yang, W., Chen, Y., Cheng, X.-L., Liu, S., Zhu, H., & Hu, Y. (2025) · Biosensors · doi:10.3390/bios15060350 · Cited by 12
Ear‐Area Soft Electronics for Advanced Healthcare Monitoring
Yu, Y., Zhang, H., Pan, X., Yuan, M., Sun, Y., Han, P., Fang, Q., Li, B., Xu, F., & Fang, Y. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202505046 · Cited by 10
Development of a wireless bioelectronic actuator for wound healing in a porcine model
Baniya, P., Tebyani, M., Hee, W. S., Li, H., Asefifeyzabadi, N., Schorger, K., Yang, H., Gallegos, A., Zhu, K., Lu, F., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-26161-3 · Cited by 11
Radiolabeled Risperidone microSPECT/CT Imaging for Intranasal Implant Studies Development
Simón, J. A., Utomo, E., Pareja, F., Collantes, M., Quincoces, G., Otero, A., Ecay, M., Domínguez‐Robles, J., Larrañeta, E., & Peñuelas, I. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15030843 · Cited by 10
RETRACTED ARTICLE: Effective sound detection system in commercial car vehicles using Msp430 launchpad development
Alam, S., Mohammad, O. K. J., Alfurhood, B. S., Saxena, K. K., Anand, M. V., Mahaveerakannan, R., & Savitha, V. (2023) · Multimedia Tools and Applications · doi:10.1007/s11042-023-15373-2 · Cited by 10
Retracted
Magnetic Backscatter for In-body Communication and Localization
Tao, Y., Sie, E., Shenoy, J., & Vasisht, D. (2023) · ACM Annual International Conference on Mobile Computing and Networking (MobiCom) · doi:10.1145/3570361.3613301 · Cited by 13
Smart Polymer Systems: A Futuristic Approach to Enhance Therapeutic Efficacy
Seth, A. K., Parmar, G. R., Aundhia, C. J., Shah, N. V., & Gohil, D. (2024) · Current Organic Chemistry · doi:10.2174/0113852728305580240429100851 · Cited by 9
A Conjugated Oligomer with Drug Efflux Pump Inhibition and Photodynamic Therapy for Synergistically Combating Resistant Bacteria
Li, M., Li, L., Zhang, X., Yuan, Q., Bao, B., & Tang, Y. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c20278 · Cited by 9
Polymeric microneedle advancements in macromolecule drug delivery: current trends, challenges, and future perspectives
Kenchegowda, M., Angolkar, M., Hani, U., Fatease, A. M. A., Fatima, F., Talath, S., Dera, A. A., Paramshetti, S., Gangadharappa, H. V., Osmani, R. A. M., et al. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04117-8 · Cited by 9
Nanoparticle and Gene Therapy Strategies for Site‐Specific Pain Management: A Review
Nagaraj, K. (2025) · Advanced Therapeutics · doi:10.1002/adtp.202500356 · Cited by 10
Effect of continuous local dexamethasone on tissue biomechanics and histology after inhalational burn in a preclinical model
Malka, R. E., Gonzales, G., Detar, W., Marinelli, L. M., Lee, C. M., Isaac, A., Miar, S., Cook, S., Guda, T., & Dion, G. R. (2023) · Laryngoscope Investigative Otolaryngology · doi:10.1002/lio2.1093 · Cited by 9
Recent advances in versatile cellulose-based 3D-printed drug delivery systems: A review
Wang, K., Wu, Y., Remón, J., & Ding, W. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.144433 · Cited by 8
Solution Blow Spun Poly(ethylene oxide)/Poly-ε-caprolactone System: Properties and Dissolution in Water
Lorente, M. Á., González‐Gaitano, G., Valero, M., & González‐Benito, J. (2023) · ACS Applied Polymer Materials · doi:10.1021/acsapm.3c01109 · Cited by 8
Implantable conductive polymer bioelectrode with enzymatic antioxidant activity for enhanced tissue responses and in vivo performance
Lee, S., Min, K., Jung, J., Yi, J., Tae, G., & Lee, J. Y. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.152861 · Cited by 7
Microwave Revolution: Transforming Biomedical Synthesis for Tissue Engineering Advancements
Sridhar, S. K., Bhavani, P. D., Noothi, S., Gajula, L. R., Prakash Goudanavar, S. O. P., Gowthami, B., & Naveen, N. R. (2024) · Current Microwave Chemistry · doi:10.2174/0122133356321729240715094501 · Cited by 7
Liquid metal-based biomaterials and flexible devices for injectable and implantable healthcare
Luo, Y., Yu, Y., Chen, Y., Li, R., Zhang, Y., & Chen, S. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.09.038 · Cited by 7
Biocompatible batteries: Powering the future of wearable and implantable medical devices
Khalid, H., Majeed, M. K., Mansoor, M. A., Aiman, V., Saleem, A., & Iqbal, R. (2026) · Journal of Energy Storage · doi:10.1016/j.est.2026.121429 · Cited by 7
Nanomechanical probing of bacterial adhesion to biodegradable Zn alloys
Yang, K., Wang, L., Zhang, D., Yan, Y. J., Ji, X., Cao, M., Shi, Z., & Wang, L. (2022) · Biomaterials Advances · doi:10.1016/j.bioadv.2022.213243 · Cited by 7
The application of biosensors in precision medicine
Brazaca, L. C., & Sempionatto, J. R. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15380-8.00006-0 · Cited by 8
Exploring the vast potentials and probable limitations of novel and nanostructured implantable drug delivery systems for cancer treatment
Ebrahimnia, M., Alavi, S., Vaezi, H., Iradmousa, M. K., & Haeri, A. (2023) · EXCLI journal · doi:10.17179/excli2023-6747 · Cited by 10
Design and fabrication of durable poly(3-hydroxybutyrate) (PHB) coating with high adhesion and desirable anti-corrosion performance on Mg alloy for bio-application
Yang, J., Sun, B., Dai, J., Li, X., Zhao, Y., Zhang, L., Bai, J., Xue, F., & Chu, C. (2024) · Progress in Organic Coatings · doi:10.1016/j.porgcoat.2024.108577 · Cited by 7
Negative Pressure Smart Patch to Sense and Heal the Wound
Liu, X., Zhao, P., Wu, X., Zhao, Y., Zhou, F., Luo, Y., Jia, X., Zhong, W., Xing, M. M. Q., & Lyu, G. (2024) · Advanced Science · doi:10.1002/advs.202408077 · Cited by 7
Citrate-Assisted Regulation of Protein Stability and Secretability from Synthetic Amyloids
López‐Laguna, H., Favaro, M. T. D. P., Chellou-Bakkali, S., Voltà‐Durán, E., Parladé, E., Sánchez, J. M., Corchero, J. L., Unzueta, U., Villaverde, A., & Vázquez, E. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c20784 · Cited by 6
Treatment Considerations to Overcome the Barriers Associated with Skin Cancer Targeting
Kumari, P., Alam, A., Dhoundiyal, S., Kaur, A., & Yadav, S. (2023) · Current Cancer Therapy Reviews · doi:10.2174/0115733947253349231027043858 · Cited by 6
Temperature and Near Infrared Light-Responsive Asymmetric Poly(N-isopropylacrylamide)-based Hydrogel Tunable Actuators
Cui, Z., Fang, H., Wei, X., He, S., & Shao, W. (2024) · ACS Applied Nano Materials · doi:10.1021/acsanm.4c05042 · Cited by 6
Reviews on Flexible Force Sensors Based on Fiber Assemblies with Mass Production Efficiency
Wu, L., Jin, Y., Xia, Z., Han, J., Han, W., Dong, K., Tang, Y., & Jiang, Q. (2024) · Advanced Materials Technologies · doi:10.1002/admt.202302162 · Cited by 6

Authors: Kar, A., Ahamad, N., Dewani, M., Awasthi, L., Patil, R., & Banerjee, R.
Affiliations: Indian Institute of Technology Bombay (IN)
Corresponding author: Ahamad, Nadim
Banerjee, Rinti
ORCID: Ahamad, Nadim
Dewani, Mahima
Awasthi, Lisha
Patil, Runali
Banerjee, Rinti
Venue: Biomaterials
Publisher: Elsevier BV
Published: 2022-04
Volume: 283
Pages: 121435
ISSN: 0142-9612 (ISSN-L)
DOI: 10.1016/j.biomaterials.2022.121435
OpenAlex: W4214555582
Cited by: 179
References: 274
Citations by year: 2026: 36 · 2025: 53 · 2024: 42 · 2023: 39 · 2022: 9
FWCI: 3.13
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Biomaterials (publishedVersion)
PubMed (publishedVersion)
Funders: Ministry of Education, India
Department of Biotechnology, Ministry of Science and Technology, India
Indian Institute of Technology Bombay (20001208)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords: implantable drug delivery, medication adherence, drug-eluting contact lenses, coronary stents, intrauterine devices, chronic disease treatment, non-invasive drug delivery
MeSH terms: Wearable Electronic Devices, Diabetes Mellitus, Pharmaceutical Preparations, Female, Humans, Drug Delivery Systems, Prostheses and Implants

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Wearable and implantable devices for drug delivery: Applications and challenges

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks