Cited by 179Advancements in Transdermal Drug DeliveryAdvanced Drug Delivery SystemsTissue Engineering and Regenerative Medicine

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Wearable and implantable devices for drug delivery: Applications and challenges

Kar, Abhinanda, Ahamad, Nadim, Dewani, Mahima, Awasthi, Lisha, Patil, Runali, Banerjee, Rinti·2022·Biomaterials

DOI 10.1016/j.biomaterials.2022.121435

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Abstract

Poor adherence to drug dosing schedule is responsible for ∼50% of hospitalization cases. Most patients fail to adhere to a strict dosing schedule due to invasive drug administration, off-target toxicities, or medical conditions like dementia. The emerging concept of wearable devices (WDs), implantable devices (IDs) and combined wearable and implantable devices (WIDs) for drug delivery has created new opportunities for treating patients with chronic diseases needing repeated and long-term medical attention like diabetes, ocular disorders, cancer, wound healing, cardiovascular diseases, and contraception. WDs, worn on the body surface have created appealing non-invasive, self-administrable drug delivery platforms which receive huge patient compliance. Microneedle-skin patches, wound healing patches, drug-eluting contact lenses, mouth guards, intra-vaginal rings, pharmaceutical jewelry, and drug-loaded self-care textiles are popular WDs explored in drug delivery. In contrast, IDs are surgically placed inside body tissue allowing higher payload and enhanced localized effect for an extended duration. Hormone micropumps, hydrogel/nanofibrous depot, coronary stents, intravitreal devices, and intrauterine devices are some representative examples of IDs. In this review, we have described the past 10 years of research progress on drug-delivering WDs and IDs in the context of treating diseases that demand repeated and long-term medication, especially those affecting soft tissues. We highlighted several technical challenges that need to be addressed before considering the translation of such technologies to clinics.

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Cross-organ translation of antifibrotic strategies from skin and lung fibrosis to glaucoma filtration surgery
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Authors: Kar, A., Ahamad, N., Dewani, M., Awasthi, L., Patil, R., & Banerjee, R.
Affiliations: Indian Institute of Technology Bombay (IN)
Corresponding author: Ahamad, Nadim
Banerjee, Rinti
ORCID: Ahamad, Nadim
Dewani, Mahima
Awasthi, Lisha
Patil, Runali
Banerjee, Rinti
Venue: Biomaterials
Publisher: Elsevier BV
Published: 2022-04
Volume: 283
Pages: 121435
ISSN: 0142-9612 (ISSN-L)
DOI: 10.1016/j.biomaterials.2022.121435
OpenAlex: W4214555582
Cited by: 179
References: 274
Citations by year: 2026: 36 · 2025: 53 · 2024: 42 · 2023: 39 · 2022: 9
FWCI: 3.13
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Biomaterials (publishedVersion)
PubMed (publishedVersion)
Funders: Ministry of Education, India
Department of Biotechnology, Ministry of Science and Technology, India
Indian Institute of Technology Bombay (20001208)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords: implantable drug delivery, medication adherence, drug-eluting contact lenses, coronary stents, intrauterine devices, chronic disease treatment, non-invasive drug delivery
MeSH terms: Wearable Electronic Devices, Diabetes Mellitus, Pharmaceutical Preparations, Female, Humans, Drug Delivery Systems, Prostheses and Implants

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Wearable and implantable devices for drug delivery: Applications and challenges

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