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Cited by 1,118Electrochemical sensors and biosensorsAdvanced Sensor and Energy Harvesting MaterialsAdvancements in Transdermal Drug Delivery

Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module

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Lee, Hyunjae, Song, Changyeong, Hong, Yong Seok, Kim, Minsung, Cho, Hye Rim, Kang, Taegyu, Shin, Kwangsoo, Choi, Seung Hong +2 more·2017·Science Advances
DOI 10.1126/sciadv.1601314PMC PMC5342654
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Abstract

A sweat-based glucose monitoring device with transdermal drug delivery is developed for noninvasive diabetes treatment.

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Crossref · 10.1126/sciadv.1601314

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  • Most wearable sweat sensors are unable to draw low volumes of resting sweat rapidly into the device, limiting real-time assessment.

    “They are unable to draw low volumes of resting sweat rapidly into the device, limiting real-time assessment.”

    From A wearable patch for continuous analysis of thermoregulatory sweat at rest (2021) · cites this paper as [12]

    The Introduction says sweat collection is tedious and collection times vary with environmental conditions. Results (Sweat control optimization) say fast collection of small sweat volumes enables rapid sensing. The paper does not establish that most wearable sensors cannot rapidly draw resting sweat into a device or that this specifically limits real-time assessment. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • Most wearable sweat sensors have focused on exercise, thermal, or chemically stimulated sweat produced at rates of 10's or 100's of nL min−1 cm−2 or higher.

    “For this reason, most wearable sweat sensors have focused on exercise, thermal, or chemically stimulated sweat produced at rates of 10’s or 100’s of nL min−1 cm−2 or higher10–23.”

    From A wearable patch for continuous analysis of thermoregulatory sweat at rest (2021) · cites this paper as [12]

    The Introduction describes wearable sweat biosensors, and the Results sections describe this device’s sweat collection and testing on human subjects (pages unavailable). Our copy does not say that this device focuses on exercise-, thermal-, or chemically stimulated sweat, give a sweat-production rate, or establish that most wearable sensors do so. Searches for the stimulation methods and the stated rate found no decisive passage. (LLM, conf=0.72)

    Experimental — accuracy not yet measured

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Research works printed but not linked: 32

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Authors
Lee, H., Song, C., Hong, Y. S., Kim, M., Cho, H. R., Kang, T., Shin, K., Choi, S. H., Hyeon, T., & Kim, D.-H.
Affiliations
  • Seoul National University (KR)
  • Center for Nanoparticle Research, Institute for Basic Science, Seoul 08826, Republic of Korea.
Corresponding author
  • Lee, Hyunjae
  • Song, Changyeong
  • Hyeon, Taeghwan
  • Kim, Dae-Hyeong
ORCID
Venue
Science Advances
Publisher
American Association for the Advancement of Science (AAAS)
Published
2017-03-03
Volume
3
Issue
3
Pages
e1601314-e1601314
ISSN
2375-2548 (ISSN-L)
DOI
10.1126/sciadv.1601314
PMC
PMC5342654
OpenAlex
W2594844894
Cited by
1,118
References
6
Citations by year
2026: 51 · 2025: 100 · 2024: 117 · 2023: 143 · 2022: 154 · 2021: 138 · 2020: 146 · 2019: 153 · 2018: 84 · 2017: 31
FWCI
47.07
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Science Advances (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Seoul National University Open Repository (Seoul National University) (submittedVersion)
Funders
Institute for Basic Science (ID0EEWCI15509, IBS-R006-D1)
Topics
  • Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
  • Physical Sciences › Engineering › Biomedical Engineering › Advanced Sensor and Energy Harvesting Materials
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
Keywords
non-invasive glucose monitoring, wearable biosensors, transdermal drug delivery, glucose oxidase, soft bioelectronics, temperature-responsive drug release, multimodal sensing
MeSH terms
Wearable Electronic Devices, Administration, Cutaneous, Glucose, Humans, Monitoring, Physiologic, Sweat, Drug Delivery Systems, Point-of-Care Systems

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