The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Biomimetic glycopeptide hydrogel coated PCL/nHA scaffold for enhanced cranial bone regeneration via macrophage M2 polarization-induced osteo-immunomodulation
Abstract
The reconstruction of large cranial bone defects by bioactive materials without exogenous cells or growth factors remains a substantial clinical challenge. Here, synthetic fibrous glycopeptide hydrogel (GRgel) self-assembled by β-sheet RADA16-grafted glucomannan was designed to mimic the glycoprotein composition and the fibrillar architecture of natural extracellular matrix (ECM), which was non-covalently composited with 3D-printed polycaprolactone/nano hydroxyapatite (PCL/nHA) scaffold for cranial bone regeneration. The glycopeptide hydrogel significantly promoted the proliferation, osteogenic differentiation of bone mesenchymal stem cells (BMSCs), which was further augmented by GRgel-induced macrophage M2-phonotype polarization and the effective M2 macrophage-BMSC crosstalk. The repair of critical-size skull bone defect in rat indicated a superior efficacy of PCL/nHA@GRgel implant on bone regeneration and osseointegration, with an average bone area of 83.3% throughout the defect location at 12 weeks post treatment. Furthermore, the osteo-immunomodulatory GRgel induced a reparative microenvironment similar with that in normal cranium, as characterized by an increased percentage of anti-inflammatory M2 macrophages and osteoblasts, and high-level vascularization. Collectively, the composite scaffold developed here with macrophage polarization-mediated osteo-immunomodulation may represent a promising implant for expediting in situ bone regeneration by providing biochemical and osteoinductive cues at the injured tissue.
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Cites
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Cited by
Wu, M., Liu, H., Zhu, Y., Wu, P., Chen, Y., Deng, Z., Zhu, X., & Cai, L. (2024) · Theranostics · doi:10.7150/thno.97335 · Cited by 189
Chen, L., Zhu, J., Ge, N., Liu, Y., Yan, Z., Liu, G., Li, Y., Wang, Y., Wu, G., Qiu, T., et al. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2024.122992 · Cited by 53
Self-citationWu, M., Wang, Y., Liu, H., Chen, F., Zhang, Y., Wu, P., Deng, Z., & Cai, L. (2023) · Materials & Design · doi:10.1016/j.matdes.2023.111705 · Cited by 28
Self-citationIs there a role for N1-N2 neutrophil phenotypes in bone regeneration? A systematic review
Lu, F., Verleg, S. M. N. E., Groven, R. V. M., Poeze, M., van Griensven, M., & Blokhuis, T. J. (2024) · Bone · doi:10.1016/j.bone.2024.117021 · Cited by 25
Metadata
- Authors
- Wang, Y., Wang, J., Gao, R., Liu, X., Feng, Z., Zhang, C., Huang, P., Dong, A., Kong, D., & Wang, W.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2022-06
- Volume
- 285
- Pages
- 121538
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W4224657282
- Cited by
- 268
- References
- 49
- FWCI
- 15.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wang, Y., Wang, J., Gao, R., Liu, X., Feng, Z., Zhang, C., Huang, P., Dong, A., Kong, D., & Wang, W. (2022). Biomimetic glycopeptide hydrogel coated PCL/nHA scaffold for enhanced cranial bone regeneration via macrophage M2 polarization-induced osteo-immunomodulation. Biomaterials. https://doi.org/10.1016/j.biomaterials.2022.121538
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