Chemical composition, antioxidant potential, macromolecule damage and neuroprotective activity of Convolvulus pluricaulis
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Herbal medicines are known to mitigate radical induced cell damage. Hence identification and scientific validation of herbal medicines contribute to better use in Ayurvedic/Unani research. In the present study, we investigated antioxidant and anti-apoptotic properties of Convolvulus pluricaulis (C. pluricaulis). C. pluricaulis exhibited antioxidant potential evident by free radical scavenging activities. C. pluricaulis pretreatment inhibited H2O2 induced macromolecule damage such as plasmid DNA damage and AAPH induced oxidation of bovine serum albumin and lipid peroxidation of rat hepatic tissues. Further to identify the neuroprotective properties of C. pluricaulis, SHSY5Y cells were treated with H2O2 with or without pretreatment of C. pluricaulis. The C. pluricaulis pretreatment at 50 μg/ml dose exhibited 50% cell survival against 100 μM H2O2 challenge for 24 h and it also decreased the lactate dehydrogenase leakage. Further C. pluricaulis pretreatment restored and regulated the antioxidant and apoptosis markers such as SOD, CAT, p53, and caspase-3 and inhibited, reactive oxygen species generation and depolarization of the mitochondrial membrane. C. pluricaulis possess a high content of flavonoids and polyphenols and GC-MS and FTIR analysis showed a wide variety of compounds which may contribute to the observed effects.
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Pre-treatment of Convolvulus pluricaulis reduces oxidative stress and apoptosis caused by H2O2 that causes neuronal damage.
“In this regard, Rachita and the group reported that pre-treatment of CP reduces oxidative stress and reduces apoptosis caused by the H 2 O 2 that causes neuronal damage.”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [139]
Convolvulus pluricaulis shows antioxidant potential by scavenging free radicals.
“CP has been reported to show antioxidant potential by its capacity to scavenge free radicals.”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [139]
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- Authors
- Rachitha, P., Krupashree, K., Jayashree, G. V., Kandikattu, H. K., Amruta, N., Gopalan, N., Rao, M. K., & Khanum, F.
- Affiliations
- Defence Food Research Laboratory (IN)
- University of Agricultural Sciences, Bangalore (IN)
- Defence Research and Development Establishment (IN)
- Corresponding author
- Khanum, Farhath
- Venue
- Journal of Traditional and Complementary Medicine
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 8
- Issue
- 4
- Pages
- 483-496
- ISSN
- 2225-4110 (ISSN-L)
- PMC
- PMC6174265
- OpenAlex
- W2793595803
- Cited by
- 53
- References
- 90
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 5 · 2023: 7 · 2022: 4 · 2021: 5 · 2020: 8 · 2019: 8 · 2018: 2
- FWCI
- 7.89
- Type
- journal article
- Language
- en
- Update notices
- erratum (2020-11-01)
- Open access
- diamond
- doi.org
- Licence
- Locations
- Journal of Traditional and Complementary Medicine (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- Convolvulus pluricaulis, antioxidant activity, neuroprotection, oxidative stress, hydrogen peroxide, apoptosis, lipid peroxidation, DNA damage, SH-SY5Y cells, reactive oxygen species, caspase-3, p53, superoxide dismutase, catalase, flavonoids, polyphenols, mitochondrial depolarization, herbal medicine, Ayurveda
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