Molecular aging in human prefrontal cortex is selective and continuous throughout adult life

Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing

Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482

Gene Ontology: tool for the unification of biology

Ashburner, M., Ball, C. A., Blake, J. A., Botstein, D., Butler, H., Cherry, J. M., Davis, A. P., Dolinski, K., Dwight, S. S., Eppig, J. T., et al. (2000) · Nature Genetics · doi:10.1038/75556 · Cited by 43,206

Cluster analysis and display of genome-wide expression patterns

Eisen, M. B., Spellman, P. T., Brown, P. O., & Botstein, D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14863 · Cited by 16,184

Summaries of Affymetrix GeneChip probe level data

Irizarry, R. A. (2003) · Nucleic Acids Research · doi:10.1093/nar/gng015 · Cited by 4,837

Mapping cortical change across the human life span

Sowell, E. R., Peterson, B. S., Thompson, P. M., Welcome, S. E., Henkenius, A. L., & Toga, A. W. (2003) · Nature Neuroscience · doi:10.1038/nn1008 · Cited by 2,328

Insights into the ageing mind: a view from cognitive neuroscience

Hedden, T., & Gabrieli, J. D. E. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1323 · Cited by 2,223

Models of visuospatial and verbal memory across the adult life span.

Park, D. C., Lautenschlager, G. J., Hedden, T., Davidson, N. S., Smith, A. D., & Smith, P. K. (2002) · Psychology and Aging · doi:10.1037/0882-7974.17.2.299 · Cited by 1,929

Gene regulation and DNA damage in the ageing human brain

Lu, T., Pan, Y., Kao, S.-Y., Li, C., Kohane, I., Chan, J., & Yankner, B. A. (2004) · Nature · doi:10.1038/nature02661 · Cited by 1,874

Gene expression profile of aging and its retardation by caloric restriction

Lee, C.-K., Klopp, R. G., Weindruch, R., & Prolla, T. A. (1999) · Science · doi:10.1126/science.285.5432.1390 · Cited by 1,473

Longitudinal Magnetic Resonance Imaging Studies of Older Adults: A Shrinking Brain

Resnick, S. M., Pham, D. L., Kraut, M. A., Zonderman, A. B., & Davatzikos, C. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03295.2003 · Cited by 1,425

Neural mechanisms of ageing and cognitive decline

Bishop, N. A., Lu, T., & Yankner, B. A. (2010) · Nature · doi:10.1038/nature08983 · Cited by 1,323

The Aging Brain

Yankner, B. A., Lu, T., & Loerch, P. (2008) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathmechdis.2.010506.092044 · Cited by 677

Gene expression changes in the course of normal brain aging are sexually dimorphic

Berchtold, N. C., Cribbs, D. H., Coleman, P. D., Rogers, J., Head, E., Kim, R., Beach, T., Miller, C., Troncoso, J., Trojanowski, J. Q., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806883105 · Cited by 626

Epigenetic mechanisms in neurological disease

Jakovcevski, M., & Akbarian, S. (2012) · Nature Medicine · doi:10.1038/nm.2828 · Cited by 450

Major Shifts in Glial Regional Identity Are a Transcriptional Hallmark of Human Brain Aging

Soreq, L., Rose, J., Soreq, E., Hardy, J., Trabzuni, D., Cookson, M. R., Smith, C., Ryten, M., Patani, R., & Ule, J. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.011 · Cited by 419

Transcriptional neoteny in the human brain

Somel, M., Franz, H., Zheng, Y., Lorenc, A., Guo, S., Giger, T., Kelso, J. F., Nickel, B., Dannemann, M., Bahn, S., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900544106 · Cited by 422

Molecular evidence for BDNF- and GABA-related dysfunctions in the amygdala of female subjects with major depression

Guilloux, J.-P., Douillard-Guilloux, G., Kota, R., Wang, X., Gardier, A. M., Martinowich, K., Tseng, G. C., Lewis, D. A., & Sibille, E. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.113 · Cited by 378

Anatomy of the Prefrontal Cortex

Fuster, J. M. (2008) · The Prefrontal Cortex · doi:10.1016/b978-0-12-373644-4.00002-5 · Cited by 364

Oxidative Stress and Epilepsy: Literature Review

Aguiar, C. C. T., Almeida, A. B., Araújo, P. V. P., de Abreu, R. N. D. C., Chaves, E. M. C., do Vale, O. C., Macêdo, D. S., Woods, D. J., Fonteles, M. M. D. F., & Vasconcelos, S. M. M. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/795259 · Cited by 334

MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain

Somel, M., Guo, S., Fu, N., Yan, Z., Hu, H. Y., Xu, Y., Yuan, Y., Ning, Z., Hu, Y., Menzel, C., et al. (2010) · Genome Research · doi:10.1101/gr.106849.110 · Cited by 297

Synaptic genes are extensively downregulated across multiple brain regions in normal human aging and Alzheimer's disease

Berchtold, N. C., Coleman, P. D., Cribbs, D. H., Rogers, J., Gillen, D. L., & Cotman, C. W. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.11.024 · Cited by 298

Altered expression of genes involved in ATP biosynthesis and GABAergic neurotransmission in the ventral prefrontal cortex of suicides with and without major depression

Klempan, T. A., Sequeira, A., Canetti, L., Lalovic, A., Ernst, C., ffrench-Mullen, J., & Turecki, G. (2009) · Molecular Psychiatry · doi:10.1038/sj.mp.4002110 · Cited by 294

The Beneficial Roles of SIRT1 in Neuroinflammation-Related Diseases

Jiao, F., & Gong, Z. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/6782872 · Cited by 294

Beyond modules and hubs: the potential of gene coexpression networks for investigating molecular mechanisms of complex brain disorders

Gaiteri, C., Ding, Y., French, B., Tseng, G. C., & Sibille, E. (2014) · Genes, Brain and Behavior · doi:10.1111/gbb.12106 · Cited by 289

Anatomy of the Prefrontal Cortex

Fuster, J. M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-407815-4.00002-7 · Cited by 282

Blood-brain barrier dysfunction in aging induces hyperactivation of TGFβ signaling and chronic yet reversible neural dysfunction

Senatorov, V. V., Friedman, A. R., Milikovsky, D. Z., Ofer, J., Saar-Ashkenazy, R., Charbash, A., Jahan, N., Chin, G., Mihaly, E., Lin, J. M., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aaw8283 · Cited by 257

Analysis of alternative splicing associated with aging and neurodegeneration in the human brain

Tollervey, J. R., Wang, Z., Hortobágyi, T., Witten, J. T., Zarnack, K., Kayikci, M., Clark, T. A., Schweitzer, A. C., Rot, G., Curk, T., et al. (2011) · Genome Research · doi:10.1101/gr.122226.111 · Cited by 252

Whole-transcriptome brain expression and exon-usage profiling in major depression and suicide: evidence for altered glial, endothelial and ATPase activity

Pantazatos, S. P., Huang, Y.-Y., Rosoklija, G. B., Dwork, A. J., Arango, V, & Mann, J. J. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.130 · Cited by 229

Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer's disease

Bossers, K., Wirz, K. T. S., Meerhoff, G. F., Essing, A. H. W., van Dongen, J. W., Houba, P., Kruse, C. G., Verhaagen, J., & Swaab, D. F. (2010) · Brain · doi:10.1093/brain/awq258 · Cited by 230

Using the Gene Ontology for Microarray Data Mining: A Comparison of Methods and Application to Age Effects in Human Prefrontal Cortex

Pavlidis, P., Qin, J., Arango, V., Mann, J. J., & Sibille, E. L. (2004) · Neurochemical Research · doi:10.1023/b:nere.0000023608.29741.45 · Cited by 238

Altered GABA-mediated information processing and cognitive dysfunctions in depression and other brain disorders

Prévot, T. D., & Sibille, E. L. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0727-3 · Cited by 238

Evidence for Neuronal Desynchrony in the Aged Suprachiasmatic Nucleus Clock

Farajnia, S., Michel, S., Deboer, T., vanderLeest, H. T., Houben, T., Rohling, J. H. T., Ramkisoensing, A., Yasenkov, R., & Meijer, J. H. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.0469-12.2012 · Cited by 230

GABA-related transcripts in the dorsolateral prefrontal cortex in mood disorders

Sibille, E., Morris, H. M., Kota, R. S., & Lewis, D. A. (2011) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710001616 · Cited by 217

Analysis of whole genome biomarker expression in blood and brain

Rollins, B. L., Martin, M. V., Morgan, L. Z., & Vawter, M. P. (2010) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31062 · Cited by 217

Widespread splicing changes in human brain development and aging

Mazin, P., Xiong, J., Liu, X., Yan, Z., Zhang, X., Li, M., He, L., Somel, M., Yuan, Y., Phoebe Chen, Y., et al. (2013) · Molecular Systems Biology · doi:10.1038/msb.2012.67 · Cited by 216

A Molecular Signature of Depression in the Amygdala

Sibille, E. L., Wang, Y., Joeyen-Waldorf, J., Gaiteri, C., Surget, A., Oh, S., Belzung, C., Tseng, G. C., & Lewis, D. A. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.08121760 · Cited by 216

Corticolimbic Transcriptome Changes are State-Dependent and Region-Specific in a Rodent Model of Depression and of Antidepressant Reversal

Surget, A., Wang, Y., Leman, S., Ibargüen-Vargas, Y., Edgar, N. M., Griebel, G., Belzung, C., & Sibille, E. L. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.76 · Cited by 203

Opportunities and challenges of pluripotent stem cell neurodegenerative disease models

Sandoe, J., & Eggan, K. C. (2013) · Nature Neuroscience · doi:10.1038/nn.3425 · Cited by 198

Reduced somatostatin in subgenual anterior cingulate cortex in major depression

Tripp, A., Kota, R. S., Lewis, D. A., & Sibille, E. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.01.014 · Cited by 190

Shared Gene Expression Alterations in Schizophrenia and Bipolar Disorder

Shao, L., & Vawter, M. P. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.11.010 · Cited by 183

Cognitive dysfunction with aging and the role of inflammation

Simen, A. A., Bordner, K. A., Martin, M. P., Moy, L. A., & Barry, L. C. (2011) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622311399145 · Cited by 186

The Effects of Vitamin B in Depression

Mikkelsen, K., Stojanovska, L., & Apostolopoulos, V. (2016) · Current Medicinal Chemistry · doi:10.2174/0929867323666160920110810 · Cited by 177

Opposing effects of acute versus chronic blockade of frontal cortex somatostatin-positive inhibitory neurons on behavioral emotionality in mice

Soumier, A., & Sibille, E. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.76 · Cited by 136

Molecular underpinnings of prefrontal cortex development in rodents provide insights into the etiology of neurodevelopmental disorders

Schubert, D., Martens, G. J. M., & Kolk, S. M. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.147 · Cited by 157

Inflammatory processes in the aging mouse brain: Participation of dendritic cells and T-cells

Stichel, C. C., & Luebbert, H. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.07.022 · Cited by 151

Aging, Synaptic Dysfunction, and Insulin-Like Growth Factor (IGF)-1

Deák, F., & Sonntag, W. E. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls118 · Cited by 151

Exploring Sex-Related Differences in Microglia May Be a Game-Changer in Precision Medicine

Lynch, M. A. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.868448 · Cited by 146

Genetic and epigenetic regulation of human aging and longevity

Morris, B. J., Willcox, B. J., & Donlon, T. A. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.08.039 · Cited by 140

Dystrophic microglia in late‐onset Alzheimer's disease

Streit, W. J., Khoshbouei, H., & Bechmann, I. (2020) · Glia · doi:10.1002/glia.23782 · Cited by 152

Arousal increases neural gain via the locus coeruleus–noradrenaline system in younger adults but not in older adults

Lee, T., Greening, S. G., Ueno, T., Clewett, D., Ponzio, A., Sakaki, M., & Mather, M. (2018) · Nature Human Behaviour · doi:10.1038/s41562-018-0344-1 · Cited by 148

Adding fuel to the fire: the impact of stress on the ageing brain

Prenderville, J. A., Kennedy, P. J., Dinan, T. G., & Cryan, J. F. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2014.11.001 · Cited by 136

Molecular aging of the brain, neuroplasticity, and vulnerability to depression and other brain-related disorders

Sibille, E. L. (2013) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2013.15.1/esibille · Cited by 131

Biological Markers of Age-Related Memory Deficits

Foster, T. C. (2006) · CNS Drugs · doi:10.2165/00023210-200620020-00006 · Cited by 119

Transcript and protein expression decoupling reveals RNA binding proteins and miRNAs as potential modulators of human aging

Wei, Y.-N., Hu, H.-Y., Xie, G.-C., Fu, N., Ning, Z.-B., Zeng, R., & Khaitovich, P. (2015) · Genome Biology · doi:10.1186/s13059-015-0608-2 · Cited by 117

Reduced brain somatostatin in mood disorders: a common pathophysiological substrate and drug target?

Lin, L., & Sibille, E. L. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00110 · Cited by 122

Methodological considerations for gene expression profiling of human brain

Atz, M. E., Walsh, D. M. A., Cartagena, P. M., Li, J. Z., Evans, S. J., Choudary, P. V., Overman, K., Stein, R., Tomita, H., Potkin, S. G., et al. (2007) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2007.03.022 · Cited by 115

Neurodegenerative model of schizophrenia: Growing evidence to support a revisit

Stone, W. S., Phillips, M. R., Yang, L. H., Kegeles, L. S., Susser, E., & Lieberman, J. A. (2022) · Schizophrenia Research · doi:10.1016/j.schres.2022.03.004 · Cited by 114

The Role of BDNF in Age-Dependent Changes of Excitatory and Inhibitory Synaptic Markers in the Human Prefrontal Cortex

Oh, H., Lewis, D. A., & Sibille, E. L. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.126 · Cited by 113

Brain molecular aging, promotion of neurological disease and modulation by Sirtuin5 longevity gene polymorphism

Glorioso, C. A., Oh, S., Douillard‐Guilloux, G., & Sibille, E. L. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.09.016 · Cited by 105

Transcriptome analysis of male–female differences in prefrontal cortical development

Weickert, C. S., Elashoff, M. R., Richards, A., Sinclair, D., Bahn, S., Pääbo, S., Khaitovich, P., & Webster, M. J. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.5 · Cited by 86

Advances in transcriptome analysis of human brain aging

Ham, S., & Lee, S. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00522-6 · Cited by 82

Cognitive decline: A vitamin B perspective

Mikkelsen, K., Stojanovska, L., Tangalakis, K., Bosevski, M., & Apostolopoulos, V. (2016) · Maturitas · doi:10.1016/j.maturitas.2016.08.001 · Cited by 86

Genomic and biochemical approaches in the discovery of mechanisms for selective neuronal vulnerability to oxidative stress

Wang, X., Zaidi, A., Pal, R., Garrett, A. S., Braceras, R., Chen, X., Michaelis, M. L., & Michaelis, E. K. (2009) · BMC Neuroscience · doi:10.1186/1471-2202-10-12 · Cited by 90

Stress-induced changes in primate prefrontal profiles of gene expression

Karssen, A. M., Her, S., Li, J. Z., Patel, P. D., Meng, F., Bunney, W. E., Jones, E. G., Watson, S. J., Akil, H., Myers, R., et al. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002095 · Cited by 86

Between destiny and disease: Genetics and molecular pathways of human central nervous system aging

Glorioso, C. A., & Sibille, E. L. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.11.006 · Cited by 83

Menopause leads to elevated expression of macrophage-associated genes in the aging frontal cortex: rat and human studies identify strikingly similar changes

Sárvári, M., Hrabovszky, E., Kalló, I., Solymosi, N., Likó, I., Berchtold, N. C., Cotman, C. W., & Liposits, Z. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-264 · Cited by 81

Gene Expression in the Human Brain: The Current State of the Study of Specificity and Spatiotemporal Dynamics

Naumova, O. Y., Lee, M., Rychkov, S. Y., Vlasova, N. V., & Grigorenko, E. L. (2012) · Child Development · doi:10.1111/cdev.12014 · Cited by 81

Neurobiology of the aging dog

Head, E. (2010) · AGE · doi:10.1007/s11357-010-9183-3 · Cited by 81

Molecular and cellular aspects of age-related cognitive decline and Alzheimer’s disease

Hullinger, R., & Puglielli, L. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.05.008 · Cited by 68

Genomics of human longevity

Slagboom, P. E., Beekman, M., Passtoors, W. M., Deelen, J., Vaarhorst, A. A. M., Boer, J. M., van den Akker, E. B., van Heemst, D., de Craen, A. J. M., Maier, A. B., et al. (2010) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2010.0284 · Cited by 71

Understanding the pathogenesis of Alzheimer’s disease: will RNA‐Seq realize the promise of transcriptomics?

Sutherland, G. T., Janitz, M., & Kril, J. J. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07157.x · Cited by 67

The Age-by-Disease Interaction Hypothesis of Late-Life Depression

McKinney, B. C., & Sibille, E. L. (2013) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2013.01.053 · Cited by 71

Tissue preparation and banking

Webster, M. J. (2006) · Progress in Brain Research · doi:10.1016/s0079-6123(06)58001-x · Cited by 67

Transcriptomic profiling of the human brain reveals that altered synaptic gene expression is associated with chronological aging

Dillman, A., Majounie, E., Ding, J., Gibbs, J. R., Hernandez, D. G., Arepalli, S., Traynor, B. J., Singleton, A., Galter, D., & Cookson, M. R. (2017) · Scientific Reports · doi:10.1038/s41598-017-17322-0 · Cited by 65

Lack of serotonin1B receptor expression leads to age-related motor dysfunction, early onset of brain molecular aging and reduced longevity

Sibille, E. L., Su, J., Leman, S., Guisquet, A. M. L., Ibargüen-Vargas, Y., Joeyen-Waldorf, J., Glorioso, C. A., Tseng, G. C., Pezzone, M. A., Hen, R., et al. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001990 · Cited by 66

The first decade and beyond of transcriptional profiling in schizophrenia

Sequeira, A., Martin, M. V., & Vawter, M. P. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.03.001 · Cited by 64

DNA Methylation of Synaptic Genes in the Prefrontal Cortex Is Associated with Aging and Age-Related Cognitive Impairment

Ianov, L., Riva, A., Kumar, A., & Foster, T. C. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00249 · Cited by 65

Ageing-associated changes in the expression of lncRNAs in human tissues reflect a transcriptional modulation in ageing pathways

Marttila, S., Chatsirisupachai, K., Palmer, D. H., & de Magalhães, J. P. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2019.111177 · Cited by 62

Expression profiles of schizophrenia susceptibility genes during human prefrontal cortical development

Choi, K. H., Zepp, M. E., Higgs, B. W., Weickert, C. S., & Webster, M. J. (2009) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0956 · Cited by 68

Anticipated brain molecular aging in major depression

Douillard-Guilloux, G., Guilloux, J.-P., Lewis, D. A., & Sibille, E. (2013) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2013.01.040 · Cited by 62

Neurochemical correlation between major depressive disorder and neurodegenerative diseases

Réus, G. Z., Titus, S. E., Abelaira, H. M., Freitas, S. M., Tuon, T., Quevedo, J., & Budni, J. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.06.027 · Cited by 67

Gene expression in the hippocampus: Regionally specific effects of aging and caloric restriction

Zeier, Z. R., Madorsky, I., Xu, Y., Ogle, W. O., Notterpek, L. M., & Foster, T. C. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.10.006 · Cited by 63

Age-Dependent Changes in the Activation and Regulation of Microglia

Cornejo, F., & Rommy von Bernhardi, M. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-40764-7_10 · Cited by 61

Non-CG methylation and multiple histone profiles associate child abuse with immune and small GTPase dysregulation

Lutz, P.-É., Chay, M.-A., Pacis, A., Chen, G. G., Aouabed, Z., Maffioletti, E., Théroux, J., Grenier, J., Yang, J., Aguirre, M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21365-3 · Cited by 59

Stem Cells on the Brain: Modeling Neurodevelopmental and Neurodegenerative Diseases Using Human Induced Pluripotent Stem Cells

Srikanth, P., & Young‐Pearse, T. L. (2014) · Journal of Neurogenetics · doi:10.3109/01677063.2014.881358 · Cited by 61

Dietary methyl donor deficiency during pregnancy in rats shapes learning and anxiety in offspring

Konycheva, G., Dziadek, M. A., Ferguson, L. R., Krägeloh, C. U., Coolen, M. W., Davison, M., & Breier, B. H. (2011) · Nutrition Research · doi:10.1016/j.nutres.2011.09.015 · Cited by 58

Transcription Profile of Aging and Cognition-Related Genes in the Medial Prefrontal Cortex

Ianov, L., Rani, A., Beas, B. S., Kumar, A., & Foster, T. C. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00113 · Cited by 55

Gain in Brain Immunity in the Oldest-Old Differentiates Cognitively Normal from Demented Individuals

Katsel, P., Tan, W., & Haroutunian, V. H. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007642 · Cited by 57

Targeting specific HATs for neurodegenerative disease treatment: translating basic biology to therapeutic possibilities

Pirooznia, S. K., & Elefant, F. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00030 · Cited by 53

Biological substrates underpinning diagnosis of major depression

Sibille, E. L., & French, B. J. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000436 · Cited by 53

Older molecular brain age in severe mental illness

Lin, C., Chang, L., Ma, T., Oh, H., French, B. J., Puralewski, R., Mathews, F., Fang, Y., Lewis, D. A., Kennedy, J. L., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0834-1 · Cited by 52

Coping with Stress During Aging: The Importance of a Resilient Brain

Sampedro-Piquero, P., Alvarez-Suarez, P., & Begega, A. (2018) · Current Neuropharmacology · doi:10.2174/1570159x15666170915141610 · Cited by 41

Therapeutic potential of mangiferin in the treatment of various neuropsychiatric and neurodegenerative disorders

Walia, V., Chaudhary, S. K., & Kumar Sethiya, N. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2020.104939 · Cited by 51

Inflammation-related transcripts define “high” and “low” subgroups of individuals with schizophrenia and bipolar disorder in the midbrain

Zhu, Y., Owens, S. J., Murphy, C. E., Ajulu, K., Rothmond, D. A., Purves-Tyson, T. D., Middleton, F. A., Webster, M. J., & Weickert, C. S. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.06.012 · Cited by 49

Transcriptional Profiling of Human Familial Longevity Indicates a Role for ASF1A and IL7R

Passtoors, W. M., Boer, J. M., Goeman, J. J., van den Akker, E. B., Deelen, J., Zwaan, B. J., Scarborough, A., van der Breggen, R., Vossen, R. H. A. M., Houwing‐Duistermaat, J. J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0027759 · Cited by 48

Effects of aging on the electrophysiological properties of layer 5 pyramidal cells in the monkey prefrontal cortex

Luebke, J. I., & Chang, Y. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.09.042 · Cited by 48

Translational Research in Late-Life Mood Disorders: Implications for Future Intervention and Prevention Research

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