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Cited by 136Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and OutcomesNeural and Behavioral Psychology Studies

Cerebral metabolic dysfunction and impaired vigilance in recently abstinent methamphetamine abusers

London, Edythe D., Berman, Steven M., Voytek, Bradley, Simon, Sara L., Mandelkern, Mark A., Monterosso, John, Thompson, Paul M., Brody, Arthur L. +5 more·2005·Biological Psychiatry
DOI 10.1016/j.biopsych.2005.04.039
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Abstract

Background Methamphetamine (MA) abusers have cognitive deficits, abnormal metabolic activity and structural deficits in limbic and paralimbic cortices, and reduced hippocampal volume. The links between cognitive impairment and these cerebral abnormalities are not established.Methods We assessed cerebral glucose metabolism with [F-18]fluorodeoxyglucose positron emission tomography in 17 abstinent (4 to 7 days) methamphetamine users and 16 control subjects performing an auditory vigilance task and obtained structural magnetic resonance brain scans. Regional brain radioactivity served as a marker for relative glucose metabolism. Error rates on the task were related to regional radioactivity and hippocampal morphology.Results Methamphetamine users had higher error rates than control subjects on the vigilance task. The groups showed different relationships between error rates and relative activity in the anterior and middle cingulate gyrus and the insula. Whereas the MA user group showed negative correlations involving these regions, the control group showed positive correlations involving the cingulate cortex. Across groups, hippocampal metabolic and structural measures were negatively correlated with error rates.Conclusions Dysfunction in the cingulate and insular cortices of recently abstinent MA abusers contribute to impaired vigilance and other cognitive functions requiring sustained attention. Hippocampal integrity predicts task performance in methamphetamine users as well as control subjects.

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  • Insula and anterior cingulate activation are atypical in individuals with addiction disorders during decision-making and risk-taking.

    “Similarly, insula and anterior cingulate activation have been found to be atypical in individuals with addiction disorders during decision-making and risk-taking (Gowin et al., 2014; Hoffman et al., 2008; London et al., 2005; Nestor et al., 2011; Paulus, Hozack, et al., 2003).”

    From Atypical interoception as a common risk factor for psychopathology: A review (2021) · cites this paper as London et al., 2005

    The Results (p. 2) report atypical relationships between activity in the anterior cingulate and insula and task errors in recently abstinent methamphetamine users. But the task measured vigilance, not decision-making or risk-taking; the decision-making finding mentioned on p. 2 concerns prefrontal activation in another study. (LLM, conf=0.88)

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  1. First MB, Spitzer RL, Gibbon M, Williams J (1996): Structured Clinical Interview for DSM-IV Axis I Disorders-Patient Edition (SCID-IP, Version 2.0) . New York: Biometrics Research Department, New York State Psychiatric Institute.

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Authors
London, E. D., Berman, S. M., Voytek, B., Simon, S. L., Mandelkern, M. A., Monterosso, J., Thompson, P. M., Brody, A. L., Geaga, J. A., Hong, M. S., Hayashi, K. M., Rawson, R. A., & Ling, W.
Affiliations
  • University of California, Los Angeles (US)
  • University of California, Irvine (US)
Corresponding author
London, Edythe D.
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2005-11
Volume
58
Issue
10
Pages
770-778
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/j.biopsych.2005.04.039
OpenAlex
W2149639222
Cited by
136
References
60
Citations by year
2026: 1 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 8 · 2019: 8 · 2018: 7 · 2017: 6 · 2016: 2 · 2015: 6 · 2014: 5 · 2013: 10 · 2012: 10
FWCI
3.33
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • National Institute on Drug Abuse (1 Y01 DA 50038, R01DA015179)
  • National Center for Research Resources (RR08655, RR12169, M01RR000865, C06RR012169)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
methamphetamine, brain glucose metabolism, sustained attention, cognitive impairment, hippocampal volume, anterior cingulate cortex, insula, cingulate gyrus, hippocampal metabolism, drug abstinence, error rate
MeSH terms
Adult, Central Nervous System Stimulants, Arousal, Atrophy, Brain, Brain Mapping, Female, Glucose, Gyrus Cinguli, Hippocampus, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Methamphetamine, Neuropsychological Tests, Substance Withdrawal Syndrome, Fluorodeoxyglucose F18, Substance-Related Disorders, Positron-Emission Tomography

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