Striatum and insula dysfunction during reinforcement learning differentiates abstinent and relapsed methamphetamine-dependent individuals: Striatum dysfunction associated with relapse
Open accessAbstract
BACKGROUND AND AIMS: Individuals with methamphetamine dependence (MD) exhibit dysfunction in brain regions involved in goal maintenance and reward processing when compared with healthy individuals. We examined whether these characteristics also reflect relapse vulnerability within a sample of MD patients. DESIGN: Longitudinal, with functional magnetic resonance imaging (fMRI) and clinical interview data collected at baseline and relapse status collected at 1-year follow-up interview. SETTING: Keck Imaging Center, University of California San Diego, USA. PARTICIPANTS: MD patients (n = 60) enrolled into an in-patient drug treatment program at baseline. MD participants remaining abstinent at 1-year follow-up (abstinent MD group; n = 42) were compared with MD participants who relapsed within this period (relapsed MD group; n = 18). MEASUREMENTS: Behavioral and neural responses to a reinforcement learning (paper-scissors-rock) paradigm recorded during an fMRI session at time of treatment. FINDINGS: The relapsed MD group exhibited greater bilateral inferior frontal gyrus (IFG) and right striatal activation than the abstinent MD group during the learning of reward contingencies (Cohen's d range: 0.60-0.83). In contrast, the relapsed MD group displayed lower bilateral striatum, bilateral insula, left IFG and left anterior cingulate activation than the abstinent MD group (Cohen's d range: 0.90-1.23) in response to winning, tying and losing feedback. CONCLUSIONS: Methamphetamine-dependent individuals who achieve abstinence and then relapse show greater inferior frontal gyrus activation during learning, and relatively attenuated striatal, insular and frontal activation in response to feedback, compared with methamphetamine-dependent people who remain abstinent.
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Abstinent methamphetamine-dependent individuals who relapsed demonstrated attenuated bilateral insula, bilateral striatum, left inferior frontal gyrus, and left ACC activation in response to outcomes of winning, tying, and losing feedback in a reinforcement learning task, compared to those who remained abstinent.
“Additionally, abstinent methamphetamine-dependent individuals who relapsed demonstrated attenuated bilateral insula, bilateral striatum, left inferior frontal gyrus, and left ACC activation in response to outcomes of winning, tying, and losing feedback in a reinforcement learning task, compared to those who remained abstinent (Stewart et al., 2014).”
From The Insula: A Brain Stimulation Target for the Treatment of Addiction (2019) · cites this paper as Stewart et al., 2014
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- [26]Lee B London ED Poldrack RA Farahi J Nacca A Monterosso JR Striatal dopamine d2/d3 receptor availability is reduced in methamphetamine dependence and is linked to impulsivity J Neurosci 2009 29 47 14734 14740 19940168 PMC2822639
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- Authors
- Stewart, J. L., Connolly, C. G., May, A. C., Tapert, S. F., Wittmann, M., & Paulus, M. P.
- Affiliations
- University of California San Diego (US)
- University of California, San Francisco (US)
- Corresponding author
- Stewart, Jennifer L.
- ORCID
- Venue
- Addiction
- Publisher
- Wiley
- Published
- 2013-12-15
- Volume
- 109
- Issue
- 3
- Pages
- 460-471
- ISSN
- 0965-2140 (ISSN-L)
- PMC
- PMC3945155
- OpenAlex
- W2167904220
- Cited by
- 68
- References
- 67
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 6 · 2022: 3 · 2021: 5 · 2020: 8 · 2019: 5 · 2018: 8 · 2017: 4 · 2016: 9 · 2015: 5 · 2014: 4
- FWCI
- 2.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Addiction (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- U.S. Department of Veterans Affairs
- University of California, San Diego
- National Institute on Drug Abuse (R01DA018307)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- methamphetamine dependence, relapse, reinforcement learning, striatum, insula, inferior frontal gyrus, anterior cingulate cortex, reward processing, goal maintenance, abstinence, feedback response
- MeSH terms
- Adult, Cerebral Cortex, Decision Making, Female, Frontal Lobe, Gyrus Cinguli, Humans, Learning, Longitudinal Studies, Magnetic Resonance Imaging, Male, Methamphetamine, Middle Aged, Recurrence, Reinforcement, Psychology, Reward, Case-Control Studies, Neostriatum, Prefrontal Cortex, Amphetamine-Related Disorders, Young Adult, Functional Neuroimaging
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