Emotional Dysregulation in Adult ADHD and Response to Atomoxetine
Abstract
Background Before 1980, attention-deficit/hyperactivity disorder (ADHD) was called minimal brain dysfunction and included emotional symptoms now listed as "associated features" in DSM-IV. Data from two multicenter, placebo-controlled studies with 536 patients were reexamined to assess: 1) the pervasiveness of these symptoms in samples of adults with ADHD; 2) the response of these symptoms to atomoxetine; and 3) their association with depressive/anxiety symptoms.Methods The Wender-Reimherr Adult Attention Deficit Disorder Scale (WRAADDS) was used to assess temper, affective lability, and emotional overreactivity, thus identifying patients exhibiting "emotional dysregulation." Other DSM-IV Axis I diagnoses were exclusionary. Outcome measures were the Conners' Adult ADHD Rating Scale (CAARS) and the WRAADDS.Results Thirty-two percent of the sample met post hoc criteria for emotional dysregulation and had higher baseline scores on ADHD measures, a lower response to placebo, and greater response to atomoxetine (p = .048). Symptoms of emotional dysregulation had a treatment effect (p < .001) at least as large as the CAARS (p = .002) and the total WRAADDS (p = .001). Emotional dysregulation was present in the absence of anxiety or depressive diagnosis.Conclusions Symptoms of emotional dysregulation were present in many patients with ADHD and showed a treatment response similar to other ADHD symptoms.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Among non-stimulant treatments, improvement of emotion regulation on atomoxetine paralleled improvement in core symptoms of ADHD among adults.
“Among the non-stimulant treatments, improvement of emotion regulation on atomoxetine paralleled improvement in core symptoms of ADHD among adults (71).”
From Emotion Dysregulation in Attention Deficit Hyperactivity Disorder (2014) · cites this paper as [71]
Recent clinic-based studies report impairing emotion dysregulation in between 34-70% of adults with ADHD, although population based studies are needed.
“This has been supported to some extent by recent clinic-based studies reporting impairing emotion dysregulation in between 34-70% of adults with ADHD, although population based studies are needed (69-73)–Table 1.”
From Emotion Dysregulation in Attention Deficit Hyperactivity Disorder (2014) · cites this paper as [71]
Atomoxetine may be indicated in patients with comorbid substance use disorders, emotional dysregulation or social anxiety.
“Atomoxetine may be indicated in patients with comorbid substance use disorders, emotional dysregulation or social anxiety [295-297].”
From European consensus statement on diagnosis and treatment of adult ADHD: The European Network Adult ADHD (2010) · cites this paper as [296]
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
Multiple regression in behavioral research
Kerlinger, F. N., & Pedhazur, E. J. (1973) · Medical Entomology and Zoology · Cited by 4,877 · see citing works
(1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.12.1073 · Cited by 3,372 · see citing works
Multiple Regression in Behavioral Research.
Amick, D. J., Kerlinger, F. N., & Pedhazur, E. J. (1974) · Contemporary Sociology A Journal of Reviews · doi:10.2307/2061986 · Cited by 1,937 · see citing works
ADHD and The Nature of Self-Control
Barkley, R. A., & Wasserstein, J. (2000) · Journal of Cognitive Psychotherapy · doi:10.1891/0889-8391.14.1.111 · Cited by 1,639 · see citing works
ADHD and the Nature of Self-Control
Hinshaw, S. P. (1998) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/00004703-199806000-00010 · Cited by 1,209 · see citing works
THE BEHAVIOR OF CHILDREN RECEIVING BENZEDRINE
Bradley, C. (1937) · American Journal of Psychiatry · doi:10.1176/ajp.94.3.577 · Cited by 1,035 · see citing works
ADHD Comorbidity Findings From the MTA Study: Comparing Comorbid Subgroups
JENSEN, P. S., HINSHAW, S. P., KRAEMER, H. C., LENORA, N., NEWCORN, J. H., ABIKOFF, H. B., MARCH, J. S., ARNOLD, L. E., CANTWELL, D. P., CONNERS, C. K., et al. (2001) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200102000-00009 · Cited by 974 · see citing works
(1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.12.1792 · Cited by 950 · see citing works
Self-citationAtomoxetine in adults with ADHD: two randomized, placebo-controlled studies
Michelson, D., Adler, L., Spencer, T., Reimherr, F. W., West, S. A., Allen, A. J., Kelsey, D., Wernicke, J., Dietrich, A., & Milton, D. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01671-2 · Cited by 790 · see citing works
Self-citationMinimal brain dysfunction in children
Rumer, D. (1971) · Behavior Therapy · doi:10.1016/s0005-7894(71)80127-2 · Cited by 779 · see citing works
ATTENTION-DEFICIT HYPERACTIVITY DISORDER IN ADULTS
Wender, P. H. (1998) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(05)70039-3 · Cited by 728 · see citing works
Conners' Adult ADHD Rating Scales (CAARS).
Macey, K. (2003) · Archives of Clinical Neuropsychology · doi:10.1016/s0887-6177(03)00021-0 · Cited by 689 · see citing works
Attention-deficit/hyperactivity disorder in adults: an overview
Faraone, S. V., Biederman, J., Spencer, T. J., Wilens, T., Seidman, L. J., Mick, E. O., & Doyle, A. E. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00889-1 · Cited by 676 · see citing works
Self-citationHyperkinetic behavior syndrome in children
Laufer, M. W., & Denhoff, E. (1957) · The Journal of Pediatrics · doi:10.1016/s0022-3476(57)80257-1 · Cited by 464 · see citing works
Some Abnormal Psychical Conditions in Children
Still, G. (2006) · Journal of Attention Disorders · doi:10.1177/1087054706288114 · Cited by 348 · see citing works
Wender, P. H. (1981) · Archives of General Psychiatry · doi:10.1001/archpsyc.1981.01780290083009 · Cited by 337 · see citing works
Diagnosis and treatment of minimal brain dysfunction in adults: a preliminary report.
Wood, D. R., Reimherr, F., Wender, P., & Johnson, G. (1976) · Archives of General Psychiatry · doi:10.1001/archpsyc.1976.01770120057005 · Cited by 323 · see citing works
GREENHILL, L. L., SWANSON, J. M., VITIELLO, B., DAVIES, M., CLEVENGER, W., WU, M., ARNOLD, L. E., ABIKOFF, H. B., BUKSTEIN, O. G., CONNERS, C. K., et al. (2001) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200102000-00012 · Cited by 287 · see citing works
A Controlled Clinical Trial of Bupropion for Attention Deficit Hyperactivity Disorder in Adults
Wilens, T. E., Spencer, T. J., Biederman, J., Girard, K., Doyle, R., Prince, J., Polisner, D., Solhkhah, R., Comeau, S., Monuteaux, M. C., et al. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.2.282 · Cited by 272 · see citing works
Self-citationWender, P. H., Reimherr, F. W., Wood, D., & Ward, M. F. (1985) · American Journal of Psychiatry · doi:10.1176/ajp.142.5.547 · Cited by 257 · see citing works
Self-citationMarch, J. S., Swanson, J. M., Arnold, L. E., Hoza, B., Conners, C. K., Hinshaw, S. P., Hechtman, L. T., KRAEMER, H. C., Greenhill, L. L., Abikoff, H., et al. (2000) · Research on Child and Adolescent Psychopathology · doi:10.1023/a:1005179014321 · Cited by 250 · see citing works
Drenth, M. (2001) · Cited by 238 · see citing works
Bupropion treatment of attention-deficit hyperactivity disorder in adults
Wender, P. H., & Reimherr, F. W. (1990) · American Journal of Psychiatry · doi:10.1176/ajp.147.8.1018 · Cited by 134 · see citing works
Self-citationAn open trial of venlafaxine in adult patients with attention deficit hyperactivity disorder.
Hedges, D., Reimherr, F. W., Rogers, A., Strong, R. E., & Wender, P. H. (1995) · PubMed · Cited by 81 · see citing works
Self-citationControlled Trial of High Doses of Pemoline for Adults With Attention-Deficit/Hyperactivity Disorder
Wilens, T. E., Biederman, J., Spencer, T. J., Frazier, J. A., Prince, J. B., Bostic, J. Q., Rater, M. A., Soriano, J., Hatch, M., Sienna, M., et al. (1999) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-199906000-00009 · Cited by 65 · see citing works
Self-citationThe Syndrome of Minimal Brain Damage in Childhood
Pincus, J. H., & Glaser, G. H. (1966) · New England Journal of Medicine · doi:10.1056/nejm196607072750106 · Cited by 61 · see citing works
The Syndrome of Minimal Brain Dysfunction: Psychological Aspects
Conners, C. K. (1967) · Pediatric Clinics of North America · doi:10.1016/s0031-3955(16)32053-3 · Cited by 56 · see citing works
Minimal brain dysfunction in children
Gardner‐Medwin, D. (1973) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(73)90148-2 · Cited by 12 · see citing works
Flagged first, then by citations
1 of the 30 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Emotion Dysregulation in Attention Deficit Hyperactivity Disorder
Shaw, P., Stringaris, A., Nigg, J., & Leibenluft, E. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.13070966 · Cited by 1,232 · see citing works
Kooij, S. J., Bejerot, S., Blackwell, A., Caci, H., Casas-Brugué, M., Carpentier, P. J., Edvinsson, D., Fayyad, J., Foeken, K., Fitzgerald, M., et al. (2010) · BMC Psychiatry · doi:10.1186/1471-244x-10-67 · Cited by 928 · see citing works
“Atomoxetine may be indicated in patients with comorbid substance use disorders, emotional dysregulation or social anxiety [295-297].”
Adult ADHD and comorbid disorders: clinical implications of a dimensional approach
Katzman, M. A., Bilkey, T. S., Chokka, P. R., Fallu, A., & Klassen, L. J. (2017) · BMC Psychiatry · doi:10.1186/s12888-017-1463-3 · Cited by 732 · see citing works
Faraone, S. V., Rostain, A. L., Blader, J., Busch, B., Childress, A. C., Connor, D. F., & Newcorn, J. H. (2019) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12899 · Cited by 400 · see citing works
Faraone, S. V., & Glatt, S. J. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04902pur · Cited by 387 · see citing works
Maternal emotion and cognitive control capacities and parenting: A conceptual framework
Crandall, A., Deater-Deckard, K. D., & Riley, A. W. (2015) · Developmental Review · doi:10.1016/j.dr.2015.01.004 · Cited by 373 · see citing works
Adult attention-deficit hyperactivity disorder: key conceptual issues
Asherson, P., Buitelaar, J., Faraone, S. V., & Rohde, L. A. (2016) · The Lancet Psychiatry · doi:10.1016/s2215-0366(16)30032-3 · Cited by 347 · see citing works
Diagnosis and evaluation of adults with attention-deficit/hyperactivity disorder
Adler, L., & Cohen, J. (2004) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2003.12.003 · Cited by 290 · see citing works
Self-citationEmotion dysregulation in adults with attention deficit hyperactivity disorder: a meta-analysis
Beheshti, A., Chavanon, M.-L., & Christiansen, H. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-2442-7 · Cited by 247 · see citing works
Skirrow, C., & Asherson, P. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.10.011 · Cited by 230 · see citing works
Skirrow, C., McLoughlin, G., Kuntsi, J., & Asherson, P. (2009) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.2 · Cited by 217 · see citing works
Choi, W.-S., Woo, Y. S., Wang, S.-M., Lim, H. K., & Bahk, W.-M. (2022) · PLOS ONE · doi:10.1371/journal.pone.0277175 · Cited by 221 · see citing works
Mitchell, J. T., McIntyre, E., English, J. S., Dennis, M. F., Beckham, J. C., & Kollins, S. H. (2013) · Journal of Attention Disorders · doi:10.1177/1087054713513328 · Cited by 193 · see citing works
Hirsch, O., Chavanon, M., Riechmann, E., & Christiansen, H. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.02.007 · Cited by 190 · see citing works
Distinguishing comorbidity and successful management of adult ADHD
Kooij, J. J. S., Huss, M., Asherson, P., Akehurst, R., Beusterien, K., French, A., Sasané, R., & Hodgkins, P. (2012) · Journal of Attention Disorders · doi:10.1177/1087054711435361 · Cited by 172 · see citing works
Emotional dysregulation in adult ADHD: what is the empirical evidence?
Retz, W., Stieglitz, R., Corbisiero, S., Retz‐Junginger, P., & Rösler, M. (2012) · Expert Review of Neurotherapeutics · doi:10.1586/ern.12.109 · Cited by 168 · see citing works
Young, S., Adamou, M., Bolea-Alamanac, B. M., Gudjonsson, G. H., Müller, U., Pitts, M. E., Thome, J., & Asherson, P. J. (2011) · BMC Psychiatry · doi:10.1186/1471-244x-11-32 · Cited by 169 · see citing works
Rösler, M., Retz, W., Thome, J., Schneider, M., Stieglitz, R., & Falkai, P. (2006) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-006-1001-7 · Cited by 171 · see citing works
How is affective instability defined and measured? A systematic review
Marwaha, S., He, Z., Broome, M. R., Singh, S. P., Scott, J. L., Eyden, J., & Dieter Wolke, C. (2013) · Psychological Medicine · doi:10.1017/s0033291713002407 · Cited by 160 · see citing works
Attention-Deficit/Hyperactivity Disorder (ADHD) and Emotion Regulation Over the Life Span
Christiansen, H., Hirsch, O., Albrecht, B., & Chavanon, M. (2019) · Current Psychiatry Reports · doi:10.1007/s11920-019-1003-6 · Cited by 160 · see citing works
Surman, C. B. H., Biederman, J., Spencer, T., Miller, C. A., McDermott, K. M., & Faraone, S. V. (2013) · ADHD Attention Deficit and Hyperactivity Disorders · doi:10.1007/s12402-012-0100-8 · Cited by 155 · see citing works
Self-citationon behalf of the study group, Rösler, M., Fischer, R., Ammer, R., Ose, C., & Retz, W. (2009) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-008-0845-4 · Cited by 155 · see citing works
Sobanski, E., Brüggemann, D., Alm, B., Kern, S., Philipsen, A., Schmalzried, H., Heßlinger, B., Waschkowski, H., & Rietschel, M. (2007) · European Psychiatry · doi:10.1016/j.eurpsy.2007.09.007 · Cited by 153 · see citing works
Evidence of emotion dysregulation as a core symptom of adult ADHD: A systematic review
Soler-Gutiérrez, A.-M., Pérez-González, J.-C., & Mayas, J. (2023) · PLOS ONE · doi:10.1371/journal.pone.0280131 · Cited by 152 · see citing works
Park, J. H., Lee, Y. S., Sohn, J. H., & Han, D. H. (2016) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2559 · Cited by 152 · see citing works
Attention deficit hyperactivity disorder in adults
Rösler, M., Casas, M., Konofal, É., & Buitelaar, J. K. (2010) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2010.483249 · Cited by 140 · see citing works
Is emotional dysregulation part of the psychopathology of ADHD in adults?
Corbisiero, S., Stieglitz, R.-D., Retz, W., & Rösler, M. (2013) · ADHD Attention Deficit and Hyperactivity Disorders · doi:10.1007/s12402-012-0097-z · Cited by 139 · see citing works
Surman, C. B. H., Biederman, J., Spencer, T., Yorks, D., Miller, C. A., Petty, C. R., & Faraone, S. V. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.10081172 · Cited by 135 · see citing works
Self-citationRösler, M., Retz, W., Fischer, R., Ose, C., Alm, B., Deckert, J., Philipsen, A., Herpertz, S., & Ammer, R. (2010) · The World Journal of Biological Psychiatry · doi:10.3109/15622971003624197 · Cited by 131 · see citing works
Asherson, P., Young, A., Eich-Höchli, D., Moran, P., Porsdal, V., & Deberdt, W. (2014) · Current Medical Research and Opinion · doi:10.1185/03007995.2014.915800 · Cited by 138 · see citing works
Attention deficit hyperactivity disorder and critical incidents in a Scottish prison population
Young, S., Gudjonsson, G., Wells, J., Asherson, P., Theobald, D., Oliver, B., Scott, C., & Mooney, A. (2009) · Personality and Individual Differences · doi:10.1016/j.paid.2008.10.003 · Cited by 123 · see citing works
Oppositional Defiant Disorder Is Better Conceptualized as a Disorder of Emotional Regulation
Cavanagh, M., Quinn, D., Duncan, D., Graham, T., & Balbuena, L. (2014) · Journal of Attention Disorders · doi:10.1177/1087054713520221 · Cited by 119 · see citing works
Lara, D. R., Pinto, O., Akiskal, K. K., & Akiskal, H. H. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.02.025 · Cited by 119 · see citing works
An update on the pharmacotherapy of attention-deficit/hyperactivity disorder in adults
Wilens, T. E., Morrison, N. R., & Prince, J. B. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.11.137 · Cited by 113 · see citing works
ADHD and Anxiety: Clinical Significance and Treatment Implications
Reimherr, F. W., Marchant, B. K., Gift, T. E., & Steans, T. A. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0859-6 · Cited by 113 · see citing works
Self-citationADHD in Children and Adults: Diagnosis and Prognosis
Leffa, D. T., Caye, A., & Rohde, L. A. (2022) · Current topics in behavioral neurosciences · doi:10.1007/7854_2022_329 · Cited by 117 · see citing works
Weiss, M. D., & Hechtman, L. T. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n0412 · Cited by 106 · see citing works
An update on the debated association between ADHD and bipolar disorder across the lifespan
Skirrow, C., Hosang, G. M., FARMER, A. E., & Asherson, P. J. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.04.003 · Cited by 105 · see citing works
Bodalski, E. A., Knouse, L. E., & Kovalev, D. (2018) · Journal of Psychopathology and Behavioral Assessment · doi:10.1007/s10862-018-9695-1 · Cited by 104 · see citing works
Nigg, J. T., Karalunas, S. L., Gustafsson, H., Bhatt, P. R., Ryabinin, P., Mooney, M. A., Faraone, S. V., Fair, D. A., & Wilmot, B. (2019) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13132 · Cited by 101 · see citing works
Mazursky-Horowitz, H., Felton, J. W., MacPherson, L., Ehrlich, K. B., Cassidy, J. A., Lejuez, C. W., & Chronis-Tuscano, A. M. (2014) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-014-9894-5 · Cited by 97 · see citing works
Corbisiero, S., Mörstedt, B., Bitto, H., & Stieglitz, R. (2016) · Journal of Clinical Psychology · doi:10.1002/jclp.22317 · Cited by 96 · see citing works
Merwood, A., Chen, W., Rijsdijk, F., Skirrow, C., Larsson, H., Thapar, A., Kuntsi, J., & Asherson, P. (2014) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.11.006 · Cited by 84 · see citing works
Retz, W., Rösler, M., Ose, C., Scherag, A., Alm, B., Philipsen, A., Fischer, R., Ammer, R., & The Study Group (2012) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2010.540257 · Cited by 79 · see citing works
Biederman, J., Spencer, T., Lomedico, A., Day, H., Petty, C. R., & Faraone, S. V. (2012) · Psychological Medicine · doi:10.1017/s0033291711001644 · Cited by 78 · see citing works
Self-citationRösler, M., Retz, W., Retz‐Junginger, P., Stieglitz, R., Kessler, H., Reimherr, F. W., & Wender, P. H. (2008) · Der Nervenarzt · doi:10.1007/s00115-007-2375-0 · Cited by 78 · see citing works
Self-citationA One Year Trial of Methylphenidate in the Treatment of ADHD
Wender, P. H., Reimherr, F. W., Marchant, B. K., Sanford, M. E., Czajkowski, L. A., & Tomb, D. A. (2010) · Journal of Attention Disorders · doi:10.1177/1087054709356188 · Cited by 77 · see citing works
Self-citationSkirrow, C., Ebner‐Priemer, U., Reinhard, I., Malliaris, Y., Kuntsi, J., & Asherson, P. J. (2014) · Psychological Medicine · doi:10.1017/s0033291714001032 · Cited by 70 · see citing works
Huntley, Z., Maltezos, S., Williams, C. L., Morinan, A., Hammon, A., Ball, D. M., Marshall, E., Keaney, F., Young, S., Bolton, P., et al. (2012) · BMC Psychiatry · doi:10.1186/1471-244x-12-223 · Cited by 75 · see citing works
Affect Recognition in Adults With ADHD
Miller, M. R., Hanford, R. B., Fassbender, C., Duke, M. P., & Schweitzer, J. B. (2010) · Journal of Attention Disorders · doi:10.1177/1087054710368636 · Cited by 68 · see citing works
Hirsch, O., Chavanon, M., & Christiansen, H. (2019) · Scientific Reports · doi:10.1038/s41598-019-42018-y · Cited by 67 · see citing works
Mitchell, J. T., Robertson, C. D., Anastopolous, A. D., Nelson‐Gray, R. O., & Kollins, S. H. (2012) · Journal of Psychopathology and Behavioral Assessment · doi:10.1007/s10862-012-9297-2 · Cited by 66 · see citing works
The impact of cyclothymic temperament in adult ADHD.
Landaas, E. T., Halmøy, A., Oedegaard, K., Fasmer, O. B., & Haavik, J. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.04.034 · Cited by 53 · see citing works
Psychometric properties of the Wender-Reimherr Adult Attention Deficit Disorder Scale.
Marchant, B. K., Reimherr, F. W., Robison, D., Robison, R. J., & Wender, P. H. (2013) · Psychological Assessment · doi:10.1037/a0032797 · Cited by 63 · see citing works
Self-citationBipolar Symptoms in Adult Attention-Deficit/Hyperactivity Disorder
Halmøy, A., Halleland, H. B., Dramsdahl, M., Bergsholm, P., Fasmer, O. B., & Haavik, J. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04722ora · Cited by 63 · see citing works
Santosh, P. J., Sattar, S., & Canagaratnam, M. (2011) · CNS Drugs · doi:10.2165/11593070-000000000-00000 · Cited by 62 · see citing works
A critical appraisal of atomoxetine in the management of ADHD
Childress, A. C. (2015) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s59270 · Cited by 62 · see citing works
Similarities between emotional dysregulation in adults suffering from ADHD and bipolar patients
Richard-Lepouriel, H., Étain, B., Hasler, R., Bellivier, F., Gard, S., Kahn, J., Prada, P., Nicastro, R., Ardu, S., Dayer, A. G., et al. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.03.047 · Cited by 60 · see citing works
Wilens, T. E., Martelon, M., Anderson, J. P., Shelley-Abrahamson, R., & Biederman, J. (2013) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2013.01.015 · Cited by 58 · see citing works
Dunne, E. M., Hearn, L. E., Rose, J. J., & Latimer, W. W. (2014) · Addictive Behaviors · doi:10.1016/j.addbeh.2014.07.009 · Cited by 57 · see citing works
Moukhtarian, T. R., Cooper, R. E., Vassos, E., Moran, P., & Asherson, P. (2017) · European Psychiatry · doi:10.1016/j.eurpsy.2017.05.021 · Cited by 56 · see citing works
Halmøy, A., Johansson, S., Winge, I., McKinney, J. A., Knappskog, P. M., & Haavik, J. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.124 · Cited by 56 · see citing works
Abnormal Affective Responsiveness in Attention-Deficit/Hyperactivity Disorder: Subtype Differences
Conzelmann, A., Mucha, R. F., Jacob, C., Weyers, P., Romanos, J., Gerdes, A. B. M., Baehne, C. G., Boreatti‐Hümmer, A., Heine, M., Alpers, G. W., et al. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.10.038 · Cited by 56 · see citing works
Frustration Tolerance in Youth With ADHD
Seymour, K. E., Macatee, R. J., & Chronis-Tuscano, A. M. (2016) · Journal of Attention Disorders · doi:10.1177/1087054716653216 · Cited by 54 · see citing works
Rucklidge, J. J., Taylor, M. R., & Whitehead, K. (2010) · Journal of Attention Disorders · doi:10.1177/1087054709356173 · Cited by 54 · see citing works
Carmassi, C., Conti, L., Gravina, D., Nardi, B., & Dell’Osso, L. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.900277 · Cited by 55 · see citing works
Reimherr, F. W., Marchant, B. K., Gift, T. E., Steans, T. A., & Wender, P. H. (2015) · ADHD Attention Deficit and Hyperactivity Disorders · doi:10.1007/s12402-015-0176-z · Cited by 54 · see citing works
Self-citationDetecting attention-deficit/hyperactivity disorder (ADHD) in adults with intellectual disability
Malfa, G. L., Lassi, S., Bertelli, M. O., Pallanti, S., & Albertini, G. (2007) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2007.02.002 · Cited by 53 · see citing works
Alexithymia, emotion processing and social anxiety in adults with ADHD
Edel, M.-A., Rudel, A., Hubert, C., Scheele, D., Brüne, M., Juckel, G., & Assion, H.-J. (2010) · European Journal of Medical Research · doi:10.1186/2047-783x-15-9-403 · Cited by 51 · see citing works
Methylphenidate Transdermal System in Adult ADHD and Impact on Emotional and Oppositional Symptoms
Marchant, B. K., Reimherr, F. W., Robison, R. J., Olsen, J. L., & Kondo, D. G. (2011) · Journal of Attention Disorders · doi:10.1177/1087054710365986 · Cited by 51 · see citing works
Self-citationPerroud, N. A., Badoud, D., Weibel, S., Nicastro, R., Hasler, R., Küng, A., Luyten, P., Fonagy, P., Dayer, A. G., Aubry, J., et al. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.06.087 · Cited by 53 · see citing works
Chen, M., Pan, T., Hsu, J.-W., Huang, K., Su, T., Li, C., Lin, W.-C., Tsai, S., Chang, W.-H., Chen, T., et al. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.09.369 · Cited by 50 · see citing works
Marchant, B. K., Reimherr, F. W., Halls, C., Williams, E. D., Strong, R. E., Kondo, D. G., Soni, P., & Robison, R. J. (2011) · ADHD Attention Deficit and Hyperactivity Disorders · doi:10.1007/s12402-011-0054-2 · Cited by 49 · see citing works
Self-citationSánchez, M., Lavigne-Cerván, R., Romero, J. F., & Elósegui, E. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.01092 · Cited by 49 · see citing works
Perugi, G., Ceraudo, G., Vannucchi, G., Rizzato, S., Toni, C., & Dell'Osso, L. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.12.010 · Cited by 46 · see citing works
Bamford, S., Broyd, S. J., Benikos, N., Ward, R. D., Wiersema, J. R., & Sonuga-Barke, E. J. S. (2015) · Biological Psychology · doi:10.1016/j.biopsycho.2015.01.009 · Cited by 51 · see citing works
Emotion Dysregulation in Attention Deficit Hyperactivity Disorder
Shaw, P., Stringaris, A. K., Nigg, J. T., & Leibenluft, E. (2016) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.140102 · Cited by 51 · see citing works
Moukhtarian, T. R., Mintah, R. S., Moran, P., & Asherson, P. J. (2018) · Borderline Personality Disorder and Emotion Dysregulation · doi:10.1186/s40479-018-0086-8 · Cited by 49 · see citing works
Internalizing and externalizing behavior in adult ADHD
Jacob, C., Groß‐Lesch, S., Jans, T., Geissler, J. M., Reif, A., Dempfle, A., & Lesch, K. (2014) · ADHD Attention Deficit and Hyperactivity Disorders · doi:10.1007/s12402-014-0128-z · Cited by 45 · see citing works
Hwang, S., White, S. F., Nolan, Z. T., Craig Williams, W., Sinclair, S., & Blair, R. J. R. (2015) · NeuroImage Clinical · doi:10.1016/j.nicl.2015.10.005 · Cited by 43 · see citing works
Optimal management of ADHD in older adults
Torgersen, T., Gjervan, B., Lensing, M. B., & Rasmussen, K. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s59271 · Cited by 42 · see citing works
Young, S., Misch, P., Collins, P., & Gudjonsson, G. H. (2011) · Journal of Forensic Psychiatry and Psychology · doi:10.1080/14789949.2010.495991 · Cited by 40 · see citing works
Childhood clumsiness and peer victimization: a case–control study of psychiatric patients
Bejerot, S., & Humble, M. B. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-68 · Cited by 40 · see citing works
Varrasi, S., Boccaccio, F. M., Guerrera, C. S., Platania, G. A., Pirrone, C., & Castellano, S. (2022) · Education Sciences · doi:10.3390/educsci13010037 · Cited by 46 · see citing works
Altered event-related potentials in adults with ADHD during emotional faces processing
Raz, S., & Dan, O. (2014) · Clinical Neurophysiology · doi:10.1016/j.clinph.2014.06.023 · Cited by 37 · see citing works
Syrstad, V. E. G., Oedegaard, K., Fasmer, O. B., Halmøy, A., Haavik, J., Dilsaver, S., & Gjestad, R. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.08.047 · Cited by 26 · see citing works
Vidal, R., Valero, S., Nogueira, M., Palomar, G., Corrales, M., Richarte, V., Bosch, R., Gómez-Barros, N., Corominas, M., Casas, M., et al. (2014) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2014.07.001 · Cited by 36 · see citing works
Lower CSF HVA and 5-HIAA in bipolar disorder type 1 with a history of childhood ADHD
Rydén, E., Johansson, C., Blennow, K., & Landén, M. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0300-3 · Cited by 36 · see citing works
Ben-Dor Cohen, M., Eldar, E., Maeir, A., & Nahum, M. (2021) · Health and Quality of Life Outcomes · doi:10.1186/s12955-021-01904-8 · Cited by 35 · see citing works
The use of stimulants and atomoxetine in adults with comorbid ADHD and bipolar disorder
Perugi, G., & Vannucchi, G. (2015) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2015.1079620 · Cited by 38 · see citing works
Maier, S. J., Szalkowski, A., Kamphausen, S. B., Feige, B., Perlov, E., Kalisch, R., Jacob, G. A., Philipsen, A., Tüscher, O., & van Elst, L. T. (2013) · Psychological Medicine · doi:10.1017/s0033291713000469 · Cited by 35 · see citing works
Gamlı, İ. S., & Tahiroğlu, A. Y. (2018) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s164807 · Cited by 34 · see citing works
Surman, C. B. H., Biederman, J., Spencer, T., Miller, C. A., Petty, C. R., & Faraone, S. V. (2015) · Journal of Attention Disorders · doi:10.1177/1087054713476548 · Cited by 35 · see citing works
Self-citationPerugi, G., Pallucchini, A., Rizzato, S., Pinzone, V., & Rossi, P. D. (2019) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2019.1618270 · Cited by 25 · see citing works
Nonmedication treatments for adult ADHD: Evaluating impact on daily functioning and well-being.
Ramsay, J. R. (2010) · American Psychological Association eBooks · doi:10.1037/12056-000 · Cited by 33 · see citing works
Wehmeier, P. M., Schacht, A., Lehmann, M., Dittmann, R., Silva, S. G., & March, J. S. (2008) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/1753-2000-2-11 · Cited by 33 · see citing works
Robison, R. J., Reimherr, F. W., Gale, P. D., Marchant, B. K., Williams, E. D., Soni, P., Halls, C., & Strong, R. E. (2010) · Annals of Clinical Psychiatry · doi:10.1177/104012371002200204 · Cited by 32 · see citing works
Self-citationBiederman, J., DiSalvo, M., Woodworth, K. Y., Fried, R., Uchida, M., Biederman, I., Spencer, T. J., Surman, C., & Faraone, S. V. (2020) · European Psychiatry · doi:10.1192/j.eurpsy.2019.11 · Cited by 31 · see citing works
Self-citationOros Methylphenidate in the Treatment of Adults with Adhd: A 6-Month, Open-Label, Follow-Up Study
Marchant, B. K., Reimherr, F. W., Halls, C., Williams, E. D., & Strong, R. E. (2010) · Annals of Clinical Psychiatry · doi:10.1177/104012371002200309 · Cited by 27 · see citing works
Self-citationAdult ADHD and emerging models of maladaptive personality: a meta-analytic review
Jacobsson, P., Hopwood, C. J., Söderpalm, B., & Nilsson, T. (2021) · BMC Psychiatry · doi:10.1186/s12888-021-03284-1 · Cited by 30 · see citing works
- Authors
- Reimherr, F. W., Marchant, B. K., Strong, R. E., Hedges, D. W., Adler, L., Spencer, T. J., West, S. A., & Soni, P.
- Affiliations
- University of Utah (US)
- Brigham Young University (US)
- New York University (US)
- Harvard University (US)
- CNS Healthcare (US)
- Corresponding author
- Reimherr, Frederick W.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2005-07
- Volume
- 58
- Issue
- 2
- Pages
- 125-131
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2020006801
- Cited by
- 258
- References
- 30
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 10 · 2023: 11 · 2022: 12 · 2021: 10 · 2020: 6 · 2019: 11 · 2018: 12 · 2017: 17 · 2016: 14 · 2015: 17 · 2014: 22 · 2013: 16 · 2012: 15
- FWCI
- 4.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- adult ADHD, emotional dysregulation, atomoxetine, temper, emotional lability, treatment response, depressive symptoms, anxiety symptoms, Conners' Adult ADHD Rating Scale
- MeSH terms
- Atomoxetine Hydrochloride, Adult, Affective Symptoms, Analysis of Variance, Anxiety Disorders, Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Double-Blind Method, Female, Humans, Male, Middle Aged, Norepinephrine, Propylamines, Adrenergic Uptake Inhibitors, Mood Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
