CoChat
Sign Up
Cited by 58Bipolar Disorder and TreatmentSubstance Abuse Treatment and OutcomesChild and Adolescent Psychosocial and Emotional Development

Difficulties in emotional regulation and substance use disorders: A controlled family study of bipolar adolescents

Open access
Wilens, Timothy E., Martelon, MaryKate, Anderson, Jesse P., Shelley-Abrahamson, Rachel, Biederman, Joseph·2013·Drug and Alcohol Dependence
DOI 10.1016/j.drugalcdep.2013.01.015PMC PMC3683118
Open this paper in CoChat — free account

Abstract

Background Self-regulatory mechanisms appear etiologically operant in the context of both substance use disorders (SUD) and bipolar disorder (BD), however, little is known about the role of deficits in emotional self-regulation (DESR) as it relates to SUD in context to mood dysregulation. To this end, we examined to what extent DESR was associated with SUD in a high-risk sample of adolescents with and without BD. Methods 203 families were assessed with a structured psychiatric interview. Using the Child Behavior Checklist (CBCL), a subject was considered to have DESR when he or she had an average elevation of 1 standard deviation (SD) above the norm on 3 clinical scale T scores (attention, aggression, and anxiety/depression; scores: 60 × 3 ≥ 180). Results Among probands and siblings with CBCL data (N=303), subjects with DESR were more likely to have any SUD, alcohol use disorder, drug use disorder, and cigarette smoking compared to subjects with scores <180 (all p values <0.001), even when correcting for BD. We found no significant differences in the risk of any SUD and cigarette smoking between those with 1SD and 2SD above the mean (all p values >0.05). Subjects with cigarette smoking and SUD had more DESR compared to those without these disorders. Conclusions Adolescents with DESR are more likely to smoke cigarettes and have SUD. More work is needed to explore DESR in longitudinal samples.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.drugalcdep.2013.01.015

Cites

60 of 60 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Treatment of mood symptoms may oppose the effect of mood symptoms and prominent mood dysregulation driving the onset or recurrence of SUD.

    “Whereas mood symptoms and prominent mood dysregulation drive the onset or recurrence of SUD, the current findings support that treatment of mood symptoms may oppose this effect (Wilens et al. 2013; Fatseas et al. 2018).”

    From The Impact of Pharmacotherapy of Childhood-Onset Psychiatric Disorders on the Development of Substance Use Disorders (2022) · cites this paper as Wilens et al. 2013

    The Discussion (page unavailable) links emotional dysregulation to SUD risk and earlier onset, and suggests it may contribute to SUD maintenance. But the authors say their cross-sectional study cannot establish that dysregulation predicts SUD; it does not establish that mood symptoms drive onset or recurrence. The statement about treatment opposing that effect is presented as the citing authors’ own finding, not as a finding attributed to Wilens et al. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

2 of the 62 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. McMain S Korman LM Dimeff L Dialectical behavior therapy and the treatment of emotion dysregulation J. Clin. Psychol 2001 57 183 196 11180146

Cited by

Sorted by citations

Related

Authors
Wilens, T. E., Martelon, M., Anderson, J. P., Shelley-Abrahamson, R., & Biederman, J.
Affiliations
  • Massachusetts General Hospital (US)
  • Harvard University (US)
ORCID
Venue
Drug and Alcohol Dependence
Publisher
Elsevier BV
Published
2013-09
Volume
132
Issue
1-2
Pages
114-121
ISSN
0376-8716 (ISSN-L)
DOI
10.1016/j.drugalcdep.2013.01.015
PMC
PMC3683118
OpenAlex
W2094834233
Cited by
58
References
62
Citations by year
2026: 3 · 2025: 2 · 2024: 3 · 2023: 6 · 2022: 3 · 2021: 6 · 2020: 4 · 2019: 8 · 2018: 4 · 2017: 4 · 2016: 6 · 2015: 4 · 2014: 4 · 2013: 1
FWCI
3.56
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Drug and Alcohol Dependence (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Drug Abuse (K24DA016264, R01DA012945, R01 DA12945)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Keywords
substance use disorders, bipolar disorder, adolescents, mood dysregulation, alcoholism, drug use disorders, cigarette smoking, high-risk families, attention deficits, aggression, anxiety and depression
MeSH terms
Adolescent, Aggression, Alcoholism, Anxiety, Attention, Attention Deficit Disorder with Hyperactivity, Bipolar Disorder, Child, Child Behavior, Depression, Emotions, Female, Humans, Male, Psychiatric Status Rating Scales, Schools, Smoking, Comorbidity, Conduct Disorder, Substance-Related Disorders, Diagnostic and Statistical Manual of Mental Disorders

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review