Cited by 222Stress Responses and CortisolNeurotransmitter Receptor Influence on BehaviorPosttraumatic Stress Disorder Research

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Neurobiological Sequelae of Witnessing Stressful Events in Adult Mice

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Warren, Brandon L., Vialou, Vincent F., Iñiguez, Sergio D., Alcantara, Lyonna F., Wright, Katherine N., Feng, Jiang, Kennedy, Pamela J., LaPlant, Quincey, Shen, Li, Nestler, Eric J., Bolaños-Guzmán, Carlos A.·2013·Biological Psychiatry

DOI 10.1016/j.biopsych.2012.06.006PMC PMC3498570

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Abstract

Background It is well known that exposure to severe stress increases the risk for developing mood disorders. However, most chronic stress models in rodents involve at least some form of physically experiencing traumatic events.Methods This study assessed the effects of a novel social stress paradigm that is insulated from the effects of physical stress. Specifically, adult male C57BL/6J mice were exposed to either emotional (ES) or physical stress (PS) for 10 minutes per day for 10 days. The ES mice were exposed to the social defeat of a PS mouse by a larger, more aggressive CD-1 mouse from the safety of an adjacent compartment.Results Like PS mice, ES mice exhibited a range of depression- and anxiety-like behaviors both 24 hours and 1 month after the stress. Increased levels of serum corticosterone, part of the stress response, accompanied these behavioral deficits. Based on previous work that implicated gene expression changes in the ventral tegmental area (a key brain reward region) in the PS phenotype, we compared genome-wide mRNA expression patterns in this brain region of ES and PS mice using RNA-seq. We found significant overlap between these conditions, which suggests several potential gene targets for mediating the behavioral abnormalities observed.Conclusions These findings demonstrate that witnessing traumatic events is a potent stress in adult male mice capable of inducing long-lasting neurobiological perturbations.

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Authors: Warren, B. L., Vialou, V. F., Iñiguez, S. D., Alcantara, L. F., Wright, K. N., Feng, J., Kennedy, P. J., LaPlant, Q., Shen, L., Nestler, E. J., & Bolaños-Guzmán, C. A.
Affiliations: Florida State University (US)
Icahn School of Medicine at Mount Sinai (US)
ORCID: Warren, Brandon L.
Vialou, Vincent F.
Iñiguez, Sergio D.
Wright, Katherine N.
Kennedy, Pamela J.
LaPlant, Quincey
Shen, Li
Nestler, Eric J.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2013-01
Volume: 73
Issue: 1
Pages: 7-14
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2012.06.006
PMC: PMC3498570
OpenAlex: W2052639257
Cited by: 222
References: 63
Citations by year: 2026: 9 · 2025: 14 · 2024: 16 · 2023: 23 · 2022: 24 · 2021: 23 · 2020: 18 · 2019: 16 · 2018: 16 · 2017: 16 · 2016: 11 · 2015: 9 · 2014: 19 · 2013: 6
FWCI: 4.64
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (P50 MH66172, P50MH096890, R01 MH-51399, R01MH051399, P50MH066172)
National Institute on Drug Abuse (F31DA027300, R21DA022351, R01DA026854)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Keywords: social defeat, emotional stress, physical stress, chronic stress, depression-like behavior, anxiety-like behavior, corticosterone, ventral tegmental area, gene expression, mood disorders, traumatic events
MeSH terms: Animals, Anxiety, Behavior, Animal, Corticosterone, Depression, Disease Models, Animal, Fluoxetine, Male, Mice, Inbred C57BL, Mice, Inbred ICR, Photic Stimulation, Social Behavior, Stress, Physiological, Stress, Psychological, Ventral Tegmental Area, Gene Expression Profiling, Mice

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Neurobiological Sequelae of Witnessing Stressful Events in Adult Mice

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