The DOI matches its Crossref record; 120 of the 120 references it cites were found in a registry or an index.
Ghrelin's role in the hypothalamic-pituitary-adrenal axis stress response: implications for mood disorders
Abstract
Ghrelin is a stomach hormone normally associated with feeding behavior and energy homeostasis. Recent studies highlight that ghrelin targets the brain to regulate a diverse number of functions, including learning, memory, motivation, stress responses, anxiety, and mood. In this review, we discuss recent animal and human studies showing that ghrelin regulates the hypothalamic-pituitary-adrenal axis and affects anxiety and mood disorders, such as depression and fear. We address the neural sites of action through which ghrelin regulates the hypothalamic-pituitary-adrenal axis and associated stress-induced behaviors, including the centrally projecting Edinger-Westphal nucleus, the hippocampus, amygdala, locus coeruleus, and the ventral tegmental area. Stressors modulate many behaviors associated with motivation, fear, anxiety, depression, and appetite; therefore, we assess the potential role for ghrelin as a stress feedback signal that regulates these associated behaviors. Finally, we briefly discuss important areas for future research that will help us move closer to potential ghrelin-based therapies to treat stress responses and related disorders.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“However, different stressors, such as social defeat and restraint stress in rodents, can increase long-term ghrelin levels in the stomach [309][310][311].”
From Anxiety, depression, and the microbiome: A role for gut peptides (2018) · cites this paper as [311]
In the citing paper
“Mice lacking endogenous ghrelin have a dampened circulating glucocorticoid response following an acute stressor due a deficit in the PVN response needed to stimulate ACTH from the pituitary [295,311].”
From Anxiety, depression, and the microbiome: A role for gut peptides (2018) · cites this paper as [311]
Citations
Cites
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K. (1999) · Nature · doi:10.1038/45230 · Cited by 8,479
Sapolsky, R. M., Romero, L. M., & Munck, A. U. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.1.0389 · Cited by 7,541
Sapolsky, R. M. (2000) · Endocrine Reviews · doi:10.1210/er.21.1.55 · Cited by 7,533
Stress and the brain: from adaptation to disease
de Kloet, E. R., Joëls, M., & Holsboer, F. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1683 · Cited by 4,621
Ghrelin induces adiposity in rodents
Tschöp, M., Smiley, D. L., & Heiman, M. L. (2000) · Nature · doi:10.1038/35038090 · Cited by 3,949
A role for ghrelin in the central regulation of feeding
Nakazato, M., Murakami, N., Date, Y., Kojima, M., Matsuo, H., Kangawa, K., & Matsukura, S. (2001) · Nature · doi:10.1038/35051587 · Cited by 3,443
Chronic stress, drug use, and vulnerability to addiction
Sinha, R. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1441.030 · Cited by 1,904
Cowley, M. A., Smith, R. G., Diano, S., Tschöp, M., Pronchuk, N., Grove, K. L., Strasburger, C. J., Bidlingmaier, M., Esterman, M., Heiman, M. L., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00063-1 · Cited by 1,679
Biological studies of post-traumatic stress disorder
Pitman, R. K., Rasmusson, A. M., Koenen, K. C., Shin, L. M., Orr, S. P., Gilbertson, M. W., Milad, M. R., & Liberzon, I. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3339 · Cited by 1,529
Joëls, M., & Baram, T. Z. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2632 · Cited by 1,521
Gold, P. W., & Chrousos, G. P. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001032 · Cited by 1,274
Yang, J. H., Brown, M. S., Liang, G., Grishin, N. V., & Goldstein, J. L. (2008) · Cell · doi:10.1016/j.cell.2008.01.017 · Cited by 1,207
Guan, X.-M., Yu, H., Palyha, O., McKee, K., Feighner, S., Sirinathsinghji, D., Smith, R. G., van der Ploeg, L., & Howard, A. (1997) · Brain Research. Molecular Brain Research · doi:10.1016/s0169-328x(97)00071-5 · Cited by 1,185
Stetler, C., & Miller, G. E. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31820ad12b · Cited by 1,123
Expression of ghrelin receptor mRNA in the rat and the mouse brain
Zigman, J. M., Jones, J. E., Lee, C. E., Saper, C. B., & Elmquist, J. K. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.20823 · Cited by 1,074
Pattern and time course of immediate early gene expression in rat brain following acute stress
Cullinan, W. E., Herman, J. P., Battaglia, D. F., Akil, H., & Watson, S. J. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00355-9 · Cited by 1,056
Kreek, M. J., Nielsen, D. A., Butelman, E. R., & LaForge, K. S. (2005) · Nature Neuroscience · doi:10.1038/nn1583 · Cited by 1,024
Dynamic adaptation of large-scale brain networks in response to acute stressors
Hermans, E. J., Henckens, M. J. A. G., Joëls, M., & Fernández, G. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.03.006 · Cited by 988
Abizaid, A., Liu, Z.-W., Andrews, Z. B., Shanabrough, M., Borok, E., Elsworth, J. D., Roth, R. H., Sleeman, M. W., Picciotto, M. R., Tschöp, M. H., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29867 · Cited by 984
Ghrelin octanoylation mediated by an orphan lipid transferase
Gutierrez, J. A., Solenberg, P. J., Perkins, D., Willency, J. A., Knierman, M. D., Jin, Z., Witcher, D. R., Luo, S., Onyia, J. E., & Hale, J. E. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800708105 · Cited by 825
Hair cortisol, stress exposure, and mental health in humans: A systematic review
Staufenbiel, S. M., Penninx, B. W. J. H., Spijker, A. T., Elzinga, B. M., & van Rossum, E. F. C. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.11.015 · Cited by 736
Banks, W. A., Tschöp, M., Robinson, S. M., & Heiman, M. L. (2002) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.034827 · Cited by 691
Lamers, F., Vogelzangs, N., Merikangas, K. R., de Jonge, P., Beekman, A. T. F., & Penninx, B. W. J. H. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.144 · Cited by 691
The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress
Lutter, M., Sakata, I., Osborne-Lawrence, S., Rovinsky, S. A., Anderson, J. G., Jung, S., Birnbaum, S., Yanagisawa, M., Elmquist, J. K., Nestler, E. J., et al. (2008) · Nature Neuroscience · doi:10.1038/nn.2139 · Cited by 644
Arvat, E., Maccario, M., Vito, L. D., Broglio, F., Benso, A. S., Gottero, C., Papotti, M. G., Muccioli, G., Diéguez, C., Casanueva, F. F., et al. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.3.7314 · Cited by 553
Dayas, C. V., Buller, K. M., Crane, J. W., Xu, Y., & Day, T. A. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01733.x · Cited by 514
Ghrelin-Induced Food Intake Is Mediated via the Orexin Pathway
Toshinai, K., Date, Y., Murakami, N., Shimada, M., Mondal, M. S., Shimbara, T., Guan, J., Wang, Q., Funahashi, H., Sakurai, T., et al. (2003) · Endocrinology · doi:10.1210/en.2002-220788 · Cited by 470
Zhao, T., Liang, G., Li, R. L., Xie, X., Sleeman, M. W., Murphy, A. J., Valenzuela, D. M., Yancopoulos, G. D., Goldstein, J. L., & Brown, M. S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002271107 · Cited by 435
Requirement of central ghrelin signaling for alcohol reward
Jerlhag, E., Egecioglu, E., Landgren, S., Salomé, N., Heilig, M. A., Moechars, D., Datta, R., Perrissoud, D., Dickson, S. L., & Engel, J. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812809106 · Cited by 430
Naleid, A. M., Grace, M. K., Cummings, D. E., & Levine, A. S. (2005) · Peptides · doi:10.1016/j.peptides.2005.04.025 · Cited by 409
Pacák, K., Palkovits, M., Kopin, I. J., & Goldstein, D. S. (1995) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1995.1004 · Cited by 395
Tomiyama, A. J., Dallman, M. F., & Epel, E. S. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.04.005 · Cited by 394
Regulation of the Hypothalamic-Pituitary-Adrenal Axis
Papadimitriou, A., & Priftis, K. Ν. (2009) · NeuroImmunoModulation · doi:10.1159/000216184 · Cited by 382
Ghrelin increases anxiety-like behavior and memory retention in rats
Carlini, V. P., Monzon, M. E., Varas, M., Cragnolini, A. B., Schiöth, H. B., Scimonelli, T. N., & de Barioglio, S. R. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02740-7 · Cited by 373
Holsboer, F., Lauer, C. J., Schreiber, W., & Krieg, J.-C. (2008) · Neuroendocrinology · doi:10.1159/000127023 · Cited by 369
A Role of Ghrelin in Neuroendocrine and Behavioral Responses to Stress in Mice
Asakawa, A., Inui, A., Kaga, T., Yuzuriha, H., Nagata, T., Fujimiya, M., Katsuura, G., Makino, S., Fujino, M., & Kasuga, M. (2001) · Neuroendocrinology · doi:10.1159/000054680 · Cited by 363
Jerlhag, E., Egecioglu, E., Dickson, S. L., Andersson, M. A., Svensson, L., & Engel, J. A. (2006) · Addiction Biology · doi:10.1111/j.1369-1600.2006.00002.x · Cited by 360
Arvat, E. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.3.1169 · Cited by 359
Ghrelin mediates stress-induced food-reward behavior in mice
Chuang, J.-C., Perelló, M., Sakata, I., Osborne-Lawrence, S. L., Savitt, J. M., Lutter, M. L., & Zigman, J. M. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57660 · Cited by 347
Carlini, V., Varas, M., Cragnolini, A., Schiöth, H., Scimonelli, T., & Debarioglio, S. R. (2004) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2003.11.150 · Cited by 347
Kern, A., Albarran-Zeckler, R. G., Walsh, H. E., & Smith, R. G. (2012) · Neuron · doi:10.1016/j.neuron.2011.10.038 · Cited by 330
Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons
Schaeffer, M., Langlet, F., Lafont, C., Molino, F., Hodson, D. J., Roux, T., Lamarque, L., Verdié, P., Bourrier, E., Dehouck, B., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1212137110 · Cited by 325
Dayas, C. V., Buller, K. M., & Day, T. A. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00645.x · Cited by 303
Jiang, H. F., Betancourt, L., & Smith, R. G. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0084 · Cited by 290
Immunocytochemical observation of ghrelin-containing neurons in the rat arcuate nucleus
Lu, S., Guan, J.-L., Wang, Q., Uehara, K., Yamada, S., Noboru, G. O. T. O., Date, Y., Nakazato, M., Kojima, M., Kangawa, K., et al. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02544-7 · Cited by 265
Ghrelin regulates the hypothalamic-pituitary-adrenal axis and restricts anxiety after acute stress
Spencer, S. J., Xu, L., Clarke, M. A., Lemus, M., Reichenbach, A., Geenen, B., Kozicz, T., & Andrews, Z. B. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.03.010 · Cited by 241
Orexin Signaling Mediates the Antidepressant-Like Effect of Calorie Restriction
Lutter, M., Krishnan, V., Russo, S. J., Jung, S., McClung, C. A., & Nestler, E. J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5584-07.2008 · Cited by 234
Tang-Christensen, M., Vrang, N., Ortmann, S., Bidlingmaier, M., Horvath, T. L., & Tschöp, M. (2004) · Endocrinology · doi:10.1210/en.2004-0529 · Cited by 226
Jerlhag, E., Egecioglu, E., Dickson, S. L., & Engel, J. A. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1907-7 · Cited by 219
Kozicz, T., Bittencourt, J. C., May, P. J., Reiner, A. J., Gamlin, P. D., Palkovits, M., Horn, A. K. E., Toledo, C. A. B., & Ryabinin, A. E. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22580 · Cited by 204
The extra-hypothalamic actions of ghrelin on neuronal function
Andrews, Z. B. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.10.001 · Cited by 199
Zhao, T., Sakata, I., Li, R. L., Liang, G., Richardson, J. A., Brown, M. S., Goldstein, J. L., & Zigman, J. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011116107 · Cited by 191
Schmid, D. A., Held, K., Ising, M., Uhr, M., Weikel, J. C., & Steiger, A. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300670 · Cited by 181
Acute psychological stress raises plasma ghrelin in the rat
Kristenssson, E., Sundqvist, M., Astin, M., Kjerling, M., Mattsson, H., de la Cour, C. D., Håkanson, R., & Lindström, E. (2006) · Regulatory Peptides · doi:10.1016/j.regpep.2006.02.003 · Cited by 179
Mani, B. K., Walker, A. K., Soto, E. J. L., Raingo, J., Lee, C. E., Perelló, M., Andrews, Z. B., & Zigman, J. M. (2014) · The Journal of Comparative Neurology · doi:10.1002/cne.23627 · Cited by 178
A ghrelin-growth hormone axis drives stress-induced vulnerability to enhanced fear
Meyer, R. M., Burgos-Robles, A., Liu, E., Correia, S. S., & Goosens, K. A. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.135 · Cited by 169
Álvarez-Crespo, M., Skibicka, K. P., Farkas, I., Molnár, C. S., Egecioglu, E., Hrabovszky, E., Liposits, Z., & Dickson, S. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046321 · Cited by 169
Walker, A. K., Rivera, P. D., Wang, Q., Chuang, J.-C., Tran, S., Osborne-Lawrence, S., Estill, S. J., Starwalt, R., Huntington, P., Morlock, L., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.34 · Cited by 161
Sato, T., Fukue, Y., Teranishi, H., Yoshida, Y., & Kojima, M. (2005) · Endocrinology · doi:10.1210/en.2005-0174 · Cited by 160
Rouach, V., Bloch, M., Rosenberg, N., Gilad, S., Limor, R., Stern, N., & Greenman, Y. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.04.010 · Cited by 159
Banks, W., Burney, B. O., & Robinson, S. (2008) · Peptides · doi:10.1016/j.peptides.2008.07.001 · Cited by 155
Myers, B., Dolgas, C. M., Kasckow, J., Cullinan, W. E., & Herman, J. P. (2013) · Brain Structure and Function · doi:10.1007/s00429-013-0566-y · Cited by 155
Brain Circuits Involved in Corticotropin‐Releasing Factor‐Norepinephrine Interactions during Stress
DUNN, A. J., SWIERGIEL, A. H., & PALAMARCHOUK, V (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1296.003 · Cited by 155
Schellekens, H., van Oeffelen, W. E. P. A., Dinan, T. G., & Cryan, J. F. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.382473 · Cited by 151
Reppermund, S., Zihl, J., Lucae, S., Horstmann, S., Kloiber, S., Holsboer, F., & Ising, M. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.09.027 · Cited by 147
Ghrelin's Roles in Stress, Mood, and Anxiety Regulation
Chuang, J.-C., & Zigman, J. M. (2010) · International Journal of Peptides · doi:10.1155/2010/460549 · Cited by 144
Effect of chronic stress on gastric emptying and plasma ghrelin levels in rats
Ochi, M., Tominaga, K., Tanaka, F., Tanigawa, T., Shiba, M., Watanabe, T., Fujiwara, Y., Oshitani, N., Higuchi, K., & Arakawa, T. (2008) · Life Sciences · doi:10.1016/j.lfs.2008.01.020 · Cited by 136
Jerlhag, E., & Engel, J. A. (2011) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2011.01.010 · Cited by 135
The glucocorticoid contribution to obesity
Spencer, S. J., & Tilbrook, A. J. (2011) · Stress · doi:10.3109/10253890.2010.534831 · Cited by 132
Delhanty, P. J. D., Sun, Y., Visser, J. A., van Kerkwijk, A., Huisman, M., van IJcken, W. F. J., Swagemakers, S. M. A., Smith, R. G., Themmen, A. P. N., & van der Lely, A. J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011749 · Cited by 131
Patterson, Z. R., Khazall, R., MacKay, H., Anisman, H., & Abizaid, A. B. (2013) · Endocrinology · doi:10.1210/en.2012-1834 · Cited by 130
Raspopow, K., Abizaid, A. B., Matheson, K., & Anisman, H. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.06.003 · Cited by 130
Ghrelin Indirectly Activates Hypophysiotropic CRF Neurons in Rodents
Cabral, A., Olga, S., Zigman, J. M., & Perelló, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031462 · Cited by 129
Ghrelin Regulates Hippocampal Neurogenesis in Adult Mice
Moon, M., Kim, S., Hwang, L., & Seungjoon, P. A. R. K. (2009) · Endocrine Journal · doi:10.1507/endocrj.k09e-089 · Cited by 122
Kaur, S., & Ryabinin, A. E. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01237.x · Cited by 121
Valentino, R. J., Curtis, A. L., Page, M. E., Pavcovich, L. A., & Florin-Lechner, S. M. (1997) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60863-7 · Cited by 120
Investigation of the presence of ghrelin in the central nervous system of the rat and mouse
Furness, J. B., Hunne, B., Matsuda, N., Yin, L., Russo, D., Kato, I., Fujimiya, M., Patterson, M., McLeod, J. L., Andrews, Z. B., et al. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.07.063 · Cited by 120
Effects of repeated restraint stress on gastric motility in rats
Zheng, J., Dobner, A., Babygirija, R., Ludwig, K., & Takahashi, T. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90928.2008 · Cited by 119
Cabral, A., Valdivia, S., Fernández, G., Reynaldo, M., & Perelló, M. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12168 · Cited by 114
Des-Acyl Ghrelin: A Metabolically Active Peptide
Delhanty, P. J. D., Neggers, S. J. C. M. M., & van der Lely, A. J. (2013) · Endocrine development · doi:10.1159/000346059 · Cited by 113
Chemical stimulation of the dorsomedial hypothalamus elevates plasma ACTH in conscious rats
Bailey, T. W., & DiMicco, J. A. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.280.1.r8 · Cited by 112
Hou, Z., Miao, Y., Gao, L., Pan, H., & Zhu, S. (2006) · Regulatory Peptides · doi:10.1016/j.regpep.2006.02.005 · Cited by 104
Barim, A. Ö., Aydın, S., Çolak, R., Dağ, E., Deniz, O., & Şahin, İ. (2009) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2009.02.020 · Cited by 103
Jerlhag, E., Landgren, S., Egecioglu, E., Dickson, S. L., & Engel, J. A. (2010) · Alcohol · doi:10.1016/j.alcohol.2010.10.002 · Cited by 101
Functional implications of limited leptin receptor and ghrelin receptor coexpression in the brain
Perelló, M., Scott, M. M., Sakata, I., Lee, C. E., Chuang, J.-C., Osborne-Lawrence, S. L., Rovinsky, S. A., Elmquist, J. K., & Zigman, J. M. (2011) · The Journal of Comparative Neurology · doi:10.1002/cne.22690 · Cited by 99
Currie, P. J., Khelemsky, R., Rigsbee, E. M., Dono, L. M., Coiro, C. D., Chapman, C. D., & Hinchcliff, K. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.08.037 · Cited by 97
Characterization of a novel ghrelin cell reporter mouse
Sakata, I., Nakano, Y., Osborne-Lawrence, S. L., Rovinsky, S. A., Lee, C. E., Perelló, M., Anderson, J. G., Coppari, R., Xiao, G., Lowell, B. B., et al. (2009) · Regulatory Peptides · doi:10.1016/j.regpep.2009.04.001 · Cited by 97
Taking two to tango: a role for ghrelin receptor heterodimerization in stress and reward
Schellekens, H., Dinan, T. G., & Cryan, J. F. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00148 · Cited by 96
Administration of antisense DNA for ghrelin causes an antidepressant and anxiolytic response in rats
Kanehisa, M., Akiyoshi, J., Kitaichi, T., Matsushita, H., Etsuhiro, T., Kodama, K., Hanada, H., & Isogawa, K. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.05.005 · Cited by 95
Patterson, Z. R., Ducharme, R., Anisman, H., & Abizaid, A. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07310.x · Cited by 95
Kluge, M., SCHÜSSLER, P., Dresler, M., Schmidt, D., Yassouridis, A., Uhr, M., & Steiger, A. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.09.002 · Cited by 93
Kobelt, P., Wisser, A.-S., Stengel, A., Goebel, M., Inhoff, T., Noetzel, S., Veh, R. W., Bannert, N., van der Voort, I., Wiedenmann, B., et al. (2008) · Brain Research · doi:10.1016/j.brainres.2008.01.054 · Cited by 83
Analysis of brain nuclei accessible to ghrelin present in the cerebrospinal fluid
Cabral, A., Fernandez, G., & Perello, M. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.09.008 · Cited by 83
Dickson, S. L., Hrabovszky, E., Hansson, C., Jerlhag, E., Álvarez-Crespo, M., Skibicka, K. P., Molnar, C. S., Liposits, Z., Engel, J., & Egecioglu, E. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.10.005 · Cited by 82
Ziegler, D. R., & Herman, J. P. (2000) · Endocrinology · doi:10.1210/endo.141.12.7949 · Cited by 80
Clifford, P. S., Rodriguez, J. A., Schul, D. L., Hughes, S., Kniffin, T. C., Hart, N., Eitan, S., Brunel, L., Fehrentz, J., Martínez, J., et al. (2011) · Addiction Biology · doi:10.1111/j.1369-1600.2011.00339.x · Cited by 80
Serum Ghrelin and Leptin Levels in Patients with Depression and the Effects of Treatment
Özsoy, S., Beşirli, A., Abdülrezzak, Ü., & Baştürk, M. (2014) · Psychiatry Investigation · doi:10.4306/pi.2014.11.2.167 · Cited by 79
Das, M., Vihlen, C. S., & Légrádi, G. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21212 · Cited by 75
Reduced locomotor responses to cocaine in ghrelin-deficient mice
Abizaid, A. B., Mineur, Y. S., Roth, R. H., Elsworth, J. D., Sleeman, M., Picciotto, M. R., & Horváth, T. L. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.06.001 · Cited by 72
Légrádi, G., Hannibal, J., & Lechan, R. M. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00255-9 · Cited by 70
Lloyd, R. B., & Nemeroff, C. B. (2011) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026611109060609 · Cited by 67
Kádár, A., Sánchez, E., Wittmann, G., Singru, P. S., Füzesi, T., Marsili, A., Larsen, P. R., Liposits, Z., Lechan, R. M., & Fekete, C. (2010) · Journal of Comparative Neurology · doi:10.1002/cne.22432 · Cited by 66
Norrholm, S. D., Das, M., & Légrádi, G. (2005) · Regulatory Peptides · doi:10.1016/j.regpep.2004.12.023 · Cited by 65
Ghrelin Plasma Levels Are Not Altered in Major Depression
Kluge, M., SCHÜSSLER, P., Schmid, D. A., Uhr, M., Kleyer, S., Yassouridis, A., & Steiger, A. (2009) · Neuropsychobiology · doi:10.1159/000223731 · Cited by 64
Albarran-Zeckler, R. G., Brantley, A. F., & Smith, R. G. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.03.012 · Cited by 64
Kurt, E., Güler, Ö., Serteser, M., Cansel, N., Özbulut, Ö., Altınbaş, K., Alataş, G., SAVAS, H. A., & Geçici, Ö. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.08.018 · Cited by 62
Ghrelin gene polymorphism is associated with depression, but not panic disorder
Nakashima, K., Akiyoshi, J., Hatano, K., Hanada, H., Tanaka, Y., Tsuru, J., Matsushita, H., Kodama, K., & Isogawa, K. (2008) · Psychiatric Genetics · doi:10.1097/ypg.0b013e328306c979 · Cited by 60
Systemic ghrelin sensitizes cocaine-induced hyperlocomotion in rats
Wellman, P. J., Hollas, C. N., & Elliott, A. E. (2007) · Regulatory Peptides · doi:10.1016/j.regpep.2007.07.007 · Cited by 57
Ghrelin and Eating Disturbances in Psychiatric Disorders
Schanze, A., Reulbach, U., Scheuchenzuber, M., Gröschl, M., Kornhuber, J., & Kraus, T. (2008) · Neuropsychobiology · doi:10.1159/000138915 · Cited by 54
Wellman, P. J., Clifford, P. S., Rodriguez, J. A., Hughes, S., Eitan, S., Brunel, L., Fehrentz, J., & Martínez, J. (2011) · Regulatory Peptides · doi:10.1016/j.regpep.2011.08.014 · Cited by 50
The hormonal signature of energy deficit: Increasing the value of food reward
Lockie, S. H., & Andrews, Z. B. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.08.003 · Cited by 50
Reichenbach, A., Steyn, F. J., Sleeman, M. W., & Andrews, Z. B. (2012) · Endocrinology · doi:10.1210/en.2012-1622 · Cited by 49
Ishitobi, Y., Kohno, K., Kanehisa, M., Inoue, A., Imanaga, J., Maruyama, Y., Ninomiya, T., Higuma, H., Okamoto, S., Tanaka, Y., et al. (2012) · Neuropsychobiology · doi:10.1159/000339948 · Cited by 45
Neural correlates of plasma acylated ghrelin level in individuals with major depressive disorder
Matsuo, K., Nakano, M., Nakashima, M., Watanuki, T., Egashira, K., Matsubara, T., & Watanabe, Y. (2012) · Brain Research · doi:10.1016/j.brainres.2012.07.027 · Cited by 35
Sarker, M. R., Franks, S. F., & Caffrey, J. L. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.09.046 · Cited by 31
Smith, J. T., Reichenbach, A., Lemus, M. B., Mani, B. K., Zigman, J. M., & Andrews, Z. B. (2013) · Peptides · doi:10.1016/j.peptides.2013.06.012 · Cited by 25
A possible association between panic disorder and a polymorphism in the preproghrelingene
Hansson, C., Annerbrink, K., Nilsson, S., Bah, J., Olsson, M., Allgulander, C., Andersch, S., Sjödin, I., Eriksson, E., & Dickson, S. L. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2012.09.051 · Cited by 23
Wittmann, G. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01748.x · Cited by 22
Jansen, A. S. P., Schmidt, E. D., Voorn, P., & Tilders, F. J. H. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02453.x · Cited by 19
BIOMARKERS IN PEDIATRIC DEPRESSION
Rao, U. (2013) · Depression and Anxiety · doi:10.1002/da.22171 · Cited by 18
Cited by
Sorted by citations
Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants
Duman, R. S., Aghajanian, G. K., Sanacora, G., & Krystal, J. H. (2016) · Nature Medicine · doi:10.1038/nm.4050 · Cited by 1,750
Müller, T. D., Nogueiras, R., Andermann, M. L., Andrews, Z. B., Anker, S. D., Argente, J., Batterham, R. L., Benoit, S. C., Bowers, C. Y., Broglio, F., et al. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.03.005 · Cited by 1,034
Anxiety, depression, and the microbiome: A role for gut peptides
Lach, G., Schellekens, H., Dinan, T. G., & Cryan, J. F. (2018) · Neurotherapeutics · doi:10.1007/s13311-017-0585-0 · Cited by 573
Posttraumatic stress disorder: A metabolic disorder in disguise?
Michopoulos, V., Vester, A., & Neigh, G. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.05.038 · Cited by 152
Farokhnia, M., Grodin, E. N., Lee, M. R., Oot, E. N., Blackburn, A. N., Stangl, B. L., Schwandt, M. L., Farinelli, L. A., Momenan, R., Ramchandani, V. A., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.226 · Cited by 127
Metadata
- Authors
- Spencer, S. J., Emmerzaal, T. L., Kozicz, T., & Andrews, Z. B.
- Affiliations
- RMIT University (AU)
- Radboud University Medical Center (NL)
- Monash University (AU)
- Corresponding author
- Andrews, Zane B.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 78
- Issue
- 1
- Pages
- 19-27
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W1999468851
- Cited by
- 129
- References
- 119
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 16 · 2023: 4 · 2022: 13 · 2021: 10 · 2020: 12 · 2019: 18 · 2018: 13 · 2017: 16 · 2016: 11 · 2015: 8
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- RMIT Research Repository (RMIT University Library) (submittedVersion)
- Figshare (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- Australian Research Council (ARC) (DP130100508)
- NHMRC (APP1011274)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- ghrelin, hypothalamic-pituitary-adrenal axis, stress response, anxiety, depression, mood disorders, Edinger-Westphal nucleus, hippocampus, amygdala, locus coeruleus, ventral tegmental area, appetite
- MeSH terms
- Animals, Humans, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Stress, Psychological, Mood Disorders, Feedback, Physiological, Ghrelin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review