Effect of Novel Allosteric Modulators of Metabotropic Glutamate Receptors on Drug Self-administration and Relapse: A Review of Preclinical Studies and Their Clinical Implications

Caprioli, Daniele; Justinova, Zuzana; Venniro, Marco; Shaham, Yavin

doi:10.1016/j.biopsych.2017.08.018

Cited by 55Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchSubstance Abuse Treatment and Outcomes

Effect of Novel Allosteric Modulators of Metabotropic Glutamate Receptors on Drug Self-administration and Relapse: A Review of Preclinical Studies and Their Clinical Implications

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Caprioli, Daniele, Justinova, Zuzana, Venniro, Marco, Shaham, Yavin·2018·Biological Psychiatry

DOI 10.1016/j.biopsych.2017.08.018PMC PMC5837933

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Abstract

Results from preclinical rodent studies during the last 20 years implicated glutamate neurotransmission in different brain regions in drug self-administration and rodent models of relapse. These results, along with evidence for drug-induced neuroadaptations in glutamatergic neurons and receptors, suggested that addiction might be treatable by medications that inhibit glutamatergic responses to drugs of abuse, drug-associated cues, and stressors. This idea is supported by findings in rodent and primate models that drug self-administration and relapse are reduced by systemic injections of antagonists of ionotropic glutamate receptors or metabotropic glutamate receptors (mGluRs) or orthosteric agonists of mGluR2/3. However, these compounds have not advanced to clinical use because of potential side effects and other factors. This state of affairs has led to the development of positive allosteric modulators (PAMs) and negative allosteric modulators (NAMs) of mGluRs. PAMs and NAMs of mGluRs, either of which can inhibit evoked glutamate release, may be suitable for testing in humans. We reviewed results from recent studies of systemically injected PAMs and NAMs of mGluRs in rodents and monkeys, focusing on whether they reduce drug self-administration, reinstatement of drug seeking, and incubation of drug craving. We also review results from rat studies in which PAMs or NAMs of mGluRs were injected intracranially to reduce drug self-administration and reinstatement. We conclude that PAMs and NAMs of mGluRs should be considered for clinical trials.

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Several studies established a causal role for reduced prefrontal metabotropic glutamate receptor 2 function in craving and relapse responses in preclinical models of alcohol dependence.
“Several studies established a causal role for reduced prefrontal metabotropic glutamate receptor 2 (mGluR2) function in craving and relapse responses in preclinical models of alcohol dependence [48–52].”
From Psilocybin-assisted therapy for severe alcohol use disorder: protocol for a double-blind, randomized, placebo-controlled, 7-month parallel-group phase II superiority trial (2024) · cites this paper as [50]
The Group II metabotropic glutamate receptors > Reinstatement section (page unavailable) reports that an mGluR2 modulator reduced cue-induced alcohol seeking in rats, but not in rats lacking functional mGluR2, supporting a causal role for mGluR2 in that relapse response. It does not establish that reduced *prefrontal* mGluR2 function causes craving and relapse in models of alcohol dependence; its alcohol finding concerns cue-induced reinstatement, not craving broadly. (LLM, conf=0.85)
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Autoradiographic localization of dopamine D1 and D2 receptors in rat nucleus accumbens: Resistance to differential rearing conditions
Bardo, M. T., & Hammer, R. P. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90226-e · Cited by 3,229 · see citing works
PHARMACOLOGY AND FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTORS
Conn, P. J., & Pin, J. (1997) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.37.1.205 · Cited by 3,083 · see citing works
Context, ambiguity, and unlearning: sources of relapse after behavioral extinction
Bouton, M. E. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01546-9 · Cited by 1,662 · see citing works
The reinstatement model of drug relapse: history, methodology and major findings
Shaham, Y., Shalev, U., Lu, L., de Wit, H., & Stewart, J. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1224-x · Cited by 1,615 · see citing works
Self-citation
The glutamate homeostasis hypothesis of addiction
Kalivas, P. W. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2515 · Cited by 1,350 · see citing works
Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies
Vanderschuren, L. J. M. J., & Kalivas, P. W. (2000) · Psychopharmacology · doi:10.1007/s002130000493 · Cited by 1,337 · see citing works
A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants
Pierce, R. C., & Kalivas, P. W. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00021-0 · Cited by 1,239 · see citing works
Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons
Ungless, M. A., Whistler, J. L., Malenka, R. C., & Bonci, A. (2001) · Nature · doi:10.1038/35079077 · Cited by 1,106 · see citing works
Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders
Jeffrey Conn, P., Christopoulos, A., & Lindsley, C. W. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2760 · Cited by 1,063 · see citing works
Pharmacological agents acting at subtypes of metabotropic glutamate receptors
Schoepp, D. D., Jane, D. E., & Monn, J. A. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(99)00092-1 · Cited by 1,061 · see citing works
The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants
Wolf, M. E. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00090-7 · Cited by 934 · see citing works
The circuitry mediating cocaine-induced reinstatement of drug-seeking behavior
McFarland, K., & Kalivas, P. W. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-21-08655.2001 · Cited by 905 · see citing works
Prefrontal Glutamate Release into the Core of the Nucleus Accumbens Mediates Cocaine-Induced Reinstatement of Drug-Seeking Behavior
McFarland, K., Lapish, C. C., & Kalivas, P. W. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03531.2003 · Cited by 884 · see citing works
Neurobiology of relapse to heroin and cocaine seeking: a review
Shalev, U., Grimm, J. W., & Shaham, Y. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.1.1 · Cited by 880 · see citing works
Self-citation
Metabotropic glutamate receptors: electrophysiological properties and role in plasticity
Anwyl, R. (1999) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00050-2 · Cited by 776 · see citing works
Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4-phosphonobutyrate
Nakajima, Y., Iwakabe, H., Akazawa, C., Nawa, H., Shigemoto, R., Mizuno, N., & Nakanishi, S. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50280-0 · Cited by 739 · see citing works
2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist
Gasparini, F., Lingenhöhl, K., Stoehr, N., Flor, P. J., Heinrich, M., Vranesic, I., Biollaz, M., Allgeier, H., Heckendorn, R., Urwyler, S., et al. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(99)00082-9 · Cited by 725 · see citing works
Long-term potentiation of excitatory inputs to brain reward areas by nicotine
Mansvelder, H. D., & McGehee, D. S. (2000) · Neuron · doi:10.1016/s0896-6273(00)00042-8 · Cited by 720 · see citing works
Applying extinction research and theory to cue‐exposure addiction treatments
Conklin, C. A., & Tiffany, S. T. (2002) · Addiction · doi:10.1046/j.1360-0443.2002.00014.x · Cited by 702 · see citing works
Methods of Assessing the Reinforcing Properties of Abused Drugs
Bozarth, M. A. (1987) · Springer eBooks · doi:10.1007/978-1-4612-4812-5 · Cited by 693 · see citing works
Unveiling the Functions of Presynaptic Metabotropic Glutamate Receptors in the Central Nervous System
Schoepp, D. D. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29296-x · Cited by 693 · see citing works
Neurobiology of the incubation of drug craving
Pickens, C. L., Airavaara, M., Theberge, F. R. M., Fanous, S., Hope, B. T., & Shaham, Y. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.06.001 · Cited by 634 · see citing works
Self-citation
Brain circuitry and the reinstatement of cocaine-seeking behavior
Kalivas, P., & McFarland, K. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1393-2 · Cited by 613 · see citing works
Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat
Ohishi, H., Shigemoto, R., Nakanishi, S., & Mizuno, N. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90485-x · Cited by 560 · see citing works
Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice
Chiamulera, C., Epping-Jordan, M. P., Zocchi, A., Marcon, C., Cottiny, C., Tacconi, S., Corsi, M., Orzi, F., & Conquet, F. (2001) · Nature Neuroscience · doi:10.1038/nn0901-873 · Cited by 554 · see citing works
Glutamate Transmission in the Nucleus Accumbens Mediates Relapse in Cocaine Addiction
Cornish, J. L., & Kalivas, P. W. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-15-j0006.2000 · Cited by 546 · see citing works
Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain
Shigemoto, R., Nomura, S., Ohishi, H., Sugihara, H., Nakanishi, S., & Mizuno, N. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90227-c · Cited by 521 · see citing works
Neuroadaptations involved in amphetamine and cocaine addiction
White, F. J., & Kalivas, P. W. (1998) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(98)00072-6 · Cited by 509 · see citing works
Emerging paradigms in GPCR allostery: implications for drug discovery
Wootten, D., Christopoulos, A., & Sexton, P. M. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4052 · Cited by 498 · see citing works
Blockade of “reverse tolerance” to cocaine and amphetamine by MK-801
Karler, R., Calder, L. I., Chaudhry, I. A., & Turkanis, S. A. (1989) · Life Sciences · doi:10.1016/0024-3205(89)90045-3 · Cited by 488 · see citing works
The reinstatement model of drug relapse: recent neurobiological findings, emerging research topics, and translational research
Bossert, J. M., Marchant, N. J., Calu, D. J., & Shaham, Y. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3120-y · Cited by 453 · see citing works
Self-citation
Stress-induced reinstatement of drug seeking: 20 years of progress
Mantsch, J. R., Baker, D. A., Funk, D., Lê, A. D., & Shaham, Y. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.142 · Cited by 438 · see citing works
Self-citation
Molecular Neurobiology of Addiction
Nestler, E. J. (2001) · American Journal on Addictions · doi:10.1080/105504901750532094 · Cited by 412 · see citing works
Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptors
Hermans, E., & Challiss, R. A. J. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3590465 · Cited by 402 · see citing works
Synaptic mechanisms underlying persistent cocaine craving
Wolf, M. E. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.39 · Cited by 389 · see citing works
Involvement of N-methyl-D-aspartate receptor stimulation in the ventral tegmental area and amygdala in behavioral sensitization to cocaine.
Kalivas, P. W., & Alesdatter, J. E. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)39530-3 · Cited by 368 · see citing works
Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: differential location relative to pre- and postsynaptic sites
Tamaru, Y., Nomura, S., Mizuno, N., & Shigemoto, R. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00305-0 · Cited by 345 · see citing works
Direct Interactions between the Basolateral Amygdala and Nucleus Accumbens Core Underlie Cocaine-Seeking Behavior by Rats
Ciano, P. D., & Everitt, B. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1581-04.2004 · Cited by 333 · see citing works
Cocaine Administered into the Medial Prefrontal Cortex Reinstates Cocaine-Seeking Behavior by Increasing AMPA Receptor-Mediated Glutamate Transmission in the Nucleus Accumbens
Park, W.-K., Bari, A., Jey, A. R., Anderson, S. M., Spealman, R. D., Rowlett, J. K., & Pierce, R. C. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02916.2002 · Cited by 310 · see citing works
Fenobam: A Clinically Validated Nonbenzodiazepine Anxiolytic Is a Potent, Selective, and Noncompetitive mGlu5 Receptor Antagonist with Inverse Agonist Activity
Porter, R. H. P., Jaeschke, G., Spooren, W., Ballard, T. M., Büttelmann, B., Kolczewski, S., Peters, J.-U., Prinssen, E., Wichmann, J., Vieira, E., et al. (2005) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.089839 · Cited by 308 · see citing works
Different neural substrates mediate cocaine seeking after abstinence versus extinction training: a critical role for the dorsolateral caudate-putamen
Fuchs, R. A., Branham, R. K., & See, R. E. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.5146-05.2006 · Cited by 298 · see citing works
Time to connect: bringing social context into addiction neuroscience
Heilig, M., Epstein, D. H., Nader, M. A., & Shaham, Y. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.67 · Cited by 298 · see citing works
Self-citation
Synthesis, Pharmacological Characterization, and Molecular Modeling of Heterobicyclic Amino Acids Related to (+)-2-Aminobicyclo[3.1.0]hexane- 2,6-dicarboxylic Acid (LY354740): Identification of Two New Potent, Selective, and Systemically Active Agonists for Group II Metabotropic Glutamate Receptors
Monn, J. A., Valli, M. J., Massey, S. M., Hansen, M. M., Kress, T. J., Wepsiec, J. P., Harkness, A. R., John L. Grutsch, Wright, R. A., Johnson, B. G., et al. (1999) · Journal of Medicinal Chemistry · doi:10.1021/jm980616n · Cited by 293 · see citing works
Dissociable Effects of Antagonism of NMDA and AMPA/KA Receptors in the Nucleus Accumbens Core and Shell on Cocaine-seeking Behavior
Ciano, P. D. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00235-4 · Cited by 287 · see citing works
Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptors
Hermans, E., & Challiss, R. A. J. (2001) · Biochemical Journal · doi:10.1042/bj3590465 · Cited by 270 · see citing works
Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders
Conn, P. J., Lindsley, C. W., Meiler, J., & Niswender, C. M. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4308 · Cited by 259 · see citing works
Neural substrates of conditioned-cued relapse to drug-seeking behavior
See, R. E. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00682-7 · Cited by 257 · see citing works
Cocaine‐induced neuroadaptations in glutamate transmission
Schmidt, H. D., & Pierce, R. C. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05144.x · Cited by 254 · see citing works
A role for nucleus accumbens glutamate transmission in the relapse to cocaine-seeking behavior
Cornish, J. L., Duffy, P., & Kalivas, P. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00214-6 · Cited by 249 · see citing works
Distribution and synaptic localisation of the metabotropic glutamate receptor 4 (mGluR4) in the rodent CNS
Corti, C., Aldegheri, L., Somogyi, P., & Ferraguti, F. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00591-7 · Cited by 243 · see citing works
A Role of Ventral Tegmental Area Glutamate in Contextual Cue-Induced Relapse to Heroin Seeking
Bossert, J. M., Liu, S. Y., Lu, L., & Shaham, Y. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3207-04.2004 · Cited by 241 · see citing works
Self-citation
A selective metabotropic glutamate receptor 7 agonist: Activation of receptor signaling via an allosteric site modulates stress parameters in vivo
Mitsukawa, K., Yamamoto, R., Ofner, S., Nozulak, J., Pescott, O. L., Lukić, S., Stoehr, N., Mombereau, C., Kuhn, R. R., McAllister, K. H., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508063102 · Cited by 240 · see citing works
Repeated administration of MK-801 produces sensitization to its own locomotor stimulant effects but blocks sensitization to amphetamine
Wolf, M. E., & Khansa, M. R. (1991) · Brain Research · doi:10.1016/0006-8993(91)91202-c · Cited by 237 · see citing works
Preferential Effects of the Metabotropic Glutamate 2/3 Receptor Agonist LY379268 on Conditioned Reinstatement versus Primary Reinforcement: Comparison between Cocaine and a Potent Conventional Reinforcer
Baptista, M. A. S., Martin‐Fardon, R., & Weiss, F. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0176-04.2004 · Cited by 235 · see citing works
A Common Mechanism Mediates Long-Term Changes in Synaptic Transmission after Chronic Cocaine and Morphine
Bonci, A., & Williams, J. T. (1996) · Neuron · doi:10.1016/s0896-6273(00)80082-3 · Cited by 228 · see citing works
The ups and downs of addiction: role of metabotropic glutamate receptors
Kenny, P. J., & Markou, A. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.03.009 · Cited by 223 · see citing works
Rate-dependent effects of drugs: A review of the literature
Sanger, D. J., & Blackman, D. E. (1976) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(76)90178-7 · Cited by 222 · see citing works
Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals
Vendruscolo, L. F., Estey, D., Goodell, V., Macshane, L. G., Logrip, M. L., Schlosburg, J. E., McGinn, M. A., Zamora-Martinez, E. R., Belanoff, J. K., Hunt, H. J., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci79828 · Cited by 218 · see citing works
AMPA Receptor Synaptic Plasticity Induced by Psychostimulants: The Past, Present, and Therapeutic Future
Bowers, M. S., Chen, B. T., & Bonci, A. (2010) · Neuron · doi:10.1016/j.neuron.2010.06.004 · Cited by 218 · see citing works
Increased Responsiveness of Ventral Tegmental Area Dopamine Neurons to Glutamate after Repeated Administration of Cocaine or Amphetamine Is Transient and Selectively Involves AMPA Receptors
Zhang, X. F., Hu, X.-T., White, F. J., & Wolf, M. E. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36671-6 · Cited by 210 · see citing works
Metabotropic Glutamate Receptor Ligands as Potential Therapeutics for Addiction
Olive, M. F. (2009) · Current Drug Abuse Reviews · doi:10.2174/1874473710902010083 · Cited by 201 · see citing works
Metabotropic Glutamate 2/3 Receptors in the Ventral Tegmental Area and the Nucleus Accumbens Shell Are Involved in Behaviors Relating to Nicotine Dependence
Liechti, M. E., Lhuillier, L., Kaupmann, K., & Markou, A. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1766-07.2007 · Cited by 193 · see citing works
Systemic and Central Amygdala Injections of the mGluR2/3 Agonist LY379268 Attenuate the Expression of Incubation of Cocaine Craving
Lü, L., Uejima, J. L., Gray, S. M., Bossert, J. M., & Shaham, Y. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.04.011 · Cited by 192 · see citing works
Self-citation
Modulation of Group II Metabotropic Glutamate Receptor Signaling by Chronic Cocaine
Xi, Z., Ramamoorthy, S., Baker, D. L., Shen, H., Samuvel, D. J., & Kalivas, P. W. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.039735 · Cited by 181 · see citing works
Development of both conditioning and sensitization of the behavioral activating effects of amphetamine is blocked by the non-competitive NMDA receptor antagonist, MK-801
Stewart, J., & Druhan, J. P. (1993) · Psychopharmacology · doi:10.1007/bf02246961 · Cited by 179 · see citing works
Rational Development of Addiction Pharmacotherapies: Successes, Failures, and ProspectsPreprint
Pierce, R. C., O'Brien, C. P., Kenny, P. J., & Vanderschuren, L. J. M. J. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a012880 · Cited by 178 · see citing works
Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB‐1893 and MPEP
Mathiesen, J. M., Svendsen, N., Bräuner‐Osborne, H., Thomsen, C., & Ramirez, M. T. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705159 · Cited by 173 · see citing works
Discovery of Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 5 from a Series of N-(1,3-Diphenyl-1H- pyrazol-5-yl)benzamides That Potentiate Receptor Function in Vivo
Lindsley, C. W., Wisnoski, D. D., Leister, W., O’Brien, J. A., Lemaire, W., David L. Williams, Burno, M., Sur, C., Kinney, G. G., Pettibone, D. J., et al. (2004) · Journal of Medicinal Chemistry · doi:10.1021/jm049400d · Cited by 170 · see citing works
Biphenyl-indanone A, a Positive Allosteric Modulator of the Metabotropic Glutamate Receptor Subtype 2, Has Antipsychotic- and Anxiolytic-Like Effects in Mice
Galici, R., Jones, C. K., Hemstapat, R., Nong, Y., Echemendia, N. G., Williams, L. C., de Paulis, T., & Conn, P. J. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.102046 · Cited by 169 · see citing works
The Central Amygdala Nucleus is Critical for Incubation of Methamphetamine Craving
Li, X., Zeric, T., Kambhampati, S., Bossert, J. M., & Shaham, Y. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.320 · Cited by 163 · see citing works
Self-citation
The anterior insular cortex→central amygdala glutamatergic pathway is critical to relapse after contingency management
Venniro, M., Caprioli, D., Zhang, M., Whitaker, L. R., Zhang, S., Warren, B. L., Cifani, C., Marchant, N. J., Yizhar, O., Bossert, J. M., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.09.024 · Cited by 162 · see citing works
Self-citation
The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats
Schroeder, J. P., Overstreet, D. H., & Hodge, C. W. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2175-9 · Cited by 161 · see citing works
The Corticotropin Releasing Hormone-1 (CRH1) Receptor Antagonist Pexacerfont in Alcohol Dependence: A Randomized Controlled Experimental Medicine Study
Kwako, L. E., Spagnolo, P. A., Schwandt, M. L., Thorsell, A., George, D. T., Momenan, R., Rio, D. E., Huestis, M. A., Anizan, S., Concheiro, M., et al. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.306 · Cited by 160 · see citing works
The CRF1 antagonist verucerfont in anxious alcohol-dependent women: translation of neuroendocrine, but not of anti-craving effects
Schwandt, M. L., Cortes, C. R., Kwako, L. E., George, D. T., Momenan, R., Sinha, R., Grigoriadis, D. E., Pich, E. M., Leggio, L., & Heilig, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.61 · Cited by 159 · see citing works
Synaptic depression via mGluR1 positive allosteric modulation suppresses cue-induced cocaine craving
Loweth, J. A., Scheyer, A. F., Milovanovic, M., LaCrosse, A. L., Flores-Barrera, E., Werner, C. T., Li, X., Ford, K. A., Le, T., Olive, M. F., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3590 · Cited by 157 · see citing works
Cue exposure and relapse prevention in the treatment of addictive behaviors
Marlatt, G. A. (1990) · Addictive Behaviors · doi:10.1016/0306-4603(90)90048-3 · Cited by 156 · see citing works
The metabotropic glutamate receptor 5 antagonist MPEP decreased break points for nicotine, cocaine and food in rats
Paterson, N. E., & Markou, A. (2004) · Psychopharmacology · doi:10.1007/s00213-004-2070-9 · Cited by 155 · see citing works
A Double-Blind Placebo-Controlled Trial of N-Acetylcysteine in the Treatment of Cocaine Dependence
Larowe, S., Kalivas, P., Nicholas, J. S., Randall, P., Mardikian, P., & Malcolm, R. (2013) · American Journal on Addictions · doi:10.1111/j.1521-0391.2013.12034.x · Cited by 154 · see citing works
The mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL/6J mice
Hodge, C. W., Miles, M. F., Sharko, A. C., Stevenson, R. A., Hillmann, J. R., Lepoutre, V., Besheer, J., & Schroeder, J. P. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0217-y · Cited by 153 · see citing works
Distribution of metabotropic glutamate receptor 7 messenger RNA in the developing and adult rat brain
Kinzie, J. M., Saugstad, J. A., Westbrook, G. L., & Segerson, T. P. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00244-d · Cited by 149 · see citing works
Expression and Coupling to Polyphosphoinositide Hydrolysis of Group I Metabotropic Glutamate Receptors in Early Postnatal and Adult Rat Brain
Casabona, G., Knöpfel, T., Kühn, R., et al. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01348.x · Cited by 149 · see citing works
Recent developments in animal models of drug relapse
Marchant, N. J., Li, X., & Shaham, Y. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.01.003 · Cited by 148 · see citing works
Self-citation
Incubation of Methamphetamine but not Heroin Craving After Voluntary Abstinence in Male and Female Rats
Vènniro, M., Zhang, M. H., Shaham, Y., & Caprioli, D. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.287 · Cited by 147 · see citing works
Self-citation
Effect of the Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor 2 AZD8529 on Incubation of Methamphetamine Craving After Prolonged Voluntary Abstinence in a Rat Model
Caprioli, D., Venniro, M., Zeric, T., Li, X., Adhikary, S., Madangopal, R., Marchant, N. J., Lucantonio, F., Schoenbaum, G., Bossert, J. M., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.02.018 · Cited by 145 · see citing works
Self-citation
Intravenous Self-Administration: Response Rates, the Effects of Pharmacological Challenges, and Drug Preference
Yokel, R. A. (1987) · Springer eBooks · doi:10.1007/978-1-4612-4812-5_1 · Cited by 143 · see citing works
Role of Dorsomedial Striatum Neuronal Ensembles in Incubation of Methamphetamine Craving after Voluntary Abstinence
Caprioli, D., Vènniro, M., Zhang, M. H., Bossert, J. M., Warren, B. L., Hope, B. T., & Shaham, Y. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3091-16.2016 · Cited by 143 · see citing works
Self-citation
JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor antagonist
Lavreysen, H., Wouters, R., Bischoff, F., et al. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.08.007 · Cited by 140 · see citing works
In Vitro Pharmacological Characterization of Novel Isoxazolopyridone Derivatives as Allosteric Metabotropic Glutamate Receptor 7 Antagonists
Suzuki, G., Tsukamoto, N., Fushiki, H., Kawagishi, A., Nakamura, M., Kurihara, H., Mitsuya, M., Ohkubo, M., & Ohta, H. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.124701 · Cited by 132 · see citing works
Behavioral and neurochemical interactions between Group 1 mGluR antagonists and ethanol: Potential insight into their anti-addictive properties
Lominac, K. D., Kapasova, Z., Hannun, R. A., Patterson, C., Middaugh, L. D., & Szumlinski, K. K. (2006) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2006.04.003 · Cited by 124 · see citing works
mGluR5 Antagonists 2-Methyl-6-(phenylethynyl)-pyridine and (E)-2-Methyl-6-(2-phenylethenyl)-pyridine Reduce Traumatic Neuronal Injury In Vitro and In Vivo by AntagonizingN-Methyl-d-aspartate Receptors
Movsesyan, V. A., O’Leary, D. M., Fan, L., Bao, W., Mullins, P. G., Knoblach, S. M., & Faden, A. I. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29660-9 · Cited by 121 · see citing works
Loss of metabotropic glutamate receptor 2 escalates alcohol consumption
Zhou, Z., Karlsson, C., Liang, T., Xiong, W., Kimura, M., Tapocik, J. D., Yuan, Q., Barbier, E., Feng, A. Y., Flanigan, M. E., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1309839110 · Cited by 115 · see citing works
[3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine Binding to Metabotropic Glutamate Receptor Subtype 5 in Rodent Brain: In Vitro and in Vivo Characterization
Anderson, J. J., Rao, S. P., Rowe, B. A., Giracello, D. R., Holtz, G., Chapman, D. F., Tehrani, L. R., BRADBURY, M. J., Cosford, N. D. P., & Varney, M. A. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.040618 · Cited by 104 · see citing works
Clonidine Maintenance Prolongs Opioid Abstinence and Decouples Stress From Craving in Daily Life: A Randomized Controlled Trial With Ecological Momentary Assessment
Kowalczyk, W. J., Phillips, K. A., Jobes, M. L., Kennedy, A. P., Ghitza, U. E., Agage, D. A., Schmittner, J. P., Epstein, D. H., & Preston, K. L. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14081014 · Cited by 101 · see citing works
Recent updates on incubation of drug craving: a mini‐review
Li, X., Caprioli, D., & Marchant, N. J. (2014) · Addiction Biology · doi:10.1111/adb.12205 · Cited by 98 · see citing works
Self-citation
AMPA Receptor Plasticity in Accumbens Core Contributes to Incubation of Methamphetamine Craving
Scheyer, A. F., Loweth, J. A., Christian, D., Uejima, J. L., Rabei, R., Le, T. Q., Dolubizno, H., Stefanik, M. T., Murray, C. H., Sakas, C., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.04.003 · Cited by 98 · see citing works
Regulation of Motivation to Self‐Administer Ethanol by mGluR5 in Alcohol‐Preferring (P) Rats
Besheer, J., Faccidomo, S., Grondin, J. J. M., & Hodge, C. W. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00570.x · Cited by 97 · see citing works
mGlu1 receptor blockade attenuates cue- and nicotine-induced reinstatement of extinguished nicotine self-administration behavior in rats
Драволина, О. А., Захарова, Е. С., Шекунова, Е. В., Zvartau, E. E., Danysz, W., & Bespalov, A. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.07.023 · Cited by 93 · see citing works
Neurochemical and operant behavioral studies of a strain of alcohol-preferring rats
Penn, P. E., McBride, W. J., Lumeng, L., Gaff, T. M., & Li, T. (1978) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(78)90087-4 · Cited by 89 · see citing works
Pharmacological Stimulation of Group II Metabotropic Glutamate Receptors Reduces Cocaine Self-Administration and Cocaine-Induced Reinstatement of Drug Seeking in Squirrel Monkeys
Adewale, A. S., Platt, D. M., & Spealman, R. D. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.105387 · Cited by 89 · see citing works
The metabotropic glutamate 2/3 receptor agonist LY404039 reduces alcohol-seeking but not alcohol self-administration in alcohol-preferring (P) rats
Rodd, Z. A., McKinzie, D. L., Bell, R. L., McQueen, V. K., MURPHY, J., Schoepp, D. D., & McBride, W. J. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.03.032 · Cited by 86 · see citing works
Effects of mGluR1 antagonism in the dorsal hippocampus on drug context-induced reinstatement of cocaine-seeking behavior in rats
Xie, X., Ramirez, D. R., Lasseter, H. C., & Fuchs, R. A. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1700-7 · Cited by 85 · see citing works
Metabotropic and ionotropic glutamate receptors as potential targets for the treatment of alcohol use disorder
Goodwani, S., Saternos, H. C., Alasmari, F. F., & Sari, Y. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.02.024 · Cited by 83 · see citing works
Enhancement of Extinction Learning Attenuates Ethanol-Seeking Behavior and Alters Plasticity in the Prefrontal Cortex
Gass, J. T., Trantham‐Davidson, H., Kassab, A. S., Glen, W. B., Olive, M. F., & Chandler, L. J. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.5616-12.2014 · Cited by 81 · see citing works
Cognitive effects of Group I metabotropic glutamate receptor ligands in the context of drug addiction
Olive, M. F. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.01.029 · Cited by 80 · see citing works
Role of the Glutamatergic System in Nicotine Dependence
Liechti, M. E., & Markou, A. (2008) · CNS Drugs · doi:10.2165/00023210-200822090-00001 · Cited by 79 · see citing works
The mGluR2 Positive Allosteric Modulator BINA Decreases Cocaine Self-Administration and Cue-Induced Cocaine-Seeking and Counteracts Cocaine-Induced Enhancement of Brain Reward Function in Rats
Jin, X., Semenova, S., Yang, L., Ardecky, R., Sheffler, D. J., Dahl, R. S., Conn, P. J., Cosford, N. D. P., & Markou, A. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.82 · Cited by 78 · see citing works
Radioligand Binding Properties and Pharmacological Characterization of 6-Amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide (YM-298198), a High-Affinity, Selective, and Noncompetitive Antagonist of Metabotropic Glutamate Receptor Type 1
Kohara, A., Toya, T., Tamura, S., Watabiki, T., Nagakura, Y., Shitaka, Y., Hayashibe, S., Kawabata, S., & Okada, M. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.087171 · Cited by 78 · see citing works
Drug-Evoked Synaptic Plasticity Causing Addictive Behavior
Lüscher, C. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3406-13.2013 · Cited by 75 · see citing works
Evidence that the metabotropic glutamate receptor 5 antagonist MPEP may act as an inhibitor of the norepinephrine transporter in vitro and in vivo
Heidbreder, C. A., Bianchi, M., Lacroix, L. P., Faedo, S., Perdonà, E., Remelli, R., Cavanni, P., & Crespi, F. (2003) · Synapse · doi:10.1002/syn.10261 · Cited by 74 · see citing works
The mGluR2/3 agonist LY379268 attenuates context- and discrete cue-induced reinstatement of sucrose seeking but not sucrose self-administration in rats
Bossert, J. M., Poles, G. C., Sheffler-Collins, S. I., & Ghitza, U. E. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.06.008 · Cited by 72 · see citing works
Activation of mGluR7s inhibits cocaine‐induced reinstatement of drug‐seeking behavior by a nucleus accumbens glutamate‐mGluR2/3 mechanism in rats
Li, X., Li, J., Gardner, E. L., et al. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06851.x · Cited by 71 · see citing works
Metabotropic Glutamate Receptor 7 Modulates the Rewarding Effects of Cocaine in Rats: Involvement of a Ventral Pallidal GABAergic Mechanism
Li, X., Li, J., Peng, X., Spiller, K. J., Gardner, E. L., & Xi, Z. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.236 · Cited by 70 · see citing works
Estradiol Facilitation of Cocaine Self-Administration in Female Rats Requires Activation of mGluR5
Martinez, L. A., Gross, K. S., Himmler, B. T., et al. (2016) · eNeuro · doi:10.1523/eneuro.0140-16.2016 · Cited by 67 · see citing works
Deficits in Ventromedial Prefrontal Cortex Group 1 Metabotropic Glutamate Receptor Function Mediate Resistance to Extinction during Protracted Withdrawal from an Extensive History of Cocaine Self-Administration
Ben‐Shahar, O., Sacramento, A. D., Miller, B. W., Webb, S. M., Wroten, M. G., Silva, H. E., Caruana, A. L., Gordon, E. J., Ploense, K. L., Ditzhazy, J., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3710-12.2013 · Cited by 64 · see citing works
The Novel Metabotropic Glutamate Receptor 2 Positive Allosteric Modulator, AZD8529, Decreases Nicotine Self-Administration and Relapse in Squirrel Monkeys
Justinová, Z., Panlilio, L. V., Secci, M. E., Redhi, G. H., Schindler, C. W., Cross, A. J., Mrzljak, L., Medd, A. M., Shaham, Y., & Goldberg, S. R. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.01.014 · Cited by 63 · see citing works
Self-citation
Nonselective suppression of operant ethanol and sucrose self-administration by the mGluR7 positive allosteric modulator AMN082
Salling, M. C., Faccidomo, S., & Hodge, C. W. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.06.006 · Cited by 62 · see citing works
Subregion‐specific role of glutamate receptors in the nucleus accumbens on drug context‐induced reinstatement of cocaine‐seeking behavior in rats
Xie, X., Lasseter, H. C., Ramirez, D. R., Ponds, K. L., Wells, A. M., & Fuchs, R. A. (2011) · Addiction Biology · doi:10.1111/j.1369-1600.2011.00325.x · Cited by 59 · see citing works
Negative Allosteric Modulators of Metabotropic Glutamate Receptors Subtype 5 in Addiction: a Therapeutic Window
Mihov, Y., & Hasler, G. (2016) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw002 · Cited by 54 · see citing works
Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A‐841720, a novel non‐competitive mGluR1 receptor antagonist
El-Kouhen, O. F., Lehto, S. G., Pan, J. B., et al. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706877 · Cited by 52 · see citing works
Design and Synthesis of an Orally Active Metabotropic Glutamate Receptor Subtype-2 (mGluR2) Positive Allosteric Modulator (PAM) That Decreases Cocaine Self-Administration in Rats
Dhanya, R.-P., Sidique, S., Sheffler, D. J., Nickols, H. H., Herath, A., Yang, L., Dahl, R. S., Ardecky, R., Semenova, S., Markou, A., et al. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm1012165 · Cited by 52 · see citing works
Attenuation of methamphetamine seeking by the mGluR2/3 agonist LY379268 in rats with histories of restricted and escalated self-administration
Kufahl, P. R., Watterson, L. R., Nemirovsky, N. E., Hood, L. E., Villa, A., Halstengard, C., Zautra, N., & Olive, M. F. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.05.037 · Cited by 50 · see citing works
Lost in Translation: CRF1 Receptor Antagonists and Addiction Treatment
Shaham, Y., & de Wit, H. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.94 · Cited by 50 · see citing works
Self-citation
N-Aryl Piperazine Metabotropic Glutamate Receptor 5 Positive Allosteric Modulators Possess Efficacy in Preclinical Models of NMDA Hypofunction and Cognitive Enhancement
Gregory, K. J., Herman, E. J., Ramsey, A. J., Hammond, A. S., Byun, N. E., Stauffer, S. R., Manka, J. T., Jadhav, S. B., Bridges, T. M., Weaver, C. D., et al. (2013) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.113.206623 · Cited by 49 · see citing works
Effects of mGlu1-receptor blockade on ethanol self-administration in inbred alcohol-preferring rats
Besheer, J., Faccidomo, S., Grondin, J. J. M., & Hodge, C. W. (2008) · Alcohol · doi:10.1016/j.alcohol.2007.11.001 · Cited by 46 · see citing works
Allosteric modulation of Class C GPCRs: a novel approach for the treatment of CNS disorders
Engers, D. W., & Lindsley, C. W. (2013) · Drug Discovery Today: Technologies · doi:10.1016/j.ddtec.2012.10.007 · Cited by 45 · see citing works
Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy
Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, Á., van Rijn, C. M., D’Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., et al. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.01.007 · Cited by 44 · see citing works
Recent progress in the discovery and development of negative allosteric modulators of mGluR5.
Lindsley, C. W., & Emmitte, K. A. (2009) · PubMed · Cited by 44 · see citing works
The mGluR2 Positive Allosteric Modulator, AZD8529, and Cue-Induced Relapse to Alcohol Seeking in Rats
Augier, E., Dulman, R. S., Rauffenbart, C., Augier, G., Cross, A. J., & Heilig, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.107 · Cited by 44 · see citing works
A novel mGluR5 antagonist, MFZ 10‐7, inhibits cocaine‐taking and cocaine‐seeking behavior in rats
Keck, T. M., Zou, M., Bi, G., Zhang, H., Wang, X., Yang, H., Srivastava, R., Gardner, E. L., Xi, Z., & Newman, A. H. (2013) · Addiction Biology · doi:10.1111/adb.12086 · Cited by 39 · see citing works
Antagonism of Metabotropic Glutamate 1 Receptors Attenuates Behavioral Effects of Cocaine and Methamphetamine in Squirrel Monkeys
Achat‐Mendes, C., Platt, D. M., & Spealman, R. D. (2012) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.196295 · Cited by 39 · see citing works
The group II metabotropic glutamate receptor agonist, LY379268, decreases methamphetamine self-administration in rats
Crawford, J. T., Roberts, D. C. S., & Beveridge, T. J. R. (2013) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2013.07.024 · Cited by 39 · see citing works
Attenuation of reinstatement of methamphetamine-, sucrose-, and food-seeking behavior in rats by fenobam, a metabotropic glutamate receptor 5 negative allosteric modulator
Watterson, L. R., Kufahl, P. R., Nemirovsky, N. E., Sewalia, K., Hood, L. E., & Olive, M. F. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2804-z · Cited by 38 · see citing works
Group <scp>I</scp> metabotropic glutamate receptor‐mediated activation of <scp>PKC</scp> gamma in the nucleus accumbens core promotes the reinstatement of cocaine seeking
Schmidt, H. D., Kimmey, B. A., Arreola, A. C., & Pierce, R. C. (2015) · Addiction Biology · doi:10.1111/adb.12122 · Cited by 38 · see citing works
Design and Synthesis of Systemically Active Metabotropic Glutamate Subtype-2 and -3 (mGlu2/3) Receptor Positive Allosteric Modulators (PAMs): Pharmacological Characterization and Assessment in a Rat Model of Cocaine Dependence
Dhanya, R.-P., Sheffler, D. J., Dahl, R. S., Davis, M., Lee, P. S., Yang, L., Nickols, H. H., Cho, H. P., Smith, L. H., D’Souza, M. S., et al. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm5000563 · Cited by 38 · see citing works
Fenobam sulfate inhibits cocaine-taking and cocaine-seeking behavior in rats: implications for addiction treatment in humans
Keck, T. M., Yang, H.-J., Bi, G., Huang, Y., Zhang, H., Srivastava, R., Gardner, E. L., Newman, A. H., & Xi, Z. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3106-9 · Cited by 37 · see citing works
A new and specific non-NMDA receptor antagonist, FG 9065, blocks L-AP4-evoked depolarization in rat cerebral cortex
Sheardown, M. J. (1988) · European Journal of Pharmacology · doi:10.1016/0014-2999(88)90131-8 · Cited by 34 · see citing works
Group III metabotropic glutamate receptors and drug addiction
Mao, L., Guo, M., Jin, D., Xue, B., & Wang, J. Q. (2013) · Frontiers of Medicine · doi:10.1007/s11684-013-0291-1 · Cited by 33 · see citing works
Incubation of Cocaine Seeking following Brief Cocaine Experience in Mice Is Enhanced by mGluR1 Blockade
Halbout, B., Bernardi, R. E., Hansson, A. C., & Spanagel, R. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1076-13.2014 · Cited by 31 · see citing works
Differential effects of the metabotropic glutamate 2/3 receptor agonist LY379268 on nicotine versus cocaine self-administration and relapse in squirrel monkeys
Justinová, Z., Foll, B. L., Redhi, G. H., Markou, A., & Goldberg, S. R. (2015) · Psychopharmacology · doi:10.1007/s00213-015-3994-y · Cited by 30 · see citing works
Novel, centrally active mGlu1 antagonists: In vitro and in vivo pharmacology
Lesage, A., Bischoff, F., van Beijsterveldt, L., et al. (2002) · Neuropharmacology · Cited by 30 · see citing works
Pharmacological profiling of native group II metabotropic glutamate receptors in primary cortical neuronal cultures using a FLIPR
Sanger, H., Hanna, L., Colvin, E. M., Grubisha, O., Ursu, D., Heinz, B. A., Findlay, J. D., Vivier, R. G., Sher, E., Lodge, D., et al. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.05.023 · Cited by 29 · see citing works
Attenuation of nicotine-taking and nicotine-seeking behavior by the mGlu2 receptor positive allosteric modulators AZD8418 and AZD8529 in rats
Li, X., D’Souza, M. S., Ramirez-Niño, A. M., Doherty, J., Cross, A. J., & Markou, A. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4220-2 · Cited by 29 · see citing works
Positive Allosteric Modulation of mGluR5 Accelerates Extinction Learning but Not Relearning Following Methamphetamine Self-Administration
Kufahl, P. R., Hood, L. E., Nemirovsky, N. E., Barabas, P., Halstengard, C., Villa, A., Moore, E., Watterson, L. R., & Olive, M. F. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00194 · Cited by 28 · see citing works
Orally Active Metabotropic Glutamate Subtype 2 Receptor Positive Allosteric Modulators: Structure–Activity Relationships and Assessment in a Rat Model of Nicotine Dependence
Sidique, S., Dhanya, R.-P., Sheffler, D. J., et al. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm3005306 · Cited by 26 · see citing works
The metabotropic glutamate 5 receptor is necessary for extinction of cocaine‐associated cues
Perry, C. J., Reed, F. M., Zbukvic, I., Kim, J. H., & Lawrence, A. J. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13437 · Cited by 22 · see citing works
The Mglur5 Positive Allosteric Modulator CDPPB Does not Alter Extinction or Contextual Reinstatement of Methamphetamine-Seeking Behavior in Rats
Widholm, J. J., Gass, J. T., & Cleva, R. M. (2012) · Journal of Addiction Research & Therapy · doi:10.4172/2155-6105.s1-004 · Cited by 21 · see citing works
Substituted 1-Phenyl-3-(pyridin-2-yl)urea Negative Allosteric Modulators of mGlu5: Discovery of a New Tool Compound VU0463841 with Activity in Rat Models of Cocaine Addiction
Amato, R. J., Felts, A. S., Rodriguez, A. L., Venable, D. F., Morrison, R. D., Byers, F. W., Daniels, J. S., Niswender, C. M., Conn, P. J., Lindsley, C. W., et al. (2013) · ACS Chemical Neuroscience · doi:10.1021/cn400070k · Cited by 20 · see citing works
Neurobiological insights and novel therapeutic opportunities for CNS disorders from mGlu receptor allosteric and biased modulation
Hellyer, S. D., Leach, K., & Gregory, K. J. (2016) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2016.10.007 · Cited by 19 · see citing works
In Vitro and in Vivo Metabolism of the Antianxiolytic Agent Fenobam in the Rat
Wu, W., McKown, L. A., & O'Neill, P. J. (1995) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600840212 · Cited by 18 · see citing works
Perirhinal Cortex mGlu5 Receptor Activation Reduces Relapse to Methamphetamine Seeking by Restoring Novelty Salience
Peters, J., Scofield, M. D., Ghee, S. M., Heinsbroek, J. A., & Reichel, C. M. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.283 · Cited by 17 · see citing works
From bench to bedside: mGluR2 positive allosteric modulators as medications to treat substance use disorders
Acri, J. B., Cross, A. J., & Skolnick, P. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4501-9 · Cited by 17 · see citing works
Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators as Novel Tools for in Vivo Investigation
Keck, T. M., Zou, M., Zhang, P., et al. (2012) · ACS Medicinal Chemistry Letters · doi:10.1021/ml3000726 · Cited by 13 · see citing works

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Improving translation of animal models of addiction and relapse by reverse translation
Venniro, M., Banks, M. L., Heilig, M., Epstein, D. H., & Shaham, Y. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-0378-z · Cited by 212 · see citing works
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Meinhardt, M. W., Pfarr, S., Fouquet, G., Rohleder, C., Meinhardt, M. L., Barroso-Flores, J., Hoffmann, R., Jeanblanc, J., Paul, E., Wagner, K., et al. (2021) · Science Advances · doi:10.1126/sciadv.abh2399 · Cited by 89 · see citing works
Drug addiction: from bench to bedside
Cheron, J., & Kerchove d’Exaerde, A. D. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01542-0 · Cited by 75 · see citing works
Shared Behavioral and Neurocircuitry Disruptions in Drug Addiction, Obesity, and Binge Eating Disorder: Focus on Group I mGluRs in the Mesolimbic Dopamine Pathway
Yohn, S. E., Galbraith, J., Calipari, E. S., & Conn, P. J. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00601 · Cited by 36 · see citing works
Identification of the Risk Genes Associated With Vulnerability to Addiction: Major Findings From Transgenic Animals
Jordan, C. J., & Xi, Z.-X. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.811192 · Cited by 20 · see citing works
Psilocybin-assisted therapy for severe alcohol use disorder: protocol for a double-blind, randomized, placebo-controlled, 7-month parallel-group phase II superiority trial
Vanderijst, L., Hever, F., Buot, A., Dauré, C., Benoit, J., Hanak, C., Veeser, J., Morgiève, M., Campanella, S., Kornreich, C., et al. (2024) · BMC Psychiatry · doi:10.1186/s12888-024-05502-y · Cited by 13 · see citing works

Behavioral and Functional Evidence of Metabotropic Glutamate Receptor 2/3 and Metabotropic Glutamate Receptor 5 Dysregulation in Cocaine-Escalated Rats: Factor in the Transition to Dependence
Hao, Y., Martin‐Fardon, R., & Weiss, F. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.02.011 · Cited by 123 · see citing works
[Metabotropic glutamate receptors as a possible target of antiepileptic therapy].
Lojková, D., & Mareš, P. (2007) · PubMed
Functional Study of Glutamate Receptor Channels in Brain Slices
Jones, S. M., & Yakel, J. L. (2003) · Humana Press eBooks · doi:10.1385/0-89603-612-x:247
(2S,4S)-2-Amino-4-(2,2-diphenylethyl)pentanedioic acid selective group 2 metabotropic glutamate receptor antagonist
Escribano, A., Ezquerra, J., Pedregal, C., et al. (1998) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(98)00091-2 · Cited by 31 · see citing works
Pharmacology of ionotropic and metabotropic glutamate receptors
Lodge, D., & Bond, A. (1993) · European Neuropsychopharmacology · doi:10.1016/0924-977x(93)90013-c

Authors: Caprioli, D., Justinova, Z., Venniro, M., & Shaham, Y.
Affiliations: Sapienza University of Rome (IT)
National Institutes of Health (US)
Corresponding author: Caprioli, Daniele
ORCID: Caprioli, Daniele
Shaham, Yavin
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2018-08
Volume: 84
Issue: 3
Pages: 180-192
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2017.08.018
PMC: PMC5837933
OpenAlex: W2753071628
Cited by: 55
References: 152
Citations by year: 2026: 3 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 6 · 2021: 9 · 2020: 6 · 2019: 10 · 2018: 6
FWCI: 0.74
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Funders: National Institutes of Health
National Institute on Drug Abuse (ZIADA000434)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords: metabotropic glutamate receptors, positive allosteric modulators, negative allosteric modulators, self-administration, relapse, reinstatement of drug seeking, drug craving, addiction treatment, glutamatergic neurotransmission, mGluR2/3 agonist
MeSH terms: Allosteric Regulation, Animals, Disease Models, Animal, Humans, Self Administration, Receptors, Metabotropic Glutamate, Excitatory Amino Acid Agents, Substance-Related Disorders, Drug-Seeking Behavior, Craving

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Effect of Novel Allosteric Modulators of Metabotropic Glutamate Receptors on Drug Self-administration and Relapse: A Review of Preclinical Studies and Their Clinical Implications

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