The anterior insular cortex→central amygdala glutamatergic pathway is critical to relapse after contingency management
Open accessAbstract
Despite decades of research on neurobiological mechanisms of psychostimulant addiction, the only effective treatment for many addicts is contingency management, a behavioral treatment that uses alternative non-drug reward to maintain abstinence. However, when contingency management is discontinued, most addicts relapse to drug use. The brain mechanisms underlying relapse after cessation of contingency management are largely unknown, and, until recently, an animal model of this human condition did not exist. Here we used a novel rat model, in which the availability of a mutually exclusive palatable food maintains prolonged voluntary abstinence from intravenous methamphetamine self-administration, to demonstrate that the activation of monosynaptic glutamatergic projections from anterior insular cortex to central amygdala is critical to relapse after the cessation of contingency management. We identified the anterior insular cortex-to-central amygdala projection as a new addiction- and motivation-related projection and a potential target for relapse prevention.
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Inactivation of the aIC is capable of attenuating relapse to methamphetamine taking following the removal of contingency management.
“Inactivation of the aIC is capable of attenuating relapse to methamphetamine taking following the removal of contingency management”
From The Insula: A Brain Stimulation Target for the Treatment of Addiction (2019) · cites this paper as Venniro et al., 2017
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Ibrahim, C., Rubin-Kahana, D. S., Pushparaj, A., Musiol, M., Blumberger, D. M., Daskalakis, Z. J., Zangen, A., & Le Foll, B. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00720 · Cited by 133 · see citing works
Operant Social Reward Decreases Incubation of Heroin Craving in Male and Female Rats
Venniro, M., Russell, T. I., Zhang, M., & Shaham, Y. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.05.018 · Cited by 127 · see citing works
Self-citationEfficacy of invasive and non-invasive brain modulation interventions for addiction
Luigjes, J., Segrave, R., de Joode, N., Figee, M., & Denys, D. (2019) · Neuropsychology Review · doi:10.1007/s11065-018-9393-5 · Cited by 125 · see citing works
Dorsal tegmental dopamine neurons gate associative learning of fear
Groessl, F., Munsch, T., Meis, S., Griessner, J., Kaczanowska, J., Pliota, P., Kargl, D., Badurek, S., Kraitsy, K., Rassoulpour, A., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0174-5 · Cited by 118 · see citing works
Rogers-Carter, M. M., Djerdjaj, A., Gribbons, K. B., Varela, J. A., & Christianson, J. P. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.0316-19.2019 · Cited by 79 · see citing works
A genetically defined insula-brainstem circuit selectively controls motivational vigor
Deng, H., Xiao, X., Yang, T., Ritola, K., Hantman, A., Li, Y., Huang, Z. J., & Li, B. (2021) · Cell · doi:10.1016/j.cell.2021.11.019 · Cited by 75 · see citing works
Caprioli, D., Justinova, Z., Venniro, M., & Shaham, Y. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.08.018 · Cited by 55 · see citing works
Self-citationMesolimbic dopamine release precedes actively sought aversive stimuli in mice
Yawata, Y., Shikano, Y., Ogasawara, J., Makino, K., Kashima, T., Ihara, K., Yoshimoto, A., Morikawa, S., Yagishita, S., Tanaka, K. F., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38130-3 · Cited by 24 · see citing works
- Authors
- Venniro, M., Caprioli, D., Zhang, M., Whitaker, L. R., Zhang, S., Warren, B. L., Cifani, C., Marchant, N. J., Yizhar, O., Bossert, J. M., Chiamulera, C., Morales, M., & Shaham, Y.
- Affiliations
- Sapienza University of Rome (IT)
- National Institute on Drug Abuse (US)
- National Institutes of Health (US)
- Università di Camerino (IT)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Weizmann Institute of Science (IL)
- University of Verona (IT)
- Corresponding author
- Shaham, Yavin
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2017-10
- Volume
- 96
- Issue
- 2
- Pages
- 414-427.e8
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC5687288
- OpenAlex
- W2762152147
- Cited by
- 162
- References
- 97
- Citations by year
- 2026: 12 · 2025: 7 · 2024: 5 · 2023: 20 · 2022: 14 · 2021: 23 · 2020: 33 · 2019: 21 · 2018: 24 · 2017: 2 · 2016: 1
- FWCI
- 10.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Unicam Scientific Publications (University of Camerino) (submittedVersion, other-oa)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Intramural Research Program of NIDA (Z01 DA000434-17)
- NARSAD
- Italian Ministry of University and Research (FIRB-RBFR12DELS)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- relapse, contingency management, anterior insula, central amygdala, glutamatergic pathways, methamphetamine self-administration, addiction, motivation, relapse prevention, rat model
- MeSH terms
- Animals, Cerebral Cortex, Eating, Injections, Intravenous, Male, Methamphetamine, Neural Pathways, Recurrence, Self Administration, Behavior, Addictive, Rats, Sprague-Dawley, Rats, Central Amygdaloid Nucleus
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