Do the same genetic and environmental effects underlie the covariation of alcohol dependence, smoking, and aggressive behaviour?
Abstract
We investigated genetic and environmental effects on alcohol dependence, smoking, and aggressive behaviour, as well as sex differences in these effects and whether these effects were the same for the three phenotypes. There were 3141 male (mean age 26.2 [S.E.=0.1]) and 6026 female (mean age 26.1 [S.E.=0.1]) participants in this extended twin study. Alcohol Use Disorder Identification Test (AUDIT), number of cigarettes smoked, and two subscales of Aggression Questionnaire (AQ) were used to assess the phenotypes. All three were positively interrelated with males exhibiting higher levels on each phenotype. Multivariate model fitting identified genetic effects on all phenotypes for both men and women ranging between 69% (aggressive behaviour in women) and 78% (alcohol dependence in men). The effects were stronger in men for alcohol dependence and smoking. There were no qualitative genetic sex differences. Genetic correlations between all phenotypes were substantial.
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Studies including adult twins do not report finding any shared environmental influences.
“Similarly, studies including adult twins do not report finding any shared environmental influences (Table 8.2; e.g., Coccaro et al., 1997; Finkel and McGue, 1997; von der Pahlen et al., 2008; but for an exception see Czajkowski et al., 2008).”
From Human Aggression Across the Lifespan (2011) · cites this paper as von der Pahlen et al., 2008
Cites
SAUNDERS, J. B., AASLAND, O. G., BABOR, T. F., DE LA FUENTE, J. R., & GRANT, M. (1993) · Addiction · doi:10.1111/j.1360-0443.1993.tb02093.x · Cited by 13,482 · see citing works
The Fagerstrom Test for Nicotine Dependence: a revision of the Fagerstrom Tolerance Questionnaire
HEATHERTON, T. F., KOZLOWSKI, L. T., FRECKER, R. C., & FAGERSTROM, K. (1991) · British Journal of Addiction · doi:10.1111/j.1360-0443.1991.tb01879.x · Cited by 10,738 · see citing works
Akaike, H. (1987) · Psychometrika · doi:10.1007/bf02294359 · Cited by 5,264 · see citing works
Role of genotype in the cycle of violence in maltreated children
Caspi, A., McClay, J., Moffitt, T. E., Mill, J., Martin, J., Craig, I. W., Taylor, A., & Poulton, R. (2002) · Science · doi:10.1126/science.1072290 · Cited by 4,842 · see citing works
Buss, A. H., & Perry, M. (1992) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.63.3.452 · Cited by 4,693 · see citing works
Akaike, H. (1987) · Springer Series in Statistics · doi:10.1007/978-1-4612-1694-0_29 · Cited by 4,027 · see citing works
Sex differences in aggression between heterosexual partners: a meta-analytic review
Archer, J. (2000) · Psychological Bulletin · doi:10.1037/0033-2909.126.5.651 · Cited by 2,507 · see citing works
Cloninger, C. R. (1981) · Archives of General Psychiatry · doi:10.1001/archpsyc.1981.01780330019001 · Cited by 1,858 · see citing works
Gender differences in risk factors and consequences for alcohol use and problems
Nolen–Hoeksema, S. (2004) · Clinical Psychology Review · doi:10.1016/j.cpr.2004.08.003 · Cited by 1,005 · see citing works
Heath, A. C., Bucholz, K. K., Madden, P. A. F., Dinwiddie, S. H., Slutske, W. S., Bierut, L. J., Statham, D. J., Dunne, M. P., Whitfield, J. B., & Martin, N. G. (1997) · Psychological Medicine · doi:10.1017/s0033291797005643 · Cited by 846 · see citing works
The familial incidence of alcoholism: a review.
Cotton, N. S. (1979) · Journal of Studies on Alcohol · doi:10.15288/jsa.1979.40.89 · Cited by 796 · see citing works
Prescott, C. A., & Kendler, K. S. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.1.34 · Cited by 606 · see citing works
Genetic and environmental architecture on human aggression.
Miles, D. R., & Carey, G. (1997) · Journal of Personality and Social Psychology · doi:10.1037//0022-3514.72.1.207 · Cited by 490 · see citing works
Assessment of life history of aggression: development and psychometric characteristics
Coccaro, E. F., Berman, M. E., & Kavoussi, R. J. (1997) · Psychiatry Research · doi:10.1016/s0165-1781(97)00119-4 · Cited by 478 · see citing works
The Alcohol Use Disorders Identification Test (AUDIT) in a College Sample
Fleming, M. F., Barry, K. L., & Macdonald, R. (1991) · International Journal of the Addictions · doi:10.3109/10826089109062153 · Cited by 458 · see citing works
Common Genetic Vulnerability for Nicotine and Alcohol Dependence in Men
True, W. R., Xian, H., Scherrer, J. F., Madden, P. A. F., Bucholz, K. K., Heath, A. C., Eisen, S. A., Lyons, M. J., Goldberg, J., & Tsuang, M. T. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.7.655 · Cited by 453 · see citing works
A population-based twin study in women of smoking initiation and nicotine dependence
Kendler, K. S., Neale, M. C., Sullivan, P. F., Corey, L. A., GARDNER, C. O., & Prescott, C. A. (1999) · Psychological Medicine · doi:10.1017/s0033291798008022 · Cited by 438 · see citing works
Diagnosis of Twin Zygosity by Mailed Questionnaire
Sarna, S. J., Kaprio, J. A., Sistonen, P., & Koskenvuo, M. J. (1978) · Human Heredity · doi:10.1159/000152964 · Cited by 432 · see citing works
Eath, A. C. H., Ucholz, K. K. B., Adden, P. A. F. M., Inwiddie, S. H. D., Lutske, W. S. S., Ierut, L. J. B., Tatham, D. J. S., Hitfield, J. B. W., & Artin, N. G. M. (1997) · Cited by 423 · see citing works
Theory and practice in quantitative genetics
Posthuma, D., Beem, A. L., de Geus, E. J. C., van Baal, G. C. M., von Hjelmborg, J. B., Iachine, I., & Boomsma, D. I. (2003) · Twin Research · doi:10.1375/136905203770326367 · Cited by 416 · see citing works
Genetic and environmental architecture on human aggression.
Miles, D. R., & Carey, G. (1997) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.72.1.207 · Cited by 414 · see citing works
Nicotine addiction and comorbidity with alcohol abuse and mental illness
Dani, J. A., & Harris, R. A. (2005) · Nature Neuroscience · doi:10.1038/nn1580 · Cited by 382 · see citing works
Heritability of Smoking Initiation and Nicotine Dependence
Vink, J. M., Willemsen, G. A. H. M., & Boomsma, D. I. (2005) · Behavior Genetics · doi:10.1007/s10519-004-1327-8 · Cited by 342 · see citing works
Parenting: A genetic-epidemiologic perspective
(1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.1.11 · Cited by 313 · see citing works
Reif, A., Rösler, M., Freitag, C. M., Schneider, M., Eujen, A., Kissling, C., Wenzler, D., Jacob, C. P., Retz-Junginger, P., Thome, J., et al. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301359 · Cited by 277 · see citing works
Determining zygosity in the Vietnam Era Twin Registry: an approach using questionnaires
Eisen, S. A., Neuman, R. J., Goldberg, J. H., Rice, J. P., & True, W. (1989) · Clinical Genetics · doi:10.1111/j.1399-0004.1989.tb02967.x · Cited by 273 · see citing works
MAES, H. H. M., Sullivan, P. F., Bulik, C. M., Neale, M. C., Prescott, C. A., Eaves, L. J., & Kendler, K. S. (2004) · Psychological Medicine · doi:10.1017/s0033291704002405 · Cited by 254 · see citing works
Genetic and environmental contributions to smoking
True, W. R., Heath, A. C., Scherrer, J. F., Waterman, B. M., Goldberg, J., Lin, N., Eisen, S. A., Lyons, M. J., & Tsuang, M. T. (1997) · Addiction · doi:10.1111/j.1360-0443.1997.tb02847.x · Cited by 248 · see citing works
Han, C., Mcgue, M. K., & Iacono, W. G. (1999) · Addiction · doi:10.1046/j.1360-0443.1999.9479814.x · Cited by 225 · see citing works
A further evaluation of The Aggression Questionnaire: Issues of validity and reliability
Harris, J. A. (1997) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(97)00064-8 · Cited by 224 · see citing works
Coccaro, E. F., Bergeman, C. S., Kavoussi, R. J., & Seroczynski, A. D. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00257-0 · Cited by 222 · see citing works
REVIEW: The genetics of alcoholism: identifying specific genes through family studies
Edenberg, H. J., & Foroud, T. (2006) · Addiction Biology · doi:10.1111/j.1369-1600.2006.00035.x · Cited by 214 · see citing works
Genetic and Environmental Influences on the Development of Alcoholism
Enoch, M. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1376.019 · Cited by 214 · see citing works
The genetics of alcohol dependence
Dick, D. M., & Bierut, L. J. (2006) · Current Psychiatry Reports · doi:10.1007/s11920-006-0015-1 · Cited by 185 · see citing works
Defining nicotine dependence for genetic research: evidence from Australian twins
LESSOV, C. N., MARTIN, N. G., STATHAM, D. J., TODOROV, A. A., SLUTSKE, W. S., BUCHOLZ, K. K., HEATH, A. C., & MADDEN, P. A. F. (2004) · Psychological Medicine · doi:10.1017/s0033291703001582 · Cited by 185 · see citing works
Exploring gene-environment interactions: Socioregional moderation of alcohol use.
Dick, D. M., Rose, R. J., Viken, R. J., Kaprio, J. A., & Koskenvuo, M. (2001) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.110.4.625 · Cited by 175 · see citing works
Studies with reversible inhibitors of monoamine oxidase: Harmaline and related compounds
Udenfriend, S., Witkop, B., Redfield, B. G., & Weissbach, H. (1958) · Biochemical Pharmacology · doi:10.1016/0006-2952(58)90025-x · Cited by 174 · see citing works
van Beijsterveldt, C. E. M., Bartels, M., Hudziak, J. J., & Boomsma, D. I. (2003) · Behavior Genetics · doi:10.1023/a:1025735002864 · Cited by 173 · see citing works
McGue, M. K., Sharma, A., & Benson, P. (1996) · Journal of Studies on Alcohol · doi:10.15288/jsa.1996.57.8 · Cited by 167 · see citing works
The genetics of alcoholism and alcohol abuse
Enoch, M., & Goldman, D. A. (2001) · Current Psychiatry Reports · doi:10.1007/s11920-001-0012-3 · Cited by 165 · see citing works
Uhl, G. R., Liu, Q., Drgon, T., Johnson, C., Walther, D. M., & Rose, J. E. (2007) · BMC Genetics · doi:10.1186/1471-2156-8-10 · Cited by 156 · see citing works
Personality and the inheritance of smoking behavior: A genetic perspective
Heath, A. C., Madden, P. A. F., Slutske, W. S., & Martin, N. G. (1995) · Behavior Genetics · doi:10.1007/bf02196921 · Cited by 156 · see citing works
Widom, C. S., Schuck, A. M., & WHITE, H. R. (2006) · Violence and Victims · doi:10.1891/0886-6708.21.6.675 · Cited by 148 · see citing works
Heavy consumption of cigarettes, alcohol and coffee in male twins.
Swan, G. E., Carmelli, D., & Cardon, L. R. (1997) · Journal of Studies on Alcohol · doi:10.15288/jsa.1997.58.182 · Cited by 146 · see citing works
Hudziak, J. J., van Beijsterveldt, C. E. M., Bartels, M., Rietveld, M. J. H., Rettew, D. C., Derks, E. M., & Boomsma, D. I. (2003) · Behavior Genetics · doi:10.1023/a:1025782918793 · Cited by 144 · see citing works
Multivariate Genetic Analysis of Sex Limitation and G × E Interaction
Neale, M. C., Røysamb, E., & Jacobson, K. C. (2006) · Twin Research and Human Genetics · doi:10.1375/183242706778024937 · Cited by 142 · see citing works
Exploring gene–environment interactions: Socioregional moderation of alcohol use.
Dick, D. M., Rose, R. J., Viken, R. J., et al. (2001) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.110.4.625 · Cited by 139 · see citing works
Hettema, J. M., Corey, L. A., & Kendler, K. S. (1999) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(99)00053-8 · Cited by 137 · see citing works
Swan, G. E., Carmelli, D., & Cardon, L. R. (1996) · Journal of Substance Abuse · doi:10.1016/s0899-3289(96)90055-3 · Cited by 135 · see citing works
Sher, L., Oquendo, M. A., Galfalvy, H., Grunebaum, M. F., Burke, A. K., Zalsman, G., & Mann, J. J. (2004) · Addictive Behaviors · doi:10.1016/j.addbeh.2004.12.001 · Cited by 132 · see citing works
The course of early smoking: a population‐based cohort study over three years
Patton, G. C., Carlin, J. B., Coffey, C., Wolfe, R. S., Hibbert, M., & Bowes, G. (1998) · Addiction · doi:10.1046/j.1360-0443.1998.938125113.x · Cited by 131 · see citing works
Koopmans, J. R., van Doornen, L. J. P., & Boomsma, D. I. (1997) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1997.tb03800.x · Cited by 129 · see citing works
Approach to the genetics of alcoholism: A review based on pathophysiology
Köhnke, M. D. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.06.021 · Cited by 124 · see citing works
John, U., Meyer, C., Rumpf, H., & Hapke, U. (2003) · Addiction · doi:10.1046/j.1360-0443.2003.00381.x · Cited by 116 · see citing works
Comparison of two aggression inventories
Archer, J. E., Kilpatrick, G., & Bramwell, R. S. (1995) · Aggressive Behavior · doi:10.1002/1098-2337(1995)21:5 · Cited by 106 · see citing works
The importance of stress and genetic variation in human aggression
Craig, I. (2007) · BioEssays · doi:10.1002/bies.20538 · Cited by 104 · see citing works
Laboratory models of alcoholism: treatment target identification and insight into mechanisms
Lovinger, D. M., & Crabbe, J. C. (2005) · Nature Neuroscience · doi:10.1038/nn1581 · Cited by 97 · see citing works
Genetics of nicotine dependence and pharmacotherapy
Lessov‐Schlaggar, C. N., Pergadia, M. L., Khroyan, T. V., & Swan, G. E. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.08.018 · Cited by 95 · see citing works
Physical and Psychological Partner Aggression Across a Decade: A Growth Curve Analysis
Fritz, P. A. T., & O’Leary, K. D. (2004) · Violence and Victims · doi:10.1891/088667004780842886 · Cited by 91 · see citing works
Single and double sexual standards in Finland, Estonia, and St. Petersburg
Haavio‐Mannila, E., & Kontula, O. (2003) · The Journal of Sex Research · doi:10.1080/00224490309552165 · Cited by 90 · see citing works
Rice, J. P., Saccone, N. L., & Rasmussen, E. (2001) · Advances in genetics · doi:10.1016/s0065-2660(01)42015-3 · Cited by 86 · see citing works
The μ-opioid receptor gene and smoking initiation and nicotine dependence
Zhang, L., Kendler, K. S., & Chen, X. (2006) · Behavioral and Brain Functions · doi:10.1186/1744-9081-2-28 · Cited by 83 · see citing works
Biosocial bases of aggressive and violent behavior—implications for nursing studies
Liu, J., & Wuerker, A. K. (2004) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2004.06.007 · Cited by 82 · see citing works
Grucza, R. A., & Bierut, L. J. (2006) · PubMed Central · Cited by 77 · see citing works
Mäkelä, P., Bloomfield, K., Gustafsson, N.-K. J., Huhtanen, P., & Room, R. (2007) · Addiction · doi:10.1111/j.1360-0443.2007.02049.x · Cited by 76 · see citing works
Malone, S. M., Taylor, J. E., Marmorstein, N. R., McGue, M. K., & Iacono, W. G. (2004) · Development and Psychopathology · doi:10.1017/s0954579404040088 · Cited by 70 · see citing works
Smoking and the genetic contribution to alcohol-dependence risk.
Madden, P. A. F., Bucholz, K. K., Martin, N. G., & Heath, A. C. (2000) · Europe PMC (PubMed Central) · Cited by 68 · see citing works
Shared Genetic Vulnerability in Alcohol and Cigarette Use and Dependence
Madden, P. A. F., & Heath, A. C. (2002) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2002.tb02503.x · Cited by 64 · see citing works
A longitudinal study of alcohol use and antisocial behaviour in young people
Young, R., Sweeting, H. N., & West, P. (2007) · Alcohol and Alcoholism · doi:10.1093/alcalc/agm147 · Cited by 63 · see citing works
Sexual behavior in young adulthood: A population-based twin study.
Mustanski, B. S., Viken, R. J., Kaprio, J. A., Winter, T., & Rose, R. J. (2007) · Health Psychology · doi:10.1037/0278-6133.26.5.610 · Cited by 60 · see citing works
QUALITATIVE AND QUANTITATIVE SEX DIFFERENCES IN SELF-REPORTED AGGRESSIVE BEHAVIORAL CHARACTERISTICS
Gladue, B. A. (1991) · Psychological Reports · doi:10.2466/pr0.1991.68.2.675 · Cited by 59 · see citing works
Hughes, J. R., Rose, G. L., & CALLAS, P. W. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2000.tb01964.x · Cited by 59 · see citing works
Assessing the generalizability of smoking studies
Hughes, J. R., Giovino, G. A., KUEVENS, R. M., & Fiore, M. C. (1997) · Addiction · doi:10.1111/j.1360-0443.1997.tb03378.x · Cited by 55 · see citing works
THE EPIDEMIOLOGY OF TOBACCO USE, DEPENDENCE, AND CESSATION IN THE UNITED STATES
Smith, S. S., & Fiore, M. C. (1999) · Primary Care Clinics in Office Practice · doi:10.1016/s0095-4543(05)70112-3 · Cited by 54 · see citing works
Regular Daily Smoking Among 14-Year-Old Adolescents Increases the Subsequent Risk for Suicide
Riala, K., Alaräisänen, A., Taanila, A. M., Hakko, H. H., Timonen, M., & Räsänen, P. K. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0518 · Cited by 48 · see citing works
Marmorstein, N. R., & Iacono, W. G. (2005) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000181039.75842.85 · Cited by 47 · see citing works
A multidimensional model for characterizing tobacco dependence
Hudmon, K. S., Marks, J. L., Pomerleau, C. S., Bolt, D. M., Brigham, J., & Swan, G. E. (2003) · Nicotine & Tobacco Research · doi:10.1080/1462220031000158672 · Cited by 46 · see citing works
Prescott, C. A., Sullivan, P. F., Myers, J., et al. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000156085.50418.07 · Cited by 46 · see citing works
Mathieu, F., Miot, S., Étain, B., Khoury, M. E., Chevalier, F., Bellivier, F., Leboyer, M., Bruno Giros, A., & Tzavara, E. T. (2008) · Behavioral and Brain Functions · doi:10.1186/1744-9081-4-2 · Cited by 41 · see citing works
Behavioral genetic models of alcoholism and drinking.
McGue, M. K. (1999) · Cited by 41 · see citing works
Multiple substance use among young males
Kapusta, N. D., Plener, P. L., Schmid, R. W., Thau, K., Walter, H., & Lesch, O. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.10.007 · Cited by 39 · see citing works
New findings on the genetic influences on alcohol use and dependence
Higuchi, S., Matsushita, S., & Kashima, H. (2006) · Current Opinion in Psychiatry · doi:10.1097/01.yco.0000218595.54054.7a · Cited by 38 · see citing works
Xian, H., Scherrer, J. F., Eisen, S. A., Lyons, M. J., Tsuang, M. T., True, W. R., & Bucholz, K. K. (2006) · Addictive Behaviors · doi:10.1016/j.addbeh.2006.03.031 · Cited by 37 · see citing works
Vernon, P. A., McCarthy, J. M., Johnson, A. M., et al. (1999) · Twin Research · doi:10.1375/136905299320566068 · Cited by 35 · see citing works
Fu, Q. J., Heath, A. C., Bucholz, K. K., Lyons, M. J., Tsuang, M. T., True, W. R., & Eisen, S. A. (2007) · Twin Research and Human Genetics · doi:10.1375/twin.10.3.470 · Cited by 26 · see citing works
Vernon, P. A., McCarthy, J. M., Johnson, A. M., et al. (1999) · Twin Research · doi:10.1375/twin.2.1.16 · Cited by 25 · see citing works
Trait Aggression and Hostility in Recovered Alcoholics
Ziherl, S., Čebašek Travnik, Z., Kores Plesničar, B., Tomori, M., & Zalar, B. (2007) · European Addiction Research · doi:10.1159/000097938 · Cited by 17 · see citing works
The minisequencing method: a simple strategy for genetic screening of MEN 2 families.
Bugalho, M. J., Domingues, R., & Sobrinho, L. G. (2002) · BMC Genetics · doi:10.1186/1471-2156-3-8 · Cited by 10 · see citing works
Direction of causality: A comment
Carey, G. (1994) · Genetic Epidemiology · doi:10.1002/gepi.1370110604 · Cited by 8 · see citing works
The Psychobiology of Aggressive Behaviour
Träskman‐Bendz, L., & Westling, S. (2006) · Advances in health economics and health services research · doi:10.1016/s0731-2199(05)16001-4 · Cited by 3 · see citing works
Young (2000) · doi:10.1002/1096-8628(20001009)96:5
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Human Aggression Across the Lifespan
Tuvblad, C., & Baker, L. A. (2011) · Advances in Genetics · doi:10.1016/b978-0-12-380858-5.00007-1 · Cited by 139 · see citing works
“Similarly, studies including adult twins do not report finding any shared environmental influences (Table 8.2; e.g., Coccaro et al., 1997; Finkel and McGue, 1997; von der Pahlen et al., 2008; but for an exception see Czajkowski et al., 2008).”
BackgroundInfluentialAntón-Galindo, E., Cabana-Domínguez, J., Torrico, B., Corominas, R., Cormand, B., & Fernàndez-Castillo, N. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1293663 · Cited by 13 · see citing works
- Authors
- von der Pahlen, B., Santtila, P., Johansson, A., Varjonen, M., Jern, P., Witting, K., & Kenneth Sandnabba, N.
- Affiliations
- Åbo Akademi University (FI)
- Venue
- Biological Psychology
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 78
- Issue
- 3
- Pages
- 269-277
- ISSN
- 0301-0511 (ISSN-L)
- OpenAlex
- W1999508333
- Cited by
- 26
- References
- 91
- Citations by year
- 2024: 1 · 2023: 2 · 2021: 2 · 2020: 1 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 1 · 2013: 3 · 2012: 2
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychology (publishedVersion)
- PubMed (publishedVersion)
- Åbo Akademi University Research Portal (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- alcoholism, smoking, aggression, genetic factors, environmental effects, sex differences, genetic correlation, twin studies
- MeSH terms
- Adult, Aggression, Alcoholism, Environment, Female, Humans, Male, Phenotype, Surveys and Questionnaires, Sex Characteristics, Smoking, Models, Statistical, Twin Studies as Topic
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