Salivary dehydroepiandrosterone secretion in response to acute psychosocial stress and its correlations with biological and psychological changes
Abstract
We investigated dehydroepiandrosterone (DHEA) secretion in response to acute psychosocial stress and the relations of DHEA secretion to cortisol secretion, cardiovascular activity, and negative mood changes. Thirty-three male students (mean age 22.6 years) were subjected to the psychosocial stress test "Trier Social Stress Test" (TSST), in which the participants were asked to deliver a speech and perform a mental arithmetic task in front of two audiences. Collections of saliva, measurements of blood pressure and heart rate, and assessments of negative mood by visual analog scales were conducted before, during, and after TSST. Acute psychosocial stress significantly increased salivary DHEA level by an average of 60% immediately after TSST. The peak of DHEA concentration preceded that of cortisol concentration by about 10 min. DHEA response was moderately correlated to cortisol response (r=.34, r(s)=.49) but not to cardiovascular response. Lower DHEA level and elevated cortisol/DHEA ratio during TSST were significantly and moderately correlated with increased negative mood during and after TSST. These results indicated that an acute increase in DHEA concentration under stressful situations might be partly mediated by the activity of hypothalamus-pituitary-adrenal axis and could have some significance in the improvement of negative mood.
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DHEA is secreted synchronously with cortisol in response to ACTH and is elevated in response to psychosocial stress.
“DHEA is secreted synchronously with cortisol in response to ACTH, and has been shown to be elevated in response to psychosocial stress (Izawa et al., 2008; Lennartsson et al., 2012; Morgan et al., 2004).”
From Effect of oxytocin on craving and stress response in marijuana-dependent individuals: A pilot study (2013) · cites this paper as Izawa et al., 2008
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- Authors
- Izawa, S., Sugaya, N., Shirotsuki, K., Yamada, K. C., Ogawa, N., Ouchi, Y., Nagano, Y., Suzuki, K., & Nomura, S.
- Affiliations
- Waseda University (JP)
- Nihon University (JP)
- Bunkyo Gakuin University (JP)
- Corresponding author
- Izawa, Shuhei
- ORCID
- Venue
- Biological Psychology
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 79
- Issue
- 3
- Pages
- 294-298
- ISSN
- 0301-0511 (ISSN-L)
- OpenAlex
- W1993202266
- Cited by
- 126
- References
- 30
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 6 · 2023: 5 · 2022: 6 · 2021: 4 · 2020: 8 · 2019: 12 · 2018: 4 · 2017: 12 · 2016: 8 · 2015: 5 · 2014: 8 · 2013: 9 · 2012: 8
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- dehydroepiandrosterone, acute psychosocial stress, Trier Social Stress Test, cortisol, cortisol/DHEA ratio, negative mood, cardiovascular response, heart rate, blood pressure, hypothalamic-pituitary-adrenal axis, stress response
- MeSH terms
- Adult, Analysis of Variance, Blood Pressure, Dehydroepiandrosterone, Heart Rate, Humans, Hydrocortisone, Immunoassay, Male, Saliva, Stress, Psychological, Linear Models, Young Adult
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