Neurohormonal and inflammatory hyper-responsiveness to acute mental stress in depression.
Open accessAbstract
Depression is associated with dysregulated hypothalamic-pituitary-adrenal (HPA) axis function, overactivity of the sympathoadrenal system, and increased levels of inflammation markers. It is not known whether these biological processes are disproportionately elevated in response to acute negative emotional arousal by mental stress (MS). The present study investigates responses of neurohormones and inflammatory markers to MS in 14 clinically depressed (age: 42+/-10 years; 50% female) and 14 non-depressed control (age: 39+/-6 years; 50% female) participants. Heightened acute MS reactivity was documented in depressed participants (adrenocorticotropic hormone, rho=0.001; norepinephrine, rho=0.042; epinephrine, rho=0.039), and a delayed increase in cortisol was observed (rho=0.002). Inflammation markers increased more strongly in depressed versus non-depressed participants (IL-6, rho=0.027; tumor necrosis factor-alpha, rho=0.050; and recovery C-reactive protein, rho=0.003). It is concluded that depressed individuals display hyper-reactivity of neuroimmunological markers in response to acute negative emotions. This hyper-reactivity may serve a pathologic role in the elevated morbidity and mortality risk associated with depression.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Depressed participants exhibited greater TSST-induced increases in several markers of SNS and HPA axis activity, including epinephrine, norepinephrine, adrenocorticotropic hormone, and cortisol, compared to nondepressed participants.
“Compared to nondepressed participants, depressed participants exhibited greater TSST-induced increases in several markers of SNS and HPA axis activity, including epinephrine, norepinephrine, adrenocorticotropic hormone, and cortisol.”
From From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. (2014) · cites this paper as Weinstein et al., 2010
The Results (Neurohormonal Response to Acute Mental Stress) report greater ACTH, cortisol, norepinephrine, and epinephrine responses in depressed participants than in controls. But the Methods (Procedures) identify the stressors as anger recall and mental arithmetic tasks, not the TSST, so the claim misidentifies what induced those responses. (LLM, conf=0.91)
Experimental — accuracy not yet measuredDepressed participants also exhibited greater increases in plasma levels of the proinflammatory cytokines TNFα and IL-6 and the inflammatory marker CRP.
“Depressed participants also exhibited greater increases in plasma levels of the proinflammatory cytokines TNFα and IL-6 and the inflammatory marker CRP”
From From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. (2014) · cites this paper as Weinstein et al., 2010
Individuals with diagnosed depression have demonstrated stronger increases in proinflammatory cytokines in response to laboratory stress than non-depressed individuals.
“Individuals with diagnosed depression have demonstrated stronger increases in proinflammatory cytokines in response to laboratory stress than non-depressed individuals (Weinstein et al., 2010; Fagundes et al., 2013)”
From The interplay between stress, inflammation, and emotional attention: relevance for depression (2019) · cites this paper as Weinstein et al., 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · see citing works
Development of a Rating Scale for Primary Depressive Illness
Hamilton, M. (1967) · British Journal of Social and Clinical Psychology · doi:10.1111/j.2044-8260.1967.tb00530.x · Cited by 8,410 · see citing works
C-reactive protein: a critical update
Pepys, M. B., & Hirschfield, G. M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18921 · Cited by 4,576 · see citing works
Depression Following Myocardial Infarction
Frasure‐Smith, N. (1993) · JAMA · doi:10.1001/jama.1993.03510150053029 · Cited by 2,028 · see citing works
Depression and poor glycemic control: a meta-analytic review of the literature.
Lustman, P. J., Anderson, R. J., Freedland, K. E., de Groot, M., Carney, R. M., & Clouse, R. E. (2000) · Diabetes Care · doi:10.2337/diacare.23.7.934 · Cited by 1,854 · see citing works
Association of depression and diabetes complications: a meta-analysis
de Groot, M., Anderson, R., Freedland, K. E., Clouse, R. E., & Lustman, P. J. (2001) · Psychosomatic Medicine · doi:10.1097/00006842-200107000-00015 · Cited by 1,799 · see citing works
Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms
Pittenger, C., & Duman, R. S. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301574 · Cited by 1,795 · see citing works
Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly
Harris, T. B., Ferrucci, L., Tracy, R. P., Corti, M. C., Wacholder, S., Ettinger, W. H., Heimovitz, H., Cohen, H. J., & Wallace, R. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00066-2 · Cited by 1,488 · see citing works
Self-citationNicholson, A., Kuper, H., & Hemingway, H. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl338 · Cited by 1,353 · see citing works
Depression and cortisol responses to psychological stress: A meta-analysis
Burke, H. M., Davis, M. C., Otte, C., & Mohr, D. C. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.02.010 · Cited by 1,194 · see citing works
Siegle, G. J., Steinhauer, S. R., Thase, M. E., Stenger, V. A., & Carter, C. S. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01314-8 · Cited by 859 · see citing works
Tracy, R. P., Lemaitre, R. N., Psaty, B. M., Ives, D. G., Evans, R. W., Cushman, M., Meilahn, E. N., & Kuller, L. H. (1997) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.17.6.1121 · Cited by 836 · see citing works
Self-citationDepression and immunity: A meta-analytic review.
Herbert, T. B., & Cohen, S. (1993) · Psychological Bulletin · doi:10.1037/0033-2909.113.3.472 · Cited by 812 · see citing works
Pace, T. W. W., Mletzko, T. C., Alagbe, O., Musselman, D. L., Nemeroff, C. B., Miller, A. H., & Heim, C. M. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.9.1630 · Cited by 810 · see citing works
Macy, E. M., Hayes, T. E., & Tracy, R. P. (1997) · Clinical Chemistry · doi:10.1093/clinchem/43.1.52 · Cited by 797 · see citing works
Self-citationMaes, M., Song, C., Lin, A., De Jongh, R., Van Gastel, A., Kenis, G., Bosmans, E., De Meester, I., Benoy, I., Neels, H., et al. (1998) · Cytokine · doi:10.1006/cyto.1997.0290 · Cited by 772 · see citing works
Wulsin, L. R., & Singal, B. M. (2003) · Psychosomatic Medicine · doi:10.1097/01.psy.0000058371.50240.e3 · Cited by 730 · see citing works
Lespérance, F., Frasure‐Smith, N., Talajic, M. R., & Bourassa, M. G. (2002) · Circulation · doi:10.1161/hc0902.104707 · Cited by 722 · see citing works
Major depressive disorder predicts cardiac events in patients with coronary artery disease.
Carney, R. M., Rich, M. W., Freedland, K. E., Saini, J., teVelde, A., Simeone, C., & Clark, K. A. (1988) · Psychosomatic Medicine · doi:10.1097/00006842-198811000-00009 · Cited by 669 · see citing works
Depression following Myocardial Infarction
Forrester, A. W., Lipsey, J. R., Teitelbaum, M. L., DePaulo, J. R., Andrzejewski, P. L., & Robinson, R. G. (1992) · The International Journal of Psychiatry in Medicine · doi:10.2190/cj9d-32c2-8cm7-ft3d · Cited by 635 · see citing works
Lyubomirsky, S., Caldwell, N. D., & Nolen–Hoeksema, S. (1998) · Journal of Personality and Social Psychology · doi:10.1037//0022-3514.75.1.166 · Cited by 587 · see citing works
Depression and cardiovascular disease: mechanisms of interaction
Joynt, K. E., Whellan, D. J., & O’Connor, C. M. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00568-7 · Cited by 508 · see citing works
Zhou, D., Kusnecov, A. W., Shurin, M. R., DePaoli, M., & Rabin, B. S. (1993) · Endocrinology · doi:10.1210/endo.133.6.8243274 · Cited by 494 · see citing works
A re-evaluation of the concept of ‘non-specificity’ in stress theory
Mason, J. W. (1971) · Journal of Psychiatric Research · doi:10.1016/0022-3956(71)90028-8 · Cited by 479 · see citing works
Laboratory methods and quality assurance in the Cardiovascular Health Study
Cushman, M., Cornell, E. S., Howard, P. R., Bovill, E. G., & Tracy, R. P. (1995) · Clinical Chemistry · doi:10.1093/clinchem/41.2.264 · Cited by 439 · see citing works
Self-citationMaladaptive cognitive structures in depression
Kovacs, M., & Beck, A. T. (1978) · American Journal of Psychiatry · doi:10.1176/ajp.135.5.525 · Cited by 409 · see citing works
Kop, W. J., Gottdiener, J. S., Tangen, C. M., Fried, L. P., McBurnie, M. A., Walston, J. D., Newman, A. B., Hirsch, C. H., & Tracy, R. P. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)02264-0 · Cited by 325 · see citing works
Self-citationA MAIL SURVEY OF PHYSICAL ACTIVITY HABITS AS RELATED TO MEASURED PHYSICAL FITNESS
Kohl, H. W., Blair, S. N., Paffenbarger, R. S., MACERA, C. A., & Kronenfeld, J. J. (1988) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114915 · Cited by 325 · see citing works
The effects of psychological stress on plasma interleukin-6 activity in rats
LeMay, L. G., Vander, A. J., & Kluger, M. J. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90024-x · Cited by 313 · see citing works
Role of norepinephrine in the pathophysiology and treatment of mood disorders
Ressler, K. J., & Nemeroff, C. B. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00127-4 · Cited by 307 · see citing works
Interleukin‐6 Serum Levels in Depressed Patients before and after Treatment with Fluoxetine
Sluzewska, A., RYBAKOWSKI, J. K., Łaciak, M., Mackiewicz, A., Sobieska, M., & WIKTOROWICV, K. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb32372.x · Cited by 306 · see citing works
Life stress, mood disturbance, and elevated interleukin-6 in healthy older women
Lutgendorf, S. K., Garand, L., Buckwalter, K. C., Reimer, T. T., Hong, S.-Y., & Lubaroff, D. M. (1999) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/54.9.m434 · Cited by 305 · see citing works
A Mail Survey of Physical Activity Habits as Related to Measured Physical Fitness
Kohl, H. W., Blair, S. N., Paffenbarger, R. S., Macera, C. A., & Kronenfeld, J. J. (1988) · Journal of Cardiopulmonary Rehabilitation · doi:10.1097/00008483-198810000-00012 · Cited by 298 · see citing works
Kunz-Ebrecht, S., Mohamed‐Ali, V., Feldman, P. J., Kirschbaum, C., & Steptoe, A. (2003) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(03)00029-1 · Cited by 290 · see citing works
Dentino, A. N., Pieper, C. F., Rao, K. M. K., Currie, M. S., Harris, T., Blazer, D. G., & Cohen, H. J. (1999) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1999.tb01894.x · Cited by 287 · see citing works
Increased salivary cortisol after waking in depression
Bhagwagar, Z., Hafizi, S., & Cowen, P. J. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0062-z · Cited by 281 · see citing works
Vaccarino, V., Johnson, B. D., Sheps, D. S., Reís, S. E., Kelsey, S. F., Bittner, V., Rutledge, T., Shaw, L. J., Sopko, G. S., & Merz, C. N. B. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.07.069 · Cited by 263 · see citing works
Ischemic, Hemodynamic, and Neurohormonal Responses to Mental and Exercise Stress
Goldberg, A. D., Becker, L. C., Bonsall, R. W., Cohen, J. D., Ketterer, M. W., Kaufman, P. G., Krantz, D. S., Light, K. C., McMahon, R. P., Noreuil, T., et al. (1996) · Circulation · doi:10.1161/01.cir.94.10.2402 · Cited by 262 · see citing works
Self-citationCortisol Secretion in Endogenous Depression
Halbreich, U. M. (1985) · Archives of General Psychiatry · doi:10.1001/archpsyc.1985.01790320076010 · Cited by 255 · see citing works
Clinical depression and regulation of the inflammatory response during acute stress
Miller, G. E., Rohleder, N., Stetler, C., & Kirschbaum, C. (2005) · Psychosomatic Medicine · doi:10.1097/01.psy.0000174172.82428.ce · Cited by 253 · see citing works
The psychoneuroimmunology of depression
Leonard, B. E., & Myint, A.-M. (2009) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.1011 · Cited by 236 · see citing works
Effects of anger on left ventricular ejection fraction in coronary artery disease
Ironson, G. H., Taylor, C. B., Boltwood, M. D., Bartzokis, T. C., Dennis, C. A., Chesney, M. A., Spitzer, S. B., & Segall, G. M. (1992) · The American Journal of Cardiology · doi:10.1016/0002-9149(92)90605-x · Cited by 213 · see citing works
Stetler, C., & Miller, G. E. (2005) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.114.4.697 · Cited by 200 · see citing works
Gerra, G., Zaimovic, A., Franchini, D., Palladino, M., Giucastro, G., Reali, N., Maestri, D., Caccavari, R., Delsignore, R., & Brambilla, F. (1998) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(97)00071-8 · Cited by 197 · see citing works
Song, C., Dinan, T. G., & Leonard, B. E. (1994) · Journal of Affective Disorders · doi:10.1016/0165-0327(94)90135-x · Cited by 193 · see citing works
Enhanced cardiovascular and catecholamine responses in women with depressive symptoms
Light, K. C., Kothandapani, R. V., & Allen, M. T. (1998) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(97)00093-7 · Cited by 189 · see citing works
Pupillary and reaction time measures of sustained processing of negative information in depression
Siegle, G. J., Granholm, E. L., Ingram, R. E., & Matt, G. E. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01024-6 · Cited by 188 · see citing works
New aspects of the hormone and cytokine response to training
Steinacker, J., Lormes, W., Reissnecker, S., & Liu, Y.-F. (2004) · European Journal of Applied Physiology · doi:10.1007/s00421-003-0960-x · Cited by 173 · see citing works
Raff, H., & Findling, J. W. (1989) · Clinical Chemistry · doi:10.1093/clinchem/35.4.596 · Cited by 167 · see citing works
Immobilization Stress May Increase Plasma lnterleukin-6 via Central and Peripheral Catecholamines
Takaki, A., Huang, Q.-H., Somogyvári-Vigh, A., & Arimura, A. (1995) · NeuroImmunoModulation · doi:10.1159/000097185 · Cited by 167 · see citing works
Cohen, S., & Hamrick, N. (2003) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(03)00110-7 · Cited by 160 · see citing works
Gottdiener, J. S., Krantz, D. S., Howell, R. H., Hecht, G. M., Klein, J., Falconer, J. J., & Rozanski, A. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90169-4 · Cited by 151 · see citing works
Kop, W. J., & Gottdiener, J. S. (2005) · Psychosomatic Medicine · doi:10.1097/01.psy.0000162256.18710.4a · Cited by 149 · see citing works
Self-citationIncreased serum interleukin-1-receptor-antagonist concentrations in major depression
Maes, M. H. J., Vandoolaeghe, E., Ranjan, R., Bosmans, E., Bergmans, R., & Desnyder, R. (1995) · Journal of Affective Disorders · doi:10.1016/0165-0327(95)00049-6 · Cited by 149 · see citing works
Sluiter, J. K., Frings‐Dresen, M. H. W., Meijman, T. F., & van der Beek, A. J. (2000) · Occupational and Environmental Medicine · doi:10.1136/oem.57.5.298 · Cited by 140 · see citing works
Hypothalamic–pituitary–adrenal axis function in patients with chronic depression
WATSON, S., GALLAGHER, P., DEL-ESTAL, D., HEARN, A., FERRIER, I. N., & YOUNG, A. H. (2002) · Psychological Medicine · doi:10.1017/s0033291702005998 · Cited by 130 · see citing works
Kop, W. J., Weissman, N. J., Zhu, J., Bonsall, R. W., Doyle, M. F., Stretch, M. R., Glaes, S. B., Krantz, D. S., Gottdiener, J. S., & Tracy, R. P. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2007.11.006 · Cited by 117 · see citing works
Self-citationDifferences in plasma ACTH and cortisol between depressed patients and normal controls
PFOHL, B. M., Sherman, B. M., Schlechte, J., & Winokur, G. (1985) · Biological Psychiatry · doi:10.1016/0006-3223(85)90004-6 · Cited by 101 · see citing works
Hamer, M., Tanaka, G., Okamura, H., Tsuda, A., & Steptoe, A. (2006) · Biological Psychology · doi:10.1016/j.biopsycho.2006.06.003 · Cited by 100 · see citing works
Wulsin, L. R. (2004) · Harvard Review of Psychiatry · doi:10.1080/10673220490447191 · Cited by 74 · see citing works
Stress, norepinephrine and depression
Leonard, B. E. (2002) · PubMed · doi:10.13025/23620 · Cited by 71 · see citing works
Use of the dexamethasone suppression test in depression.
Carroll, B. J. (1982) · PubMed · Cited by 70 · see citing works
Stress, norepinephrine and depression
Leonard, B. E. (2002) · Acta Neuropsychiatrica · doi:10.1034/j.1601-5215.2002.140403.x · Cited by 68 · see citing works
Modulation of the immune response by emotional stress
Croiset, G., Heijnen, C. J., Veldhuis, H. D., de Wied, D., & BALLIEUX, R. E. (1987) · Life Sciences · doi:10.1016/0024-3205(87)90305-5 · Cited by 66 · see citing works
Woo, J. (2000) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601036 · Cited by 58 · see citing works
Grewen, K., Girdler, S. S., Hinderliter, A. L., & Light, K. C. (2004) · Psychosomatic Medicine · doi:10.1097/01.psy.0000106881.60228.16 · Cited by 43 · see citing works
The Psychophysiological Investigations of Myocardial Ischemia (PIMI) Study
Kaufmann, P., McMahon, R. P., Becker, L. C., et al. (1998) · Psychosomatic Medicine · doi:10.1097/00006842-199801000-00014 · Cited by 41 · see citing works
Rogers, P. J., Tyce, G. M., Weinshilboum, R. M., et al. (1991) · Circulation · doi:10.1161/01.cir.84.6.2346 · Cited by 39 · see citing works
Effects of chronic and acute exercise on cardiovascular beta-adrenergic responses
Martin, W. H., Spina, R. J., Korte, E., & Ogawa, T. (1991) · Journal of Applied Physiology · doi:10.1152/jappl.1991.71.4.1523 · Cited by 26 · see citing works
Stress Responsive Neurohormones in Depression and Anxiety
Ströhle, A., & Holsboer, F. (2003) · Pharmacopsychiatry · doi:10.1055/s-2003-45132
Laffel (1999) · doi:10.1002/(sici)1520-7560(199911/12)15:6
Flagged first, then by citations
Research works printed but not linked: 1
- Hedlund JL Virmani R 1979 The Hamilton rating scale for depression: A comprehensive review Journal of Operational Psychiatry 11 48 65
Cited by
Sorted by citations
Slavich, G. M., & Irwin, M. R. (2014) · Psychological Bulletin · doi:10.1037/a0035302 · Cited by 2,206 · see citing works
Haapakoski, R., Mathieu, J., Ebmeier, K. P., Alenius, H., & Kivimäki, M. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.06.001 · Cited by 1,129 · see citing works
Inflammation: Depression Fans the Flames and Feasts on the Heat
Kiecolt-Glaser, J. K., Derry, H. M., & Fagundes, C. P. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.15020152 · Cited by 844 · see citing works
Cortisol stress reactivity across psychiatric disorders: a systematic review and meta-analysis
Zorn, J. V., Schür, R. R., Boks, M. P., Kahn, R. S., Joëls, M., & Vinkers, C. H. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.11.036 · Cited by 697 · see citing works
Marsland, A. L., Walsh, C., Lockwood, K., & John-Henderson, N. A. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.01.011 · Cited by 691 · see citing works
Association between plasma IL-6 response to acute stress and early-life adversity in healthy adults
Carpenter, L. L., Gawuga, C. E., Tyrka, A. R., Lee, J. K., Anderson, G. M., & Price, L. H. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.159 · Cited by 464 · see citing works
Rohleder, N. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.02.021 · Cited by 439 · see citing works
Wolkowitz, O. M., Mellon, S. H., Epel, E. S., Lin, J., Dhabhar, F. S., Su, Y., Reus, V. I., Rosser, R., Burke, H. M., Kupferman, E., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017837 · Cited by 421 · see citing works
Antidepressant therapies inhibit inflammation and microglial M1-polarization
Kalkman, H. O., & Feuerbach, D. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.04.001 · Cited by 212 · see citing works
The interplay between stress, inflammation, and emotional attention: relevance for depression
Maydych, V. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00384 · Cited by 193 · see citing works
Telomere length and cortisol reactivity in children of depressed mothers
Gotlib, I. H., LeMoult, J., Colich, N. L., Foland-Ross, L. C., Hallmayer, J., Joormann, J., Lin, J., & Wolkowitz, O. M. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.119 · Cited by 186 · see citing works
Dooley, L. N., Kuhlman, K. R., Robles, T. F., Eisenberger, N. I., Craske, M. G., & Bower, J. E. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.006 · Cited by 176 · see citing works
Prakhinkit, S., Suppapitiporn, S., Tanaka, H., & Suksom, D. (2014) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2013.0205 · Cited by 144 · see citing works
Sleep Disturbance and Older Adults' Inflammatory Responses to Acute Stress
Heffner, K. L., Ng, H. M., Suhr, J. A., France, C. R., Marshall, G. D., Pigeon, W. R., & Moynihan, J. A. (2012) · The American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e31824361de · Cited by 52 · see citing works
- Authors
- Weinstein, A. A., Deuster, P. A., Francis, J. L., Bonsall, R. W., Tracy, R. P., & Kop, W. J.
- Affiliations
- George Mason University (US)
- Uniformed Services University of the Health Sciences (US)
- Emory University (US)
- University of Vermont (US)
- University of Maryland Medical Center (US)
- Corresponding author
- Weinstein, Ali A.
- Venue
- Biological Psychology
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 84
- Issue
- 2
- Pages
- 228-234
- ISSN
- 0301-0511 (ISSN-L)
- PMC
- PMC2875322
- OpenAlex
- W2163435166
- Cited by
- 113
- References
- 71
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 8 · 2023: 12 · 2022: 6 · 2021: 5 · 2020: 5 · 2019: 12 · 2018: 6 · 2017: 4 · 2016: 7 · 2015: 8 · 2014: 6 · 2013: 7 · 2012: 4
- FWCI
- 3.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychology (publishedVersion)
- Research portal (Tilburg University) (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL079376)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- depression, acute psychological stress, neurohormones, inflammatory markers, hypothalamic-pituitary-adrenal axis, sympathoadrenal system, ACTH, cortisol, norepinephrine, epinephrine, interleukin-6, TNF-α, C-reactive protein, neuroinflammation, stress reactivity
- MeSH terms
- Adrenocorticotropic Hormone, Adult, Analysis of Variance, C-Reactive Protein, Catecholamines, Depression, Female, Humans, Hydrocortisone, Male, Middle Aged, Stress, Psychological, Tumor Necrosis Factor-alpha, Interleukin-6, Cytokines
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
