Cited by 55Stress Responses and CortisolSmoking Behavior and CessationNeuropeptides and Animal Physiology

Stress response dysregulation and stress-induced analgesia in nicotine dependent men and women

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al’Absi, Mustafa, Nakajima, Motohiro, Grabowski, John·2013·Biological Psychology

Abstract

Alterations in the stress response and endogenous pain regulation mechanisms may contribute directly and indirectly to maintenance of nicotine dependence and relapse. We examined the extent to which nicotine dependence alters endogenous pain regulatory systems, including the hypothalamic-pituitary-adrenocortical axis, cardiovascular activity, and stress-induced analgesia. Smokers and nonsmokers attended a laboratory session that included assessment of hormonal and cardiovascular responses to stress. Smokers smoked at their regular rate prior to the session. The hand cold pressor and heat thermal pain tests were completed twice, once after acute stress (public speaking and math tasks) and the other after rest. While smokers and nonsmokers exhibited significant hormonal and cardiovascular responses to stress, smokers exhibited blunted stress responses relative to nonsmokers. They also exhibited diminished stress-induced analgesia. Results demonstrate altered stress response and diminished stress-induced analgesia among chronic smokers, and suggest that these dysregulated physiological responding may contribute to altered endogenous pain regulation.

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Authors
al’Absi, M., Nakajima, M., & Grabowski, J.
Affiliations
University of Minnesota (US)
Corresponding author
al’Absi, Mustafa
Venue
Biological Psychology
Publisher
Elsevier BV
Published
2013-04
Volume
93
Issue
1
Pages
1-8
ISSN
0301-0511 (ISSN-L)
OpenAlex
W2047275187
Cited by
55
References
83
Citations by year
2026: 1 · 2024: 5 · 2023: 1 · 2022: 6 · 2021: 2 · 2020: 8 · 2019: 2 · 2018: 6 · 2017: 5 · 2016: 9 · 2015: 5 · 2014: 5
FWCI
1.33
Type
journal article
Language
en
Open access
Locations
  • Biological Psychology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute on Drug Abuse (R01DA016351, R01DA027232)
  • National Center for Research Resources (M01RR000400)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
nicotine dependence, stress response, stress-induced analgesia, hypothalamic-pituitary-adrenal axis, cardiovascular stress response, blunted stress response, thermal pain, smoking, sex differences
MeSH terms
Adult, Affect, Analgesia, Blood Pressure, Female, Humans, Hydrocortisone, Male, Nicotine, Pain Measurement, Surveys and Questionnaires, Saliva, Stress, Psychological, Substance Withdrawal Syndrome, Tobacco Use Disorder, Pain Threshold, Pain Perception

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