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A stretchable and screen-printed electrochemical sensor for glucose determination in human perspiration
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Here we present two types of all-printable, highly stretchable, and inexpensive devices based on platinum (Pt)-decorated graphite for glucose determination in physiological fluids. Said devices are: a non-enzymatic sensor and an enzymatic biosensor, the latter showing promising results. Glucose has been quantified by measuring hydrogen peroxide (H 2 O 2) reduction by chronoamperometry at -0.35V (vs pseudo-Ag/AgCl) using glucose oxidase immobilized on Pt-decorated graphite. The sensor performs well for the quantification of glucose in phosphate buffer solution (0.25M PBS, pH 7.0), with a linear range between 0 mM and 0.9mM, high sensitivity and selectivity, and a low limit of detection (LOD). Thus, it provides an alternative non-invasive and on-body quantification of glucose levels in human perspiration. This biosensor has been successfully applied on real human perspiration samples and results also show a significant correlation between glucose concentration in perspiration and glucose concentration in blood measured by a commercial glucose meter.
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“This device was applied on human perspiration samples and demonstrated a strong correlation between glucose concentration in perspiration and glucose concentration in blood, as measured via a commercial glucose meter.”
From Wearable sensors for monitoring the physiological and biochemical profile of the athlete (2019) · cites this paper as [64]
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Metadata
- Authors
- Abellán-Llobregat, A., Jeerapan, I., Bandodkar, A., Vidal, L., Canals, A., Wang, J., & Morallón, E.
- Affiliations
- University of Alicante (ES)
- University of California San Diego (US)
- Corresponding author
- Morallón, E.
- Venue
- Biosensors and Bioelectronics
- Publisher
- Elsevier BV
- Published
- 2017-05
- Volume
- 91
- Pages
- 885-891
- ISSN
- 0956-5663 (ISSN-L)
- PMC
- PMC5328638
- OpenAlex
- W2580319474
- Cited by
- 348
- References
- 32
- Citations by year
- 2026: 17 · 2025: 31 · 2024: 34 · 2023: 38 · 2022: 46 · 2021: 43 · 2020: 42 · 2019: 54 · 2018: 32 · 2017: 11
- FWCI
- 15.79
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Biosensors and Bioelectronics (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion)
- Repositorio Institucional de la Universidad de Alicante (Universidad de Alicante) (submittedVersion)
- Funders
- Universidad de Alicante
- University of San Diego
- National Institutes of Health (R21EB019698)
- Ministerio de Economía y Competitividad (MAT2016-76595-R)
- Generalitat Valenciana (Prometeo2013/038)
- National Institute of Biomedical Imaging and Bioengineering
- Topics
- Physical Sciences › Chemistry › Analytical Chemistry › Electrochemical sensors and biosensors
- Physical Sciences › Engineering › Biomedical Engineering › Advanced Sensor and Energy Harvesting Materials
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Keywords
- glucose biosensor, sweating, stretchable sensors, screen-printed electrodes, glucose oxidase, non-enzymatic glucose sensing, hydrogen peroxide reduction, chronoamperometry, non-invasive glucose monitoring, on-body sensing
- MeSH terms
- Adult, Elasticity, Electrodes, Enzymes, Immobilized, Equipment Design, Female, Glucose, Glucose Oxidase, Graphite, Humans, Hydrogen Peroxide, Male, Platinum, Sweat, Biosensing Techniques, Electrochemical Techniques, Young Adult, Limit of Detection
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