Inhibitory effects of fucoidan on activation of epidermal growth factor receptor and cell transformation in JB6 Cl41 cells

Lee, Na Yeon; Ermakova, Svetlana P.; Zvyagintseva, Tatyana N.; Kang, Keon Wook; Dong, Zigang; Choi, Hong Seok

doi:10.1016/j.fct.2008.01.025

Cited by 75Seaweed-derived Bioactive CompoundsMarine and coastal plant biologyEchinoderm biology and ecology

Inhibitory effects of fucoidan on activation of epidermal growth factor receptor and cell transformation in JB6 Cl41 cells

Lee, Na Yeon, Ermakova, Svetlana P., Zvyagintseva, Tatyana N., Kang, Keon Wook, Dong, Zigang, Choi, Hong Seok·2008·Food and Chemical Toxicology

DOI 10.1016/j.fct.2008.01.025

Open this paper in CoChat — free account

Abstract

Algal fucoidan is a marine sulfated polysaccharide with a wide variety of biological activities including anti-thrombotic, anti-inflammatory, and anti-tumor activities. In this study, we tested the hypothesis that fucoidan may suppress neoplastic cell transformation by inhibiting the phosphorylation of epidermal growth factor receptor (EGFR) in mouse epidermal JB6 Cl41 cells. Our results provided the first evidence that fucoidan from Laminaria guryanovae exerted a potent inhibitory effect on EGF-induced phosphorylation of EGFR. Consistent with its inhibitory action on phosphorylation of EGFR, fucoidan clearly suppressed the phosphorylation of extracellular signal-regulated kinase or c-jun N-terminal kinases induced by EGF. Moreover, EGF-induced the c-fos and c-jun transcriptional activities were inhibited by fucoidan, resulting to suppressing of activator protein-1 (AP-1) activity and cell transformation induced by EGF. Taken together, these results indicate that fucoidan might exert chemopreventive effects through the inhibition of phosphorylation of the EGFR.

Integrity signals

Registry

Crossref · 10.1016/j.fct.2008.01.025

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Anticarcinogenic action of fucoidan from S. cichorioides is connected with its ability to interact directly with EGF and prevent its binding to EGFR.
“It has been suggested that the anticarcinogenic action of fucoidan from S. cichorioides is connected with its ability to interact directly with epidermal growth factor (EGF) and prevents its binding to EGF receptor (EGFR).”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [67]
In experiments with neoplastic transformation of JB6 mouse epidermal cells induced by EGF or TPA, inhibition of EGFR phosphorylation was followed by inhibition of some ERK activities, resulting in inhibition of AP-1 nuclear factor transactivation.
“Actually, in experiments with neoplastic transformation of JB6 mouse epidermal cells induced by EGF or 12-O-tetradecanoylphorbol-13 acetate, a Russian-Korean group of scientists reported that inhibition of EGFR phosphorylation was followed by inhibition of the activities of some extracellular signal regulated kinases that resulted in the inhibition of AP-1 nuclear factor transactivation [66,67].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [67]

Colorimetric Method for Determination of Sugars and Related Substances
DuBois, M., Gilles, K. A., Hamilton, J. K., Rebers, P. A., & Smith, F. (1956) · Analytical Chemistry · doi:10.1021/ac60111a017 · Cited by 52,269 · see citing works
A PHOTOMETRIC ADAPTATION OF THE SOMOGYI METHOD FOR THE DETERMINATION OF GLUCOSE
Nelson, N. (1944) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)71980-7 · Cited by 10,376 · see citing works
Untangling the ErbB signalling network
Yarden, Y., & Sliwkowski, M. X. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35052073 · Cited by 6,974 · see citing works
The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation
Angel, P. E., & Karin, M. (1991) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(91)90011-9 · Cited by 3,390 · see citing works
AP-1 as a regulator of cell life and death
Shaulian, E., & Karin, M. (2002) · Nature Cell Biology · doi:10.1038/ncb0502-e131 · Cited by 2,961 · cited 1× · see citing works
“EGF-induced c-jun transcriptional activation is closely connected with cell proliferation, differentiation, and neoplastic cell transformation (Shaulian and Karin, 2002).”
Background
The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases
Karin, M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.28.16483 · Cited by 2,432 · see citing works
AP-1: a double-edged sword in tumorigenesis
Eferl, R., & Wagner, E. F. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1209 · Cited by 2,218 · see citing works
Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells
Cowley, S. A. (1994) · Cell · doi:10.1016/0092-8674(94)90133-3 · Cited by 1,988 · see citing works
Primary response genes induced by growth factors and tumor promoters.
Herschman, H. (1991) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.60.070191.001433 · Cited by 1,077 · see citing works
A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds
Cumashi, A., Ushakova, N. A., Preobrazhenskaya, M. E., D'Incecco, A., Piccoli, A., Totani, L., Tinari, N., Morozevich, G. E., Berman, A. E., Bilan, M. I., et al. (2007) · Glycobiology · doi:10.1093/glycob/cwm014 · Cited by 1,026 · see citing works
Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor
Chen, W. S., Lazar, C. S., Poenie, M., Tsien, R. Y., Gill, G. N., & Rosenfeld, M. G. (1987) · Nature · doi:10.1038/328820a0 · Cited by 593 · see citing works
Algal Polysaccharides
PAINTER, T. J. (1983) · The Polysaccharides · doi:10.1016/b978-0-12-065602-8.50009-1 · Cited by 506 · see citing works
Oversulfation of fucoidan enhances its anti-angiogenic and antitumor activities
Koyanagi, S., Tanigawa, N., Nakagawa, H., Soeda, S., & Shimeno, H. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01478-8 · Cited by 479 · see citing works
Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma.
Humphrey, P. A., Wong, A. J., Vogelstein, B., Zalutsky, M. R., Fuller, G. N., Archer, G. E., Friedman, H. S., Kwatra, M. M., Bigner, S. H., & Bigner, D. D. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.11.4207 · Cited by 382 · see citing works
Inhibition of tumor promoter-induced activator protein 1 activation and cell transformation by tea polyphenols, (-)-epigallocatechin gallate, and theaflavins.
Dong, Z., Ma, W., Huang, C., & Yang, C. S. (1997) · PubMed · Cited by 352 · see citing works
Self-citation
A study of fucoidan from the brown seaweed Chorda filum
Chizhov, A. O., Dell, A., Morris, H. R., Haslam, S. M., McDowell, R. A., Shashkov, A. S., Nifant’ev, N. E., Khatuntseva, E. A., & Usov, A. I. (1999) · Carbohydrate Research · doi:10.1016/s0008-6215(99)00148-2 · Cited by 326 · see citing works
Structural studies on fucoidans from the brown seaweed Sargassum stenophyllum
Duarte, M. E. R., Cardoso, M. A., Noseda, M. D., & Cerezo, A. S. (2001) · Carbohydrate Research · doi:10.1016/s0008-6215(01)00149-5 · Cited by 319 · see citing works
A disaccharide repeat unit is the major structure in fucoidans from two species of brown algae
Chevolot, L., Mulloy, B., Ratiskol, J., Foucault, A. P., & Colliec‐Jouault, S. (2001) · Carbohydrate Research · doi:10.1016/s0008-6215(00)00314-1 · Cited by 304 · see citing works
The pathogenesis of squamous cell cancer: lessons learned from studies of skin carcinogenesis
Yuspa, S. H. (1998) · Journal of Dermatological Science · doi:10.1016/s0923-1811(97)00071-6 · Cited by 301 · see citing works
Mitogen-Activated Protein Kinase Activation in UV-Induced Signal Transduction
Bode, A. M., & Dong, Z. (2003) · Science s STKE · doi:10.1126/stke.2003.167.re2 · Cited by 295 · see citing works
Self-citation
Suppression of skin tumorigenesis in c-Jun NH(2)-terminal kinase-2-deficient mice.
Chen, N., Nomura, M., She, Q., Ma, W. Y., Bode, A. M., Wang, L. Q., Flavell, R. A., & Dong, Z. (2001) · PubMed · Cited by 213 · see citing works
Self-citation
A new procedure for the separation of water-soluble polysaccharides from brown seaweeds
Zvyagintseva, T. N., Shevchenko, N. M., Popivnich, I. B., Isakov, V. V., Scobun, A. S., Sundukova, E. V., & Elyakova, L. A. (1999) · Carbohydrate Research · doi:10.1016/s0008-6215(99)00206-2 · Cited by 198 · see citing works
Use of Sulfated Fucans as Anticoagulant and Antithrombotic Agents: Future Perspectives
Mourao, P. (2004) · Current Pharmaceutical Design · doi:10.2174/1381612043452730 · Cited by 195 · see citing works
Dissociation of mitogenesis and late-stage promotion of tumor cell phenotype by phorbol esters: mitogen-resistant variants are sensitive to promotion.
Colburn, N. H., Wendel, E. J., & Abruzzo, G. K. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.11.6912 · Cited by 185 · see citing works
Interaction of ATF6 and serum response factor
Zhu, C., Johansen, F., & Prywes, R. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.9.4957 · Cited by 184 · see citing works
Antitumor activity and immunological properties of marine algal polysaccharides, especially fucoidan, prepared from Sargassum thunbergii of Phaeophyceae.
(1993) · PubMed · Cited by 171 · see citing works
Isolation and partial characterization of a noval amino sugar-containing fucan sulfate from commercial Fucus vesiculosus fucoidan
Nishino, T., Nishioka, C., Ura, H., & Nagumo, T. (1994) · Carbohydrate Research · doi:10.1016/s0008-6215(00)90980-7 · Cited by 157 · see citing works
The Role of NK cells in Antitumor Activity of Dietary Fucoidan from Undaria pinnatifida Sporophylls (Mekabu)
Maruyama, H., Tamauchi, H., Iizuka, M., & Nakano, T. (2006) · Planta Medica · doi:10.1055/s-2006-951703 · Cited by 151 · see citing works
Neoplastic transformation of rat thyroid cells requires the junB and fra‐1 gene induction which is dependent on the HMGI‐C gene product
Vallone, D., Battista, S., Pierantoni, G. M., Fedele, M., Casalino, L., Santoro, M. M., Viglietto, G., Fusco, A., & Verde, P. (1997) · The EMBO Journal · doi:10.1093/emboj/16.17.5310 · Cited by 143 · see citing works
Grape seed extract inhibits EGF-induced and constitutively active mitogenic signaling but activates JNK in human prostate carcinoma DU145 cells: possible role in antiproliferation and apoptosis
Tyagi, A., Agarwal, R., & Agarwal, C. (2003) · Oncogene · doi:10.1038/sj.onc.1206265 · Cited by 139 · see citing works
Fucoidan induces nitric oxide production via p38 mitogen-activated protein kinase and NF-κB-dependent signaling pathways through macrophage scavenger receptors
Nakamura, T., Suzuki, H., Wada, Y., Kodama, T., & Doi, T. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.02.146 · Cited by 138 · see citing works
Low Molecular Weight Fucoidan Increases VEGF165-induced Endothelial Cell Migration by Enhancing VEGF165 Binding to VEGFR-2 and NRP1
Lake, A. C., Vassy, R., Benedetto, M. D., Lavigne, D., Visage, C. L., Perret, G. Y., & Letourneur, D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600686200 · Cited by 129 · see citing works
Inhibition of AP-1 transcription factor causes blockade of multiple signal transduction pathways and inhibits breast cancer growth
Liu, Y., Ludes-Meyers, J. H., Zhang, Y., Munoz‐Medellin, D., Kim, H.-T., Lü, C., Ge, G., Schiff, R., Hilsenbeck, S. G., Osborne, C. K., et al. (2002) · Oncogene · doi:10.1038/sj.onc.1205883 · Cited by 128 · see citing works
Anticoagulant and antithrombin activities of oversulfated fucans
Nishino, T., & Nagumo, T. (1992) · Carbohydrate Research · doi:10.1016/s0008-6215(00)90581-0 · Cited by 122 · see citing works
Expression ofHMGI-C, a member of the high mobility group protein family, in a subset of breast cancers: Relationship to histologic grade
Rogalla, P., Drechsler, K., Kazmierczak, B., Rippe, V., Bonk, U., & BULLERDIEK, J. (1997) · Molecular Carcinogenesis · doi:10.1002/(sici)1098-2744(199707)19:3 · Cited by 109 · see citing works
Polysaccharide and lipid composition of the brown seaweed Laminaria gurjanovae
Шевченко, Н. М., Anastyuk, S. D., Ивановна, Г. Н., Dmitrenok, P. S., Isakov, V. V., & Николаевна, З. Т. (2007) · Russian Journal of Bioorganic Chemistry · doi:10.1134/s1068162007010116 · Cited by 97 · see citing works
JNK Activation Is Required for JB6 Cell Transformation Induced by Tumor Necrosis Factor-α but Not by 12-O-Tetradecanoylphorbol-13-Acetate
Huang, C., Li, J., Ma, W., & Dong, Z. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.42.29672 · Cited by 93 · see citing works
Self-citation
Antiviral activity of Undaria pinnatiﬁda against herpes simplex virus
Thompson, K. D., & Dragar, C. (2004) · Phytotherapy Research · doi:10.1002/ptr.1487 · Cited by 85 · see citing works
Expression of EGF, TGF-alpha and EGFR in squamous cell lung carcinomas.
Gorgoulis, V. G., Aninos, D., Mikou, P., Kanavaros, P., Karameris, A., Joardanoglou, J., Rasidakis, A., Veslemes, M., Ozanne, B. W., & Spandidos, D. A. (1992) · PubMed · Cited by 84 · see citing works
ATF1 Phosphorylation by the ERK MAPK Pathway Is Required for Epidermal Growth Factor-induced c-jun Expression
Gupta, P., & Prywes, R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209799200 · Cited by 83 · see citing works
Anti-sense transforming growth factor alpha oligonucleotides inhibit autocrine stimulated proliferation of a colon carcinoma cell line.
Sizeland, A. M., & Burgess, A. W. (1992) · Molecular Biology of the Cell · doi:10.1091/mbc.3.11.1235 · Cited by 77 · see citing works
Constitutive ap‐1 dna binding and transactivating ability of malignant but not benign mouse epidermal cells
Domann, F. E., Levy, J. P., Finch, J. S., & Bowden, G. T. (1994) · Molecular Carcinogenesis · doi:10.1002/mc.2940090202 · Cited by 71 · see citing works
Dietary seaweed (Laminaria) and mammary carcinogenesis in rats.
Teas, J., Harbison, M. L., & Gelman, R. S. (1984) · PubMed · Cited by 69 · see citing works
Seasonal variation in the lipid content of culturedLaminaria japonica: fatty acids, sterols, β-carotene and tocopherol
Honya, M., Kinoshita, T., Ishikawa, M., Mori, H., & Nisizawa, K. (1994) · Journal of Applied Phycology · doi:10.1007/bf02185900 · Cited by 68 · see citing works
A comparative study of specificity of fucoidanases from marine microorganisms and invertebrates
Игоревич, К. М., Chizhov, A. O., Grachev, A. A., Alekseeva, S. A., Bakunina, I. Y., Nedashkovskaya, O. I., Сова, В. В., & Николаевна, З. Т. (2006) · Journal of Applied Phycology · doi:10.1007/s10811-006-9042-x · Cited by 49 · see citing works
Manganese superoxide dismutase expression inhibits soft agar growth in JB6 clone41 mouse epidermal cells
Amstad, P. (1997) · Carcinogenesis · doi:10.1093/carcin/18.3.479 · Cited by 47 · see citing works
Harvesting Cells Under Anchorage-Independent Cell Transformation Conditions for Biochemical Analyses
Dong, Z., & Cmarik, J. L. (2002) · Science s STKE · doi:10.1126/stke.2002.130.pl7 · Cited by 42 · see citing works
Self-citation
A comparative study of specificity of fucoidanases from marine microorganisms and invertebrates
Игоревич, К. М., Chizhov, A. O., Grachev, A. A., Alekseeva, S. A., Bakunina, I. Y., Nedashkovskaya, O. I., Сова, В. В., & Николаевна, З. Т. (2008) · Springer eBooks · doi:10.1007/978-1-4020-5670-3_18 · Cited by 37 · see citing works
Cell Lung Carcinomas
Sun, M., Zheng, S., & Zhao, J. (2009) · Cited by 2 · see citing works

Flagged first, then by citations

2 of the 51 references couldn’t be matched to a known paper.

Sorted by citations

Biological activities and potential industrial applications of fucose rich sulfated polysaccharides and fucoidans isolated from brown seaweeds: A review
Wijesinghe, W. A. J. P., & Jeon, Y.-J. (2012) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2011.12.029 · Cited by 449 · see citing works
Fucoidan and Cancer: A Multifunctional Molecule with Anti-Tumor Potential
Atashrazm, F., Lowenthal, R. M., Woods, G. M., Holloway, A. F., & Dickinson, J. L. (2015) · Marine Drugs · doi:10.3390/md13042327 · Cited by 361 · see citing works
Brown seaweed fucoidan: Biological activity and apoptosis, growth signaling mechanism in cancer
Senthilkumar, K., Manivasagan, P., Venkatesan, J., & Kim, S.-K. (2013) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2013.06.030 · Cited by 340 · see citing works
Sulfated polysaccharides as bioactive agents from marine algae
Ngo, D.-H., & Kim, S. (2013) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2013.08.036 · Cited by 290 · see citing works
Fucoidan from Sargassum sp. and Fucus vesiculosus reduces cell viability of lung carcinoma and melanoma cells in vitro and activates natural killer cells in mice in vivo
Ale, M. T., Maruyama, H., Tamauchi, H., Mikkelsen, J. D., & Meyer, A. S. (2011) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2011.05.009 · Cited by 267 · see citing works
Seaweed polysaccharides and their potential biomedical applications
Venkatesan, J., Lowe, B., Anil, S., Manivasagan, P., Kheraif, A. A. A., Kang, K., & Kim, S. (2015) · Starch - Stärke · doi:10.1002/star.201400127 · Cited by 216 · see citing works
Self-citation
A review about the development of fucoidan in antitumor activity: Progress and challenges
Wu, L., Sun, J., Su, X., Yu, Q., Yu, Q., & Zhang, P. (2016) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2016.08.005 · Cited by 214 · see citing works
Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects
Fedorov, S., Ermakova, S., Zvyagintseva, T., & Stonik, V. (2013) · Marine Drugs · doi:10.3390/md11124876 · Cited by 189 · see citing works
Self-citation
Biological activities and potential cosmeceutical applications of bioactive components from brown seaweeds: a review
Wijesinghe, W. A. J. P., & Jeon, Y. (2011) · Phytochemistry Reviews · doi:10.1007/s11101-011-9214-4 · Cited by 155 · see citing works
Fucoidan Extract Enhances the Anti-Cancer Activity of Chemotherapeutic Agents in MDA-MB-231 and MCF-7 Breast Cancer Cells
Zhang, Z., Teruya, K., Yoshida, T., Eto, H., & Shirahata, S. (2013) · Marine Drugs · doi:10.3390/md11010081 · Cited by 147 · see citing works
Inhibition of Influenza A Virus Infection by Fucoidan Targeting Viral Neuraminidase and Cellular EGFR Pathway
Wang, W., Wu, J., Zhang, X., Hao, C., Zhao, X., Jiao, G., Shan, X., Tai, W., & Yu, G. (2017) · Scientific Reports · doi:10.1038/srep40760 · Cited by 147 · see citing works
Anti-inflammatory activity of edible brown alga Saccharina japonica and its constituents pheophorbide a and pheophytin a in LPS-stimulated RAW 264.7 macrophage cells
Islam, M. N., Ishita, I. J., Jin, S. E., Choi, R. J., Lee, C. M., Kim, Y. S., Jung, H. A., & Choi, J. S. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.01.054 · Cited by 146 · see citing works
Multifunctional role of fucoidan, sulfated polysaccharides in human health and disease: A journey under the sea in pursuit of potent therapeutic agents
Pradhan, B., Patra, S., Nayak, R., Behera, C., Dash, S. R., Nayak, S., Sahu, B. B., Bhutia, S. K., & Jena, M. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.09.019 · Cited by 142 · see citing works
Gold from the sea: Marine compounds as inhibitors of the hallmarks of cancer
Schumacher, M., Kelkel, M., Dicato, M., & Diederich, M. (2011) · Biotechnology Advances · doi:10.1016/j.biotechadv.2011.02.002 · Cited by 138 · see citing works
Preparation of low molecular weight fucoidan by gamma-irradiation and its anticancer activity
Choi, J., & Kim, H. (2013) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2013.05.002 · Cited by 129 · see citing works
Kinase Inhibitors of Marine Origin
Bharate, S. B., Sawant, S. D., Singh, P. P., & Vishwakarma, R. A. (2013) · Chemical Reviews · doi:10.1021/cr300410v · Cited by 130 · see citing works
Structural Characteristics and Anticancer Activity of Fucoidan from the Brown Alga Sargassum mcclurei
Thinh, P. D., Menshova, R. V., Ermakova, S. P., Anastyuk, S. D., Ly, B., & Николаевна, З. Т. (2013) · Marine Drugs · doi:10.3390/md11051456 · Cited by 129 · see citing works
Self-citation
Anticancer activity in vitro of a fucoidan from the brown alga Fucus evanescens and its low-molecular fragments, structurally characterized by tandem mass-spectrometry
Anastyuk, S. D., Шевченко, Н. М., Ermakova, S. P., Malyarenko, O. S., Назаренко, Е. Л., Dmitrenok, P. S., & Николаевна, З. Т. (2011) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2011.07.036 · Cited by 122 · see citing works
Self-citation
The fucoidans from brown algae of Far-Eastern seas: Anti-tumor activity and structure-function relationship
Vishchuk, O. S., Ermakova, S. P., & Zvyagintseva, T. N. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2013.03.065 · Cited by 117 · see citing works
Self-citation
Marine Cyanobacteria and Microalgae Metabolites—A Rich Source of Potential Anticancer Drugs
Mondal, A., Bose, S., Banerjee, S., Patra, J. K., Malik, J., Mandal, S. K., Kilpatrick, K. L., Das, G., Kerry, R. G., Fimognari, C., et al. (2020) · Marine Drugs · doi:10.3390/md18090476 · Cited by 119 · see citing works
Anticancer Compounds from Marine Macroalgae and Their Application as Medicinal Foods
Kim, S., Thomas, N. V., & Li, X. (2011) · Advances in food and nutrition research · doi:10.1016/b978-0-12-387669-0.00016-8 · Cited by 87 · see citing works
Anti-tumor effects of proteoglycan from Phellinus linteus by immunomodulating and inhibiting Reg IV/EGFR/Akt signaling pathway in colorectal carcinoma
Li, Y., Ji, D.-F., Zhong, S. S., Zhu, J., Chen, S., & Hu, G.-Y. (2011) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2011.01.014 · Cited by 82 · see citing works
Seaweed-Derived Sulfated Polysaccharides; The New Age Chemopreventives: A Comprehensive Review
Bhuyan, P. P., Nayak, R., Patra, S., Abdulabbas, H. S., Jena, M., & Pradhan, B. (2023) · Cancers · doi:10.3390/cancers15030715 · Cited by 81 · see citing works
Fucoidan’s Molecular Targets: A Comprehensive Review of Its Unique and Multiple Targets Accounting for Promising Bioactivities Supported by In Silico Studies
Zayed, A., Al-Saedi, D. A., Mensah, E. O., Kanwugu, O. N., Adadi, P., & Ulber, R. (2023) · Marine Drugs · doi:10.3390/md22010029 · Cited by 77 · see citing works
Laminaran from brown alga Dictyota dichotoma and its sulfated derivative as radioprotectors and radiosensitizers in melanoma therapy
Malyarenko, O. S., Usoltseva, R. V., Николаевна, З. Т., & Ermakova, S. P. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.11.008 · Cited by 69 · see citing works
Self-citation
Prospects for the therapeutic application of sulfated polysaccharides of brown algae in diseases of the cardiovascular system: review
Zaporozhets, T. S., & Besednova, N. N. (2016) · Pharmaceutical Biology · doi:10.1080/13880209.2016.1185444 · Cited by 63 · see citing works
PDZ-binding kinase/T-LAK cell-originated protein kinase is a target of the fucoidan from brown alga Fucus evanescens in the prevention of EGF-induced neoplastic cell transformation and colon cancer growth
Vishchuk, O. S., Sun, H., Wang, Z., Ermakova, S. P., Xiao, J., Lu, T., Xue, P., Николаевна, З. Т., Xiong, H., Shao, C., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.7708 · Cited by 57 · see citing works
Self-citation
Structural Characteristics and Biological Activity of Fucoidans from the Brown Algae Alaria sp. and Saccharina japonica of Different Reproductive Status
Vishchuk, O. S., Tarbeeva, D. V., Ermakova, S. P., & Zvyagintseva, T. N. (2012) · Chemistry & Biodiversity · doi:10.1002/cbdv.201100266 · Cited by 56 · see citing works
Self-citation
The Effect of Sulfated (1→3)-α-l-Fucan from the Brown Alga Saccharina cichorioides Miyabe on Resveratrol-Induced Apoptosis in Colon Carcinoma Cells
Vishchuk, O., Ermakova, S., & Zvyagintseva, T. (2013) · Marine Drugs · doi:10.3390/md11010194 · Cited by 50 · see citing works
Self-citation
Exploiting the Amazing Diversity of Natural Source-Derived Polysaccharides: Modern Procedures of Isolation, Engineering, and Optimization of Antiviral Activities
Ray, B., Schütz, M., Mukherjee, S., Jana, S., Ray, S., & Marschall, M. (2020) · Polymers · doi:10.3390/polym13010136 · Cited by 50 · see citing works
New therapeutic targets for the prevention of infectious acute exacerbations of COPD: role of epithelial adhesion molecules and inflammatory pathways
Atto, B., Eapen, M. S., Sharma, P. K., Frey, U., Ammit, A. J., Markos, J., Chia, C., Larby, J., Haug, G., Weber, H. C., et al. (2019) · Clinical Science · doi:10.1042/cs20181009 · Cited by 49 · see citing works
Natural polysaccharides and their derivatives targeting the tumor microenvironment: A review
Wang, W., Zhao, B., Zhang, Z., Kikuchi, T., Li, W., Jantrawut, P., Feng, F., Liu, F., & Zhang, J. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.131789 · Cited by 46 · see citing works
Mycalamide A Shows Cytotoxic Properties and Prevents EGF-Induced Neoplastic Transformation through Inhibition of Nuclear Factors
Dyshlovoy, S. A., Fedorov, S. N., Kalinovsky, A. I., Shubina, L. K., Bokemeyer, C., Stonik, V. A., & Honecker, F. U. (2012) · Marine Drugs · doi:10.3390/md10061212 · Cited by 45 · see citing works
Sulfation of Various Polysaccharide Structures: Different Methods and Perspectives
Berezhnaya, Y. D., Kazachenko, А. S., Казаченко, А. С., Malyar, Y. N., & Borovkova, V. S. (2024) · Chemistry · doi:10.3390/chemistry6040038 · Cited by 44 · see citing works
Fermentation-Derived Bioactive Components from Seaweeds: Functional Properties and Potential Applications
Chye, F. Y., Ooi, P. W., Ng, S. Y., & Sulaiman, M. R. (2017) · Journal of Aquatic Food Product Technology · doi:10.1080/10498850.2017.1412375 · Cited by 37 · see citing works
Anticancer Effects of Fucoidan
Kalimuthu, S., & Kim, S. (2014) · Advances in food and nutrition research · doi:10.1016/b978-0-12-800269-8.00011-7 · Cited by 35 · see citing works
The natural compound fucoidan from New Zealand Undaria pinnatifida synergizes with the ERBB inhibitor lapatinib enhancing melanoma growth inhibition
Thakur, V., Lu, J., Roscilli, G., Aurisicchio, L., Cappelletti, M., Pavoni, E., White, W. L., & Bedogni, B. (2017) · Oncotarget · doi:10.18632/oncotarget.14437 · Cited by 33 · see citing works
Fucoidans: The importance of processing on their anti-tumoral properties
Torres, M. D., Flórez-Fernández, N., Simón‐Vázquez, R., Giménez-Abián, J. F., Díaz, J. F., González‐Fernández, Á., & Domı́nguez, H. (2019) · Algal Research · doi:10.1016/j.algal.2019.101748 · Cited by 33 · see citing works
Sulfated galactans from the red seaweed Gracilaria fisheri exerts anti-migration effect on cholangiocarcinoma cells
Sae-lao, T., Luplertlop, N., Janvilisri, T., Tohtong, R., Bates, D. O., & Wongprasert, K. (2017) · Phytomedicine · doi:10.1016/j.phymed.2017.09.014 · Cited by 32 · see citing works
Molecular Mechanisms Underlying Cancer Preventive and Therapeutic Potential of Algal Polysaccharides
Sajadimajd, S., Momtaz, S., Haratipour, P., El‐Senduny, F. F., Iranpanah, A., Navabi, J., Soheilikhah, Z., Farzaei, M. H., & Rahimi, R. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190425155126 · Cited by 31 · see citing works
Antitumor properties of nonstarch polysaccharides: Fucoidans and chitosans
Khotimchenko, Y. S. (2010) · Russian Journal of Marine Biology · doi:10.1134/s1063074010050019 · Cited by 30 · see citing works
Fucoidan, A Sulfated Polysaccharides from Brown Algae as Therapeutic Target for Cancer
Kalimuthu, S., & Kim, S. (2014) · Springer eBooks · doi:10.1007/978-3-319-07145-9_7 · Cited by 26 · see citing works
Fucoidan inhibits EGFR redistribution and potentiates sorafenib to overcome sorafenib-resistant hepatocellular carcinoma
Luo, J., Li, L., Zhu, Z., Chang, B. Y., Deng, F., Wang, D., Lu, X., Zuo, D., Chen, Q., & Zhou, J. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113602 · Cited by 24 · see citing works
Investigation of Different Molecular Weight Fucoidan Fractions Derived from New Zealand Undaria pinnatifida in Combination with GroA Therapy in Prostate Cancer Cell Lines
Yang, X., Wang, S., Trangle, S. S., Li, Y., White, W. L., Li, J., Ying, T., Kong, Q., Zhao, Y., & Lu, J. (2018) · Marine Drugs · doi:10.3390/md16110454 · Cited by 24 · see citing works
Selective Suppression of Cell Growth and Programmed Cell Death-Ligand 1 Expression in HT1080 Fibrosarcoma Cells by Low Molecular Weight Fucoidan Extract
Teruya, K., Kusumoto, Y., Eto, H., Nakamichi, N., & Shirahata, S. (2019) · Marine Drugs · doi:10.3390/md17070421 · Cited by 24 · see citing works
Biomedical Applications of Fucoidan, Seaweed Polysaccharides
Senthilkumar, K., Govindan, R., Venkatesan, J., Kim, S., & Ahn, B. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809816-5.00014-1 · Cited by 22 · see citing works
A concise synthesis of single components of partially sulfated oligomannans
Mong, K. T., Shiau, K., Lin, Y., Cheng, K., & Lin, C. (2015) · Organic & Biomolecular Chemistry · doi:10.1039/c5ob01786f · Cited by 21 · see citing works
Fucoidans: Anticancer Activity and Molecular Mechanisms of Action
Malyarenko, O. S., & Ermakova, S. P. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809816-5.00010-4 · Cited by 20 · see citing works
Self-citation
Inhibition of EGF-induced migration and invasion by sulfated polysaccharide of Sepiella maindroni ink via the suppression of EGFR/Akt/p38 MAPK/MMP-2 signaling pathway in KB cells
Jiang, W., Tian, W., Ijaz, M., & Wang, F. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.08.050 · Cited by 20 · see citing works
Sulfated Galactans from Red Seaweed Gracilaria fisheri Target EGFR and Inhibit Cholangiocarcinoma Cell Proliferation
Sae-lao, T., Tohtong, R., Bates, D. O., & Wongprasert, K. (2017) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x17500367 · Cited by 20 · see citing works
Anti-inflammatory activities of some brown marine algae in LPS-stimulated RAW 264.7 cells
Hwang, J., Oh, Y.-S., & Lim, S.-B. (2014) · Food Science and Biotechnology · doi:10.1007/s10068-014-0116-2 · Cited by 16 · see citing works
3,4-dihydroxyphenyl acetic acid and (+)-epoxydon isolated from marine algae-derived microorganisms induce down regulation of epidermal growth factor activated mitogenic signaling cascade in Hela cells
Jo, M. J., Bae, S. J., Son, B. W., Kim, C. Y., & Kim, G. (2013) · Cancer Cell International · doi:10.1186/1475-2867-13-49 · Cited by 14 · see citing works
Anticancer activities of marine macroalgae: status and future perspectives
Gopeechund, A., Bhagooli, R., Neergheen, V. S., Bolton, J. J., & Bahorun, T. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819541-3.00014-1 · Cited by 14 · see citing works
Opportunity of plant oligosaccharides and polysaccharides in drug development
Kumar, V., Nagar, S., & Sharma, P. K. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816675-8.00015-4 · Cited by 12 · see citing works
5′‐Nitro‐indirubinoxime inhibits epidermal growth factor‐ and phorbol ester‐induced AP‐1 activity and cell transformation through inhibition of phosphorylation of Pin1
Khanal, P., Choi, H., Namgoong, G. M., Ahn, S., Yoon, J., Sohn, H., & Choi, H. S. (2011) · Molecular Carcinogenesis · doi:10.1002/mc.20761 · Cited by 12 · see citing works
Self-citation
Apoptosis induction by glycoprotein isolated from Laminaria japonica is associated with down-regulation of telomerase activity and prostaglandin E2 synthesis in AGS human gastric cancer cells
Choi (2010) · International Journal of Oncology · doi:10.3892/ijo.2010.853 · Cited by 11 · see citing works
Structure and chemopreventive activity of fucoidans from the brown alga Alaria angusta
Zueva, A. O., Usoltseva, R. V., Malyarenko, O. S., Surits, V. V., Silchenko, A. S., Anastyuk, S. D., Rasin, A. B., Khánh, H. H. N., Thinh, P. D., & Ermakova, S. P. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.11.127 · Cited by 10 · see citing works
Self-citation
Inhibitory Effects of Glycoprotein Isolated from Laminaria japonica on Lipopolysaccharide‐Induced Pro‐Inflammatory Mediators in BV2 Microglial Cells
Park, H., Han, M., Kim, G., Kim, N. D., Nam, T., & Choi, Y. H. (2011) · Journal of Food Science · doi:10.1111/j.1750-3841.2011.02287.x · Cited by 10 · see citing works
Antitumor effects of sulfated polysaccharides produced from marine algae
Zaporozhets, T. S., Ermakova, S. P., Николаевна, З. Т., & Besednova, N. N. (2014) · Biology Bulletin Reviews · doi:10.1134/s2079086414020078 · Cited by 10 · see citing works
Self-citation
Marine Algal Phlorotannins and their Biological Importance
Thomas, N. V., Diyya, A. S. M., Ghafour, D. D., & Kim, S. (2020) · Encyclopedia of Marine Biotechnology · doi:10.1002/9781119143802.ch65 · Cited by 10 · see citing works
Functional Properties of Brown Algal Sulfated Polysaccharides, Fucoidans
Jeon, Y., Wijesinghe, W. A. J. P., & Kim, S. (2011) · Advances in food and nutrition research · doi:10.1016/b978-0-12-387669-0.00012-0 · Cited by 8 · see citing works
The anticancer effects of Saccharina japonica on 267B1/K-ras human prostate cancer cells
Jo, M. J., Kim, H. R., & Kim, G. (2012) · International Journal of Oncology · doi:10.3892/ijo.2012.1612 · Cited by 7 · see citing works
Enzymatic extraction of bioactives from algae
Wijesinghe, W. A. J. P., & Jeon, Y. (2013) · Elsevier eBooks · doi:10.1533/9780857098689.3.517 · Cited by 7 · see citing works
Characterization of Sulphated Polysaccharide with Antiviral Activity from Marine Brown Alga Cystoseira myrica Collected from Jazan Coasts, KSA
Mohamed, S. F., Slamy, T. M., & Shaeiri, S. Y. (2015) · Cited by 6 · see citing works
Marine Algal‐derived Pharmaceuticals
Cheriyamundath, S., & Vavilala, S. L. (2020) · Wiley eBooks · doi:10.1002/9781119143802.ch120 · Cited by 5 · see citing works
Effect of Polyelectrolyte Properties of Fucoidans on Antimicrobial Activity
Brovko, O. S., Паламарчук, И. А., Gorshkova, N., Chukhchin, D. G., & Eliseeva, I. M. (2025) · Journal of Polymers and the Environment · doi:10.1007/s10924-025-03506-7 · Cited by 4 · see citing works
Fucoidans as a Potential Nutraceutical in Combating Atherosclerotic Cardiovascular Diseases
Alvarez-Leite, J. I. (2019) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2019.21.003616 · Cited by 4 · see citing works
Network pharmacology integrated molecular docking of fucoidan against oral cancer and in vitro evaluation- A study using GEO datasets
Antonisamy, A. J., Rajendran, K., & Dhanaraj, P. (2024) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2024.2316771 · Cited by 4 · see citing works
Structure, antiproliferative and cancer preventive properties of sulfated α-d-fucan from the marine bacterium Vadicella arenosi
Kokoulin, M. S., Filshtein, A. P., Romanenko, L. A., Владимировна, Ч. И., & Chernikov, O. V. (2019) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.05.086 · Cited by 4 · see citing works
Polysaccharides from seaweeds: extraction and application
Gade, J. V., Gupta, N., Pandey, A., Rawat, R., & Jain, B. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-21674-9.00011-8 · Cited by 3 · see citing works
Marine Biomaterial Treasure and Biomedical Sciences
Oggu, G. S., Velidandla, S. R., Ealla, K. K. R., Venkatesan, J., Asthana, A., Kim, S., & Bhatnagar, I. (2020) · Encyclopedia of Marine Biotechnology · doi:10.1002/9781119143802.ch50 · Cited by 2 · see citing works
The anti-cancer activity of the natural product, fucoidan, in haematological malignancies
Atashrazm, F. (2016) · UTAS Research Repository · doi:10.25959/23239562
Laminariaceae: Its Use in Food and Health Implications
Malyarenko, O. S., Usoltseva, R. V., & Ermakova, S. P. (2022) · Springer eBooks · doi:10.1007/978-3-030-92174-3_4
Self-citation
Mechanistic insights of clinically investigated natural products as anti-colorectal cancer agents
Chowdhury, S., Azme, E., Hasan, M. M., Rahman, M., Rahman, M. A., Pallab, M. R. A., Ara, S., Mohammad, N., Tanjum, F. A., Ansari, F., et al. (2026) · Precision Nutrition · doi:10.1097/pn9.0000000000000137 · Cited by 1 · see citing works
Structurally distinct enzymatic depolymerization products of Fucus evanescens fucoidan exert cell line–specific anticancer effects in vitro
Zueva, A. O., Silchenko, A. S., Shkrabov, R. A., Anastyuk, S. D., & Ermakova, S. P. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.153140
Self-citation

Abstract A47: Fucoidan from Laminaria cichorioides inhibits AP-1 transactivation and cell transformation in mouse epidermal JB6 cells
Namgoong, G. M., Cho, H.-G., & Choi, H. S. (2009) · Cancer Research · doi:10.1158/0008-5472.fbcr09-a47
Self-citation
Fucoidan from Laminaria cichorioides inhibits AP‐1 transactivation and cell transformation in the mouse epidermal JB6 cells
Lee, N. Y., Ermakova, S. P., Choi, H., Kusaykin, M. I., Shevchenko, N. M., Zvyagintseva, T. N., & Choi, H. S. (2008) · Molecular Carcinogenesis · doi:10.1002/mc.20428 · Cited by 40 · see citing works
Self-citation
PDZ-binding kinase/T-LAK cell-originated protein kinase is a target of the fucoidan from brown alga Fucus evanescens in the prevention of EGF-induced neoplastic cell transformation and colon cancer growth
Vishchuk, O. S., Sun, H., Wang, Z., Ermakova, S. P., Xiao, J., Lu, T., Xue, P., Николаевна, З. Т., Xiong, H., Shao, C., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.7708 · Cited by 57 · see citing works
Self-citation
Detoxification and anticarcinogenic effects of Fucoidan in human hepatoblastoma and rat glioma cells
Lee, J., Oh, H. Y., Kwon, D.-J., & Yoon, S. Y. (2007) · The FASEB Journal · doi:10.1096/fasebj.21.6.a1095-d · Cited by 1 · see citing works
Opportunities and challenges of fucoidan for tumors therapy
Yu, H., Zhang, Q., Farooqı, A. A., Wang, J., Yang, Y., Geng, L., & Wu, N. (2023) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2023.121555 · Cited by 69 · see citing works

Authors: Lee, N. Y., Ermakova, S. P., Zvyagintseva, T. N., Kang, K. W., Dong, Z., & Choi, H. S.
Affiliations: Chosun University (KR)
Pacific Institute of Bioorganic Chemistry. GB Elyakova Far Eastern Branch of the Russian Academy of Sciences (RU)
University of Minnesota (US)
Corresponding author: Choi, Hong Seok
ORCID: Ermakova, Svetlana P.
Kang, Keon Wook
Dong, Zigang
Choi, Hong Seok
Venue: Food and Chemical Toxicology
Publisher: Elsevier BV
Published: 2008-05
Volume: 46
Issue: 5
Pages: 1793-1800
ISSN: 0278-6915 (ISSN-L)
DOI: 10.1016/j.fct.2008.01.025
OpenAlex: W2168736594
Cited by: 75
References: 51
Citations by year: 2026: 2 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 3 · 2020: 8 · 2019: 6 · 2018: 2 · 2017: 8 · 2016: 4 · 2015: 4 · 2014: 4 · 2013: 12 · 2012: 3
FWCI: 6.01
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Food and Chemical Toxicology (publishedVersion)
PubMed (publishedVersion)
Funders: Chosun University
Topics: Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Physical Sciences › Earth and Planetary Sciences › Oceanography › Marine and coastal plant biology
Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Echinoderm biology and ecology
Keywords: fucoidan, epidermal growth factor receptor, EGFR phosphorylation, cell transformation, ERK1/2, JNK, c-fos, c-Jun, AP-1 transcription factor, chemoprevention, sulfated polysaccharides, marine algae
MeSH terms: Animals, Antineoplastic Agents, Biotransformation, Cell Survival, Cell Transformation, Neoplastic, Chromatography, Ion Exchange, Epidermal Growth Factor, Indicators and Reagents, Laminaria, Phosphorylation, Polysaccharides, Tetrazolium Salts, Thiazoles, Blotting, Western, Signal Transduction, Genes, jun, Genes, fos, Genes, Reporter, Transcription Factor AP-1, Cell Line, Tumor, Mice, ErbB Receptors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Inhibitory effects of fucoidan on activation of epidermal growth factor receptor and cell transformation in JB6 Cl41 cells

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks