Biosynthesis and bioactivities of triterpenoids from Centella asiatica: Challenges and opportunities

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Metabolic compartmentalization in yeast mitochondria: Burden and solution for squalene overproduction

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Asiatic Acid Inhibits Liver Fibrosis by Blocking TGF-beta/Smad Signaling In Vivo and In Vitro

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Comparative Studies on Different Extraction Methods of Centella asiatica and Extracts Bioactive Compounds Effects on Antimicrobial Activities

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De novo sequencing and assembly of Centella asiatica leaf transcriptome for mapping of structural, functional and regulatory genes with special reference to secondary metabolism

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Anti-inflammatory Effects of Madecassic Acid via the Suppression of NF-κB Pathway in LPS-Induced RAW 264.7 Macrophage Cells

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Centella asiatica (Gotu kola) as a neuroprotectant and its potential role in healthy ageing

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Metabolic engineering and synthetic biology for isoprenoid production in Escherichia coli and Saccharomyces cerevisiae

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Genetic and bioprocess engineering to improve squalene production in Yarrowia lipolytica

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Regeneration of NADPH Coupled with HMG-CoA Reductase Activity Increases Squalene Synthesis in Saccharomyces cerevisiae

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A review of pharmacokinetic and pharmacological properties of asiaticoside, a major active constituent of Centella asiatica (L.) Urb.

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Engineering Saccharomyces cerevisiae for high yield production of α-amyrin via synergistic remodeling of α-amyrin synthase and expanding the storage pool

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Yarrowia lipolytica Strains Engineered for the Production of Terpenoids

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Protective effects of Asiaticoside on acute liver injury induced by lipopolysaccharide/D-galactosamine in mice

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Mitoprotective Effects of Centella asiatica (L.) Urb.: Anti-Inflammatory and Neuroprotective Opportunities in Neurodegenerative Disease

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Efficient synthesis of squalene by cytoplasmic-peroxisomal engineering and regulating lipid metabolism in Yarrowia lipolytica

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Metabolic Engineering of Yarrowia lipolytica for Terpenoid Production: Tools and Strategies

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Engineering peroxisomal biosynthetic pathways for maximization of triterpene production in Yarrowia lipolytica

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Triterpenoid saponin content and the expression level of some related genes in calli of Centella asiatica

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Origin and Evolution of Polycyclic Triterpene Synthesis

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Techniques for the analysis of pentacyclic triterpenoids in medicinal plants

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Molecular cloning of an ester-forming triterpenoid: UDP-glucose 28- O -glucosyltransferase involved in saponin biosynthesis from the medicinal plant Centella asiatica

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Hydroxylases involved in terpenoid biosynthesis: a review

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Fungal elicitor-mediated enhancement in growth and asiaticoside content of Centella asiatica L. shoot cultures

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Characterization of the Asiatic Acid Glucosyltransferase, UGT73AH1, Involved in Asiaticoside Biosynthesis in Centella asiatica (L.) Urban

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Enhanced biosynthesis of triterpenoids in Centella asiatica hairy root culture by precursor feeding and elicitation

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Preparation of Centella asiatica loaded gelatin/chitosan/nonwoven fabric composite hydrogel wound dressing with antibacterial property

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Biotechnological production of centellosides in cell cultures of Centella asiatica (L) Urban

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Total Triterpenes, Polyphenols, Flavonoids, and Antioxidant Activity of Bioactive Phytochemicals of Centella asiatica by Different Extraction Techniques

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Combinatorial metabolic engineering enables the efficient production of ursolic acid and oleanolic acid in Saccharomyces cerevisiae

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Cloning of a cDNA probably encoding oxidosqualene cyclase associated with asiaticoside biosynthesis from Centella asiatica (L.) Urban

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Metabolic engineering of Yarrowia lipolytica for high-level production of squalene

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A Novel Multifunctional C-23 Oxidase, CYP714E19, is Involved in Asiaticoside Biosynthesis

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Advances and emerging research trends for modulation of centelloside biosynthesis in Centella asiatica (L.) Urban- A review

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Ultrasound-assisted extraction of asiaticoside from Centella asiatica using betaine-based natural deep eutectic solvent

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Characterization of a Group of UDP-Glycosyltransferases Involved in the Biosynthesis of Triterpenoid Saponins of Panax notoginseng

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Advances in Metabolic Engineering Paving the Way for the Efficient Biosynthesis of Terpenes in Yeasts

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Effects of methyl jasmonate on the growth and triterpenoid production of diploid and tetraploid Centella asiatica (L.) Urb. hairy root cultures

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Mining of UDP‐glucosyltrfansferases in licorice for controllable glycosylation of pentacyclic triterpenoids

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Green extraction optimization of triterpenoid glycoside-enriched extract from Centella asiatica (L.) Urban using response surface methodology (RSM)

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Regulation of Ethanol Assimilation for Efficient Accumulation of Squalene in Saccharomyces cerevisiae

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Cytochrome P450 monooxygenase-mediated tailoring of triterpenoids and steroids in plants

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Increased Accumulation of Squalene in Engineered Yarrowia lipolytica through Deletion of PEX10 and URE2

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Development of Hairy Root Cultures for Biomass and Triterpenoid Production in Centella asiatica

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Growth and centelloside production in hydroponically established medicinal plant-Centella asiatica (L.)

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Metabolic gene expression and centelloside production in elicited Centella asiatica hairy root cultures

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Medicinal value of asiaticoside for Alzheimer’s disease as assessed using single-molecule-detection fluorescence correlation spectroscopy, laser-scanning microscopy, transmission electron microscopy, and in silico docking

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Neuroprotective effects of Asiaticoside

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Compartmentalization engineering of yeasts to overcome precursor limitations and cytotoxicity in terpenoid production

Chen, L., Xiao, W., Yao, M., Wang, Y., & Yuan, Y. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1132244 · Cited by 37 · see citing works

Comparison of the Antioxidant Potency of Four Triterpenes of Centella asiatica against Oxidative Stress

Lim, J., Lee, H., Hong, S., Lee, J., & Kim, Y. (2024) · Antioxidants · doi:10.3390/antiox13040483 · Cited by 37 · see citing works

Remodeling the Homologous Recombination Mechanism of Yarrowia lipolytica for High-Level Biosynthesis of Squalene

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Pharmacological effects of pentacyclic triterpenoids isolated from Centella asiatica

Min, D.-H., Yu, Y.-B., Kim, T., Kim, H., & Lee, S. (2024) · Horticulture Environment and Biotechnology · doi:10.1007/s13580-023-00561-8 · Cited by 35 · see citing works

Asiaticoside promoted ferroptosis and suppressed immune escape in gastric cancer cells by downregulating the Wnt/β-catenin pathway

Ye, C., Yao, Z., Wang, Y., & Zhang, C. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112175 · Cited by 35 · see citing works

Madecassoside ameliorates lipopolysaccharide-induced neurotoxicity in rats by activating the Nrf2-HO-1 pathway

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Engineering of Yarrowia lipolytica for the production of plant triterpenoids: Asiatic, madecassic, and arjunolic acids

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Asiaticoside-nitric oxide promoting diabetic wound healing through the miRNA-21-5p/TGF-β1/SMAD7/TIMP3 signaling pathway

Liu, Y., Zhao, J., Mu, X., Deng, J., Wu, X., He, W., Liu, Y., Gu, R., Han, F. Y., & Nie, X. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117266 · Cited by 33 · see citing works

Characterization of a dammarenediol synthase in Centella asiatica (L.) Urban

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High-Payload Nanosuspension of Centella asiatica Extract for Improved Skin Delivery with No Irritation

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Conversion of α-amyrin into centellosides by plant cell cultures of Centella asiatica

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Cloning and expression of a farnesyl diphosphate synthase in Centella asiatica (L.) Urban

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Efficient Plant Triterpenoids Synthesis in Saccharomyces cerevisiae : from Mechanisms to Engineering Strategies

Wang, S., Meng, D., Feng, M., Li, C., & Wang, Y. (2024) · ACS Synthetic Biology · doi:10.1021/acssynbio.4c00061 · Cited by 29 · see citing works

Cloning and molecular analysis of cDNA encoding cycloartenol synthase fromCentella asiatica (L.) urban

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Analysis of expressed sequence tags from Centella asiatica (L.) Urban hairy roots elicited by methyl jasmonate to discover genes related to cytochrome P450s and glucosyltransferases

Kim, O.-T., Um, Y., Jin, M. L., Kim, Y., Bang, K.-H., Hyun, D. Y., Lee, H. S., & Lee, Y. (2013) · Plant Biotechnology Reports · doi:10.1007/s11816-013-0311-2 · Cited by 28 · see citing works

Elucidation of the Biosynthesis of Asiaticoside and Its Reconstitution in Yeast

Zhao, X., Wei, W., Li, S., Gao, S., Liu, S., Zeng, W., & Zhou, J. (2024) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.3c07046 · Cited by 28 · see citing works

Metabolic recycling of storage lipids promotes squalene biosynthesis in yeast

Son, S., Kim, J.-E., Moon, S. Y., Jang, I.-S., Yu, B. J., & Lee, J. Y. (2022) · Biotechnology for Biofuels and Bioproducts · doi:10.1186/s13068-022-02208-9 · Cited by 27 · see citing works

Production of asiaticoside from centella (Centella asiatica L. Urban) cells in bioreactor

Lộc, N. H., & Nhat, N. T. D. (2013) · Asian Pacific Journal of Tropical Biomedicine · doi:10.1016/s2221-1691(13)60159-8 · Cited by 25 · see citing works

Enhanced production of amyrin in Yarrowia lipolytica using a combinatorial protein and metabolic engineering approach

Kong, J., Miao, L., Lu, Z., Wang, S., Zhao, B., Zhang, C., Xiao, D., Teo, D., Leong, S. S. J., Wong, A., et al. (2022) · Microbial Cell Factories · doi:10.1186/s12934-022-01915-0 · Cited by 25 · see citing works

Asiatic acid-entrapped transfersomes for the treatment of hypertrophic scars: In vitro appraisal, bioactivity evaluation, and clinical study

Opatha, S. A. T., Chutoprapat, R., Khankaew, P., Titapiwatanakun, V., Ruksiriwanich, W., & Boonpisuttinant, K. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.123738 · Cited by 25 · see citing works

Reengineering the Substrate Tunnel to Enhance the Catalytic Efficiency of Squalene Epoxidase

Yin, X., Wei, W., Chen, Q., Zhang, Y.-L., Liu, S., Gao, S., Luo, Z., & Zhou, J. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c05892 · Cited by 25 · see citing works

Enhancing Squalene Production in Saccharomyces cerevisiae by Metabolic Engineering and Random Mutagenesis

Lu, X., Lv, Y., Liu, S., Yu, S., Zeng, W., & Zhou, J. (2022) · Frontiers in Chemical Engineering · doi:10.3389/fceng.2021.790261 · Cited by 24 · see citing works

Biotechnological Intervention and Secondary Metabolite Production in Centella asiatica L.

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Rhodosporidium sp. DR37: a novel strain for production of squalene in optimized cultivation conditions

Shakeri, S., Khoshbasirat, F., & Maleki, M. (2021) · Biotechnology for Biofuels · doi:10.1186/s13068-021-01947-5 · Cited by 21 · see citing works

Squalene synthase in plants – Functional intricacy and evolutionary divergence while retaining a core catalytic structure

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Construction of a UDP-Arabinose Regeneration System for Efficient Arabinosylation of Pentacyclic Triterpenoids

Sun, Q., Guo, F., Ren, S., Zhang, L., Liu, X., Li, C., & Feng, X. (2023) · ACS Synthetic Biology · doi:10.1021/acssynbio.3c00351 · Cited by 21 · see citing works

Engineering Saccharomyces cerevisiae for high-efficient production of ursolic acid via cofactor engineering and acetyl-CoA optimization

Jia, N., Li, J., Zang, G., Yuan, Y., Jin, X., He, Y., Feng, M., Na, X., Wang, Y., & Li, C. (2023) · Biochemical Engineering Journal · doi:10.1016/j.bej.2023.109189 · Cited by 21 · see citing works

Asparagus racemosus bZIP transcription factor-regulated squalene epoxidase (ArSQE) promotes germination and abiotic stress tolerance in transgenic tobacco

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Impact of potential stimulants on asiaticoside and madecassoside levels and expression of triterpenoid-related genes in axenic shoot cultures of Centella asiatica (L.) Urb

Ranjith, G. P., Jisha, S. P., Hemanthakumar, A. S., Saji, C. V., Shenoi, R. A., & Sabu, K. K. (2021) · Phytochemistry · doi:10.1016/j.phytochem.2021.112735 · Cited by 20 · see citing works

Asiaticoside alleviates cardiomyocyte apoptosis and oxidative stress in myocardial ischemia/reperfusion injury via activating the PI3K-AKT-GSK3β pathway in vivo and in vitro

Zeng, X., Yu, J., Liu, P., Liu, Y., Zeng, T., & Li, B. (2022) · Annals of Translational Medicine · doi:10.21037/atm-21-6667 · Cited by 20 · see citing works

The Electrical Conductivity of Nutrient Solution Influenced the Growth, Centellosides Content and Gene Expression of Centella asiatica in a Hydroponic System

Shawon, M. R. A., Azad, M. O. K., Ryu, B. R., Na, J.-K., & Choi, K. (2023) · Agriculture · doi:10.3390/agriculture13122236 · Cited by 20 · see citing works

The biosynthesis of asiaticoside and madecassoside reveals tandem duplication–directed evolution of glycoside glycosyltransferases in the Apiales

Han, X., Zhao, J., Zhou, H., Zhou, X., Deng, Z., Liu, Z., & Yu, Y. (2024) · Plant Communications · doi:10.1016/j.xplc.2024.101005 · Cited by 20 · see citing works

Positive selection and functional divergence of farnesyl pyrophosphate synthase genes in plants

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Systems-based Saccharomyces cerevisiae strain design for improved squalene synthesis

Paramasivan, K., Punil Kumar, H. N., & Mutturi, S. (2019) · Biochemical Engineering Journal · doi:10.1016/j.bej.2019.04.025 · Cited by 19 · see citing works

Asiaticoside inhibits epithelial-mesenchymal transition and stem cell-like properties of pancreatic cancer PANC-1 cells by blocking the activation of p65 and p38MAPK

He, Y., Peng, X., Zheng, L., Tang, Y., Li, J., & Huang, X. (2021) · Journal of Gastrointestinal Oncology · doi:10.21037/jgo-20-533 · Cited by 19 · see citing works

Genetic and biochemical stability of in vitro raised and conventionally propagated Centella asiatica - A valuable medicinal herb

Mohapatra, P., Ray, A., Sandeep, I. S., Parida, R., & Mohanty, S. (2021) · South African Journal of Botany · doi:10.1016/j.sajb.2021.01.004 · Cited by 18 · see citing works

Biomass accumulation, bioactive compounds and nutrient uptake in Centella asiatica (L.) in relation to organic nutrition in open-field and shade

Priyanka, S., Sujatha, S., Smitha, G. R., Suryanarayana, M. A., & Kalaivanan, D. (2021) · Industrial Crops and Products · doi:10.1016/j.indcrop.2021.114352 · Cited by 17 · see citing works

Enhanced squalene production by modulation of pathways consuming squalene and its precursor

Tominaga, M., Miyazaki, K., Hataya, S., Mitsui, Y., Kuroda, S., Kondo, A., & Ishii, J. (2022) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2022.04.004 · Cited by 17 · see citing works

Peroxisomal compartmentalization of amino acid biosynthesis reactions imposes an upper limit on compartment size

Gu, Y., Alam, S., & Oliferenko, S. (2023) · Nature Communications · doi:10.1038/s41467-023-41347-x · Cited by 17 · see citing works

Phytochemical content, antioxidant properties, and antibacterial activities of Centella asiatica L.

Taghizadeh, M., & Jalili, S. (2023) · Natural Product Research · doi:10.1080/14786419.2023.2258439 · Cited by 17 · see citing works

Enhancing Centelloside Production in Centella asiatica Hairy Root Lines through Metabolic Engineering of Triterpene Biosynthetic Pathway Early Genes

Alcalde, M. A., Palazón, J., Bonfill, M., & Hidalgo, D. (2023) · Plants · doi:10.3390/plants12193363 · Cited by 17 · see citing works

Sustainable biosynthesis of squalene from waste cooking oil by the yeast Yarrowia lipolytica

Wang, S., Sun, X., Han, Y., Li, Z., Lu, X., Shi, H., Zhang, C., Wong, A., & Yu, A. (2024) · Metabolic Engineering Communications · doi:10.1016/j.mec.2024.e00240 · Cited by 17 · see citing works

Growth, Triterpene Glycosides, and Antioxidant Activities of Centella asiatica L. Urban Grown in a Controlled Environment with Different Nutrient Solution Formulations and LED Light Intensities

Harakotr, B., Charoensup, L., Rithichai, P., & Jirakiattikul, Y. (2024) · Horticulturae · doi:10.3390/horticulturae10010071 · Cited by 16 · see citing works

Madecassoside induces apoptosis of keloid fibroblasts via a mitochondrial‐dependent pathway

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Overexpression of GPS and FPS from Chrysanthemum indicum var. aromaticum resulted in modified trichome formation and terpenoid biosynthesis in tobacco

Gao, W., Meng, Q., Wang, X., Chen, F., He, M., & Zhou, Y. (2022) · Plant Growth Regulation · doi:10.1007/s10725-022-00927-5 · Cited by 15 · see citing works

Research Advances in Oxidosqualene Cyclase in Plants

Wang, P., Guo, W., & Feng, L. (2022) · Forests · doi:10.3390/f13091382 · Cited by 13 · see citing works

Enhancing β-farnesene production in engineered Yarrowia lipolytica: A new process control strategy

Bao, Y., Feng, P., Xu, C., Bi, H., Wang, M., Fang, Y., & Tan, T. (2024) · Industrial Crops and Products · doi:10.1016/j.indcrop.2023.117977 · Cited by 13 · see citing works

Biosynthesis of plant-derived triterpenoid asiatic acid in Saccharomyces cerevisiae cell factories

Lian, Y., Jin, L., Wang, F., Zhang, J., & Ren, Y. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107861 · Cited by 13 · see citing works

Unravelling triterpene biosynthesis through functional characterization of an oxidosqualene cyclase (OSC) from Cleome arabica L

Ladhari, A., & Chappell, J. (2019) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2019.09.035 · Cited by 12 · see citing works

Dopamine, a key factor of mitochondrial damage and neuronal toxicity on rotenone exposure and also parkinsonic motor dysfunction—Impact of asiaticoside with a probable vesicular involvement

Gopi, M., & Vanisree, A. J. (2020) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2020.101788 · Cited by 12 · see citing works

Anti-excitotoxicity and neuroprotective action of asiaticoside encapsulated polymeric nanoparticles in pilocarpine rodent seizure model

Kunjumon, R., Viswanathan, G., Jayasree, D. V., Biju, P. G., Prakash, P., Chakrapani, P. S. B., & Baby, S. (2022) · Canadian Journal of Chemistry · doi:10.1139/cjc-2021-0281 · Cited by 12 · see citing works

Revisiting the transcriptome data of Centella asiatica identified an ester-forming triterpenoid: UDP-glucose 28-O-glucosyltransferase

Han, X., Zhao, J., Chang, X., Li, Q., Deng, Z., & Yu, Y. (2022) · Tetrahedron · doi:10.1016/j.tet.2022.133136 · Cited by 12 · see citing works

Biotechnological and endophytic-mediated production of centellosides in Centella asiatica

Mandal, S., Das, T., Nandy, S., Ghorai, M., Saha, S. C., Gopalakrishnan, A. V., Kumar, M., Radha, Ghosh, A., Mukerjee, N., et al. (2022) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-022-12316-z · Cited by 10 · see citing works

Unleashing plant synthetic capacity: navigating regulatory mechanisms for enhanced bioproduction and secondary metabolite discovery

Hu, R., Teng, X., & Li, Y. (2024) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2024.103148 · Cited by 10 · see citing works

Safety Assessment of Centella asiatica -Derived Ingredients as Used in Cosmetics

Johnson, W., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., Marks, J. G., Shank, R. C., Slaga, T. J., Snyder, P. W., et al. (2023) · International Journal of Toxicology · doi:10.1177/10915818231158272 · Cited by 9 · see citing works

Development of herbal juice from Centella asiatica: antioxidant property, nutritional value and shelf life of product

Junsi, M., & Siripongvutikorn, S. (2022) · Food Science and Technology · doi:10.1590/fst.93722 · Cited by 8 · see citing works

Enhancement of squalene synthesis in Candida tropicalis via combinatorial metabolic engineering strategies to rebuild pathways

Wei, C., Zhang, L., Shen, W., Zou, W., Xia, Y., Chen, X., & Yang, H. (2024) · Biochemical Engineering Journal · doi:10.1016/j.bej.2024.109348 · Cited by 8 · see citing works

Acetic acid stress and utilization synergistically enhance squalene biosynthesis in Candida glycerinogenes

You, Z., Du, X., Zong, H., Lu, X., & Zhuge, B. (2024) · Biochemical Engineering Journal · doi:10.1016/j.bej.2024.109413 · Cited by 7 · see citing works

Global prospects for cultivating Centella asiatica: An ecological niche modeling approach under current and future climatic scenarios

Lin, P.-C., Chiang, T., Chen, M., Hsu, T., Gean, P., Cheng, S.-T., & Hsu, Y. (2024) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2024.101380 · Cited by 7 · see citing works

Wound healing properties of biotransformed asiaticoside by aspergillus niger

Omar, M. N., Alfarra, H. Y., & Ichwan, S. J. A. (2017) · Cited by 4 · see citing works

Cloning, Expression Characteristics of Farnesyl Pyrophosphate Synthase Gene from Platycodon grandiflorus and Functional Identification in Triterpenoid Synthesis

Liu, M., Wang, Z., Chen, Q., Cao, H., Kong, L., Liu, T., Jiang, S., Ma, L., Liu, X., Ren, W., et al. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c09293 · Cited by 4 · see citing works

Multi-strategy integration improves 28-O-glucosylation of asiatic acid into asiatic acid monoglucoside

Zeng, W., Li, D., Zhang, H., Wang, X., Chen, Y., Chen, J., & Zhou, J. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.104832 · Cited by 4 · see citing works

Madecassic acid suppresses osteoclast differentiation and bone resorption by inhibiting RANKL‐induced NF‐κB, JNK and NFAT signaling pathways

Su, P., Luo, X., Zeng, C., & Zhou, L. (2023) · Rheumatology & autoimmunity · doi:10.1002/rai2.12088 · Cited by 3 · see citing works

Multi‐walled carbon nanotubes doped with Phytocompounds of Centella asiatica for food packing applications and their anti‐microbial properties

Sivakumar, S., & Hema, T. A. (2024) · Polymers for Advanced Technologies · doi:10.1002/pat.6518 · Cited by 1 · see citing works

MicroRNA‐Enriched Plant‐Derived Exosomes Alleviate Colitis by Modulating Systemic Immunity, Metabolic Homeostasis, and Gut Microbiota

Shi, R., Tan, W., Jin, H., Chan, S. I., Li, W., Lei, S. S., Cui, G., Wang, Y., Yang, D., & Zhong, Z. (2025) · Advanced Science · doi:10.1002/advs.202505921 · Cited by 30 · see citing works

Integrating network pharmacology and experimental validation to advance psoriasis treatment: Multi-target mechanistic elucidation of medicinal herbs and natural compounds

Jo, H.-G., Seo, J., Jang, B., Kim, Y., Kim, H., Baek, E., Park, S.-Y., & Lee, D. (2025) · Autoimmunity Reviews · doi:10.1016/j.autrev.2025.103836 · Cited by 15 · see citing works

Discovery and engineering of the asiaticoside, madecassoside and asiaticoside B biosynthetic pathway

Zhou, P., Yang, P., Zhang, K., Guo, H., Du, J., Huang, L., Jin, D., Alolga, R. N., Wang, H., Li, J., et al. (2025) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2025.109864 · Cited by 8 · see citing works

Modular reconstruction and multilevel regulation of Saccharomyces cerevisiae to drive the efficient synthesis of asiatic acid

Sang, C., Wei, W., Yin, X., Chen, Q., Wang, X., Zeng, W., & Zhou, J. (2026) · Synthetic and Systems Biotechnology · doi:10.1016/j.synbio.2026.01.030 · Cited by 5 · see citing works

Centella asiatica (L.) Urb. in skin health and cosmeceuticals: mechanisms, clinical evidence, and advanced delivery systems

Handayani, R., Febriyanti, R. M., Muhaimin, M., & Chearunisaa, A. Y. (2025) · Pharmacia · doi:10.3897/pharmacia.72.e167217 · Cited by 5 · see citing works

Targeted Extracellular Vesicles Deliver Asiaticoside to Inhibit AURKB/DRP1‐Mediated Mitochondrial Fission and Attenuate Hypertrophic Scar Formation

Li, L., Si, C., Wang, X., Wu, X., Shang, Y., Ge, S., Wang, Y., Zuo, Y., & Zhang, Z. (2026) · Advanced Science · doi:10.1002/advs.202517108 · Cited by 4 · see citing works

The potential of plant-derived exosome-like nanovesicles from Centella asiatica leaves (CA-PDENs) for anti-inflammation and prevention of UVB-induced photoaging

Barlian, A., Cho, Y., Rahmah, Y., Zahra, A. N. A., Maulidisya, H. A., Vanawati, N., & Nursatya, S. M. (2026) · Future Science OA · doi:10.1080/20565623.2026.2654777 · Cited by 4 · see citing works

Injectable Hydrogel with Phase-Programmed Release of Centella asiatica Nanocomposites for Infection Control and Scarless Wound Healing

Wang, G., Gong, Q., Zhao, Y., Ruan, B., Fan, L., Ma, T., Cao, X., Shu, D., Zhang, S., Xie, Y., et al. (2025) · Biomacromolecules · doi:10.1021/acs.biomac.5c01620 · Cited by 2 · see citing works

Long non-coding RNAs in plant secondary metabolite biosynthesis: mechanisms and applications

Li, H., Yang, N., Zhang, H., & Xu, D. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157710 · Cited by 2 · see citing works

Advances in nano-delivery systems for targeted natural product delivery to specific skin layers in disease therapy and skin care

Hao, L.-H., Zhang, Y., Sun, Y., Han, Y., Ye, J., Wang, H., Gao, L., Wang, D., Gao, Y. L., Yang, Y., et al. (2025) · Chinese Chemical Letters · doi:10.1016/j.cclet.2025.111597 · Cited by 2 · see citing works

Pathway Design and Optimization in Synthetic Biology for Flavonoids and Stilbenoids Bioproduction

Li, H., Song, F., & Zhou, J. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-24738-5.00015-x · Cited by 1 · see citing works

Skin-inspired biogel/nanofiber composite dressing for sustained co-delivery of asiaticoside and zinc ions enabling synergistic burn wound healing

Wang, Z., Han, H., Wu, T., Zhao, C., Zhao, F., Han, Q., Song, H., Wang, M., Zhang, T., Wang, W., et al. (2025) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2025.139797 · Cited by 1 · see citing works

Targeting the antigen 85 complex of Mycobacterium tuberculosis: A three-fold validation of antimycobacterial activity of Centella asiatica

Hazarika, R., & Patra, S. (2026) · Tuberculosis · doi:10.1016/j.tube.2026.102736 · Cited by 1 · see citing works

From gene discovery to synthetic biology: recent advances in the biosynthesis of oleanane-type pentacyclic triterpenoids

Abdelsamad, I., Abdulbagi, M., Wang, J., Xue, Z., & Xu, L. (2026) · Natural Product Reports · doi:10.1039/d6np00013d · Cited by 1 · see citing works

A Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Effects of Oral Centella asiatica Extract on Skin Aging-Related Parameters in Middle-Aged Korean Women.

Hur, N., Seo, Y., Bae, J., Kim, Y. J., Kim, E. J., & Choi, Y. J. (2026) · Nutrients · doi:10.3390/nu18101505

Structure-guided engineering to enhance the activity of glycosyltransferase CaUGT73AD1 from Centella asiatica

Zeng, W., Sun, S., Chen, Q., Ping, J., Luo, Z., Chen, J., & Zhou, J. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.107310

Modular reconstruction and multilevel regulation of Saccharomyces cerevisiae to drive the efficient synthesis of asiatic acidPreprint

Sang, C., Wei, W., Yin, X., Chen, Q., Wang, X., Zeng, W., & Zhou, J. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5765716

Modular reconstruction and multilevel regulation of Saccharomyces cerevisiae to drive the efficient synthesis of asiatic acidPreprint

Sang, C., Wei, W., Yin, X., Chen, Q., Wang, X., Zeng, W., & Zhou, J. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5765717

Strategies for Enhanced Terpenoid Production in Microalgae for Therapeutic Applications

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Centella Asiatica Alleviates Type 2 Diabetes-Related Hepatic Glycolipid Disorders via Regulating UPP1-Mediated Pyrimidine Metabolism

Shen, Y., Yao, Y., Liu, Z., Li, Y., Cao, S., & Feng, X. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48070663

Asiatic acid from Centella asiatica alleviates renal fibrosis: coordinated modulation of the gut–kidney axis and retinol metabolism

Zhu, L., Xu, Z., Chang, X., Wu, J., Chen, S., Jiang, Y., Guo, J., Du, Z., Chen, H., & Qiang, S. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1802674

Synthetic biomanufacturing of triterpenoids: From laboratory to industry

Jiao, N., Shan, Z., & Chen, X. (2026) · Biotechnology Advances · doi:10.1016/j.biotechadv.2026.108992

Integrative network pharmacology, transcriptomics, and molecular docking identify candidate Centella asiatica constituents and targets in neurodegenerative diseases

Xie, Y., Chong-Teik, L., Lam, X.-J., Cheah, P.-S., Ling, K., & Huang, T. (2026) · PLoS ONE · doi:10.1371/journal.pone.0354882

Asiatic acid remodels the gastric precancerous immune microenvironment by targeting STING

Li, H., Shen, L., Liu, J., Su, X., Meng, M., Yang, J., Chen, R., Yang, C., & Liu, Y. Y. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1896372

Niosomal Serum Containing an Optimized Blend of Thai Herbal Extracts: Physicochemical Characterization and Clinical Performance on Skin Hydration and Pigmentation

Anurukvorakun, O., Sukjoi, W., & Chokboribal, J. (2026) · Cosmetics · doi:10.3390/cosmetics13050224

Plant-based functional food products: An analysis of trends and innovations

Angriani, L., Tawali, A. B., & Ainani, A. F. (2026) · IOP Conference Series Earth and Environmental Science · doi:10.1088/1755-1315/1655/1/012073

Research progress on plant-derived exosome-like nanovesicles in regulating and promoting tissue repair

Li, J., Ji, X., Xue, Y., Shen, J., & Tan, J. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119936

Hydrogels microneedles loaded with Au@Pt nanoenzymes and Centella asiatica glycosides promote healing of infected diabetic wounds and alleviate depression-like behavior

Zhao, R., Liang, R., Liao, M., Liao, X., Zhang, G., Guo, R., & Lin, Y. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.183195

Pentacyclic Triterpenoids from the Medicinal Herb, Centella asiatica (L.) Urban

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Biotechnological production of centellosides in cell cultures of Centella asiatica (L) Urban

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Biotechnological and endophytic-mediated production of centellosides in Centella asiatica

Mandal, S., Das, T., Nandy, S., Ghorai, M., Saha, S. C., Gopalakrishnan, A. V., Kumar, M., Radha, Ghosh, A., Mukerjee, N., et al. (2022) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-022-12316-z · Cited by 10 · see citing works

Advances and emerging research trends for modulation of centelloside biosynthesis in Centella asiatica (L.) Urban- A review

Prasad, A., Mathur, A. K., & Mathur, A. (2019) · Industrial Crops and Products · doi:10.1016/j.indcrop.2019.111768 · Cited by 50 · see citing works