Centella asiatica and Its Metabolite Asiatic Acid: Wound Healing Effects and Therapeutic Potential
Open accessAbstract
An intense effort has been focused on new therapeutic approaches and the development of technologies for more efficient and rapid wound healing. The research for plants used for long time in traditional medicine in the treatment of wound has become a promising strategy to obtain drugs therapeutically useful in the acute and chronic wound management. In this context, Centella asiatica (Apiaceae) has been used to treat a variety of skin diseases, such as leprosy, lupus, varicose ulcers, eczema and psoriasis, in Asiatic traditional medicine for thousands of years. Studies have shown that Centella asiatica extracts (CAE) display activity in tissue regeneration, cell migration and wound repair process by promoting fibroblast proliferation and collagen synthesis. Preliminary findings have shown that the asiatic acid is one of the main active constituents of C. asiatica, directly associated with its healing activity. Thus, this study discusses aspects of the effects of Centella asiatica and its active component, asiatic acid, in different stages of the healing process of cutaneous wounds, including phytochemical and antimicrobial aspects that contribute to its therapeutic potential.
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Preclinical studies have demonstrated that Centella asiatica compounds exhibit antioxidant and anti-inflammatory activities, promote fibroblast proliferation, enhance collagen synthesis, and protect extracellular matrix integrity.
“Preclinical studies have demonstrated that these compounds exhibit potent antioxidant and anti-inflammatory activities, promote fibroblast proliferation, enhance collagen synthesis, and protect extracellular matrix integrity [16,17,19,22,23,24].”
From A Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Effects of Oral Centella asiatica Extract on Skin Aging-Related Parameters in Middle-Aged Korean Women. (2026) · cites this paper as [17]
Sections 3.1–3.3 report anti-inflammatory effects, fibroblast proliferation, collagen synthesis, and extracellular-matrix accumulation in experimental models. The passages do not establish antioxidant activity or specifically show protection of existing extracellular-matrix integrity; matrix accumulation is not the same as protection from degradation. (LLM, conf=0.83)
Experimental — accuracy not yet measuredThe complementary actions of Centella asiatica constituents collectively underpin benefits in tissue repair and skin-barrier maintenance.
“These constituents exert complementary actions relevant to skin biology, including stimulation of collagen synthesis and dermal matrix remodeling, modulation of pro-inflammatory signaling, and attenuation of oxidative and glycation stress that collectively underpin benefits in tissue repair and skin-barrier maintenance (Park 2021a; Diniz et al. 2023; Rashid et al. 2023).”
From Centella asiatica (L.) Urb. in skin health and cosmeceuticals: mechanisms, clinical evidence, and advanced delivery systems (2025) · cites this paper as Diniz et al. 2023
The Conclusions (section 7) link Centella asiatica extract and asiatic acid to tissue repair through reduced pro-inflammatory activity, fibroblast proliferation, and extracellular-matrix and collagen synthesis; section 3.3 also describes wound remodeling. Section 3.4 reports improvement in dry skin, but the copy does not establish skin-barrier maintenance or attenuation of glycation stress as effects of these constituents. (LLM, conf=0.85)
Experimental — accuracy not yet measuredCentella asiatica constituents attenuate oxidative and glycation stress.
“These constituents exert complementary actions relevant to skin biology, including stimulation of collagen synthesis and dermal matrix remodeling, modulation of pro-inflammatory signaling, and attenuation of oxidative and glycation stress that collectively underpin benefits in tissue repair and skin-barrier maintenance (Park 2021a; Diniz et al. 2023; Rashid et al. 2023).”
From Centella asiatica (L.) Urb. in skin health and cosmeceuticals: mechanisms, clinical evidence, and advanced delivery systems (2025) · cites this paper as Diniz et al. 2023
Section 3.4 reports that oral and topical Centella asiatica extract improved dry skin in patients with type 2 diabetes by increasing superoxide dismutase activity, supporting an antioxidant-related effect in that setting. The paper does not report attenuation of glycation stress; its discussion of diabetic skin and wounds does not establish that mechanism. (LLM, conf=0.82)
Experimental — accuracy not yet measuredCentella asiatica is a medicinal plant traditionally used in Asian and Ayurvedic medicine for wound healing and various skin disorders.
“Centella asiatica (L.) Urb. is a medicinal plant traditionally used in Asian and Ayurvedic medicine for wound healing and various skin disorders [16,17,18].”
The pharmacological activity of Centella asiatica is attributed primarily to its secondary metabolites.
“The pharmacological activity of C. asiatica is attributed primarily to its secondary metabolites.”
From Centella asiatica (L.) Urb. in skin health and cosmeceuticals: mechanisms, clinical evidence, and advanced delivery systems (2025) · cites this paper as Diniz et al. 2023
Centella asiatica constituents stimulate collagen synthesis and dermal matrix remodeling.
“These constituents exert complementary actions relevant to skin biology, including stimulation of collagen synthesis and dermal matrix remodeling, modulation of pro-inflammatory signaling, and attenuation of oxidative and glycation stress that collectively underpin benefits in tissue repair and skin-barrier maintenance (Park 2021a; Diniz et al. 2023; Rashid et al. 2023).”
From Centella asiatica (L.) Urb. in skin health and cosmeceuticals: mechanisms, clinical evidence, and advanced delivery systems (2025) · cites this paper as Diniz et al. 2023
Centella asiatica constituents modulate pro-inflammatory signaling.
“These constituents exert complementary actions relevant to skin biology, including stimulation of collagen synthesis and dermal matrix remodeling, modulation of pro-inflammatory signaling, and attenuation of oxidative and glycation stress that collectively underpin benefits in tissue repair and skin-barrier maintenance (Park 2021a; Diniz et al. 2023; Rashid et al. 2023).”
From Centella asiatica (L.) Urb. in skin health and cosmeceuticals: mechanisms, clinical evidence, and advanced delivery systems (2025) · cites this paper as Diniz et al. 2023
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- Authors
- Diniz, L. R. L., Calado, L. L., Duarte, A. B. S., & de Sousa, D. P.
- Affiliations
- Instituto Nacional do Semiárido (BR)
- Universidade Federal da Paraíba (BR)
- Departament of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa 58051-970, Paraíba, Brazil
- Venue
- Metabolites
- Publisher
- MDPI AG
- Published
- 2023-02-14
- Volume
- 13
- Issue
- 2
- Pages
- 276
- ISSN
- 2218-1989 (ISSN-L)
- PMC
- PMC9966672
- OpenAlex
- W4320919855
- Cited by
- 160
- References
- 110
- Citations by year
- 2026: 38 · 2025: 59 · 2024: 50 · 2023: 12 · 2020: 1
- FWCI
- 9.31
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Metabolites (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Brazilian agencies National Council for Scientific and Technological Development (CNPq) (306729/2019-9, PROEX TERMO AUXPE 0521/2019)
- Coordination for the Improvement of Higher Education Personnel (CAPES) (306729/2019-9, PROEX TERMO AUXPE 0521/2019)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
- Keywords
- Centella asiatica, asiatic acid, wound healing, skin wounds, traditional medicine, tissue regeneration, fibroblast proliferation, collagen synthesis, cell migration, phytochemicals, antimicrobial activity, chronic wounds
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