Cancer Chemopreventive Agents (Antitumor-promoters) from Ajuga decumbens
Abstract
Sixteen compounds (1-16) isolated from the flowering whole plant of Ajuga decumbens have been tested for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) induction by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), as a primary screening test for antitumor-promoters (potential cancer chemopreventive agents). Five compounds (6, 9, and 12-14) showed strong inhibitory effects on EBV-EA induction. Of these active compounds, two major constituents of this plant, cyasterone (6) and 8-acetylharpagide (13), showed potent antitumor-promoting activities on a mouse-skin in vivo two-stage carcinogenesis procedure, using 7, 12-dimethylbenz[a]anthracene as initiator and TPA as promoter. Further, compound 13 also exhibited potent chemopreventive activity in a mouse pulmonary tumor model.
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Decumbesterone A showed very strong inhibitory effects on EBV-EA induction by TPA.
“Evaluated inhibitory effects on EBV-EA induction by the tumorpromoter (TPA) as a primary screening test for antitumor-promoters and showed very strong inhibitory effects.”
From The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review (2021) · cites this paper as [118]
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- Authors
- Takasaki, M., Tokuda, H., Nishino, H., & Konoshima, T.
- Affiliations
- Kyoto Pharmaceutical University (JP)
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 1999-05-29
- Volume
- 62
- Issue
- 7
- Pages
- 972-975
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- OpenAlex
- W1971254849
- Cited by
- 83
- References
- 13
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 6 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 6 · 2018: 2 · 2016: 3 · 2015: 4 · 2014: 5 · 2013: 1 · 2012: 5
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Natural Products (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Natural product bioactivities and synthesis
- Keywords
- Ajuga decumbens, chemoprevention, Epstein-Barr virus early antigen, phorbol myristate acetate, cyasterone, harpagide, mouse skin carcinogenesis, 7,12-dimethylbenz(a)anthracene, natural product isolation
- MeSH terms
- Animals, Antineoplastic Agents, Phytogenic, Antiviral Agents, Carcinogens, Herpesvirus 4, Human, Female, Glycerol, Lung Neoplasms, Mice, Inbred ICR, Papilloma, Plants, Medicinal, Skin Neoplasms, Tetradecanoylphorbol Acetate, Tumor Cells, Cultured, 4-Nitroquinoline-1-oxide, Mice
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