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Cited by 85Functional Brain Connectivity StudiesPain Management and Placebo EffectTreatment of Major Depression

Salience Network Functional Connectivity Predicts Placebo Effects in Major Depression

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Sikora, Magdalena, Heffernan, Joseph, Avery, Erich T., Mickey, Brian J., Zubieta, Jon-Kar, Peciña, Marta·2016·Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
DOI 10.1016/j.bpsc.2015.10.002PMC PMC4689203
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Abstract

Background Recent neuroimaging studies have demonstrated resting-state functional connectivity (rsFC) abnormalities among intrinsic brain networks in Major Depressive Disorder (MDD); however, their role as predictors of treatment response has not yet been explored. Here, we investigate whether network-based rsFC predicts antidepressant and placebo effects in MDD. Methods We performed a randomized controlled trial of two weeklong, identical placebos (described as having either "active" fast-acting, antidepressant effects or as "inactive") followed by a ten-week open-label antidepressant medication treatment. Twenty-nine participants underwent a rsFC fMRI scan at the completion of each placebo condition. Networks were isolated from resting-state blood-oxygen-level-dependent signal fluctuations using independent component analysis. Baseline and placebo-induced changes in rsFC within the default-mode, salience, and executive networks were examined for associations with placebo and antidepressant treatment response. Results Increased baseline rsFC in the rostral anterior cingulate (rACC) within the salience network, a region classically implicated in the formation of placebo analgesia and the prediction of treatment response in MDD, was associated with greater response to one week of active placebo and ten weeks of antidepressant treatment. Machine learning further demonstrated that increased salience network rsFC, mainly within the rACC, significantly predicts individual responses to placebo administration. Conclusions These data demonstrate that baseline rsFC within the salience network is linked to clinical placebo responses. This information could be employed to identify patients who would benefit from lower doses of antidepressant medication or non-pharmacological approaches, or to develop biomarkers of placebo effects in clinical trials.

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  • The results of studies examining the impact of antidepressant medication initiation on connectivity are heterogeneous.

    “The results of studies examining the impact of ADM initiation on connectivity are heterogeneous28–39.”

    From The relationship between resting-state functional connectivity, antidepressant discontinuation and depression relapse (2020) · cites this paper as [37]

    The Introduction and Results (page unavailable) examine whether baseline functional connectivity predicts response to antidepressant treatment, not how starting medication changes connectivity. I searched for discussion of treatment-induced connectivity changes and inconsistent findings across studies, but found no passage addressing that claim. (LLM, conf=0.74)

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Cited by

Sorted by citations

Authors
Sikora, M., Heffernan, J., Avery, E. T., Mickey, B. J., Zubieta, J.-K., & Peciña, M.
Affiliations
University of Michigan (US)
Corresponding author
Peciña, Marta
ORCID
Venue
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Publisher
Elsevier BV
Published
2016-01
Volume
1
Issue
1
Pages
68-76
ISSN
2451-9022 (ISSN-L)
DOI
10.1016/j.bpsc.2015.10.002
PMC
PMC4689203
OpenAlex
W2217827730
Cited by
85
References
17
Citations by year
2026: 3 · 2025: 5 · 2024: 6 · 2023: 5 · 2022: 10 · 2021: 7 · 2020: 12 · 2019: 18 · 2018: 9 · 2017: 8 · 2016: 2
FWCI
3.81
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry Cognitive Neuroscience and Neuroimaging (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • JKZ (R01 MH086858)
  • Phil F. Jenkins Foundation
  • Michigan Institute for Clinical & Health Research (CTSA: UL1RR024986)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
major depressive disorder, placebo effect, resting-state functional connectivity, salience network, rostral anterior cingulate cortex, antidepressant response, treatment response prediction, default mode network, executive network, placebo analgesia

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