Specificity of anhedonic alterations in resting-state network connectivity and structure: A transdiagnostic approach
Abstract
Anhedonia is a prominent characteristic of depression and related pathology that is associated with a prolonged course of mood disturbance and treatment resistance. However, the neurobiological mechanisms of anhedonia are poorly understood as few studies have disentangled the specific effects of anhedonia from other co-occurring symptoms. Here, we take a transdiagnostic, dimensional approach to distinguish anhedonia alterations from other internalizing symptoms on intrinsic functional brain circuits. 53 adults with varying degrees of anxiety and/or depression completed resting-state fMRI. Neural networks were identified through independent components analysis. Dual regression was used to characterize within-network functional connectivity alterations associated with individual differences in anhedonia. Modulation of between-network functional connectivity by anhedonia was tested using region-of-interest to region-of-interest correlational analyses. Anhedonia was associated with visual network hyperconnectivity and expansion of the visual, dorsal attention, and default networks. Additionally, anhedonia was associated with decreased between-network connectivity among default, salience, dorsal attention, somatomotor, and visual networks. Findings suggest that anhedonia is associated with aberrant connectivity and structural alterations in resting-state networks that contribute to impairments in reward learning, low motivation, and negativity bias characteristic of depression. Results reveal dissociable effects of anhedonia on resting-state network dynamics, characterizing possible neurocircuit mechanisms for intervention.
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Self-citation
- Authors
- Geller, W. N., Liu, K., & Warren, S. L.
- Affiliations
- Palo Alto University (US)
- Corresponding author
- Warren, Stacie L.
- Venue
- Psychiatry Research Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2021-11
- Volume
- 317
- Pages
- 111349
- ISSN
- 0925-4927 (ISSN-L)
- OpenAlex
- W3192476036
- Cited by
- 18
- References
- 140
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 5 · 2023: 4 · 2022: 3
- FWCI
- 1.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- anhedonia, resting-state functional connectivity, intrinsic brain networks, transdiagnostic mechanisms, depression, anxiety, default mode network, dorsal attention network, salience network, sensorimotor network, between-network connectivity, individual differences, reward learning, motivation, negativity bias, network expansion
- MeSH terms
- Adult, Brain, Brain Mapping, Humans, Magnetic Resonance Imaging, Reward, Anhedonia
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