Reward Processing in Psychiatric Inpatients With Depression
Open accessAbstract
Background Previous neuroimaging studies have investigated reward-processing dysfunction in major depressive disorder and have led to the common finding that major depressive disorder is associated with reduced reward responses within the reward circuit. Yet it is unclear whether such reward-processing dysfunction is specifically associated with the severity of depressive symptoms in major depressive disorder or is associated with common comorbidities. Methods We investigated reward-processing differences using a classic juice-delivery functional magnetic resonance imaging experiment to compare psychiatric patients with severe depressive symptoms (DEPs) to both psychiatric control subjects (PCs) and healthy control subjects. In this study, the DEPs (n = 108) were matched to healthy control subjects (n = 62) for demographic characteristics and to the PCs (n = 108) for demographics and comorbid psychiatric diagnoses. An a priori region of interest, the left putamen, was selected using previous studies. An exploratory whole-brain analysis was performed to explore for nonhypothesized regions. Results Relative to the PCs and healthy control subjects, the DEP group showed smaller responses to reward stimulus in the left putamen. Whole-brain exploratory analysis revealed that DEPs had significantly lower responses to reward stimulus in the bilateral dorsal striatum (putamen and caudate), middle frontal gyrus, left precentral gyrus, and middle cingulate cortex than PCs. Conclusions Our findings suggest that DEPs may have a lesser ability to modulate behavior as a function of reward, especially in those individuals who experience the most severe depressive symptoms. In both DEPs and PCs, the severity of depressive symptoms was related to reduced reward responses in the left putamen.
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Impaired reward processing is associated with such symptoms across different psychiatric disorders.
“This is in line with previous literature suggesting that impaired reward processing is associated with such symptoms across different psychiatric disorders.56,61,121–125”
From Investigating disorder-specific and transdiagnostic alterations in model-based and model-free decision-making (2024) · cites this paper as [123]
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- Authors
- Oh, H., Lee, J., Patriquin, M. A., Oldham, J., & Salas, R.
- Affiliations
- Baylor College of Medicine (US)
- Texas Tech University (US)
- Michael E. DeBakey VA Medical Center (US)
- Corresponding author
- Salas, Ramiro
- Venue
- Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2023-07
- Volume
- 8
- Issue
- 7
- Pages
- 731-740
- ISSN
- 2451-9022 (ISSN-L)
- OpenAlex
- W3174430434
- Cited by
- 14
- References
- 17
- Citations by year
- 2026: 2 · 2024: 6 · 2023: 5 · 2022: 1
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- Locations
- Biological Psychiatry Cognitive Neuroscience and Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (publishedVersion)
- Digital Commons-TMC (Texas Medical Center) (submittedVersion)
- Funders
- Robert and Janice McNair Foundation
- Menninger Clinic
- Baylor College of Medicine
- Veterans Administration Medical Center
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- reward processing, major depressive disorder, depression severity, putamen, dorsal striatum, caudate nucleus, middle frontal gyrus, middle cingulate cortex, psychiatric inpatients
- MeSH terms
- Brain, Depression, Major Depressive Disorder, Depressive Disorder, Major, Humans, Inpatients, Reward
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