Cited by 62Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

“I won, but I'm not getting my hopes up”: Depression moderates the relationship of outcomes and reward anticipation

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Olino, Thomas M., McMakin, Dana L., Dahl, Ronald E., Ryan, Neal D., Silk, Jennifer S., Birmaher, Boris, Axelson, David A., Forbes, Erika E.·2011·Psychiatry Research: Neuroimaging

Abstract

Major Depressive Disorder (MDD) in adolescents is characterized by alterations in positive emotions and reward processing. Recent investigations using functional magnetic resonance imaging (fMRI) find depression-related differences in reward anticipation. However, it is unknown whether feedback influences subsequent reward anticipation, which may highlight the context of reward processing. Ten youth with MDD and 16 youth with no history of MDD completed an fMRI assessment using a reward task. Reward anticipation was indexed by blood oxygen level dependent signal change in the striatum following winning, losing, non-winning, and non-losing outcomes. A significant interaction between diagnostic status and outcome condition predicted reward anticipation in the caudate. Decomposition of the interaction indicated that following winning outcomes, depressed youth demonstrated reduced reward anticipation relative to healthy youth. However, no significant differences between depressed and healthy youth were found after other outcomes. Reward anticipation is altered following winning outcomes. This finding has implications for understanding the developmental pathophysiology of MDD and suggests specific contexts where altered motivational system functioning may play a role in maintaining depression.

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Crossref · 10.1016/j.pscychresns.2011.04.009

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Authors
Olino, T. M., McMakin, D. L., Dahl, R. E., Ryan, N. D., Silk, J. S., Birmaher, B., Axelson, D. A., & Forbes, E. E.
Affiliations
University of Pittsburgh (US)
Corresponding author
Olino, Thomas M.
Venue
Psychiatry Research: Neuroimaging
Publisher
Elsevier BV
Published
2011-12
Volume
194
Issue
3
Pages
393-395
ISSN
0925-4927 (ISSN-L)
OpenAlex
W2038533297
Cited by
62
References
21
Citations by year
2025: 1 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 7 · 2020: 5 · 2019: 4 · 2018: 3 · 2017: 5 · 2016: 5 · 2015: 10 · 2014: 8 · 2013: 4 · 2012: 2
FWCI
2.41
Type
journal article
Language
en
Open access
Locations
  • Psychiatry Research Neuroimaging (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • NIMH (P01 MH41712, K01 MH 074769, T32 MH018951)
  • NARSAD Young Investigator Award
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
major depressive disorder, adolescent depression, reward anticipation, outcome feedback, caudate nucleus, striatum, positive emotions, reward processing, motivation system, depression maintenance
MeSH terms
Adolescent, Brain, Brain Mapping, Child, Depression, Emotions, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Motivation, Oxygen, Reward

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