“I won, but I'm not getting my hopes up”: Depression moderates the relationship of outcomes and reward anticipation
Open accessAbstract
Major Depressive Disorder (MDD) in adolescents is characterized by alterations in positive emotions and reward processing. Recent investigations using functional magnetic resonance imaging (fMRI) find depression-related differences in reward anticipation. However, it is unknown whether feedback influences subsequent reward anticipation, which may highlight the context of reward processing. Ten youth with MDD and 16 youth with no history of MDD completed an fMRI assessment using a reward task. Reward anticipation was indexed by blood oxygen level dependent signal change in the striatum following winning, losing, non-winning, and non-losing outcomes. A significant interaction between diagnostic status and outcome condition predicted reward anticipation in the caudate. Decomposition of the interaction indicated that following winning outcomes, depressed youth demonstrated reduced reward anticipation relative to healthy youth. However, no significant differences between depressed and healthy youth were found after other outcomes. Reward anticipation is altered following winning outcomes. This finding has implications for understanding the developmental pathophysiology of MDD and suggests specific contexts where altered motivational system functioning may play a role in maintaining depression.
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Reduced mesolimbic activity in MDD is found during reward anticipation and outcomes in both adults and children, and during reward learning.
“Reduced mesolimbic activity in MDD has been found during reward anticipation and outcomes in both adults and children [210,219-227] and during reward learning [206].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [222]
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- Authors
- Olino, T. M., McMakin, D. L., Dahl, R. E., Ryan, N. D., Silk, J. S., Birmaher, B., Axelson, D. A., & Forbes, E. E.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Olino, Thomas M.
- ORCID
- Venue
- Psychiatry Research: Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 194
- Issue
- 3
- Pages
- 393-395
- ISSN
- 0925-4927 (ISSN-L)
- PMC
- PMC3225637
- OpenAlex
- W2038533297
- Cited by
- 62
- References
- 21
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 7 · 2020: 5 · 2019: 4 · 2018: 3 · 2017: 5 · 2016: 5 · 2015: 10 · 2014: 8 · 2013: 4 · 2012: 2
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIMH (P01 MH41712, K01 MH 074769, T32 MH018951)
- NARSAD Young Investigator Award
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- major depressive disorder, adolescent depression, reward anticipation, outcome feedback, caudate nucleus, striatum, positive emotions, reward processing, motivation system, depression maintenance
- MeSH terms
- Adolescent, Brain, Brain Mapping, Child, Depression, Emotions, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Motivation, Oxygen, Reward
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