Comparison of the capability of GDNF, BDNF, or both, to protect nigrostriatal neurons in a rat model of Parkinson’s disease

The rat brain in stereotaxic coordinates

Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959 · see citing works

The Rat Brain in Stereotaxic Coordinates

Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works

Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies

Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,501 · see citing works

GDNF: a Glial Cell Line-Derived Neurotrophic Factor for Midbrain Dopaminergic Neurons

Lin, L.-F. H., Doherty, D. H., Lile, J. D., Bektesh, S. L., & Collins, F. (1993) · Science · doi:10.1126/science.8493557 · Cited by 3,206 · see citing works

Cellular Scaling Rules for the Brains of Marsupials: Not as “Primitive” as Expected

Santos, S. E. D., Porfírio, J., Cunha, F., Manger, P. R., Tavares, W. C., Pessôa, L. M., Raghanti, M. A., Sherwood, C. C., & Herculano‐Houzel, S. (2017) · Brain Behavior and Evolution · doi:10.1159/000452856 · Cited by 2,651 · see citing works

NeuN, a neuronal specific nuclear protein in vertebratesxs

Mullen, R. J., Buck, C. R., & Smith, A. M. (1992) · Development · doi:10.1242/dev.116.1.201 · Cited by 2,351 · see citing works

BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra

Hyman, C., Hofer, M., Barde, Y., Juhasz, M., Yancopoulos, G. D., Squinto, S. P., & Lindsay, R. M. (1991) · Nature · doi:10.1038/350230a0 · Cited by 1,494 · see citing works

Direct brain infusion of glial cell line–derived neurotrophic factor in Parkinson disease

Gill, S. S., Patel, N. K., Hotton, G. R., O'Sullivan, K., McCarter, R., Bunnage, M., Brooks, D. J., Svendsen, C. N., & Heywood, P. (2003) · Nature Medicine · doi:10.1038/nm850 · Cited by 1,290 · see citing works

Neurodegeneration Prevented by Lentiviral Vector Delivery of GDNF in Primate Models of Parkinson's Disease

Kordower, J. H., Emborg, M. E., Bloch, J., Ma, S. Y., Chu, Y., Leventhal, L., McBride, J. L., Chen, E., Palfi, S., Roitberg, B. Z., et al. (2000) · Science · doi:10.1126/science.290.5492.767 · Cited by 1,244 · see citing works

Functional recovery in parkinsonian monkeys treated with GDNF

Gash, D. M., Zhang, Z., Ovadia, A., Cass, W. A., Yi, A., Simmerman, L., Russell, D., Martin, D., Lapchak, P. A., Collins, F., et al. (1996) · Nature · doi:10.1038/380252a0 · Cited by 955 · see citing works

Dopaminergic Neurons Protected from Degeneration by GDNF Gene Therapy

Choi-Lundberg, D. L., Lin, Q., Chang, Y., Chiang, Y. L., Hay, C. M., Mohajeri, H. M., Davidson, B. L., & Bohn, M. C. (1997) · Science · doi:10.1126/science.275.5301.838 · Cited by 622 · see citing works

Treatment of parkinsonism with levodopa.

Yahr, M., Duvoisin, R., Schear, M., Barrett, R. E., & Hoehn, M. M. (1969) · Archives of Neurology · doi:10.1001/archneur.1969.00480160015001 · Cited by 619 · see citing works

Partial lesions of the dopaminergic nigrostriatal system in rat brain: biochemical characterization

Hefti, F. F., Melamed, E., & Wurtman, R. J. (1980) · Brain Research · doi:10.1016/0006-8993(80)90871-9 · Cited by 502 · see citing works

Long-Term rAAV-Mediated Gene Transfer of GDNF in the Rat Parkinson's Model: Intrastriatal But Not Intranigral Transduction Promotes Functional Regeneration in the Lesioned Nigrostriatal System

Kirik, D., Rosenblad, C., Björklund, A., & Mandel, R. J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-12-04686.2000 · Cited by 428 · see citing works

Neural transplantation for the treatment of Parkinson's disease

Björklund, A., Dunnett, S. B., Brundin, P., Stoessl, A. J., Freed, C. R., Breeze, R. E., Levivier, M., Peschanski, M., Studer, L., & Barker, R. A. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00442-3 · Cited by 353 · see citing works

Towards a neuroprotective gene therapy for Parkinson’s disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model11Published on the World Wide Web on 10 October 2000.

Björklund, A., Kirik, D., Rosenblad, C., Georgievska, B., Lundberg, C., & Mandel, R. J. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02915-2 · Cited by 346 · see citing works

Long-Term Behavioral Recovery in Parkinsonian Rats by an HSV Vector Expressing Tyrosine Hydroxylase

During, M. J., Naegele, J. R., O’Malley, K. L., & Geller, A. I. (1994) · Science · doi:10.1126/science.266.5189.1399 · Cited by 328 · see citing works

Regulated Release and Polarized Localization of Brain-Derived Neurotrophic Factor in Hippocampal Neurons

Goodman, L. J., Valverde, J., Lim, F., Geschwind, M. D., Federoff, H. J., Geller, A. I., & Hefti, F. F. (1996) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1996.0017 · Cited by 323 · see citing works

Localized striatal delivery of GDNF as a treatment for Parkinson disease

Kirik, D., Georgievska, B., & Björklund, A. (2004) · Nature Neuroscience · doi:10.1038/nn1175 · Cited by 289 · see citing works

Evidence that the herpes simplex virus immediate early protein ICP27 acts post-transcriptionally during infection to regulate gene expression

Smith, I. L., Hardwicke, M. A., & Sandri-Goldin, R. M. (1992) · Virology · doi:10.1016/0042-6822(92)90062-t · Cited by 281 · see citing works

Brain-derived neurotrophic factor augments rotational behavior and nigrostriatal dopamine turnover in vivo.

Altar, C. A., Boylan, C. B., Jackson, C., Hershenson, S., Miller, J., Wiegand, S. J., Lindsay, R. M., & Hyman, C. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.23.11347 · Cited by 275 · see citing works

Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson’s disease

Levivier, M., Przedborski, S., Bencsics, C., & Kang, U. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-12-07810.1995 · Cited by 274 · see citing works

Helper virus-free transfer of herpes simplex virus type 1 plasmid vectors into neural cells

Fraefel, C., Song, S., Lim, F., et al. (1996) · Journal of Virology · doi:10.1128/jvi.70.10.7190-7197.1996 · Cited by 272 · see citing works

Aberrant Sprouting and Downregulation of Tyrosine Hydroxylase in Lesioned Nigrostriatal Dopamine Neurons Induced by Long-Lasting Overexpression of Glial Cell Line Derived Neurotrophic Factor in the Striatum by Lentiviral Gene Transfer

Georgievska, B. (2002) · Experimental Neurology · doi:10.1006/exnr.2002.8006 · Cited by 233 · see citing works

Continuous Low-Level Glial Cell Line-Derived Neurotrophic Factor Delivery Using Recombinant Adeno-Associated Viral Vectors Provides Neuroprotection and Induces Behavioral Recovery in a Primate Model of Parkinson's Disease

Eslamboli, A., Georgievska, B., Ridley, R. M., Baker, H. F., Muzyczka, N., Bürger, C., Mandel, R. J., Annett, L. E., & Kirik, D. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4421-04.2005 · Cited by 231 · see citing works

Lentiviral Gene Transfer to the Nonhuman Primate Brain

Kordower, J. H., Bloch, J., Ma, S. Y., Chu, Y., Palfi, S., Roitberg, B. Z., Emborg, M. E., Hantraye, P., Déglon, N., & Aebischer, P. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7178 · Cited by 198 · see citing works

Overexpression of Glial Cell Line-Derived Neurotrophic Factor Using a Lentiviral Vector Induces Time- and Dose-Dependent Downregulation of Tyrosine Hydroxylase in the Intact Nigrostriatal Dopamine System

Georgievska, B., Kirik, D., & Björklund, A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1122-04.2004 · Cited by 151 · see citing works

Astrocytes retrovirally transduced with BDNF elicit behavioral improvement in a rat model of Parkinson’s disease

Yoshimoto, Y., Lin, Q., Collier, T. J., Frim, D. M., Breakefield, X. O., & Bohn, M. C. (1995) · Brain Research · doi:10.1016/0006-8993(95)00596-i · Cited by 146 · see citing works

Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of l -dopa using rAAV-mediated gene transfer

Kirik, D., Georgievska, B., Bürger, C., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.062047599 · Cited by 140 · see citing works

Efficacy of Brain‐Derived Neurotrophic Factor and Neurotrophin‐3 on Neurochemical and Behavioral Deficits Associated with Partial Nigrostriatal Dopamine Lesions

Altar, C. A., Boylan, C. B., Fritsche, M., Jones, B. E., Jackson, C., Wiegand, S. J., Lindsay, R. M., & Hyman, C. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63031021.x · Cited by 138 · see citing works

Generation of High-Titer Defective HSV-1 Vectors Using an IE 2 Deletion Mutant and Quantitative Study of Expression in Cultured Cortical Cells

Lim, F., Hartley, D. M., Starr, P. A., et al. (1996) · BioTechniques · doi:10.2144/19962003460 · Cited by 137 · see citing works

Long‐term striatal overexpression of GDNF selectively downregulates tyrosine hydroxylase in the intact nigrostriatal dopamine system

Rosenblad, C., Georgievska, B., & Kirik, D. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02456.x · Cited by 131 · see citing works

Prevention of 6-hydroxydopamine-induced rotational behavior by BDNF somatic gene transfer

Klein, R. L., Lewis, M. H., Muzyczka, N., & Meyer, E. M. (1999) · Brain Research · doi:10.1016/s0006-8993(99)02116-2 · Cited by 128 · see citing works

In vivo gene delivery of glial cell line-derived neurotrophic factor for Parkinson's disease

Kordower, J. H. (2003) · Annals of Neurology · doi:10.1002/ana.10485 · Cited by 120 · see citing works

Morphological and functional effects of intranigrally administered GDNF in normal rhesus monkeys

Gash, D. M., Zhang, Z., Cass, W. A., Ovadia, A., Simmerman, L. A., Martin, D., Russell, D. A., Collins, F., Hoffer, B. J., & Gerhardt, G. A. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903630302 · Cited by 118 · see citing works

Inflammatory effects of gene transfer into the CNS with defective HSV-1 vectors.

Wood, M. J. A., Byrnes, A. P., Pfaff, D. W., et al. (1994) · PubMed · Cited by 101 · see citing works

Biochemical and behavioral recovery in a rodent model of Parkinson's disease following stereotactic implantation of dopamine-containing liposomes

During, M. J., Freese, A. B., Deutch, A. Y., et al. (1992) · Experimental Neurology · doi:10.1016/0014-4886(92)90053-s · Cited by 90 · see citing works

Coexpression of Tyrosine Hydroxylase, GTP Cyclohydrolase I, Aromatic Amino Acid Decarboxylase, and Vesicular Monoamine Transporter 2 from a Helper Virus-Free Herpes Simplex Virus Type 1 Vector Supports High-Level, Long-Term Biochemical and Behavioral Correction of a Rat Model of Parkinson's Disease

Sun, M., Kong, L., Wang, X., et al. (2004) · Human Gene Therapy · doi:10.1089/hum.2004.15.1177 · Cited by 78 · see citing works

An HSV‐1 Vector Containing the Rat Tyrosine Hydroxylase Promoter Enhances Both Long‐Term and Cell Type‐Specific Expression in the Midbrain

Song, S., Wang, Y., Bak, S., et al. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68051792.x · Cited by 69 · see citing works

Correction of a Rat Model of Parkinson's Disease by Coexpression of Tyrosine Hydroxylase and Aromatic Amino Acid Decarboxylase from a Helper Virus-Free Herpes Simplex Virus Type 1 Vector

Sun, M., Zhang, G., Kong, L., et al. (2003) · Human Gene Therapy · doi:10.1089/104303403321467180 · Cited by 62 · see citing works

A tyrosine hydroxylase–neurofilament chimeric promoter enhances long-term expression in rat forebrain neurons from helper virus-free HSV-1 vectors

Zhang, G., Wang, X., Yang, T., Sun, M., Zhang, W., Wang, Y., & Geller, A. I. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00197-2 · Cited by 53 · see citing works

Improved Titers for Helper Virus-Free Herpes Simplex Virus Type 1 Plasmid Vectors by Optimization of the Packaging Protocol and Addition of Noninfectious Herpes Simplex Virus-Related Particles (Previral DNA Replication Enveloped Particles) to the Packaging Procedure

Sun, M., Zhang, G. R., Yang, T., et al. (1999) · Human Gene Therapy · doi:10.1089/10430349950017365 · Cited by 47 · see citing works

Enhanced reporter gene expression in the rat brain from helper virus-free HSV-1 vectors packaged in the presence of specific mutated HSV-1 proteins that affect the virion

Yang, T., Zhang, G., Zhang, W., et al. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00059-6 · Cited by 34 · see citing works

l-Dopa and Dopamine-Producing Gene Cassettes for Gene Therapy Approaches to Parkinson's Disease

Moffat, M. A., Harmon, S., Haycock, J. W., & O’Malley, K. L. (1997) · Experimental Neurology · doi:10.1006/exnr.1996.6390 · Cited by 22 · see citing works

General Strategy for Constructing Large HSV-1 Plasmid Vectors that Co-Express Multiple Genes

Wang, X., Zhang, G., Sun, M., et al. (2001) · BioTechniques · doi:10.2144/01311dd05 · Cited by 18 · see citing works

GDNF, NGF and BDNF as Therapeutic Options for Neurodegeneration

Allen, S. J., Watson, J. J., Shoemark, D. K., Barua, N. U., & Patel, N. K. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.01.004 · Cited by 820 · see citing works

BDNF as a Promising Therapeutic Agent in Parkinson’s Disease

Palasz, E., Wysocka, A., Gasiorowska, A., Chalimoniuk, M., Niewiadomski, W., & Niewiadomska, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031170 · Cited by 504 · see citing works

Does PGC1α/FNDC5/BDNF Elicit the Beneficial Effects of Exercise on Neurodegenerative Disorders?

Jodeiri Farshbaf, M., Ghaedi, K., Megraw, T. L., Curtiss, J., Shirani Faradonbeh, M., Vaziri, P., & Nasr-Esfahani, M. H. (2016) · NeuroMolecular Medicine · doi:10.1007/s12017-015-8370-x · Cited by 101 · see citing works

Polymannuronic Acid Prebiotic plus Lacticaseibacillus Rhamnosus GG Probiotic as a Novel Synbiotic Promoted Their Separate Neuroprotection against Parkinson’s Disease

Liu, X., Du, Z. R., Wang, X., Sun, X. R., Zhao, Q., Zhao, F., Wong, W. T., Wong, K. H., & Dong, X.-L. (2022) · Food Research International · doi:10.1016/j.foodres.2022.111067 · Cited by 77 · see citing works

Neurotensin-polyplex-mediated brain-derived neurotrophic factor gene delivery into nigral dopamine neurons prevents nigrostriatal degeneration in a rat model of early Parkinson’s disease

Hernandez-Chan, N. G., Bannon, M. J., Orozco-Barrios, C. E., Escobedo, L., Zamudio, S., De la Cruz, F., Gongora-Alfaro, J. L., Armendáriz-Borunda, J., Reyes-Corona, D., Espadas-Alvarez, A. J., et al. (2015) · Journal of Biomedical Science · doi:10.1186/s12929-015-0166-7 · Cited by 73 · see citing works

Capacity of Neurotrophic Factors of the GDNF Family in Supporting the Survival of Dopaminergic Neurons in the Central Nervous System of the Aging Mouse

Goodison, T. (2013) · Griffith Research Online · doi:10.25904/1912/3778

Glial cell line-derived neurotrophic factor protects dopaminergic neurons from 6-hydroxydopamine toxicity in vitro

Eggert, K. M., Schlegel, J., Oertel, W. H., Würz, C., Krieg, J.-C., & Vedder, H. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00443-7 · Cited by 55 · see citing works

Effects of glial cell line-derived neurotrophic factor (GDNF) on dopaminergic neurons require concurrent activation of cAMP-dependent signaling pathways

Engele, J., & Franke, B. (1996) · Cell and Tissue Research · doi:10.1007/s004410050692 · Cited by 51 · see citing works

Differential Effects of Glial Cell Line‐Derived Neurotrophic Factor and Neurturin on Developing and Adult Substantia Nigra Dopaminergic Neurons

Åkerud, P., Alberch, J., Eketjäll, S., Wagner, J., & Arenas, E. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0730070.x · Cited by 171 · see citing works

GDNF acutely modulates excitability and A-type K+ channels in midbrain dopaminergic neurons

Yang, F., Feng, L., Zheng, F., Johnson, S. W., Du, J., Shen, L., Wu, C.-P., & Lu, B. (2001) · Nature Neuroscience · doi:10.1038/nn734 · Cited by 193 · see citing works