Does PGC1α/FNDC5/BDNF Elicit the Beneficial Effects of Exercise on Neurodegenerative Disorders?

How mitochondria produce reactive oxygen species

Murphy, M. P. (2009) · Biochemical Journal · doi:10.1042/bj20081386 · Cited by 8,207 · see citing works

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

Ayala, A., Muñoz, M., & Argüelles, S. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/360438 · Cited by 6,557 · see citing works

Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases

Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455 · see citing works

Anti-Vascular Endothelial Growth Factors Protect Retinal Pigment Epithelium Cells Against Oxidation by Modulating Nitric Oxide Release and Autophagy

Cillà, S. D., Farruggio, S., Vujosevic, S., Raina, G., Filippini, D. A., Gatti, V., Clemente, N., Mary, D., Vezzola, D., Casini, G., et al. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479441 · Cited by 5,154 · see citing works

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810 · see citing works

Neurotrophins: Roles in Neuronal Development and Function

Huang, E. J., & Reichardt, L. F. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.677 · Cited by 4,394 · see citing works

Mitochondria, Oxidants, and Aging

Balaban, R. S., Nemoto, S., & Finkel, T. (2005) · Cell · doi:10.1016/j.cell.2005.02.001 · Cited by 4,388 · see citing works

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80611-x · Cited by 4,139 · see citing works

A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81410-5 · Cited by 3,864 · see citing works

The Pathophysiology of Mitochondrial Cell Death

Green, D. R., & Kroemer, G. (2004) · Science · doi:10.1126/science.1099320 · Cited by 3,416 · see citing works

Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres

Lin, J., Wu, H., Tarr, P. T., Zhang, C.-Y., Wu, Z., Boss, O., Michael, L. F., Puigserver, P., Isotani, E., Olson, E. N., et al. (2002) · Nature · doi:10.1038/nature00904 · Cited by 2,546 · see citing works

Exercise builds brain health: key roles of growth factor cascades and inflammation

Cotman, C. W., Berchtold, N. C., & Christie, L.-A. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.06.011 · Cited by 2,268 · see citing works

Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators

St-Pierre, J., Drori, S., Uldry, M., Silvaggi, J. M., Rhee, J., Jäger, S., Handschin, C., Zheng, K., Lin, J., Yang, W., et al. (2006) · Cell · doi:10.1016/j.cell.2006.09.024 · Cited by 2,233 · see citing works

Neurotrophin-regulated signalling pathways

Reichardt, L. F. (2006) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1894 · Cited by 2,195 · see citing works

α-Synuclein is phosphorylated in synucleinopathy lesions

Fujiwara, H., Hasegawa, M., Dohmae, N., Kawashima, A., Masliah, E., Goldberg, M., Shen, J., Takio, K., & Iwatsubo, T. (2002) · Nature Cell Biology · doi:10.1038/ncb748 · Cited by 1,906 · see citing works

Transcriptional paradigms in mammalian mitochondrial biogenesis and function

Scarpulla, R. C. (2008) · Physiological Reviews · doi:10.1152/physrev.00025.2007 · Cited by 1,666 · see citing works

Untitled work

Binder (2004) · doi:10.1080/08977190410001723308 · Cited by 1,481 · see citing works

Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway

Wrann, C. D., White, J. P., Salogiannnis, J., Laznik-Bogoslavski, D., Wu, J., Ma, D., Lin, J. D., Greenberg, M. E., & Spiegelman, B. M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.008 · Cited by 1,440 · see citing works

Toxicity of iron and hydrogen peroxide: the Fenton reaction

Winterbourn, C. C. (1995) · Toxicology Letters · doi:10.1016/0378-4274(95)03532-x · Cited by 1,415 · see citing works

Mitochondria in innate immune responses

West, A. P., Shadel, G. S., & Ghosh, S. (2011) · Nature Reviews Immunology · doi:10.1038/nri2975 · Cited by 1,376 · see citing works

The many faces of CREB

Carlezon, W. A., Duman, R. S., & Nestler, E. J. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.06.005 · Cited by 1,351 · see citing works

Oxidative stress, mitochondrial damage and neurodegenerative diseases.

Guo, C., Sun, L., Chen, X., & Zhang, D. (2013) · PubMed Central · doi:10.3969/j.issn.1673-5374.2013.21.009 · Cited by 1,308 · see citing works

Transcriptional regulatory circuits controlling mitochondrial biogenesis and function

Kelly, D. P., & Scarpulla, R. C. (2004) · Genes & Development · doi:10.1101/gad.1177604 · Cited by 1,243 · see citing works

The Coactivator PGC-1 Cooperates with Peroxisome Proliferator-Activated Receptor α in Transcriptional Control of Nuclear Genes Encoding Mitochondrial Fatty Acid Oxidation Enzymes

Vega, R. B., Huss, J. M., & Kelly, D. P. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.5.1868-1876.2000 · Cited by 1,195 · see citing works

Defects in Adaptive Energy Metabolism with CNS-Linked Hyperactivity in PGC-1α Null Mice

Lin, J., Wu, P.-H., Tarr, P. T., Lindenberg, K. S., St-Pierre, J., Zhang, C.-Y., Mootha, V. K., Jäger, S., Vianna, C. R., Reznick, R. M., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.013 · Cited by 1,162 · see citing works

Functions of plasmalogen lipids in health and disease

Braverman, N. E., & Moser, A. B. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.05.008 · Cited by 1,082 · see citing works

Oxidative Stress in Aging Human Skin

Rinnerthaler, M., Bischof, J., Streubel, M., Trost, A., & Richter, K. (2015) · Biomolecules · doi:10.3390/biom5020545 · Cited by 1,053 · see citing works

Transcriptional Repression of PGC-1α by Mutant Huntingtin Leads to Mitochondrial Dysfunction and Neurodegeneration

Cui, L., Jeong, H., Borovecki, F., Parkhurst, C. N., Tanese, N., & Krainc, D. (2006) · Cell · doi:10.1016/j.cell.2006.09.015 · Cited by 1,012 · see citing works

PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease

Shin, J.-H., Ko, H. S., Kang, H., Lee, Y., Lee, Y.-I., Pletinkova, O., Troconso, J. C., Dawson, V. L., & Dawson, T. M. (2011) · Cell · doi:10.1016/j.cell.2011.02.010 · Cited by 953 · see citing works

Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice

Chapman, P. F., White, G. L., Jones, M. W., Cooper-Blacketer, D., Marshall, V. J., Irizarry, M., Younkin, L., Good, M. A., Bliss, T. V. P., Hyman, B. T., et al. (1999) · Nature Neuroscience · doi:10.1038/6374 · Cited by 946 · see citing works

Mitochondrial fusion protects against neurodegeneration in the cerebellum

Chen, H., McCaffery, J. M., & Chan, D. C. (2007) · Cell · doi:10.1016/j.cell.2007.06.026 · Cited by 924 · see citing works

Dietary fat intake and the risk of incident dementia in the Rotterdam study

Kalmijn, S., Launer, L. J., Ott, A., Witteman, J. C. M., Hofman, A., & Breteler, M. M. B. (1997) · Annals of Neurology · doi:10.1002/ana.410420514 · Cited by 895 · see citing works

Oxidative stress and Parkinson’s disease

Blesa, J., Trigo-Damas, I., Quiroga-Varela, A., & Jackson-Lewis, V. R. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2015.00091 · Cited by 878 · see citing works

Variant Brain-Derived Neurotrophic Factor (BDNF) (Met66) Alters the Intracellular Trafficking and Activity-Dependent Secretion of Wild-Type BDNF in Neurosecretory Cells and Cortical Neurons

Chen, Z.-Y., Patel, P. D., Sant, G., Meng, C.-X., Teng, K. K., Hempstead, B. L., & Lee, F. S. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0348-04.2004 · Cited by 874 · see citing works

PGC-1 α, A Potential Therapeutic Target for Early Intervention in Parkinson’s Disease

Zheng, B., Liao, Z., Locascio, J. J., Lesniak, K. A., Roderick, S. S., Watt, M. L., Eklund, A. C., Zhang‐James, Y., Kim, P. D., Hauser, M. A., et al. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3001059 · Cited by 854 · see citing works

Role of Oxidative Stress in Parkinson's Disease

Hwang, O. (2013) · Experimental Neurobiology · doi:10.5607/en.2013.22.1.11 · Cited by 845 · see citing works

Alzheimer's Disease: Molecular Understanding Predicts Amyloid-Based Therapeutics

Selkoe, D. J., & Schenk, D. (2003) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.43.100901.140248 · Cited by 816 · see citing works

Mitochondrial Dysfunction in Neurodegenerative Diseases

Johri, A., & Beal, M. F. (2012) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.192138 · Cited by 806 · see citing works

Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans

Lee, P., Linderman, J. D., Smith, S., Brychta, R. J., Wang, J., Idelson, C., Perron, R. M., Werner, C. D., Phan, G. Q., Kammula, U. S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.017 · Cited by 802 · see citing works

Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model

Calon, F., Lim, G. P., Yang, F., Morihara, T., Teter, B., Ubeda, O., Rostaing, P., Triller, A., Salem, N., Ashe, K. H., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.013 · Cited by 707 · see citing works

The estrogen-related receptor α (ERRα) functions in PPARγ coactivator 1α (PGC-1α)-induced mitochondrial biogenesis

Schreiber, S., Emter, R., Hock, M. B., Knutti, D., Cardenas, J., Podvinec, M., Oakeley, E. J., & Kralli, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308686101 · Cited by 657 · see citing works

Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences

Exner, N., Lutz, A. K., Haass, C., & Winklhofer, K. F. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.170 · Cited by 652 · see citing works

Role of peroxisomes in ros/rns-metabolism: Implications for human disease

Fransen, M., Nordgren, M., Wang, B., & Apanasets, O. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.12.001 · Cited by 644 · see citing works

Neuronal SIRT1 Activation as a Novel Mechanism Underlying the Prevention of Alzheimer Disease Amyloid Neuropathology by Calorie Restriction

Qin, W., Yang, T., Ho, L., Zhao, Z., Wang, J., Chen, L., Zhao, W., Thiyagarajan, M., MacGrogan, D., Rodgers, J. T., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602909200 · Cited by 626 · see citing works

Peroxisomes: A Nexus for Lipid Metabolism and Cellular Signaling

Lodhi, I. J., & Semenkovich, C. F. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.01.002 · Cited by 605 · see citing works

New Insights in the Biology of BDNF Synthesis and Release: Implications in CNS Function

Greenberg, M. E., Xu, B., Lu, B., & Hempstead, B. L. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3566-09.2009 · Cited by 597 · see citing works

Series Introduction: Neurodegeneration: What is it and where are we?

Przedborski, S., Vila, M., & Jackson-Lewis, V. R. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317522 · Cited by 585 · see citing works

New insights into brain BDNF function in normal aging and Alzheimer disease

Tapia‐Arancibia, L., Aliaga, E., Silhol, M., & Arancibia, S. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.07.007 · Cited by 571 · see citing works

The Formation of Highly Soluble Oligomers of α-Synuclein Is Regulated by Fatty Acids and Enhanced in Parkinson's Disease

Sharon, R., Bar-Joseph, I., Frosch, M. P., Walsh, D. M., Hamilton, J. A., & Selkoe, D. J. (2003) · Neuron · doi:10.1016/s0896-6273(03)00024-2 · Cited by 562 · see citing works

Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity

Song, W., Chen, J., Petrilli, A. M., Liot, G., Klinglmayr, E., Zhou, Y., Poquiz, P., Tjong, J., Pouladi, M. A., Hayden, M. R., et al. (2011) · Nature Medicine · doi:10.1038/nm.2313 · Cited by 556 · see citing works

Peroxisome Proliferator-activated Receptor γ Coactivator 1β (PGC-1β), A Novel PGC-1-related Transcription Coactivator Associated with Host Cell Factor

Lin, J., Puigserver, P., Donovan, J., Tarr, P., & Spiegelman, B. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c100631200 · Cited by 552 · see citing works

A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures

Rossignol, D. A., & Frye, R. E. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.165 · Cited by 545 · see citing works

Targeting programmed cell death in neurodegenerative diseases

Vila, M., & Przedborski, S. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1100 · Cited by 545 · see citing works

Impaired Mitochondrial Biogenesis Contributes to Mitochondrial Dysfunction in Alzheimer's Disease

Sheng, B., Wang, X.-L., Su, B., Lee, H.-G., Casadesus, G., Perry, G., & Zhu, X.-W. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07581.x · Cited by 538 · see citing works

Fatty acid analysis of blood plasma of patients with alzheimer's disease, other types of dementia, and cognitive impairment

Conquer, J. A., Tierney, M. C., Zecevic, J., Bettger, W. J., & Fisher, R. H. (2000) · Lipids · doi:10.1007/s11745-000-0646-3 · Cited by 523 · see citing works

Peroxisome biogenesis disorders

Steinberg, S. J., Dodt, G., Raymond, G. V., Braverman, N. E., Moser, A. B., & Moser, H. W. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.09.010 · Cited by 522 · see citing works

Reactive oxygen species, antioxidant systems and nitric oxide in peroxisomes

del Río, L. A., Corpas, F. J., Sandalio, L. M., Palma, J. M., Gómez, M., & Barroso, J. B. (2002) · Journal of Experimental Botany · doi:10.1093/jexbot/53.372.1255 · Cited by 494 · see citing works

PGC-1α Rescues Huntington’s Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function

Tsunemi, T., Ashe, T. D., Morrison, B. E., Epilepsia, K. S., Au, J., Vázquez‐Roque, R. A., Lazarowski, E. R., Damian, V. A., Masliah, E., & Spada, A. R. L. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003799 · Cited by 440 · see citing works

Energy intake and exercise as determinants of brain health and vulnerability to injury and disease

Mattson, M. P. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.08.012 · Cited by 434 · see citing works

Microscopic analysis of polymerization dynamics with individual actin filaments

Fujiwara, I., Takahashi, S., Tadakuma, H., Funatsu, T., & Ishiwata, S. (2002) · Nature Cell Biology · doi:10.1038/ncb841 · Cited by 420 · see citing works

Mitochondrial Diseases of the Brain

Chaturvedi, R. K., & Beal, M. F. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.03.018 · Cited by 416 · see citing works

Exercise and hormesis: oxidative stress-related adaptation for successful aging

Radak, Z. O., Chung, H. Y., & Goto, S. (2005) · Biogerontology · doi:10.1007/s10522-004-7386-7 · Cited by 413 · see citing works

New insights into PGC ‐1 coactivators: redefining their role in the regulation of mitochondrial function and beyond

Villena, J. A. (2014) · FEBS Journal · doi:10.1111/febs.13175 · Cited by 404 · see citing works

Running is the neurogenic and neurotrophic stimulus in environmental enrichment

Kobilo, T., Liu, Q.-R., Gandhi, K., Mughal, M., Shaham, Y., & van Praag, H. (2011) · Learning & Memory · doi:10.1101/lm.2283011 · Cited by 385 · see citing works

Organization and dynamics of human mitochondrial DNA

Legros, F., Malka, F., Frachon, P., Lombès, A., & Rojo, M. (2004) · Journal of Cell Science · doi:10.1242/jcs.01134 · Cited by 383 · see citing works

PGC-1α Expression Decreases in the Alzheimer Disease Brain as a Function of Dementia

Qin, W., Haroutunian, V. H., Katsel, P., Cardozo, C. P., Ho, L., Buxbaum, J. D., & Pasinetti, G. M. (2009) · Archives of Neurology · doi:10.1001/archneurol.2008.588 · Cited by 381 · see citing works

Physiology of BDNF: focus on hypothalamic function

Tapia‐Arancibia, L. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.04.001 · Cited by 367 · see citing works

The in-depth evaluation of suspected mitochondrial disease

Haas, R., Parikh, S., Falk, M. J., Saneto, R. P., Wolf, N. I., Darín, N., Wong, L.-J. C., Cohen, B. H., & Naviaux, R. K. (2008) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2007.11.018 · Cited by 363 · see citing works

Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes

Kassmann, C. M., Lappe-Siefke, C., Baes, M., Brügger, B., Mildner, A., Werner, H. B., Natt, O., Michaelis, T., Prinz, M., Frahm, J., et al. (2007) · Nature Genetics · doi:10.1038/ng2070 · Cited by 357 · see citing works

Brain-derived neurotrophic factor: role in depression and suicide

Dwivedi, Y. (2009) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s5700 · Cited by 355 · see citing works

Irisin – a myth rather than an exercise-inducible myokine

Albrecht, E., Norheim, F., Thiede, B., Holen, T., Ohashi, T., Schering, L., Lee-Ødegård, S., Brenmoehl, J., Thomas, S., Drevon, C. A., et al. (2015) · Scientific Reports · doi:10.1038/srep08889 · Cited by 346 · see citing works

Mitochondrial dysfunction in aging: Much progress but many unresolved questions

Payne, B. A. I., & Chinnery, P. F. (2015) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2015.05.022 · Cited by 335 · see citing works

The Endosomal-Lysosomal System of Neurons in Alzheimer's Disease Pathogenesis: A Review

Nixon, R., Cataldo, A., & Mathews, P. (2000) · Neurochemical Research · doi:10.1023/a:1007675508413 · Cited by 332 · see citing works

A BDNF Coding Variant is Associated with the NEO Personality Inventory Domain Neuroticism, a Risk Factor for Depression

Sen, S., Nesse, R. M., Stoltenberg, S. F., Li, S., Gleiberman, L., Chakravarti, A., Weder, A. B., & Burmeister, M. (2002) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300053 · Cited by 331 · see citing works

Neuroprotective effects of physical activity on the brain: a closer look at trophic factor signaling

Phillips, C., Baktir, M. A., Srivatsan, M., & Salehi, A. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00170 · Cited by 330 · see citing works

Intravenous Brain-Derived Neurotrophic Factor Reduces Infarct Size and Counterregulates Bax and Bcl-2 Expression After Temporary Focal Cerebral Ischemia

Schäbitz, W.-R., Sommer, C., Zoder, W., Kiessling, M., Schwaninger, M., & Schwab, S. (2000) · Stroke · doi:10.1161/01.str.31.9.2212 · Cited by 325 · see citing works

Evidence against a Beneficial Effect of Irisin in Humans

Raschke, S., Elsen, M., Gassenhuber, J., Sommerfeld, M. R., Schwahn, U., Brockmann, B., Jung, R., Wisløff, U., Tjønna, A. E., Raastad, T., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073680 · Cited by 318 · see citing works

Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson’s disease

Mudó, G., Mäkelä, J., Liberto, V. D., Tselykh, T. V., Olivieri, M., Piepponen, P., Eriksson, O., Mälkiä, A., Bonomo, A., Kairisalo, M., et al. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0850-z · Cited by 315 · see citing works

Early synaptic pathophysiology in neurodegeneration: insights from Huntington's disease

Milnerwood, A. J., & Raymond, L. A. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.08.002 · Cited by 311 · see citing works

Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1α transcription and mitochondrial biogenesis in muscle cells

Wu, Z., Huang, X., Feng, Y., Handschin, C., Feng, Y., Gullicksen, P. S., Bare, O., Labow, M., Spiegelman, B., & Stevenson, S. C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606714103 · Cited by 291 · see citing works

Apoptosis in Alzheimer’s Disease: An Understanding of the Physiology, Pathology and Therapeutic Avenues

Obulesu, M., & Lakshmi, M. J. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1454-4 · Cited by 290 · see citing works

Teaching the fundamentals of electron transfer reactions in mitochondria and the production and detection of reactive oxygen species

Mailloux, R. J. (2015) · Redox Biology · doi:10.1016/j.redox.2015.02.001 · Cited by 286 · see citing works

Peroxisomal disorders: The single peroxisomal enzyme deficiencies

Wanders, R. J. A., & Waterham, H. R. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.08.010 · Cited by 279 · see citing works

Synaptic Dysfunction in Parkinson’s Disease

Picconi, B., Piccoli, G., & Calabresi, P. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-3-7091-0932-8_24 · Cited by 277 · see citing works

Brain-Derived Neurotrophic Factor and Autoantibodies to Neural Antigens in Sera of Children with Autistic Spectrum Disorders, Landau-Kleffner Syndrome, and Epilepsy

Connolly, A. M., Chez, M. G., Streif, E. M., Keeling, R. M., Golumbek, P. T., Kwon, J. M., Riviello, J. J., Robinson, R., Neuman, R. J., & Deuel, R. K. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.07.004 · Cited by 262 · see citing works

The Nuclear Receptor Superfamily: A Rosetta Stone for Physiology

Evans, R. M. (2005) · Molecular Endocrinology · doi:10.1210/me.2005-0046 · Cited by 262 · see citing works

Stress induces peroxisome biogenesis genes

López‐Huertas, E., Charlton, W. L., Johnson, B., Graham, I. A., & Baker, A. (2000) · The EMBO Journal · doi:10.1093/emboj/19.24.6770 · Cited by 254 · see citing works

Disease and anatomic specificity of ethanolamine plasmalogen deficiency in Alzheimer's disease brain

Ginsberg, L., Rafique, S., Xuereb, J. H., Rapoport, S. I., & Gershfeld, N. L. (1995) · Brain Research · doi:10.1016/0006-8993(95)00931-f · Cited by 248 · see citing works

The PGC-1-related Protein PERC Is a Selective Coactivator of Estrogen Receptor α

Kressler, D., Schreiber, S., Knutti, D., & Kralli, A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201134200 · Cited by 239 · see citing works

Irisin-immunoreactivity in neural and non-neural cells of the rodent

Dun, S. L., Lyu, R., Chen, Y., Chang, J. K., Luo, J. J., & Dun, N. J. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.02.050 · Cited by 236 · see citing works

Mitochondrial dysfunction: A potential link between neuroinflammation and neurodegeneration?

Witte, M. E., Geurts, J. J. G., de Vries, H. E., van der Valk, P., & van Horssen, J. (2010) · Mitochondrion · doi:10.1016/j.mito.2010.05.014 · Cited by 236 · see citing works

Association between the BDNF 196 A/G polymorphism and sporadic Alzheimer's disease

Ventriglia, M., Bocchio‐Chiavetto, L., Benussi, L., Binetti, G. G., Zanetti, O. O., Riva, M. A., & Gennarelli, M. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4000952 · Cited by 234 · see citing works

Peroxisomal alterations in Alzheimer’s disease

Kou, J., Kovacs, G. G., Höftberger, R., Kulik, W., Brodde, A., Forss-Petter, S., Hönigschnabl, S., Gleiss, A., Brügger, B., Wanders, R., et al. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0836-9 · Cited by 227 · see citing works

Identification of evolutionarily conserved non-AUG-initiated N-terminal extensions in human coding sequences

Ivanov, I. P., Firth, A. E., Michel, A. M., Atkins, J. F., & Baranov, P. V. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr007 · Cited by 225 · see citing works

Regulation of mitochondrial transport in neurons

Lin, M.-Y., & Sheng, Z. (2015) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.01.004 · Cited by 223 · see citing works

Peroxisomes Are Oxidative Organelles

Antonenkov, V. D., Grunau, S., Ohlmeier, S., & Hiltunen, J. K. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2996 · Cited by 223 · see citing works

β-Amyloid Peptide at Sublethal Concentrations Downregulates Brain-Derived Neurotrophic Factor Functions in Cultured Cortical Neurons

Tong, L., Balazs, R., Thornton, P. L., & Cotman, C. W. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5463-03.2004 · Cited by 221 · see citing works

Peroxisomal disorders I: biochemistry and genetics of peroxisome biogenesis disorders

Wanders, R. J. A., & Waterham, H. R. (2004) · Clinical Genetics · doi:10.1111/j.1399-0004.2004.00329.x · Cited by 220 · see citing works

Energy deficit in Huntington disease: why it matters

Mochel, F., & Haller, R. G. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45691 · Cited by 220 · see citing works

Mitochondrial quality control and communications with the nucleus are important in maintaining mitochondrial function and cell health

Kotiadis, V. N., Duchen, M. R., & Osellame, L. D. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.10.041 · Cited by 212 · see citing works

Irisin and FNDC5 in retrospect

Erickson, H. (2013) · Adipocyte · doi:10.4161/adip.26082 · Cited by 211 · see citing works

Mitochondrial Dysfunction: Different Routes to Alzheimer’s Disease Therapy

Picone, P., Nuzzo, D., Caruana, L., Scafidi, V., & Carlo, M. D. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/780179 · Cited by 208 · see citing works

Pharmacological concentrations of irisin increase cell proliferation without influencing markers of neurite outgrowth and synaptogenesis in mouse H19-7 hippocampal cell lines

Moon, H., Dincer, F., & Mantzoros, C. S. (2013) · Metabolism · doi:10.1016/j.metabol.2013.04.007 · Cited by 207 · see citing works

Journal of Neuroscience Research

(2006) · Journal of Neuroscience Research · doi:10.1002/(issn)1097-4547 · Cited by 206 · see citing works

Mitochondria in Neurodegeneration

Lezi, E., & Swerdlow, R. H. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-2869-1_12 · Cited by 204 · see citing works

NADPH oxidase- and mitochondria-derived reactive oxygen species in proinflammatory microglial activation: A bipartisan affair?

Bordt, E. A., & Polster, B. M. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.07.033 · Cited by 202 · see citing works

The pathophysiology of mitochondrial disease as modeled in the mousePreprint

Wallace, D. C., & Fan, W. (2009) · Genes & Development · doi:10.1101/gad.1784909 · Cited by 201 · see citing works

Neural Regeneration Research

Sun, L. (2015) · Figshare · doi:10.6084/m9.figshare.2007621 · Cited by 201 · see citing works

Estrogen related receptors (ERRs): A new dawn in transcriptional control of mitochondrial gene networks

Eichner, L. J., & Giguère, V. (2011) · Mitochondrion · doi:10.1016/j.mito.2011.03.121 · Cited by 200 · see citing works

Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphisms

Momose, Y., Murata, M., Kobayashi, K., Tachikawa, M., Nakabayashi, Y., Kanazawa, I., & Toda, T. (2001) · Annals of Neurology · doi:10.1002/ana.10079 · Cited by 200 · see citing works

Intraperoxisomal redox balance in mammalian cells: oxidative stress and interorganellar cross-talk

Ivashchenko, O., Veldhoven, P. P. V., Brees, C., Ho, Y.-S., Terlecky, S. R., & Fransen, M. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-11-0919 · Cited by 199 · see citing works

Initiation of Neuronal Damage by Complex I Deficiency and Oxidative Stress in Parkinson's Disease

Tretter, L., Sipos, I., & Ádám‐Vizi, V. (2004) · Neurochemical Research · doi:10.1023/b:nere.0000014827.94562.4b · Cited by 199 · see citing works

Oxidative Stress and Energy Crises in Neuronal Dysfunction

Nicholls, D. G. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.002 · Cited by 199 · see citing works

BDNF Regulates the Intrinsic Excitability of Cortical NeuronsPreprint

Desai, N. S., Rutherford, L. C., & Turrigiano, G. G. (1999) · Learning & Memory · doi:10.1101/lm.6.3.284 · Cited by 199 · see citing works

Metabolic Stress Modulates Alzheimer’s β-Secretase Gene Transcription via SIRT1-PPARγ-PGC-1 in Neurons

Wang, R., Li, J. J., Diao, S., Kwak, Y.-D., Liu, L., Zhi, L., Büeler, H., Bhat, N. R., Williams, R. W., Park, E. A., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.03.016 · Cited by 198 · see citing works

Mitochondrial ROS metabolism: 10 Years later

Andreyev, A. Y., Kushnareva, Y. E., Murphy, A. N., & Starkov, A. A. (2015) · Biochemistry (Moscow) · doi:10.1134/s0006297915050028 · Cited by 194 · see citing works

Na+, K+-ATPase: the new face of an old player in pathogenesis and apoptotic/hybrid cell death

Yu, S. P. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(03)00531-8 · Cited by 192 · see citing works

Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes

Moreira, P. I., Santos, M. S., Seiça, R. M. F., & Oliveira, C. R. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.01.017 · Cited by 190 · see citing works

Altered Fatty Acid Composition of Dopaminergic Neurons Expressing α-Synuclein and Human Brains with α-Synucleinopathies

Sharon, R., Bar-Joseph, I., Mirick, G. E., Serhan, C. N., & Selkoe, D. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m309127200 · Cited by 187 · see citing works

Role of Mitochondria in Neurodegenerative Diseases: Mitochondria as a Therapeutic Target in Alzheimer's Disease

Reddy, P. H. (2009) · CNS Spectrums · doi:10.1017/s1092852900024901 · Cited by 186 · see citing works

Neurotrophins and neuronal differentiation in the central nervous system

McAllister, A. K. (2001) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000920 · Cited by 175 · see citing works

PPARγ and PGC-1α as Therapeutic Targets in Parkinson’s

Corona, J. C., & Duchen, M. R. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1377-0 · Cited by 169 · see citing works

Hydrogen Peroxide Produced by Mitochondrial Monoamine Oxidase Catalysis: Biological Implications

Edmondson, D. E. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113190990406 · Cited by 169 · see citing works

Mouse PeP: A novel peroxisomal protein linked to myoblast differentiation and development

Ferrer-Martı́nez, A., Ruiz‐Lozano, P., & Chien, K. R. (2002) · Developmental Dynamics · doi:10.1002/dvdy.10099 · Cited by 169 · see citing works

NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection

Volakakis, N., Kadkhodaei, B., Joodmardi, E., Wallis, K., Panman, L., Silvaggi, J., Spiegelman, B. M., & Perlmann, T. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1007088107 · Cited by 167 · see citing works

Cardiac, skeletal muscle and serum irisin responses to with or without water exercise in young and old male rats: Cardiac muscle produces more irisin than skeletal muscle

Aydın, S., Kuloğlu, T., Aydin, S., Eren, M. N., Çelik, A., Yılmaz, M., Kalaycı, M. Z., Şahin, İ., Gungor, O., Gürel, A., et al. (2013) · Peptides · doi:10.1016/j.peptides.2013.11.024 · Cited by 165 · see citing works

Mitochondrial DNA mutations in neurodegeneration

Keogh, M. J., & Chinnery, P. F. (2015) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2015.05.015 · Cited by 163 · see citing works

Staying cool in difficult times: Mitochondrial dynamics, quality control and the stress response

Shutt, T. E., & McBride, H. M. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.05.024 · Cited by 160 · see citing works

Peroxisomal Proliferation Protects from β-Amyloid Neurodegeneration

Santos, M. J., Quintanilla, R. A., Toro, A., Grandy, R. A., Dinamarca, M. C., Godoy, J. A., & Inestrosa, N. C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505160200 · Cited by 155 · see citing works

Comparison of the capability of GDNF, BDNF, or both, to protect nigrostriatal neurons in a rat model of Parkinson’s disease

Sun, M., Kong, L., Wang, X., Lu, X.-G., Gao, Q., & Geller, A. I. (2005) · Brain Research · doi:10.1016/j.brainres.2005.05.072 · Cited by 154 · see citing works

Mitochondrial- and Endoplasmic Reticulum-Associated Oxidative Stress in Alzheimer's Disease: From Pathogenesis to Biomarkers

Ferreiro, E. B., Baldeiras, I., Ferreira, I. L., Costa, R. O., Rego, A. C., Pereira, C., & Oliveira, C. R. (2012) · International Journal of Cell Biology · doi:10.1155/2012/735206 · Cited by 152 · see citing works

Mitochondria and PGC-1α in Aging and Age-Associated Diseases

Wenz, T. (2011) · Journal of Aging Research · doi:10.4061/2011/810619 · Cited by 149 · see citing works

Alzheimer's disease: Effects of β-amyloid on mitochondria

Tillement, L., Lecanu, L., & Papadopoulos, V. (2010) · Mitochondrion · doi:10.1016/j.mito.2010.08.009 · Cited by 145 · see citing works

Fndc5 knockdown significantly decreased neural differentiation rate of mouse embryonic stem cells

Hashemi, M. ‐., Ghaedi, K., Salamian, A., Karbalaie, K., Emadi‐Baygi, M., Tanhaei, S., Nasr‐Esfahani, M. H., & Baharvand, H. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.11.041 · Cited by 143 · see citing works

Dietary restriction.; mitochondrial function and aging: From yeast to humans

Ruetenik, A., & Barrientos, A. (2015) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2015.05.005 · Cited by 139 · see citing works

Nerve Growth Factor as a Signaling Molecule for Nerve Cells and also for the Neuroendocrine-Immune Systems

Fiore, M., Chaldakov, G. N., & Aloe, L. (2009) · Reviews in the Neurosciences · doi:10.1515/revneuro.2009.20.2.133 · Cited by 137 · see citing works

Peroxisome proliferator activator receptor gamma coactivator-1alpha (PGC-1α) improves motor performance and survival in a mouse model of amyotrophic lateral sclerosis

Zhao, W., Varghese, M., Yemul, S., Pan, Y., Cheng, A., Marano, P., Hassan, S., Vempati, P., Chen, F., Qian, X., et al. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-51 · Cited by 134 · see citing works

Brain-Derived Neurotrophic Factor Causes cAMP Response Element-Binding Protein Phosphorylation in Absence of Calcium Increases in Slices and Cultured Neurons from Rat Visual Cortex

Pizzorusso, T., Ratto, G. M., Putignano, E., & Maffei, L. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-08-02809.2000 · Cited by 132 · see citing works

PGC-1α, a New Therapeutic Target in Huntington's Disease?

McGill, J. K., & Beal, M. F. (2006) · Cell · doi:10.1016/j.cell.2006.10.023 · Cited by 131 · see citing works

Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection

Trempe, J., & Fon, E. A. (2013) · Frontiers in Neurology · doi:10.3389/fneur.2013.00038 · Cited by 130 · see citing works

Banting Lecture 2012

Spiegelman, B. M. (2013) · Diabetes · doi:10.2337/db12-1665 · Cited by 129 · see citing works

The gene coding for PGC-1α modifies age at onset in Huntington's Disease

Weydt, P., Soyal, S. M., Gellera, C., DiDonato, S., Weidinger, C., Oberkofler, H., Landwehrmeyer, G. B., & Patsch, W. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-3 · Cited by 128 · see citing works

PPARγ Co-Activator-1α (PGC-1α) Reduces Amyloid-β Generation Through a PPARγ-Dependent Mechanism

Katsouri, L., Parr, C., Bogdanović, N., Willem, M., & Sastre, M. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101356 · Cited by 126 · see citing works

Therapeutic role of sirtuins in neurodegenerative disease

Outeiro, T. F., Marques, O., & Kazantsev, A. G. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.02.010 · Cited by 120 · see citing works

Therapeutic prospects for mitochondrial disease

Schon, E. A., DiMauro, S., Hirano, M., & Gilkerson, R. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.04.007 · Cited by 118 · see citing works

Restoration of Peroxisomal Catalase Import in a Model of Human Cellular Aging

Koepke, J. I., Nakrieko, K., Wood, C. S., Boucher, K. K., Terlecky, L. J., Walton, P. A., & Terlecky, S. R. (2007) · Traffic · doi:10.1111/j.1600-0854.2007.00633.x · Cited by 110 · see citing works

The biology of PGC-1α and its therapeutic potential

Handschin, C. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.03.006 · Cited by 108 · see citing works

Peroxisomal Proliferator-activated Receptor-γ Coactivator-1α (PGC-1α) Enhances the Thyroid Hormone Induction of Carnitine Palmitoyltransferase I (CPT-Iα)

Zhang, Y., Ma, K., Song, S., Elam, M. B., Cook, G. A., & Park, E. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406028200 · Cited by 105 · see citing works

We need to move more: Neurobiological hypotheses of physical exercise as a treatment for Parkinson’s disease

Monteiro-Júnior, R. S., Cevada, T., Oliveira, B. R. R., Lattari, E., Portugal, E. M. M., de Carvalho, A. O., & Deslandes, A. C. (2015) · Medical Hypotheses · doi:10.1016/j.mehy.2015.07.011 · Cited by 104 · see citing works

Multifaceted deaths orchestrated by mitochondria in neurones

Nagley, P., Higgins, G. C., Atkin, J. D., & Beart, P. M. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.09.004 · Cited by 103 · see citing works

Association of PGC-1alphapolymorphisms with age of onset and risk of Parkinson's disease

Clark, J., Reddy, S., Zheng, K., Betensky, R. A., & Simon, D. K. (2011) · BMC Medical Genetics · doi:10.1186/1471-2350-12-69 · Cited by 102 · see citing works

Mitochondrial fusion provides an ‘initial metabolic complementation’ controlled by mtDNA

Yang, L., Long, Q., Liu, J., Tang, H., Li, Y., Bao, F., Qin, D., Pei, D., & Liu, X. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1863-9 · Cited by 95 · see citing works

PGC‐1α activation as a therapeutic approach in mitochondrial disease

Wenz, T. (2009) · IUBMB Life · doi:10.1002/iub.261 · Cited by 90 · see citing works

Systemic Delivery of Recombinant Brain Derived Neurotrophic Factor (BDNF) in the R6/2 Mouse Model of Huntington’s Disease

Giampà, C., Montagna, E., Dato, C., Melone, M. A. B., Bernardi, G., & Fusco, F. R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064037 · Cited by 87 · see citing works

Using neurolipidomics to identify phospholipid mediators of synaptic (dys)function in Alzheimer's Disease

Bennett, S. A. L., Valenzuela, N., Xu, H., Franko, B., Fai, S., & Figeys, D. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00168 · Cited by 86 · see citing works

Morphological and bioenergetic demands underlying the mitophagy in post-mitotic neurons: the pink–parkin pathway

Amadoro, G., Corsetti, V., Florenzano, F., Atlante, A., Bobba, A., Nicolin, V., Nori, S., & Calissano, P. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00018 · Cited by 80 · see citing works

The interrelationship between mitochondrial dysfunction and transcriptional dysregulation in Huntington disease

Jin, Y. N., & Johnson, G. V. W. (2010) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-010-9286-7 · Cited by 80 · see citing works

Implications of mitochondrial dynamics on neurodegeneration and on hypothalamic dysfunction

Zorzano, A., & Claret, M. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00101 · Cited by 79 · see citing works

Sources of superoxide/H2O2 during mitochondrial proline oxidation

Goncalves, R. L. S., Rothschild, D. E., Quinlan, C. L., Scott, G. K., Benz, C. C., & Brand, M. D. (2014) · Redox Biology · doi:10.1016/j.redox.2014.07.003 · Cited by 79 · see citing works

Abnormality in catalase import into peroxisomes leads to severe neurological disorder

Sheikh, F. G., Pahan, K., Khan, M., Barbosa, E., & Singh, I. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.2961 · Cited by 75 · see citing works

Role of the Mitochondrion in Programmed Necrosis

Baines, C. P. (2010) · Frontiers in Physiology · doi:10.3389/fphys.2010.00156 · Cited by 75 · see citing works

Chronic BDNF deficiency leads to an age-dependent impairment in spatial learning

Petzold, A., Psotta, L., Brigadski, T., Endres, T., & Leßmann, V. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.02.009 · Cited by 71 · see citing works

Fndc5 overexpression facilitated neural differentiation of mouse embryonic stem cells

Forouzanfar, M., Rabiee, F., Ghaedi, K., et al. (2015) · Cell Biology International · doi:10.1002/cbin.10427 · Cited by 65 · see citing works

Peroxisomes, myelination, and axonal integrity in the CNS

Baes, M., & Aubourg, P. (2009) · The Neuroscientist · doi:10.1177/1073858409336297 · Cited by 65 · see citing works

Parkinson’s Disease: A Complex Interplay of Mitochondrial DNA Alterations and Oxidative Stress

Ciccone, S., Maiani, E., Bellusci, G., Diederich, M. F., & Gonfloni, S. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14022388 · Cited by 64 · see citing works

Mitochondrial disorders: aetiologies, models systems, and candidate therapies

Farrar, G. J., Chadderton, N., Kenna, P. F., & Millington‐Ward, S. (2013) · Trends in Genetics · doi:10.1016/j.tig.2013.05.005 · Cited by 59 · see citing works

Mitogen- and stress-activated protein kinase 1-induced neuroprotection in Huntington's disease: role on chromatin remodeling at the PGC-1-alpha promoter

Martin, E., Bétuing, S., Pagès, C., Cambon, K., Aurégan, G., Déglon, N., Roze, E. F., & Caboche, J. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr148 · Cited by 57 · see citing works

Hypocatalasemic Fibroblasts Accumulate Hydrogen Peroxide and Display Age-Associated Pathologies

Wood, C. S., Koepke, J. I., Teng, H., Boucher, K. K., Katz, S., Chang, P., Terlecky, L. J., Papanayotou, I., Walton, P. A., & Terlecky, S. R. (2006) · Traffic · doi:10.1111/j.1600-0854.2005.00358.x · Cited by 55 · see citing works

Characterization of an oxygen-tolerant cell line derived from Chinese hamster ovary

van der Valk, P., Gille, J. J. P., Oostra, A. B., Roubos, E. W., Sminia, T., & Joenje, H. (1985) · Cell and Tissue Research · doi:10.1007/bf00214903 · Cited by 52 · see citing works

The expression of peroxisomal protein transcripts increased by retinoic acid during neural differentiation☆

Ostadsharif, M., Ghaedi, K., Nasr‐Esfahani, M. H., Mojbafan, M., Tanhaie, S., Karbalaie, K., & Baharvand, H. (2010) · Differentiation · doi:10.1016/j.diff.2010.11.003 · Cited by 46 · see citing works

Generalised and conditional inactivation of Pex genes in mice

Baes, M. I., & Veldhoven, P. P. V. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.08.018 · Cited by 45 · see citing works

Serum superoxide dismutase 3 (extracellular superoxide dismutase) activity is a sensitive indicator of Cu status in rats

Johnson, W. T., Johnson, L. A. K., & Lukaski, H. C. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.03.009 · Cited by 39 · see citing works

α‐Synuclein abnormalities in mouse models of peroxisome biogenesis disorders

Yakunin, E., Moser, A. B., Loeb, V., Saada, A., Faust, P. L., Crane, D. I., Baes, M. I., & Sharon, R. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22246 · Cited by 39 · see citing works

Enhanced expression of FNDC5 in human embryonic stem cell-derived neural cells along with relevant embryonic neural tissues

Ghahrizjani, F. A., Ghaedi, K., Salamian, A., et al. (2014) · Gene · doi:10.1016/j.gene.2014.12.010 · Cited by 34 · see citing works

Role of Oxidative Stress In Parkinsons Disease

Zafar, S. K. (1999) · Shodhganga · Cited by 34 · see citing works

Parkin’ control: regulation of PGC-1α through PARIS in Parkinson’s disease

Castillo-Quan, J. I. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.008227 · Cited by 33 · see citing works

Striatal metabolism and psychomotor speed as predictors of motor onset in Huntington’s disease

Herben-Dekker, M., van Oostrom, J. C. H., Roos, R. A. C., Jurgens, C. K., Witjes‐Ané, M. W., Kremer, H. P. H., Leenders, K. L., & Spikman, J. M. (2014) · Journal of Neurology · doi:10.1007/s00415-014-7350-7 · Cited by 31 · see citing works

Induced expression of Fndc5 significantly increased cardiomyocyte differentiation rate of mouse embryonic stem cells

Rabiee, F., Forouzanfar, M., Zadegan, F. G., Tanhaei, S., Ghaedi, K., Motovali-Bashi, M., Baharvand, H., & Nasr‐Esfahani, M. H. (2014) · Gene · doi:10.1016/j.gene.2014.08.045 · Cited by 29 · see citing works

TrkB partial agonists: Potential treatment strategy for epilepsy, mania, and autism

Tsai, S. (2005) · Medical Hypotheses · doi:10.1016/j.mehy.2005.05.033 · Cited by 26 · see citing works

Cheaper, Simpler, and Better: Tips for Treating Seniors With Parkinson Disease

Ahlskog, J. E. (2011) · Mayo Clinic Proceedings · doi:10.4065/mcp.2011.0443 · Cited by 25 · see citing works

Mitochondrial Homeostasis Molecules: Regulation by a Trio of Recessive Parkinson’s Disease Genes

Han, J., Kim, J., & Son, J. H. (2014) · Experimental Neurobiology · doi:10.5607/en.2014.23.4.345 · Cited by 21 · see citing works

BDNF as a Promising Therapeutic Agent in Parkinson’s Disease

Palasz, E., Wysocka, A., Gasiorowska, A., Chalimoniuk, M., Niewiadomski, W., & Niewiadomska, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031170 · Cited by 504 · see citing works

Lactate and BDNF: Key Mediators of Exercise Induced Neuroplasticity?

Müller, P., Duderstadt, Y., Lessmann, V., & Müller, N. G. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9041136 · Cited by 241 · see citing works

Expression of the neurotrophin receptor trkB is regulated by the cAMP/CREB pathway in neurons

Deogracias, R., Espliguero, G., Iglesias, T., & Rodríguez‐Peña, A. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.03.007 · Cited by 100 · see citing works

Saikosaponin a alleviates depressive-like behavior by regulating the BDNF-TrkB-CREB signaling pathway in a mouse model of chronic unpredictable mild stress

Liu, M., Wang, R., Yu, C.-Y., Shi, B., Shi, S.-S., Sun, Y., Zou, C.-M., Wang, Q., Wei, T., & Zhang, T. (2024) · SCIREA Journal of Clinical Medicine · doi:10.54647/cm321232

Effect of ω-3PUFAs on cognitive deficit in rats with schizophrenia

Fang, M., Qian, H., Zeng, K., et al. (2017) · Zhonghua xingwei yixue yu naokexue zazhi · doi:10.3760/cma.j.issn.1674-6554.2017.07.003

trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor

Squinto, S. P., Stitt, T. N., Aldrich, T. H., Davis, S. H., Blanco, S. M., Radziejewski, C. H., Glass, D. J., Masiakowski, P., Furth, M. E., Valenzuela, D. M., et al. (1991) · Cell · doi:10.1016/0092-8674(91)90395-f · Cited by 830 · see citing works

Retrograde Transport of Neurotrophins from the Eye to the Brain in Chick Embryos: Roles of the p75^NTRand trkB Receptors

von Bartheld, C. S., Williams, R., Lefcort, F., Clary, D. O., Reichardt, L. F., & Bothwell, M. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-09-02995.1996 · Cited by 154 · see citing works