Effects of early weaning and social isolation on the expression of glucocorticoid and mineralocorticoid receptor and 11β-hydroxysteroid dehydrogenase 1 and 2 mRNAs in the frontal cortex and hippocampus of piglets

SAS System for Mixed Models

Littell, R. C. (1996) · Medical Entomology and Zoology · Cited by 10,345 · see citing works

Real time quantitative PCR.Preprint

Heid, C., Stevens, J., Livak, K. J., & Williams, P. (1996) · Genome Research · doi:10.1101/gr.6.10.986 · Cited by 6,180 · see citing works

The Organization of Networks within the Orbital and Medial Prefrontal Cortex of Rats, Monkeys and Humans

Ongur, D. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.206 · Cited by 2,627 · see citing works

A novel method for real time quantitative RT-PCR.Preprint

Gibson, U. E., Heid, C., & Williams, P. M. (1996) · Genome Research · doi:10.1101/gr.6.10.995 · Cited by 2,090 · see citing works

The role of the medial prefrontal cortex (cingulate gyrus) in the regulation of hypothalamic-pituitary-adrenal responses to stress

Diorio, D., Viau, V, & Meaney, M. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-09-03839.1993 · Cited by 1,151 · see citing works

Early adverse experience as a developmental risk factor for later psychopathology: Evidence from rodent and primate models

SÁNCHEZ, M. M., LADD, C. O., & PLOTSKY, P. M. (2001) · Development and Psychopathology · doi:10.1017/s0954579401003029 · Cited by 1,003 · see citing works

Early Environmental Regulation of Forebrain Glucocorticoid Receptor Gene Expression: Implications for Adrenocortical Responses to Stress; pp. 49–60

Meaney, M. J., Diorio, J., Francis, D., Widdowson, J., LaPlante, P., Caldji, C., Sharma, S., Seckl, J. R., & Plotsky, P. M. (2010) · Developmental Neuroscience · doi:10.1159/000111395 · Cited by 878 · see citing works

VEGF links hippocampal activity with neurogenesis, learning and memory

Cao, L., Jiao, X., Zuzga, D. S., Liu, Y., Fong, D. M., Young, D., & During, M. J. (2004) · Nature Genetics · doi:10.1038/ng1395 · Cited by 850 · see citing works

Chronic behavioral stress induces apical dendritic reorganization in pyramidal neurons of the medial prefrontal cortex

Radley, J. J., Sisti, H. M., Hao, J., Rocher, A. B., McCall, T., Hof, P. R., McEwen, B. S., & Morrison, J. H. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.01.006 · Cited by 769 · see citing works

Chronic stress alters dendritic morphology in rat medial prefrontal cortex

Cook, S. C., & Wellman, C. L. (2004) · Journal of Neurobiology · doi:10.1002/neu.20025 · Cited by 750 · see citing works

Early life experience alters response of adult neurogenesis to stress

Mirescu, C., Peters, J. D., & Gould, E. (2004) · Nature Neuroscience · doi:10.1038/nn1290 · Cited by 625 · see citing works

Effects of early adverse experiences on brain structure and function: clinical implications

Kaufman, J., Plotsky, P. M., Nemeroff, C. B., & Charney, D. S. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00998-7 · Cited by 508 · see citing works

Stress and depression: possible links to neuron death in the hippocampus

Lee, A. L., Ogle, W. O., & Sapolsky, R. M. (2002) · Bipolar Disorders · doi:10.1034/j.1399-5618.2002.01144.x · Cited by 462 · see citing works

A Behavioral Assessment of Hippocampal Function Based on a Subregional Analysis

Kesner, R. P., Lee, I., & Gilbert, P. E. (2004) · Reviews in the Neurosciences · doi:10.1515/revneuro.2004.15.5.333 · Cited by 435 · see citing works

Glucocorticoid regulation of diverse cognitive functions in normal and pathological emotional states

Erickson, K., Drevets, W. C., & Schulkin, J. A. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(03)00033-2 · Cited by 408 · see citing works

Chronic stress attenuates glucocorticoid negative feedback: involvement of the prefrontal cortex and hippocampus

Mizoguchi, K., Ishige, A., Aburada, M., & Tabira, T. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00105-2 · Cited by 369 · see citing works

Quantitation of Dihydropyrimidine Dehydrogenase Expression by Real-Time Reverse Transcription Polymerase Chain Reaction

Johnson, M. R., Wang, K., Smith, J. B., Heslin, M. J., & Diasio, R. B. (2000) · Analytical Biochemistry · doi:10.1006/abio.1999.4461 · Cited by 337 · see citing works

Influence of Postweaning Social Isolation in the Rat on Brain Development, Conditioned Behavior, and Neurotransmission

Lapiz, M. D. S., Fulford, A., Muchimapura, S., Mason, R., Parker, T., & Marsden, C. A. (2003) · Neuroscience and Behavioral Physiology · doi:10.1023/a:1021171129766 · Cited by 305 · see citing works

Responses to maternal separation : mechanisms and mediators

Kuhn, C. M., & Schanberg, S. M. (1998) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(98)00034-3 · Cited by 287 · see citing works

11β-Hydroxysteroid Dehydrogenase in the Brain: A Novel Regulator of Glucocorticoid Action?

Seckl, J. R. (1997) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1996.0143 · Cited by 213 · see citing works

Regulation of adrenocorticosteroid receptor mRNA expression in the central nervous system

Herman, J. P. (1993) · Cellular and Molecular Neurobiology · doi:10.1007/bf00711577 · Cited by 204 · see citing works

Prefrontal Cortex and Working Memory for Spatial Response, Spatial Location, and Visual Object Information in the Rat

Kesner, R. P., Hunt, M. E., Williams, J. M., & Long, J. M. (1996) · Cerebral Cortex · doi:10.1093/cercor/6.2.311 · Cited by 201 · see citing works

Consequences of repeated early isolation in domestic piglets (Sus scrofa) on their behavioural, neuroendocrine, and immunological responses

Kanitz, E., Tuchscherer, M., Puppe, B., Tuchscherer, A., & Stabenow, B. (2004) · Brain, Behavior, and Immunity · doi:10.1016/s0889-1591(03)00085-0 · Cited by 200 · see citing works

Endogenous glucocorticoids are essential for maintaining prefrontal cortical cognitive function

Mizoguchi, K., Ishige, A., Takeda, S., Aburada, M., & Tabira, T. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0086-04.2004 · Cited by 192 · see citing works

Regulation of glucocorticoid and mineralocorticoid receptor mRNAs in the hippocampus of the maternally deprived infant rat

Vázquez, D. M., van Oers, H. J. J., Levine, S. D., & Akil, H. (1996) · Brain Research · doi:10.1016/0006-8993(96)00465-9 · Cited by 122 · see citing works

11β-Hydroxysteroid dehydrogenase type 2 in the postnatal and adult rat brain

Robson, A. C., Leckie, C. M., Seckl, J. R., & Holmes, M. C. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00161-2 · Cited by 108 · see citing works

Proceedings of the 37th International Congress of the ISAE

Mendl, M., & Taylor, N. S. (2003) · Bristol Research (University of Bristol) · Cited by 84 · see citing works

The effects of early contact with humans on the subsequent level of fear of humans in pigs

Hemsworth, P. H., & Barnett, J. L. (1992) · Applied Animal Behaviour Science · doi:10.1016/0168-1591(92)90018-7 · Cited by 82 · see citing works

Brain mineralocorticoid receptor diversity: functional implications.

de Kloet, E. D., Sutanto, W., van den Berg, D. T., Carey, M. P., van Haarst, A. D., Hornsby, C., Meijer, O., Rots, N. Y., & Oitzl, M. (1993) · Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(93)90073-6 · Cited by 77 · see citing works

The influence of early contact with humans on subsequent behavioural response of pigs to humans

Hemsworth, P. H., Barnett, J. L., Hansen, C. F., & Gonyou, H. W. (1986) · Applied Animal Behaviour Science · doi:10.1016/0168-1591(86)90022-5 · Cited by 74 · see citing works

Responses of guinea pig pups during isolation in a novel environment may represent stress-induced sickness behaviors

Hennessy, M. B., Terrence Deak, B., Schiml‐Webb, P. A., Wilson, S. E., Greenlee, T. M., & McCall, E. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2003.11.008 · Cited by 74 · see citing works

Neonatal handling permanently alters hypothalamic-pituitary- adrenal axis function, behaviour, and body weight in boars

Weaver, S., AHERNE, F. X., Meaney, M., Schaefer, A. L., & Dixon, W. T. (2000) · Journal of Endocrinology · doi:10.1677/joe.0.1640349 · Cited by 71 · see citing works

Effects of postnatal social isolation on hormonal and immune responses of pigs to an acute endotoxin challenge

Tuchscherer, M., Kanitz, E., Puppe, B., Tuchscherer, A., & Stabenow, B. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.04.056 · Cited by 66 · see citing works

11β‐Hydroxysteroid Dehydrogenases in the Brain

Holmes, M. C., Yau, J. L. W., Kotelevtsev, Y. V., Mullins, J. J., & Seckl, J. R. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1286.035 · Cited by 60 · see citing works

STEROIDS AND THE NERVOUS SYSTEM

Holmes, M. C., Yau, J. L. W., Kotelevtsev, Y. V., Mullins, J. J., & Seckl, J. R. (2003) · Cited by 57 · see citing works

Few differences found between early- and late-weaned pigs raised in the same environment.

Hohenshell, L., Cunnick, J. E., Ford, S. P., Kattesh, H. G., Zimmerman, D. R., Wilson, M. E., Matteri, R. L., Carroll, J. A., & Lay, D. C., Jr. (2000) · Journal of Animal Science · doi:10.2527/2000.78138x · Cited by 53 · see citing works

Regulation of ischemic cell death by glucocorticoids and adrenocorticotropic hormone

Antonawich, F. J., Miller, G., Rigsby, D. C., & Davis, J. N. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00213-9 · Cited by 52 · see citing works

Belly-nosing in early-weaned piglets is not influenced by diet quality or the presence of milk in the diet.

Gardner, J., de Lange, C. F., & Widowski, T. M. (2001) · Journal of Animal Science · doi:10.2527/2001.79173x · Cited by 51 · see citing works

Neuroendocrine consequences of very early weaning in swine

Hay, M., Orgeur, P., Lévy, F., Dividich, J. L., Concordet, D., Nowak, R., Schaal, B., & Mormède, P. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(00)00404-2 · Cited by 49 · see citing works

Hormones as regulators of brain development: life‐long effects related to health and disease

McEwen, B. S. (1997) · Acta Paediatrica · doi:10.1111/j.1651-2227.1997.tb18343.x · Cited by 48 · see citing works

Behavioural, growth and immune consequences of early weaning in one-week-old Large-White piglets

Orgeur, P., Hay, M., Mormède, P., Salmon, H., Dividich, J. L., Nowak, R., Schaal, B., & Lévy, F. (2001) · annales de biologie animale biochimie biophysique · doi:10.1051/rnd:2001134 · Cited by 44 · see citing works

Effects of weaning and restraint stress on glucocorticoid receptor binding capacity in limbic areas of domestic pigs

Kanitz, E., Manteuffel, G., & Otten, W. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00712-4 · Cited by 42 · see citing works

The influence of weaning age on post-mixing agonistic interactions in growing pigs

Yuan, Y., Jansen, J., Charles, D., & Zanella, A. J. (2004) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2004.01.012 · Cited by 25 · see citing works

Characterization of mineralocorticoid and glucocorticoid receptors in pigs: Comparison of Meishan and large white breeds

Perreau, V., Sarrieau, A., & Mormède, P. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00087-9 · Cited by 21 · see citing works

Loneliness matters: a theoretical and empirical review of consequences and mechanisms

Hawkley, L. C., & Cacioppo, J. T. (2010) · Annals of Behavioral Medicine · doi:10.1007/s12160-010-9210-8 · Cited by 4,782 · see citing works

Perceived social isolation and cognition

Cacioppo, J. T., & Hawkley, L. C. (2009) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2009.06.005 · Cited by 2,144 · see citing works

Early skin-to-skin contact for mothers and their healthy newborn infants

Moore, E. R., Bergman, N., Anderson, G. C., & Medley, N. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003519.pub4 · Cited by 1,797 · see citing works

Social relationships and health: The toxic effects of perceived social isolation

Cacioppo, J. T., & Cacioppo, S. (2014) · Social and Personality Psychology Compass · doi:10.1111/spc3.12087 · Cited by 1,057 · see citing works

11β-hydroxysteroid dehydrogenases: Intracellular gate-keepers of tissue glucocorticoid action

Chapman, K., Holmes, M., & Seckl, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00020.2012 · Cited by 887 · see citing works

Alone in the crowd: The structure and spread of loneliness in a large social network.

Cacioppo, J. T., Fowler, J. H., & Christakis, N. A. (2009) · Journal of Personality and Social Psychology · doi:10.1037/a0016076 · Cited by 844 · see citing works

Evolutionary mechanisms for loneliness

Cacioppo, J. T., Cacioppo, S., & Boomsma, D. I. (2014) · Cognition and Emotion · doi:10.1080/02699931.2013.837379 · Cited by 576 · see citing works

Social isolation

Cacioppo, J. T., Hawkley, L. C., Norman, G. J., & Berntson, G. G. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06028.x · Cited by 554 · see citing works

The use of pigs in neuroscience: Modeling brain disorders

Lind, N. M., Moustgaard, A., Jelsing, J., Vajta, G., Cumming, P. D., & Hansen, A. K. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.02.003 · Cited by 515 · see citing works

Early skin-to-skin contact for mothers and their healthy newborn infants

Moore, E. R., Anderson, G. C., Bergman, N., & Dowswell, T. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003519.pub3 · Cited by 474 · see citing works

Invited review: Effects of group housing of dairy calves on behavior, cognition, performance, and health

Costa, J. H. C., von Keyserlingk, M. A. G., & Weary, D. M. (2016) · Journal of Dairy Science · doi:10.3168/jds.2015-10144 · Cited by 283 · see citing works

Effects of social isolation on glucocorticoid regulation in social mammals

Hawkley, L. C., Cole, S. W., Capitanio, J. P., Norman, G. J., & Cacioppo, J. T. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.05.011 · Cited by 262 · see citing works

11β-Hydroxysteroid dehydrogenases and the brain: From zero to hero, a decade of progress

Wyrwoll, C. S., Holmes, M. C., & Seckl, J. R. (2011) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.12.001 · Cited by 244 · see citing works

Maternal deprivation and the development of stereotypic behaviour

Latham, N., & Mason, G. J. (2007) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2007.03.026 · Cited by 186 · see citing works

No Control Genes Required: Bayesian Analysis of qRT-PCR Data

Matz, M. V., Wright, R. M., & Scott, J. G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071448 · Cited by 177 · see citing works

Birth practices: Maternal‐neonate separation as a source of toxic stress

Bergman, N. (2019) · Birth Defects Research · doi:10.1002/bdr2.1530 · Cited by 165 · see citing works

A review of behavioural methods to study emotion and mood in pigs, Sus scrofa

Murphy, E., Nordquist, R. E., & van der Staay, F. J. (2014) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2014.08.002 · Cited by 123 · see citing works

Effects of Degree and Timing of Social Housing on Reversal Learning and Response to Novel Objects in Dairy Calves

Meagher, R. K., Daros, R. R., Costa, J. H. C., von Keyserlingk, M. A. G., Hötzel, M. J., & Weary, D. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132828 · Cited by 121 · see citing works

Pain Management in Farm Animals: Focus on Cattle, Sheep and Pigs

Steagall, P. V. M., Bustamante, H., Johnson, C. B., & Turner, P. V. (2021) · Animals · doi:10.3390/ani11061483 · Cited by 121 · see citing works

A Neurologic Perspective of Equine Stereotypy

McBride, S. D., & Hemmings, A. (2009) · Journal of Equine Veterinary Science · doi:10.1016/j.jevs.2008.11.008 · Cited by 99 · see citing works

Linking Animal Welfare and Antibiotic Use in Pig Farming—A Review

Albernaz-Gonçalves, R., Olmos, G., & Hötzel, M. J. (2022) · Animals · doi:10.3390/ani12020216 · Cited by 83 · see citing works

A single exposure to social isolation in domestic piglets activates behavioural arousal, neuroendocrine stress hormones, and stress-related gene expression in the brain

Kanitz, E., Puppe, B., Tuchscherer, M., Heberer, M., Viergutz, T., & Tuchscherer, A. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.05.007 · Cited by 81 · see citing works

Psychosocial Stress and Immunity—What Can We Learn From Pig Studies?

Gimsa, U., Tuchscherer, M., & Kanitz, E. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00064 · Cited by 79 · see citing works

Long-Term and Transgenerational Effects of Stress Experienced during Different Life Phases in Chickens (Gallus gallus)

Ericsson, M., Henriksen, R., Bélteky, J., Sundman, A.-S., Shionoya, K., & Jensen, P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0153879 · Cited by 73 · see citing works

The Effect of Psychological Stress and Social Isolation on Neuroimmunoendocrine Communication

Cruces, J., Venero, C., Pereda-Pérez, I., & la Fuente, M. D. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612820666140130205822 · Cited by 63 · see citing works

Advances in Swine Transcriptomics

Tuggle, C. K., Wang, Y., & Couture, O. P. (2007) · International Journal of Biological Sciences · doi:10.7150/ijbs.3.132 · Cited by 63 · see citing works

Genetics and genomics of animal behaviour and welfare—Challenges and possibilities

Jensen, P., Buitenhuis, B., Kjær, J. B., Zanella, A. J., Mormède, P., & Pizzari, T. (2008) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2008.01.012 · Cited by 62 · see citing works

The neuropeptide Pth2 dynamically senses others via mechanosensation

Anneser, L., Alcantara, I. C., Gemmer, A., Mirkes, K., Ryu, S., & Schuman, E. M. (2020) · Nature · doi:10.1038/s41586-020-2988-z · Cited by 60 · see citing works

Development of ingestive behaviour and the relationship to belly nosing in early-weaned piglets

Widowski, T. M., Torrey, S., Bench, C. J., & Gonyou, H. W. (2007) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2007.04.010 · Cited by 57 · see citing works

Welfare of Pigs in the Farrowing Environment

Johnson, A. K., & Marchant, J. N. (2008) · Animal welfare · doi:10.1007/978-1-4020-8909-1_5 · Cited by 54 · see citing works

Hormonal correlates of male life history stages in wild white-faced capuchin monkeys (Cebus capucinus)

Jack, K. M., Schoof, V. A. M., Sheller, C. R., Rich, C. I., Klingelhofer, P. P., Ziegler, T. E., & Fedigan, L. M. (2013) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2013.10.010 · Cited by 48 · see citing works

Physiological and behavioural responses to weaning conflict in free-ranging primate infants

Mandalaywala, T. M., Higham, J. P., Heistermann, M., Parker, K. J., & Dario Maestripieri, A. (2014) · Animal Behaviour · doi:10.1016/j.anbehav.2014.09.016 · Cited by 43 · see citing works

Disentangling the effects of weaning stressors on piglets’ behaviour and feed intake: Changing the housing and social environment

Hötzel, M. J., de Souza, G. P., Costa, O. A. D., & Filho, L. C. P. M. (2011) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2011.09.003 · Cited by 38 · see citing works

Behavior of Pigs Reared in Enriched Environment: Alternatives to Extend Pigs Attention

Machado, S. P., Caldara, F. R., Foppa, L., de Moura, R., Gonçalves, L. M. P., Garcia, R. G., Nääs, I. D. A., dos Santos, V. M. O., & de Oliveira, G. F. (2017) · PLoS ONE · doi:10.1371/journal.pone.0168427 · Cited by 37 · see citing works

Factors Influencing Individual Variation in Farm Animal Cognition and How to Account for These Statistically

Bushby, E. V., Friel, M., Goold, C. M., Gray, H. E., Smith, L., & Collins, L. (2018) · Frontiers in Veterinary Science · doi:10.3389/fvets.2018.00193 · Cited by 36 · see citing works

Age over experience: Consistency of aggression and mounting behaviour in male and female pigs

Clark, C. C. A., & D’Eath, R. B. (2013) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2013.04.014 · Cited by 36 · see citing works

Investigation of changes in global gene expression in the frontal cortex of early-weaned and socially isolated piglets using microarray and quantitative real-time RT-PCR

Poletto, R., Siegford, J. M., Steibel, J. P., Coussens, P. M., & Zanella, A. J. (2005) · Brain Research · doi:10.1016/j.brainres.2005.11.012 · Cited by 31 · see citing works

Environmental enrichment for pregnant sows modulates HPA-axis and behavior in the offspring

Tatemoto, P., Bernardino, T., Alves, L. R., Souza, A. C. D. O., Palme, R., & Zanella, A. J. (2019) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2019.104854 · Cited by 28 · see citing works

3. Managing the litter from hyperprolific sows

Baxter, E., Schmitt, O., & Pedersen, L. J. (2020) · Wageningen Academic Publishers eBooks · doi:10.3920/978-90-8686-894-0_3 · Cited by 26 · see citing works

Gene expression of serotonin and dopamine receptors and monoamine oxidase-A in the brain of dominant and subordinate pubertal domestic pigs (Sus scrofa) fed a β-adrenoreceptor agonist

Poletto, R., Cheng, H.-W., Meisel, R. L., Richert, B. T., & Marchant, J. N. (2010) · Brain Research · doi:10.1016/j.brainres.2010.11.035 · Cited by 26 · see citing works

Stereotypic Behavior in Sows Is Related to Emotionality Changes in the Offspring

Tatemoto, P., Bernardino, T., Morrone, B., Queiroz, M. R., & Zanella, A. J. (2020) · Frontiers in Veterinary Science · doi:10.3389/fvets.2020.00079 · Cited by 26 · see citing works

Interacting impact of maternal inflammatory response and stress on the amygdala transcriptome of pigs

Keever-Keigher, M. R., Zhang, P., Bolt, C. R., Rymut, H. E., Antonson, A. M., Caputo, M. P., Houser, A. K., Hernandez, A. G., Southey, B. R., Rund, L. A., et al. (2021) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkab113 · Cited by 24 · see citing works

Anxiety-like, novelty-seeking and memory/learning behavioral traits in male Wistar rats submitted to early weaning

Fraga, M. C., de Moura, E. G., Lima, N. D. S., Lisboa, P. C., OLIVEIRA, E. B. D., Silva, J. O., Claudio-Neto, S., Filgueiras, C. C., Abreu‐Villaça, Y., & Manhães, A. C. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.11.001 · Cited by 22 · see citing works

Sham-Chewing in Sows Is Associated With Decreased Fear Responses in Their Offspring

Tatemoto, P., Bernardino, T., Alves, L. R., & Zanella, A. J. (2019) · Frontiers in Veterinary Science · doi:10.3389/fvets.2019.00390 · Cited by 22 · see citing works

Effects of early social separation on the behaviour of kittens of the domestic cat

Martínez-Byer, S., Hudson, R., Bánszegi, O., & Szenczi, P. (2023) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2023.105849 · Cited by 20 · see citing works

Changes in Stereotypies: Effects over Time and over Generations

Tatemoto, P., Broom, D. M., & Zanella, A. J. (2022) · Animals · doi:10.3390/ani12192504 · Cited by 22 · see citing works

The in-utero experience of piglets born from sows with lameness shapes their life trajectory

Sarmiento, M. P., Bernardino, T., Tatemoto, P., Polo, G., & Zanella, A. J. (2021) · Scientific Reports · doi:10.1038/s41598-021-92507-2 · Cited by 20 · see citing works

Social Support Modulates Stress-Related Gene Expression in Various Brain Regions of Piglets

Kanitz, E., Hameister, T., Tuchscherer, A., Tuchscherer, M., & Puppe, B. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00227 · Cited by 20 · see citing works

Isolation and characterization of novel human short-chain dehydrogenase/reductase SCDR10B which is highly expressed in the brain and acts as hydroxysteroid dehydrogenase.

Huang, C., Wan, B., Gao, B., Hexige, S., & Yu, L. (2009) · Acta Biochimica Polonica · doi:10.18388/abp.2009_2460 · Cited by 19 · see citing works

Liver transcriptome profiling and functional analysis of intrauterine growth restriction (IUGR) piglets reveals a genetic correction and sexual-dimorphic gene expression during postnatal development

Gao, H., Zhang, L., Wang, L., Liu, X., Hou, X., Zhao, F., Yan, H., & Wang, L. (2020) · BMC Genomics · doi:10.1186/s12864-020-07094-9 · Cited by 18 · see citing works

Early weaning results in less active behaviour, accompanied by lower 5-HT1A and higher 5-HT2A receptor mRNA expression in specific brain regions of female pigs

SUMNER, B. E. H., D’Eath, R. B., Farnworth, M. J., Robson, S. K., Russell, J. A., Lawrence, A. B., & Jarvis, S. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.05.004 · Cited by 17 · see citing works

Pig Breeding for Increased Sustainability

Knap, P. W. (2012) · Springer eBooks · doi:10.1007/978-1-4419-0851-3_342 · Cited by 18 · see citing works

Terpenoid Backbone Biosynthesis among Pig Hippocampal Pathways Impacted by Stressors

Rymut, H. E., Rund, L. A., Southey, B. R., Johnson, R. W., & Rodriguez‐Zas, S. L. (2022) · Genes · doi:10.3390/genes13050814 · Cited by 16 · see citing works

Short-term behavioural effects of weaning age in outdoor-reared piglets

Hötzel, M. J., Filho, L. C. P. M., Irgang, R., & Filho, L. A. (2009) · animal · doi:10.1017/s1751731109990875 · Cited by 16 · see citing works

An enriched maternal environment and stereotypies of sows differentially affect the neuro-epigenome of brain regions related to emotionality in their piglets

Tatemoto, P., Pértille, F., Bernardino, T., Zanella, R., Guerrero‐Bosagna, C., & Zanella, A. J. (2023) · Epigenetics · doi:10.1080/15592294.2023.2196656 · Cited by 13 · see citing works

Social isolation elicits deficits in the ability of newly weaned female piglets to recognise conspecifics

Souza, A. S., & Zanella, A. J. (2007) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2007.03.023 · Cited by 13 · see citing works

Porcine glucocorticoid receptor (NR3C1) gene: Tissue-specificity of transcriptional strength and glucocorticoid responsiveness of alternative promoters

Jiang, Z., Qian, L., Zou, H., Jia, Y., Ni, Y., Yang, X., Jiang, Z., & Zhao, R. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.01.012 · Cited by 12 · see citing works

Characterizing the postnatal hypothalamic–pituitary–adrenal axis response of in utero heat stressed pigs at 10 and 15 weeks of age

Maskal, J. M., Brito, L. F., Duttlinger, A. W., Kpodo, K. R., McConn, B. R., Byrd, C. J., Richert, B. T., Marchant, J. N., Lay, D. C., Jr., Perry, S. D., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-01889-w · Cited by 10 · see citing works

Acute cannabidiol treatment attenuates ethanol-induced place preference and reduces aggressivity in group-housed male rats

Andaloussi, Z. I. L., Lauer, W., Zulu, S. S., Taghzouti, K., & Abboussi, O. (2021) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2021.173290 · Cited by 10 · see citing works

Artificial rearing affects the emotional state and reactivity of pigs post-weaning

Schmitt, O., O’Driscoll, K., Baxter, E., & Boye, L. (2019) · Animal Welfare · doi:10.7120/09627286.28.4.433 · Cited by 9 · see citing works

Immune and metabolic challenges induce changes in pain sensation and related pathways in the hypothalamus

Rodriguez‐Zas, S. L., Nowak, R. A., Antonson, A. M., Rund, L. A., Bhamidi, S., Gomez, A. N., Southey, B. R., & Johnson, R. W. (2024) · Physiological Genomics · doi:10.1152/physiolgenomics.00134.2023 · Cited by 8 · see citing works

Asinine milk mitigates stress-mediated immune, cortisol and behavioral responses of piglets to weaning: A study to foster future interventions in humans

Farias, S. D. S., Montechese, A. C. D., Mufalo, V. C., Sabei, L., Sarmiento, M. P., da Silva, A. N., Ferraz, P. A., Pugliesi, G., Ribeiro, C. V. D. M., Oliveira, C. A. D. A., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1139249 · Cited by 9 · see citing works

Breed-specific expression of hippocampal 11β-hydroxysteroid dehydrogenases and glucocorticoid receptors in Erhualian and Pietrain pigs exhibiting distinct stress coping characteristics

Wei, S., Xia, D., Li, L., Xiao, J.-S., Bao, J.-W., Parvizi, N., & Zhao, R. (2010) · Livestock Science · doi:10.1016/j.livsci.2010.04.007 · Cited by 8 · see citing works

Genome‐wide association study of periweaning failure‐to‐thrive syndrome (PFTS) in pigs

Zanella, R., Morés, N., Morés, M. A. Z., Peixoto, J. D. O., Zanella, E. L., Zanella, J. R. C., Ibelli, A. M. G., Gava, D., Cantão, M. E., & Ledur, M. C. (2016) · Veterinary Record · doi:10.1136/vr.103546 · Cited by 7 · see citing works

Gut Microbiome Characteristics of Horses with History of Cribbing Behavior: An Observational Study

Arias-Esquivel, A. M., Jeong, K. C., Fan, P. F., Lance, J. M., DeNotta, S. A. L., & Wickens, C. L. (2023) · Journal of Veterinary Behavior · doi:10.1016/j.jveb.2023.12.008 · Cited by 6 · see citing works

p53 Cooperates with Sp1 to Regulate Breed-Dependent Expression of Glucocorticoid Receptor in the Liver of Preweaning Piglets

Zou, H., Jiang, Z., Li, R., Jia, Y., Yang, X., Ni, Y., & Zhao, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070494 · Cited by 7 · see citing works

Inheriting the sins of their fathers: boar life experiences can shape the emotional responses of their offspring

Sabei, L., Sarmiento, M. P., Bernardino, T., Çakmakçı, C., Farias, S. D. S., Sato, D., Zanella, M. I. G., Poletto, R., & Zanella, A. J. (2023) · Frontiers in Animal Science · doi:10.3389/fanim.2023.1208768 · Cited by 5 · see citing works

Genetic Contributions to Aggressive Behaviour in Pigs: A Comprehensive Review

Kazantseva, A. V., Bilyalov, A. I., Filatov, N. S., Perepechenov, S. S., & Gusev, O. (2025) · Genes · doi:10.3390/genes16050534 · Cited by 4 · see citing works

Life-course effects of early life adversity exposure on eating behavior and metabolism

de Lima, R. M. S., Barth, B., Arcego, D. M., Krolow, R., Silveira, P. P., & Dalmaz, C. (2021) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2021.02.003 · Cited by 4 · see citing works

Influence of Maternal Immune Activation and Stressors on the Hippocampal Metabolome

Southey, B. R., Johnson, R. W., & Rodriguez‐Zas, S. L. (2023) · Metabolites · doi:10.3390/metabo13080881 · Cited by 4 · see citing works

Pig Breeding for Increased Sustainability

Knap, P. W. (2022) · Encyclopedia of sustainability science and technology series · doi:10.1007/978-1-0716-2460-9_342 · Cited by 4 · see citing works

Pig farming practices compromising biosecurity and causing poor welfare of pigs

Tatemoto, P., Vieira, F., & Broom, D. M. (2025) · Frontiers in Veterinary Science · doi:10.3389/fvets.2025.1558734 · Cited by 3 · see citing works

Biological Dogmas in Relation to the Origin of Evolutionary Novelties

Tatemoto, P., & Guerrero‐Bosagna, C. (2018) · Springer eBooks · doi:10.1007/978-3-319-95954-2_17 · Cited by 3 · see citing works

Pig Breeding for Increased Sustainability

Knap, P. W. (2013) · Springer eBooks · doi:10.1007/978-1-4614-5797-8_342 · Cited by 3 · see citing works

Housing Conditions and a Challenge with Lipopolysaccharide on the Day of Estrus Can Influence Gene Expression of the Corpus Luteum in Gilts

da Silva, A. N., Alves, L. R., Osowski, G. V., Sabei, L., Ferraz, P. A., Pugliesi, G., Marques, M. G., Zanella, R., & Zanella, A. J. (2022) · Genes · doi:10.3390/genes13050769 · Cited by 3 · see citing works

Pig Breeding for Increased Sustainability

Knap, P. W. (2022) · Springer eBooks · doi:10.1007/978-1-4939-2493-6_342-3 · Cited by 3 · see citing works

The (un-)Social Brain in Isolation

Fishman, A., Grinin, P., & RILJAK, V. (2025) · Physiological Research · doi:10.33549/physiolres.935565 · Cited by 2 · see citing works

Early weaning alters redox status in the hippocampus and hypothalamus of rat pups

RODRIGUES, K. D. S., Klein, C. P., August, P. M., dos Santos, B. G., Hözer, R. M., Maurmann, R. M., Crestani, M. S., Hoppe, J. B., & Matté, C. (2020) · International Journal of Developmental Neuroscience · doi:10.1002/jdn.10047 · Cited by 2 · see citing works

Epigenetic changes in red blood cells during the life of chickens exposed to social isolation stress or an enriched environment

Sourani, F., Pértille, F., Sharif, M. E., Fröhlich, A. S., Jensen, P., & Guerrero‐Bosagna, C. (2026) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2025.0016 · Cited by 1 · see citing works

Glucocorticoid receptor is involved in the differential expression of hepatic 3β‐hydroxysteroid dehydrogenase between barrows and boars at finishing stage

Li, X., Cong, R., Yao, W., Jia, Y., Li, R., Sun, Z., Li, X., & Zhao, R. (2017) · Animal Science Journal · doi:10.1111/asj.12853 · Cited by 1 · see citing works

Undesirable Behaviour and Stress

Pearson, G., Waran, N. K., & Fraser, A. F. (2022) · CABI eBooks · doi:10.1079/9781789242133.0013 · Cited by 1 · see citing works

Effects of weaning age and maze wall type on piglet behavior and cognition

Ferreira, A. S., Bonifácio, C. T., Júnior, G. M. D. O., Fraga, A. Z., de Oliveira, B. L., & da Silva, D. A. (2024) · Livestock Science · doi:10.1016/j.livsci.2024.105414 · Cited by 1 · see citing works

Genomic analysis of stress, aggression and boldness in rainbow trout

Sims, A. M. (2013) · University of Liverpool · doi:10.17638/00009535 · Cited by 1 · see citing works

The role of material stereotypic behaviour on developmental outcomes in piglets

Tatemoto, P. (2019) · doi:10.11606/t.10.2019.tde-30042019-110553

Current World Literature

(2007) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3281de7489

Additional file 1 of Liver transcriptome profiling and functional analysis of intrauterine growth restriction (IUGR) piglets reveals a genetic correction and sexual-dimorphic gene expression during postnatal development

Gao, H., Zhang, L., Wang, L., Liu, X., Hou, X., Zhao, F., Yan, H., & Wang, L. (2020) · Figshare · doi:10.6084/m9.figshare.13071214

The role of material stereotypic behaviour on developmental outcomes in piglets

Tatemoto, P. (2018) · doi:10.11606/t.10.2018.tde-30042019-110553

Investigation of changes in global gene expression in the frontal cortex of early-weaned and socially isolated piglets using microarray and quantitative real-time RT-PCR

Poletto, R., Siegford, J. M., Steibel, J. P., Coussens, P. M., & Zanella, A. J. (2005) · Brain Research · doi:10.1016/j.brainres.2005.11.012 · Cited by 31 · see citing works

A single exposure to social isolation in domestic piglets activates behavioural arousal, neuroendocrine stress hormones, and stress-related gene expression in the brain

Kanitz, E., Puppe, B., Tuchscherer, M., Heberer, M., Viergutz, T., & Tuchscherer, A. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.05.007 · Cited by 81 · see citing works

Early weaning results in less active behaviour, accompanied by lower 5-HT1A and higher 5-HT2A receptor mRNA expression in specific brain regions of female pigs

SUMNER, B. E. H., D’Eath, R. B., Farnworth, M. J., Robson, S. K., Russell, J. A., Lawrence, A. B., & Jarvis, S. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.05.004 · Cited by 17 · see citing works

Consequences of repeated early isolation in domestic piglets (Sus scrofa) on their behavioural, neuroendocrine, and immunological responses

Kanitz, E., Tuchscherer, M., Puppe, B., Tuchscherer, A., & Stabenow, B. (2004) · Brain, Behavior, and Immunity · doi:10.1016/s0889-1591(03)00085-0 · Cited by 200 · see citing works

The immediate effects of weaning stress on the hypothalamus‐pituitary‐adrenal alteration of newly weaned piglets

Yu, C., Chen, C., & Chang, C. (2019) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.13104 · Cited by 23 · see citing works