Prenatal tobacco exposure and self-regulation in early childhood: implications for developmental psychopathology
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Prenatal tobacco exposure (PTE) has a well-documented association with disruptive behavior in childhood, but the neurocognitive effects of exposure that underlie this link are not sufficiently understood. The present study was designed to address this gap, through longitudinal follow-up in early childhood of a prospectively enrolled cohort with well-characterized prenatal exposure. Three-year-old children (n = 151) were assessed using a developmentally sensitive battery capturing both cognitive and motivational aspects of self-regulation. PTE was related to motivational self-regulation, where children had to delay approach to attractive rewards, but not cognitive self-regulation, where children had to hold information in mind and inhibit prepotent motor responses. Furthermore, PTE predicted motivational self-regulation more strongly in boys than in girls, and when propensity scores were covaried to control for confounding risk factors, the effect of PTE on motivational self-regulation was significant only in boys. These findings suggest that PTE's impact on neurodevelopment may be greater in boys than in girls, perhaps reflecting vulnerability in neural circuits that subserve reward sensitivity and emotion regulation, and may also help to explain why PTE is more consistently related to disruptive behavior disorders than attention problems.
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Recent high-quality prospective studies using multimethod exposure measurement and propensity score modeling have delineated a coherent pattern of disruptive behavior associated with prenatal tobacco exposure beginning in early childhood.
“More recently, high quality, prospective studies using multimethod exposure measurement and propensity score modeling have delineated a coherent pattern of disruptive behavior associated with prenatal tobacco exposure, beginning in early childhood.”
From Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products (2017) · cites this paper as [152]
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- Authors
- Wiebe, S. A., Clark, C. A. C., De Jong, D. M., Chevalier, N., Espy, K. A., & Wakschlag, L.
- Affiliations
- University of Alberta (CA)
- University of Arizona (US)
- University of Edinburgh (GB)
- University of Nebraska–Lincoln (US)
- Northwestern University (US)
- Corresponding author
- Wiebe, Sandra A.
- Venue
- Development and Psychopathology
- Publisher
- Cambridge University Press (CUP)
- Published
- 2015-05
- Volume
- 27
- Issue
- 2
- Pages
- 397-409
- ISSN
- 0954-5794 (ISSN-L)
- 1469-2198
- PMC
- PMC10112534
- OpenAlex
- W2219115549
- Cited by
- 57
- References
- 129
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 7 · 2023: 6 · 2022: 7 · 2021: 5 · 2020: 5 · 2019: 2 · 2018: 4 · 2017: 6 · 2016: 8 · 2015: 1 · 2013: 1
- FWCI
- 6.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Development and Psychopathology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Funders
- National Institute on Drug Abuse (R21DA024769, R01DA023653, R01DA014661)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- prenatal tobacco exposure, self-regulation, motivational self-regulation, cognitive self-regulation, early childhood, disruptive behavior disorders, sex differences, reward sensitivity, emotion regulation, brain development, inhibitory control, delay of gratification
- MeSH terms
- Self-Control, Attention, Child, Preschool, Cognition, Female, Humans, Male, Motivation, Neuropsychological Tests, Pregnancy, Prenatal Exposure Delayed Effects, Risk Factors, Smoking
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