Rodent models for Alzheimer’s disease drug discovery

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works

Alzheimer's Disease Is a Synaptic Failure

Selkoe, D. J. (2002) · Science · doi:10.1126/science.1074069 · Cited by 4,420 · see citing works

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., & Cole, G. (1996) · Science · doi:10.1126/science.274.5284.99 · Cited by 4,210 · see citing works

Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles

Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126 · see citing works

Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation

Oakley, H., Cole, S. L., Logan, S., Maus, E., Shao, P., Craft, J., Guillozet-Bongaarts, A., Ohno, M., Disterhoft, J., Van Eldik, L., et al. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1202-06.2006 · Cited by 3,530 · cited 1× · see citing works

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

Games, D., Adams, D., Alessandrini, R., Barbour, R., Borthelette, P., Blackwell, C., Carr, T., Clemens, J., Donaldson, T., Gillespie, F., et al. (1995) · Nature · doi:10.1038/373523a0 · Cited by 2,516 · see citing works

Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

Borchelt, D. R., Thinakaran, G., Eckman, C. B., Lee, M. K., Davenport, F., Ratovitsky, T., Prada, C.-M., Kim, G., Seekins, S., Yager, D., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80230-5 · Cited by 1,478 · see citing works

Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

Duff, K., Eckman, C., Zehr, C., Yu, X., Prada, C.-M., Pérez‐Tur, J., Hutton, M., Buée, L., Harigaya, Y., Yager, D., et al. (1996) · Nature · doi:10.1038/383710a0 · Cited by 1,453 · see citing works

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

Holcomb, L., Gordon, M. N., McGowan, E., Yu, X., Benkovic, S., Jantzen, P., Wright, K., Saad, I., Mueller, R., Morgan, D., et al. (1998) · Nature Medicine · doi:10.1038/nm0198-097 · Cited by 1,386 · see citing works

Intraneuronal Aβ Causes the Onset of Early Alzheimer’s Disease-Related Cognitive Deficits in Transgenic Mice

Billings, L. M., Oddo, S., Green, K. N., McGaugh, J. L., & LaFerla, F. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.040 · Cited by 1,294 · see citing works

Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins

Borchelt, D. R., Ratovitski, T., van Lare, J., Lee, M. K., Gonzales, V., Jenkins, N. A., Copeland, N. G., Price, D. L., & Sisodia, S. S. (1997) · Neuron · doi:10.1016/s0896-6273(00)80974-5 · Cited by 1,023 · see citing works

Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice

Chapman, P. F., White, G. L., Jones, M. W., Cooper-Blacketer, D., Marshall, V. J., Irizarry, M., Younkin, L., Good, M. A., Bliss, T. V. P., Hyman, B. T., et al. (1999) · Nature Neuroscience · doi:10.1038/6374 · Cited by 946 · see citing works

A new murine model of accelerated senescence

Takeda, T., HOSOKAWA, M., TAKESHITA, S., Irino, M., Higuchi, K., Matsushita, T., Tomita, Y., Yasuhira, K., Hamamoto, H., & Shimizu, K. (1981) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(81)90084-1 · Cited by 871 · see citing works

Picomolar Amyloid-β Positively Modulates Synaptic Plasticity and Memory in Hippocampus

Puzzo, D., Privitera, L., Leznik, E., Fà, M., Staniszewski, A., Palmeri, A., & Arancio, O. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2692-08.2008 · Cited by 740 · see citing works

A learning deficit related to age and β-amyloid plaques in a mouse model of Alzheimer's disease

Chen, G., Chen, K. S., Knox, J., Inglis, J., Bernard, A., Martin, S. J., Justice, A., McConlogue, L., Games, D., Freedman, S. B., et al. (2000) · Nature · doi:10.1038/35050103 · Cited by 740 · see citing works

Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms

Andorfer, C., Kress, Y., Espinoza, M., De Silva, R., Tucker, K. L., Barde, Y., Duff, K., & Davies, P. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01879.x · Cited by 722 · see citing works

Psychiatrie: Ein Lehrbuch für Studierende und Ärzte

Kraepelin, E. (1939) · JAMA · doi:10.1001/jama.1939.02800520075036 · Cited by 689 · see citing works

Unusual spectral energy distribution of a galaxy previously reported to be at redshift 6.68

Chen, H., Lanzetta, K. M., Pascarelle, S. M., & Yahata, N. (2000) · RePEc: Research Papers in Economics · Cited by 680 · see citing works

Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease.

Jawhar, S., Trawicka, A., Jenneckens, C., Bayer, T. A., & Wirths, O. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.05.027 · Cited by 623 · cited 1× · see citing works

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

Herreman, A., Hartmann, D., Annaert, W. G., Säftig, P., Craessaerts, K., Serneels, L., Umans, L., Schrijvers, V., Checler, F., Vanderstichele, H., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.21.11872 · Cited by 518 · see citing works

Unusual spectral energy distribution of a galaxy previously reported to be at redshift 6.68

Chen, H., Lanzetta, K. M., Pascarelle, S., & Yahata, N. (2000) · Nature · doi:10.1038/35046031 · Cited by 447 · see citing works

Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment

Gong, B., Vitolo, O. V., Trinchese, F., Liu, S., Shelanski, M., & Arancio, O. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22831 · Cited by 442 · see citing works

Ubiquitin Hydrolase Uch-L1 Rescues β-Amyloid-Induced Decreases in Synaptic Function and Contextual Memory

Gong, B., Cao, Z., Zheng, P., Vitolo, O. V., Liu, S., Staniszewski, A., Moolman, D. L., Zhang, H., Shelanski, M. L., & Arancio, O. (2006) · Cell · doi:10.1016/j.cell.2006.06.046 · Cited by 424 · see citing works

Auguste D and Alzheimer's disease

Maurer, K., Volk, S., & Gerbaldo, H. (1997) · The Lancet · doi:10.1016/s0140-6736(96)10203-8 · Cited by 417 · see citing works

Formation of β-amyloid protein deposits in brains of transgenic mice

Quon, D. H., Wang, Y., Catalano, R., Scardina, J. M., Murakami, K., & Cordell, B. (1991) · Nature · doi:10.1038/352239a0 · Cited by 397 · see citing works

Comparison of Neurodegenerative Pathology in Transgenic Mice Overexpressing V717F β-Amyloid Precursor Protein and Alzheimer’s Disease

Masliah, E., Sisk, A., Mallory, M. E., Mucke, L., Schenk, D., & Games, D. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-18-05795.1996 · Cited by 387 · see citing works

Progressive age‐related development of Alzheimer‐like pathology in APP/PS1 mice

Trinchese, F., Liu, S., Battaglia, F., Walter, S., Mathews, P. M., & Arancio, O. (2004) · Annals of Neurology · doi:10.1002/ana.20101 · Cited by 369 · see citing works

Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease

McClean, P. L., & Hölscher, C. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.08.005 · Cited by 359 · see citing works

Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes

Arendash, G. W., King, D. L., Gordon, M. N., Morgan, D., Hatcher, J. M., Hope, C. E., & Diamond, D. M. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03186-3 · Cited by 349 · see citing works

Phosphodiesterase 5 Inhibition Improves Synaptic Function, Memory, and Amyloid- Load in an Alzheimer's Disease Mouse Model

Puzzo, D., Staniszewski, A., Deng, S., Privitera, L., Leznik, E., Liu, S., Zhang, H., Feng, Y., Palmeri, A., Landry, D. W., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0864-09.2009 · Cited by 333 · see citing works

Age-Dependent Impairment of Cognitive and Synaptic Function in the htau Mouse Model of Tau Pathology

Polydoro, M., Acker, C. M., Duff, K., Castillo, P. E., & Davies, P. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.1065-09.2009 · Cited by 329 · see citing works

Endogenous amyloid‐β is necessary for hippocampal synaptic plasticity and memory

Puzzo, D., Privitera, L., Fà, M., Staniszewski, A., Hashimoto, G., Aziz, F., Sakurai, M., Ribé, E. M., Troy, C. M., Mercken, M. H., et al. (2010) · Annals of Neurology · doi:10.1002/ana.22313 · Cited by 320 · see citing works

Introduction and expression of the 400 kilobase precursor amyloid protein gene in transgenic mice

Lamb, B. T., Sisodia, S. S., Lawler, A. M., Slunt, H. H., Kitt, C. A., Kearns, W. G., Pearson, P. L., Price, D. L., & Gearhart, J. D. (1993) · Nature Genetics · doi:10.1038/ng0993-22 · Cited by 311 · see citing works

Epidemiology of clinically diagnosed Alzheimer's disease

Rocca, W. A., Amaducci, L. A., & Schoenberg, B. S. (1986) · Annals of Neurology · doi:10.1002/ana.410190502 · Cited by 287 · see citing works

Molecular genetics of Alzheimer’s disease

George‐Hyslop, P. S. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00301-7 · Cited by 276 · see citing works

Behavioral characterization of the Tg2576 transgenic model of Alzheimer's disease through 19 months

King, D. L., & Arendash, G. W. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00639-x · Cited by 240 · see citing works

Genetics of Alzheimer's Disease: A Centennial Review

Ertekin‐Taner, N. (2007) · Neurologic Clinics · doi:10.1016/j.ncl.2007.03.009 · Cited by 233 · see citing works

Modeling behavioral and neuronal symptoms of Alzheimer's disease in mice: A role for intraneuronal amyloid

Giménez‐Llort, L., Blázquez, G., Cañete, T., Johansson, B. A., Oddo, S., Tobeña, A., LaFerla, F. M., & Fernández‐Teruel, A. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.07.007 · Cited by 232 · see citing works

Characterization of the 3xTg-AD mouse model of Alzheimer’s disease: Part 2. Behavioral and cognitive changes

Sterniczuk, R., Antle, M. C., LaFerla, F. M., & Dyck, R. H. (2010) · Brain Research · doi:10.1016/j.brainres.2010.06.011 · Cited by 228 · see citing works

Presenilin-1 Knockin Mice Reveal Loss-of-Function Mechanism for Familial Alzheimer’s Disease

Xia, D., Watanabe, H., Wu, B., Lee, S. H., Li, Y., Tsvetkov, E., Bolshakov, V. Y., Shen, J., & Kelleher, R. J. (2015) · Neuron · doi:10.1016/j.neuron.2015.02.010 · Cited by 226 · see citing works

Behavioral assays with mouse models of Alzheimer's disease: Practical considerations and guidelines

Puzzo, D., Lee, L. S., Palmeri, A., Calabrese, G., & Arancio, O. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.01.011 · Cited by 214 · see citing works

Curcumin Suppresses Soluble Tau Dimers and Corrects Molecular Chaperone, Synaptic, and Behavioral Deficits in Aged Human Tau Transgenic Mice

Ma, Q., Zuo, X., Yang, F., Ubeda, O. J., Gant, D. J., Alaverdyan, M., Teng, E., Hu, S., Chen, P., Maiti, P., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.393751 · Cited by 212 · see citing works

Cortical Synaptic Integration<i>In Vivo</i>Is Disrupted by Amyloid-β Plaques

Stern, E. A., Bacskai, B. J., Hickey, G. A., Attenello, F. J., Lombardo, J. A., & Hyman, B. T. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0462-04.2004 · Cited by 210 · see citing works

Behavioral disturbances in transgenic mice overexpressing the V717F Β-amyloid precursor protein.

Dodart, J., Méziane, H., Mathis, C., Bales, K. R., Paul, S. M., & Ungerer, A. (1999) · Behavioral Neuroscience · doi:10.1037//0735-7044.113.5.982 · Cited by 210 · see citing works

Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease

Trinchese, F., Fà, M., Liu, S., Zhang, H., Hidalgo, A., Schmidt, S. D., Yamaguchi, H., Yoshii, N., Mathews, P. M., Nixon, R. A., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34254 · Cited by 205 · see citing works

Specific Targeting of Tau Oligomers in Htau Mice Prevents Cognitive Impairment and Tau Toxicity Following Injection with Brain-Derived Tau Oligomeric Seeds

Castillo‐Carranza, D. L., Gerson, J. E., Sengupta, U., Guerrero‐Munoz, M. J., Lasagna‐Reeves, C. A., & Kayed, R. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-132477 · Cited by 180 · see citing works

Amyloid deposition in the hippocampus and entorhinal cortex: Quantitative analysis of a transgenic mouse model

Reilly, J. F., Games, D., Rydel, R. E., Freedman, S. B., Schenk, D., Young, W. G., Morrison, J. H., & Bloom, F. E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0330745100 · Cited by 170 · see citing works

Phosphodiesterase-5 inhibitor sildenafil prevents neuroinflammation, lowers beta-amyloid levels and improves cognitive performance in APP/PS1 transgenic mice

Zhang, J., Guo, J., Zhao, X., Chen, Z., Wang, G., Liu, A., Wang, Q., Zhou, W., Xu, Y., & Wang, C. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.05.017 · Cited by 152 · see citing works

Glia Proinflammatory Cytokine Upregulation as a Therapeutic Target for Neurodegenerative Diseases: Function‐Based and Target‐Based Discovery Approaches

Eldik, L. J. V., Thompson, W. L., Ranaivo, H. R., Behanna, H. A., & Watterson, D. M. (2007) · International review of neurobiology · doi:10.1016/s0074-7742(07)82015-0 · Cited by 141 · see citing works

Overexpression of<i>hAPPswe</i>Impairs Rewarded Alternation and Contextual Fear Conditioning in a Transgenic Mouse Model of Alzheimer's Disease

Corcoran, K. A., Lu, Y., Turner, R. S., & Maren, S. (2002) · Learning &amp; Memory · doi:10.1101/lm.51002 · Cited by 135 · see citing works

Neuroanatomical Abnormalities in Behaviorally Characterized APPV717F Transgenic Mice

Dodart, J., Mathis, C., Saura, J., Bales, K. R., Paul, S. M., & Ungerer, A. (2000) · Neurobiology of Disease · doi:10.1006/nbdi.1999.0278 · Cited by 131 · see citing works

Long-term administration of green tea catechins prevents age-related spatial learning and memory decline in C57BL/6 J mice by regulating hippocampal cyclic amp-response element binding protein signaling cascade

Li, Q., Zhao, H., Zhang, Z. F., Liu, Z. G., Pei, X., Wang, J. B., Cai, M. Y., & Li, Y. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.02.008 · Cited by 130 · see citing works

Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D

Sierksma, A. S. R., van den Hove, D., Pfau, F., Philippens, M., Bruno, O., Fedele, E., Ricciarelli, R., Steinbusch, H. W. M., Vanmierlo, T., & Prickaerts, J. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.09.015 · Cited by 125 · see citing works

Hormetic effect of amyloid-beta peptide in synaptic plasticity and memory

Puzzo, D., Privitera, L., & Palmeri, A. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.12.020 · Cited by 121 · see citing works

Transgenic mice expressing the βAPP695SWE mutation: effects on exploratory activity, anxiety, and motor coordination

Lalonde, R., Lewis, T. L., Strazielle, C., Kim, H., & Fukuchi, K.-I. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02694-5 · Cited by 113 · see citing works

Synthesis of quinoline derivatives: Discovery of a potent and selective phosphodiesterase 5 inhibitor for the treatment of Alzheimer's disease

Fiorito, J., Saeed, F., Zhang, H., Staniszewski, A., Feng, Y., Francis, Y. I., Rao, S. R., Thakkar, D. M., Deng, S., Landry, D. W., et al. (2012) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2012.12.009 · Cited by 113 · see citing works

Transgenic mouse brain histopathology resembles early Alzheimer's disease

Higgins, L. S., Holtzman, D. M., Rabin, J., Mobley, W. C., & Cordell, B. (1994) · Annals of Neurology · doi:10.1002/ana.410350514 · Cited by 112 · see citing works

Insights into CNS ageing from animal models of senescence

Yeoman, M. S., Scutt, G., & Faragher, R. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3230 · Cited by 98 · see citing works

Lamotrigine attenuates deficits in synaptic plasticity and accumulation of amyloid plaques in APP/PS1 transgenic mice

Zhang, M., Zheng, C.-Y., Zou, M., Zhu, J.-W., Zhang, Y., Wang, J., Liu, C., Li, Q., Xiao, Z., Li, S., et al. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.06.009 · Cited by 94 · see citing works

Reference and working memory deficits in the 3xTg-AD mouse between 2 and 15-months of age: a cross-sectional study

Stevens, L. M., & Brown, R. E. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.10.033 · Cited by 92 · see citing works

Phosphodiesterase 7 inhibitor reduced cognitive impairment and pathological hallmarks in a mouse model of Alzheimer's disease

Pérez‐González, R., Pascual, C., Antequera, D., Bolós, M., Redondo, M., Pérez, D. I., Pérez‐Grijalba, V., Krzyzanowska, A., Sarasa, M., Gil, C., et al. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.03.011 · Cited by 91 · see citing works

Gender- and Age-Dependent γ-Secretase Activity in Mouse Brain and Its Implication in Sporadic Alzheimer Disease

Placanica, L., Zhu, L., & Li, Y. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005088 · Cited by 88 · see citing works

Effect of phosphodiesterase-5 inhibition on apoptosis and beta amyloid load in aged mice

Puzzo, D., Loreto, C., Giunta, S., Musumeci, G., Frasca, G., Podda, M. V., Arancio, O., & Palmeri, A. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.09.002 · Cited by 88 · see citing works

Neutralization of TNFSF10 ameliorates functional outcome in a murine model of Alzheimer’s disease

Cantarella, G., Benedetto, G. D., Puzzo, D., Privitera, L., Loreto, C., Saccone, S., Giunta, S., Palmeri, A., & Bernardini, R. (2014) · Brain · doi:10.1093/brain/awu318 · Cited by 85 · see citing works

Age-dependent phenotypic characteristics of a triple transgenic mouse model of Alzheimer disease.

Pietropaolo, S., Feldon, J., & Yee, B. K. (2008) · Behavioral Neuroscience · doi:10.1037/a0012520 · Cited by 84 · see citing works

Disease modifying effect of chronic oral treatment with a neurotrophic peptidergic compound in a triple transgenic mouse model of Alzheimer's disease

Kazim, S. F., Blanchard, J., Dai, C., Tung, Y. C., LaFerla, F. M., Iqbal, I.-G., & Iqbal, K. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.07.001 · Cited by 83 · see citing works

Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction

Watterson, D. M., Grum-Tokars, V. L., Roy, S. M., Schavocky, J. P., Bradaric, B. D., Bachstetter, A. D., Xing, B., Dimayuga, E., Saeed, F., Zhang, H., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066226 · Cited by 80 · see citing works

Increase of locomotor activity underlying the behavioral disinhibition in Tg2576 mice.

Gil-Bea, F. J., Aisa, B., Schliebs, R., & Ramírez, M. J. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.2.340 · Cited by 78 · see citing works

Expression of the human beta-amyloid precursor protein gene from a yeast artificial chromosome in transgenic mice.

Pearson, B. E., & Choi, T. K. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.22.10578 · Cited by 77 · see citing works

Altered temporal patterns of anxiety in aged and amyloid precursor protein (APP) transgenic mice

Bedrosian, T. A., Herring, K. L., Weil, Z. M., & Nelson, R. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103098108 · Cited by 77 · see citing works

Inhibition of phosphodiesterase-5 rescues age-related impairment of synaptic plasticity and memory

Palmeri, A., Privitera, L., Giunta, S., Loreto, C., & Puzzo, D. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.10.060 · Cited by 76 · see citing works

Differential impairment of spatial and nonspatial cognition in a mouse model of brain aging

Wang, W., Li, S., Dong, H., Lv, S., & Tang, Y. (2009) · Life Sciences · doi:10.1016/j.lfs.2009.05.003 · Cited by 73 · see citing works

Lifelong immunization with human β-amyloid (1–42) protects Alzheimer's transgenic mice against cognitive impairment throughout aging

Jensen, M. T., Mottin, M. D., Cracchiolo, J. R., Leighty, R. E., & Arendash, G. W. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.09.055 · Cited by 69 · see citing works

Expression of the human beta-amyloid protein of Alzheimer's disease specifically in the brains of transgenic mice.

Sandhu, F. A., Salim, M., & Zain, S. B. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54637-8 · Cited by 65 · see citing works

In Vivo Application of beta Amyloid Oligomers: A Simple Tool to Evaluate Mechanisms of Action and New Therapeutic Approaches

Balducci, C., & Forloni, G. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113199990497 · Cited by 62 · see citing works

Acute Oral Bryostatin-1 Administration Improves Learning Deficits in the APP/PS1 Transgenic Mouse Model of Alzheimer’s Disease

Schrott, L. M., Jackson, K., Yi, P., Dietz, F., Johnson, G. S., Basting, T., Purdum, G., Tyler, T. A., Ríos, J. D., Castor, T. P., et al. (2015) · Current Alzheimer Research · doi:10.2174/1567205012666141218141904 · Cited by 58 · see citing works

Memantine improves spatial learning and memory impairments by regulating NGF signaling in APP/PS1 transgenic mice

Liu, M., Wang, S. R., Yao, W., Zhang, Z. J., Zhong, X., Sha, L., He, M., ZHENG, Z., & Wei, M. J. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.05.011 · Cited by 55 · see citing works

Apolipoprotein D modulates amyloid pathology in APP/PS1 Alzheimer's disease mice

Li, H., Ruberu, K. R., Muñoz, S. S., Jenner, A. M., Spiro, A. S., Zhao, H., Rassart, É., Sánchez, D., Ganfornina, M. D., Karl, T., et al. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.02.010 · Cited by 49 · see citing works

Genetic studies in Alzheimer's disease

Tang, Y., & Gershon, E. S. (2003) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2003.5.1/yptang · Cited by 48 · see citing works

Spatial and emotional memory in aged rats: a behavioral-statistical analysis

Bergado, J. A., Almaguer, W., Rojas, Y., Capdevila, V., & Frey, J. U. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.10.064 · Cited by 47 · see citing works

Hippocampal calbindin-1 immunoreactivity correlate of recognition memory performance in aged mice

Soontornniyomkij, V., Risbrough, V. B., Young, J. W., Soontornniyomkij, B., Jeste, D. V., & Achim, C. L. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.03.092 · Cited by 41 · see citing works

Effects of accelerated senescence on learning and memory, locomotion and anxiety-like behavior in APP/PS1 mouse model of Alzheimer's disease

Lok, K., Hong, Z., Zhang, C. M., He, N., Shen, H., Wang, Z., Zhao, W., & Yin, M. (2013) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2013.09.018 · Cited by 40 · see citing works

Role of F3/contactin expression profile in synaptic plasticity and memory in aged mice

Puzzo, D., Bizzoca, A., Loreto, C., Guida, C. A., Gulisano, W., Frasca, G., Bellomo, M., Castorina, S., Gennarini, G., & Palmeri, A. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.01.004 · Cited by 33 · see citing works

Behavioral impairment of APPV717F mice in fear conditioning: is it only cognition?

Gerlai, R. T., Fitch, T. E., Bales, K. R., & Gitter, B. D. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00198-5 · Cited by 32 · see citing works

Decreased Presence of Perforated Synapses in a Triple-Transgenic Mouse Model of Alzheimer's Disease

Bertoni–Freddari, C., Sensi, S. L., Giorgetti, B., Balietti, M., Stefano, G. D., Canzoniero, L. M. T., Casoli, T., & Fattoretti, P. (2008) · Rejuvenation Research · doi:10.1089/rej.2008.0660 · Cited by 19 · see citing works

Animal Models of Aging: Something Old, Something New

Sprott, R. L. (2011) · ILAR Journal · doi:10.1093/ilar.52.1.1 · Cited by 14 · see citing works

Generation of Genetically Altered Mouse Models for Aging Studies

Treuting, P. M., Hopkins, H. C., Ware, C. A., Rabinovitch, P., & Ladiges, W. (2002) · Experimental and Molecular Pathology · doi:10.1006/exmp.2001.2405 · Cited by 13 · see citing works

P4‐236: Modulation of synaptic function by extracellular tau enriched in oligomers

Moe, J. G., Chatterjee, I., Davidowitz, E. J., & Arancio, O. (2009) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.04.702 · Cited by 5 · see citing works

P1‐361: Extracellular oligomeric tau inhibits memory formation in mice

Moe, J. G., Chatterjee, I., Puzzo, D., Staniszewski, A., Fà, M., Davidowitz, E. J., & Arancio, O. (2010) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2010.05.915 · Cited by 5 · see citing works

Induced pluripotent stem cell technology: a decade of progress.

Shi, Y., Inoue, H., Wu, J. C., & Yamanaka, S. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.245 · Cited by 1,525 · see citing works

Alzheimer's disease: experimental models and reality

Drummond, E., & Wisniewski, T. (2017) · Acta Neuropathologica · doi:10.1007/s00401-016-1662-x · Cited by 810 · see citing works

APP mouse models for Alzheimer’s disease preclinical studies.

Sasaguri, H., Nilsson, P., Hashimoto, S., Nagata, K., Saito, T., De Strooper, B., Hardy, J., Vassar, R., Winblad, B., & Saido, T. C. (2017) · The EMBO Journal · doi:10.15252/embj.201797397 · Cited by 793 · see citing works

Temporal and regional progression of Alzheimer’s disease‐like pathology in 3xTg‐AD mice

Belfiore, R., Rodin, A., Ferreira, E., Velazquez, R., Branca, C., Caccamo, A., & Oddo, S. (2019) · Aging Cell · doi:10.1111/acel.12873 · Cited by 332 · see citing works

Role of Amyloid-β and Tau Proteins in Alzheimer’s Disease: Confuting the Amyloid Cascade

Gulisano, W., Maugeri, D., Baltrons, M. A., Fà, M., Amato, A., Palmeri, A., D’Adamio, L., Grassi, C., Devanand, D. P., Honig, L. S., et al. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-179935 · Cited by 313 · see citing works

The amyloid cascade hypothesis: an updated critical review

Kepp, K. P., Robakis, N. K. R. K., Høilund‐Carlsen, P. F., Sensi, S. L., & Vissel, B. (2023) · Brain · doi:10.1093/brain/awad159 · Cited by 294 · see citing works

Curcumin-loaded PLGA-PEG nanoparticles conjugated with B6 peptide for potential use in Alzheimer’s disease

Fan, S., Zheng, Y., Liu, X., Fang, W., Chen, X., Liao, W., Jing, X., Lei, M., Tao, E., Ma, Q., et al. (2018) · Drug Delivery · doi:10.1080/10717544.2018.1461955 · Cited by 263 · see citing works

Aging in a Dish: iPSC-Derived and Directly Induced Neurons for Studying Brain Aging and Age-Related Neurodegenerative Diseases

Mertens, J., Reid, D. A., Lau, S., Kim, Y., & Gage, F. H. (2018) · Annual Review of Genetics · doi:10.1146/annurev-genet-120417-031534 · Cited by 252 · see citing works

The roles of inflammation and immune mechanisms in Alzheimer's disease

Eldik, L. J. V., Carrillo, M. C., Cole, P. E., Feuerbach, D., Greenberg, B., Hendrix, J. A., Kennedy, M. E., Kozauer, N., Margolin, R. A., Molinuevo, J. L., et al. (2016) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2016.05.001 · Cited by 226 · see citing works

Bone marrow-derived mesenchymal stem cells improve cognitive impairment in an Alzheimer’s disease model by increasing the expression of microRNA-146a in hippocampus

Nakano, M., Kubota, K., Kobayashi, E., Chikenji, T., Saito, Y., Konari, N., & Fujimiya, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-67460-1 · Cited by 224 · see citing works

Clinical Trials for Disease-Modifying Therapies in Alzheimer’s Disease: A Primer, Lessons Learned, and a Blueprint for the Future

Cummings, J., Ritter, A., & Zhong, K. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-179901 · Cited by 176 · see citing works

Linking deregulation of non-coding RNA to the core pathophysiology of Alzheimer’s disease: An integrative review

Millan, M. J. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.03.004 · Cited by 146 · see citing works

Molecular pathophysiology of impaired glucose metabolism, mitochondrial dysfunction, and oxidative DNA damage in Alzheimer's disease brain

Abolhassani, N., Leon, J., Sheng, Z., Oka, S., Hamasaki, H., Iwaki, T., & Nakabeppu, Y. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.05.005 · Cited by 140 · see citing works

Alzheimer’s disease due to loss of function: A new synthesis of the available data

Kepp, K. P. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.06.004 · Cited by 123 · see citing works

Environmental Factors Promoting Neural Plasticity: Insights from Animal and Human Studies

Mandolesi, L., Gelfo, F., Serra, L., Montuori, S., Polverino, A., Curcio, G., & Sorrentino, G. (2017) · Neural Plasticity · doi:10.1155/2017/7219461 · Cited by 120 · see citing works

The keystone of Alzheimer pathogenesis might be sought in Aβ physiology

Puzzo, D., Gulisano, W., Arancio, O., & Palmeri, A. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.08.039 · Cited by 116 · see citing works

Stress as risk factor for Alzheimer’s disease

Caruso, A., Nicoletti, F., Mango, D., Saidi, A., Orlando, R., & Scaccianoce, S. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.04.017 · Cited by 99 · see citing works

Ganoderma lucidum Triterpenoids (GLTs) Reduce Neuronal Apoptosis via Inhibition of ROCK Signal Pathway in APP/PS1 Transgenic Alzheimer’s Disease Mice

Yu, N., Huang, Y., Jiang, Y., Zou, L., Liu, X., Liu, S., Chen, F., Luo, J., & Zhu, Y. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/9894037 · Cited by 92 · see citing works

Functional Connectivity of the Brain Across Rodents and Humans

Xu, N., LaGrow, T. J., Anumba, N., Lee, A., Zhang, X., Yousefi, B., Bassil, Y., Clavijo, P. G., Sharghi, V. K., Maltbie, E. A., et al. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.816331 · Cited by 91 · see citing works

Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis

Sakakibara, Y., Sekiya, M., Saito, T., Saido, T. C., & Iijima, K. M. (2018) · BMC Neuroscience · doi:10.1186/s12868-018-0446-8 · Cited by 90 · see citing works

Estrogen and Alzheimer's disease: Still an attractive topic despite disappointment from early clinical results

Merlo, S., Spampinato, S. F., & Sortino, M. A. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.05.059 · Cited by 90 · see citing works

Induced pluripotent stem cells for neural drug discovery

Farkhondeh, A., Li, R., Gorshkov, K., Chen, K. G., Might, M., Rodems, S. M., Lo, D. C., & Zheng, W. (2019) · Drug Discovery Today · doi:10.1016/j.drudis.2019.01.007 · Cited by 90 · see citing works

Silencing of Long Noncoding RNA SOX21-AS1 Relieves Neuronal Oxidative Stress Injury in Mice with Alzheimer’s Disease by Upregulating FZD3/5 via the Wnt Signaling Pathway

Zhang, L., Fang, Y., Cheng, X., Lian, Y.-J., & Xu, H.-L. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1299-y · Cited by 88 · see citing works

Environmental enrichment as a method to improve cognitive function. What can we learn from animal models?

Fischer, A. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.11.039 · Cited by 82 · see citing works

Ten Challenges of the Amyloid Hypothesis of Alzheimer’s Disease

Kepp, K. P. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160550 · Cited by 80 · see citing works

Nanoparticles in Combating Neuronal Dysregulated Signaling Pathways: Recent Approaches to the Nanoformulations of Phytochemicals and Synthetic Drugs Against Neurodegenerative Diseases

Fakhri, S., Abdian, S., Zarneshan, S. N., Moradi, S. Z., Farzaei, M. H., & Abdollahi, M. (2022) · International Journal of Nanomedicine · doi:10.2147/ijn.s347187 · Cited by 80 · see citing works

Role of a Heat Shock Transcription Factor and the Major Heat Shock Protein Hsp70 in Memory Formation and Neuroprotection

Zatsepina, O. G., Evgen’ev, M. B., & Garbuz, D. G. (2021) · Cells · doi:10.3390/cells10071638 · Cited by 79 · see citing works

Comprehensive analysis of differentially expressed profiles of Alzheimer’s disease associated circular RNAs in an Alzheimer’s disease mouse model

Huang, J.-L., Qin, M.-C., Zhou, Y., Xu, Z., Yang, S., Zhang, F., Zhong, J., Liang, M.-K., Chen, B., Zhang, W., et al. (2018) · Aging · doi:10.18632/aging.101387 · Cited by 78 · see citing works

Lead aggravates Alzheimer's disease pathology via mitochondrial copper accumulation regulated by COX17

Huang, D., Chen, L., Ji, Q., Xiang, Y., Zhou, Q., Chen, K., Zhang, X., Zou, F., Zhang, X., Zhao, Z., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102990 · Cited by 76 · see citing works

Disruption of endoplasmic reticulum-mitochondria tethering proteins in post-mortem Alzheimer's disease brain

Lau, D. H. W., Paillusson, S., Hartopp, N., Rupawala, H., Mórotz, G. M., Gómez‐Suaga, P., Greig, J., Troakes, C., Noble, W. J., & Miller, C. C. J. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105020 · Cited by 76 · see citing works

Intravenous administration of mesenchymal stem cells reduces Tau phosphorylation and inflammation in the 3xTg-AD mouse model of Alzheimer's disease

Neves, A. F., Camargo, C. J., Premer, C., Hare, J. M., Baumel, B. S., & Pinto, M. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113706 · Cited by 76 · see citing works

Potential of Caffeine in Alzheimer’s Disease—A Review of Experimental Studies

Londzin, P., Zamora, M., Kąkol, B., Taborek, A., & Folwarczna, J. (2021) · Nutrients · doi:10.3390/nu13020537 · Cited by 71 · see citing works

Comparison of memory, affective behavior, and neuropathology in APPNLGF knock-in mice to 5xFAD and APP/PS1 mice

Locci, A., Orellana, H., Rodríguez, G., Gottliebson, M., McClarty, B. M., Dominguez, S., Keszycki, R. M., & Dong, H. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113192 · Cited by 68 · see citing works

Amyloid-β plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer’s disease

Sakakibara, Y., Sekiya, M., Saito, T., Saido, T. C., & Iijima, K. M. (2019) · BMC Neuroscience · doi:10.1186/s12868-019-0496-6 · Cited by 65 · see citing works

Genetic Pathways of Aging and Their Relevance in the Dog as a Natural Model of Human Aging

Sándor, S., & Kubinyi, E. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00948 · Cited by 66 · see citing works

The two faces of synaptic failure in AppNL-G-F knock-in mice

Latif‐Hernandez, A., Sabanov, V., Ahmed, T., Craessaerts, K., Saito, T., Saido, T. C., & Balschun, D. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00667-6 · Cited by 65 · see citing works

Early effects of Aβ 1-42 oligomers injection in mice: Involvement of PI3K/Akt/GSK3 and MAPK/ERK1/2 pathways

Morroni, F., Sita, G., Tarozzi, A., Rimondini, R., & Hrelia, P. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.08.002 · Cited by 65 · see citing works

Animal Models of Metabolic Disorders in the Study of Neurodegenerative Diseases: An Overview

Bem, A. F. D., Krolow, R., Farias, H. R., de Rezende, V. L., Gelain, D. P., Moreira, J. C. F., Duarte, J. M. N., & de Oliveira, J. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.604150 · Cited by 64 · see citing works

The Emerging Role of Altered Cerebellar Synaptic Processing in Alzheimer’s Disease

Hoxha, E., Lippiello, P., Zurlo, F., Balbo, I., Santamaria, R., Tempia, F., & Miniaci, M. C. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00396 · Cited by 58 · see citing works

Aluminum chloride and D-galactose induced a zebrafish model of Alzheimer's disease with cognitive deficits and aging

Luo, L., Yan, T., Yang, L., & Zhao, M. (2024) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2024.05.036 · Cited by 55 · see citing works

Importance of GPCR-Mediated Microglial Activation in Alzheimer’s Disease

Haque, M. E., Kim, I., Jakaria, M., Akther, M., & Choi, D. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00258 · Cited by 55 · see citing works

Glucagon-like peptide 1 (GLP-1) receptor agonists in experimental Alzheimer’s disease models: a systematic review and meta-analysis of preclinical studies

Kong, F., Wu, T., Dai, J., Zhai, Z., Cai, J., Zhu, Z., Xu, Y., & Sun, T. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1205207 · Cited by 54 · see citing works

Capsaicin Attenuates Amyloid-β-Induced Synapse Loss and Cognitive Impairments in Mice

Chen, L., Huang, Z., Du, Y., Fu, M., Han, H., Wang, Y., & Dong, Z. (2017) · Journal of Alzheimer's Disease · doi:10.3233/jad-170337 · Cited by 54 · see citing works

Exploring the dual character of metformin in Alzheimer's disease

Ning, P., Luo, A., Mu, X. L., Xu, Y., & Li, T. X. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.108966 · Cited by 51 · see citing works

Acrolein, an endogenous aldehyde induces Alzheimer's disease-like pathologies in mice: A new sporadic AD animal model

Chen, C., Lu, J., Peng, W., Mak, S., Yang, Y., Zhu, Z., Wang, S., Hou, J., Zhou, X. J., Xin, W., et al. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.106003 · Cited by 51 · see citing works

Preclinical systematic review of ginsenoside Rg1 for cognitive impairment in Alzheimer’s disease

Liang, H.-Y., Zhang, P., Zhang, X., Zheng, Y., Huang, Y., Zheng, G., & Lin, Y. (2021) · Aging · doi:10.18632/aging.202619 · Cited by 49 · see citing works

Preclinical models in the study of sex differences

Buoncervello, M., Marconi, M., Carè, A., Piscopo, P., Malorni, W., & Matarrese, P. (2017) · Clinical Science · doi:10.1042/cs20160847 · Cited by 47 · see citing works

Insight into the emerging and common experimental in-vivo models of Alzheimer’s disease

Dhapola, R., Kumari, S., Sharma, P., & HariKrishnaReddy, D. (2023) · Laboratory Animal Research · doi:10.1186/s42826-023-00184-1 · Cited by 46 · see citing works

Investigations into Retinal Pathology in the Early Stages of a Mouse Model of Alzheimer’s Disease

Chidlow, G., Wood, J. P. M., Manavis, J., Finnie, J. W., & Casson, R. J. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160823 · Cited by 43 · see citing works

Neuroprotective effects of exercise in rodent models of memory deficit and Alzheimer's

Jahangiri, Z., Gholamnezhad, Z., & Hosseini, M. (2018) · Metabolic Brain Disease · doi:10.1007/s11011-018-0343-y · Cited by 43 · see citing works

Translational Assays for Assessment of Cognition in Rodent Models of Alzheimer’s Disease and Dementia

Shepherd, A. L., Tyebji, S., Hannan, A. J., & Burrows, E. L. (2016) · Journal of Molecular Neuroscience · doi:10.1007/s12031-016-0837-1 · Cited by 42 · see citing works

Association Between Metformin and Alzheimer’s Disease: A Systematic Review and Meta-Analysis of Clinical Observational Studies

Luo, A., Ning, P., Lu, H., Huang, H., Shen, Q., Zhang, D., Xu, F., Yang, L. J., & Xu, Y. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220180 · Cited by 41 · see citing works

Dexibuprofen prevents neurodegeneration and cognitive decline in APPswe/PS1dE9 through multiple signaling pathways

Ettcheto, M., Sánchez‐López, E., Pons, L., Busquets, O., Olloquequi, J., Beas‐Zárate, C., Pallàs, M., García, M. L., Auladell, C., Folch, J., et al. (2017) · Redox Biology · doi:10.1016/j.redox.2017.06.003 · Cited by 39 · see citing works

Sub-efficacious doses of phosphodiesterase 4 and 5 inhibitors improve memory in a mouse model of Alzheimer's disease

Gulisano, W., Tropea, M. R., Arancio, O., Palmeri, A., & Puzzo, D. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.06.002 · Cited by 38 · see citing works

Engineered extracellular matrices facilitate brain organoids from human pluripotent stem cells

Muñiz, A. J., Topal, T., Brooks, M. D., Sze, A., Kim, D. H., Jordahl, J. H., Nguyen, J. T., Krebsbach, P. H., Savelieff, M. G., Feldman, E. L., et al. (2023) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51820 · Cited by 35 · see citing works

Targeting SUMO-1ylation Contrasts Synaptic Dysfunction in a Mouse Model of Alzheimer’s Disease

Marcelli, S., Ficulle, E., Iannuzzi, F., Kövari, E., Nisticò, R., & Feligioni, M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0176-9 · Cited by 35 · see citing works

Neurophysiological assessment of neural network plasticity and connectivity: Progress towards early functional biomarkers for disease interception therapies in Alzheimer’s disease

Walsh, C., Drinkenburg, W. H. I. M., & Ahnaou, A. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.12.020 · Cited by 35 · see citing works

Artificial intelligence for neurodegenerative experimental models

Marzi, S. J., Schilder, B. M., Nott, A., Frigerio, C. S., Willaime‐Morawek, S., Bucholc, M., Hanger, D. P., James, C. R., Lewis, P. A., Lourida, I., et al. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13479 · Cited by 34 · see citing works

Repetitive transcranial magnetic stimulation (rTMS) for multiple neurological conditions in rodent animal models: A systematic review

Zong, X., Gu, J., Geng, D., & Gao, D. (2022) · Neurochemistry International · doi:10.1016/j.neuint.2022.105356 · Cited by 34 · see citing works

Free-floating adult human brain-derived slice cultures as a model to study the neuronal impact of Alzheimer’s disease-associated Aβ oligomers

Mendes, N. D., Fernandes, A., de Almeida, G. M., Santos, L. E., Sellés, M. C., Silva, N. M. L. E., Machado, C. D. M., Horta‐Júnior, J. D. A. C., Louzada, P. R., Felice, F. G. D., et al. (2018) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2018.05.021 · Cited by 33 · see citing works

Status of Metabolomic Measurement for Insights in Alzheimer’s Disease Progression—What Is Missing?

Yin, C., Harms, A. C., Hankemeier, T., Kindt, A. S. D., & de Lange, E. C. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054960 · Cited by 32 · see citing works

Induction of Amyloid-β 42 Production by Fipronil and Other Pyrazole Insecticides

Cam, M., Durieu, É., Bodin, M., Manousopoulou, A., Koslowski, S., Vasylieva, N., Barnych, B. B., Hammock, B. D., Bohl, B., Koch, P., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170875 · Cited by 31 · see citing works

Dampened Slow Oscillation Connectivity Anticipates Amyloid Deposition in the PS2APP Mouse Model of Alzheimer’s Disease

Leparulo, A., Mahmud, M., Scremin, E., Pozzan, T., Vassanelli, S., & Fasolato, C. (2019) · Cells · doi:10.3390/cells9010054 · Cited by 31 · see citing works

Age related weight loss in female 5xFAD mice from 3 to 12 months of age

Gendron, W. A. C., Fertan, E., Pelletier, S., Roddick, K. M., O’Leary, T. P., Anini, Y., & Brown, R. E. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113214 · Cited by 31 · see citing works

Neural Stem Cells in the Treatment of Alzheimer’s Disease: Current Status, Challenges, and Future Prospects

Chen, X., Jiang, S., Wang, R., Bao, X., & Li, Y. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220721 · Cited by 31 · see citing works

Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice

Steffen, J., Krohn, M., Schwitlick, C., Brüning, T., Paarmann, K., Pietrzik, C. U., Biverstål, H., Jansone, B., Langer, O., & Pahnke, J. (2017) · Acta Neuropathologica Communications · doi:10.1186/s40478-017-0448-2 · Cited by 31 · see citing works

Anxiolytic impact of Apelin-13 in a rat model of Alzheimer's disease: Involvement of glucocorticoid receptor and FKBP5

Aminyavari, S., Zahmatkesh, M., Khodagholi, F., & Sanati, M. (2019) · Peptides · doi:10.1016/j.peptides.2019.170102 · Cited by 30 · see citing works

The Accumulation of Tau-Immunoreactive Hippocampal Granules and Corpora Amylacea Implicates Reactive Glia in Tau Pathogenesis during Aging

Wander, C. M., Tseng, J., Song, S., Housseiny, H. A., Tart, D. S., Ajit, A., Shih, Y. I., Lobrovich, R., Song, J., Meeker, R. B., et al. (2020) · iScience · doi:10.1016/j.isci.2020.101255 · Cited by 30 · see citing works

Research Models to Study Ferroptosis’s Impact in Neurodegenerative Diseases

Costa, I. D., Barbosa, D. J., Silva, V., Benfeito, S., Borges, F., Remião, F., & Silva, R. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15051369 · Cited by 30 · see citing works

Acceleration of infectious disease drug discovery and development using a humanized model of drug metabolism

MacLeod, A., Coquelin, K.-S., Huertas, L., Simeons, F. R. C., Riley, J., Casado, P., Guijarro, L., Casanueva, R., Frame, L., Pinto, É. G., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2315069121 · Cited by 29 · see citing works

Nanoscale Structure and Spectroscopic Probing of Aβ1-40 Fibril Bundle Formation

Psonka-Antonczyk, K. M., Hammarström, P., Johansson, L. B. G., Lindgren, M., Stokke, B. T., Nilsson, K. P. R., & Nyström, S. (2016) · Frontiers in Chemistry · doi:10.3389/fchem.2016.00044 · Cited by 29 · see citing works

Adolescent binge‐ethanol accelerates cognitive impairment and β‐amyloid production and dysregulates endocannabinoid signaling in the hippocampus of APP/PSE mice

Ledesma, J. C., Rodríguez‐Arias, M., Gavito, A., Sánchez‐Pérez, A. M., Viña, J., Vera, D. M., de Fonseca, F. R., & Miñarro, J. (2020) · Addiction Biology · doi:10.1111/adb.12883 · Cited by 29 · see citing works

Current Strategies and Novel Drug Approaches for Alzheimer Disease

Ghai, R., Nagarajan, K., Arora, M., Grover, P., Ali, N., & Kapoor, G. T. (2020) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527319666200717091513 · Cited by 29 · see citing works

Role of PDE9 in Cognition

Dorner‐Ciossek, C., Kroker, K. S., & Rosenbrock, H. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-58811-7_9 · Cited by 29 · see citing works

Disease‐modifying treatment with I2 imidazoline receptor ligand LSL60101 in an Alzheimer's disease mouse model: a comparative study with donepezil

Vasilopoulou, F., Rodríguez‐Arévalo, S., Bagán, A., Escolano, C., Griñán‐Ferré, C., & Pallàs, M. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15478 · Cited by 29 · see citing works

Early Preclinical Changes in Hippocampal CREB-Binding Protein Expression in a Mouse Model of Familial Alzheimer’s Disease

Ettcheto, M., Abad, S., Petrov, D., Pedrós, I., Busquets, O., Sánchez‐López, E., Casadesús, G., Beas‐Zárate, C., Carro, E., Auladell, C., et al. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0690-4 · Cited by 28 · see citing works

A human induced pluripotent stem cell‐derived cortical neuron human‐on‐a chip system to study Aβ 42 and tau‐induced pathophysiological effects on long‐term potentiation

Caneus, J., Akanda, N., Rumsey, J. W., Guo, X., Jackson, M., Long, C. J., Sommerhage, F., Georgieva, S., Kanaan, N. M., Morgan, D., et al. (2020) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12029 · Cited by 28 · see citing works

Influence of Genetic Background on Apathy-Like Behavior in Triple Transgenic AD Mice

Pardossi‐Piquard, R., Lauritzen, I., Bauer, C., Sacco, G., Robert, P. H., & Checler, F. (2016) · Current Alzheimer Research · doi:10.2174/1567205013666160404120106 · Cited by 28 · see citing works

REMOVED: Novel Treatment Strategies Using TiO2-Nanowired Delivery of Histaminergic Drugs and Antibodies to Tau With Cerebrolysin for Superior Neuroprotection in the Pathophysiology of Alzheimer's Disease

Sharma, A., Menon, P. K., Patnaik, R., Muresanu, D. F., Lafuente, J. V., Tian, Z. R., Ozkızılcık, A., Mössler, H., & Sharma, H. S. (2017) · International review of neurobiology · doi:10.1016/bs.irn.2017.09.002 · Cited by 27 · see citing works

Accelerating the in vitro emulation of Alzheimer’s disease-associated phenotypes using a novel 3D blood-brain barrier neurosphere co-culture model

Ko, E. C., Spitz, S., Pramotton, F. M., Barr, O. M., Xu, C., Pavlou, G., Zhang, S., Tsai, A., Maaser‐Hecker, A., Jorfi, M., et al. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1251195 · Cited by 27 · see citing works

Transgenic Mouse Models as Tools for Understanding How Increased Cognitive and Physical Stimulation Can Improve Cognition in Alzheimer’s Disease

Shepherd, A. L., Zhang, T. D., Zeleznikow-Johnston, A., Hannan, A. J., & Burrows, E. L. (2018) · Brain Plasticity · doi:10.3233/bpl-180076 · Cited by 27 · see citing works

Blood-based systems biology biomarkers for next-generation clinical trials in Alzheimer’s disease

Hampel, H. J., Vergallo, A., Afshar, M., Akman-Anderson, L., Arenas, J., Benda, N., Batrla, R., Broich, K., Caraci, F., Cuello, A. C., et al. (2019) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2019.21.2/hhampel · Cited by 27 · see citing works

Chronic vitamin D3 supplementation alleviates cognition impairment via inhibition of oxidative stress regulated by PI3K/AKT/Nrf2 in APP/PS1 transgenic mice

Lin, J., Niu, Z., Xue, Y., Gao, J., Zhang, M., Li, M., Peng, Y., Zhang, S., Li, W., Zhang, Q., et al. (2022) · Neuroscience Letters · doi:10.1016/j.neulet.2022.136725 · Cited by 26 · see citing works

Survival Bias and Crosstalk between Chronological and Behavioral Age: Age- and Genotype-Sensitivity Tests Define Behavioral Signatures in Middle-Aged, Old, and Long-Lived Mice with Normal and AD-Associated Aging

Giménez‐Llort, L., Marín-Pardo, D., Marazuela, P., & Hernández‐Guillamón, M. (2021) · Biomedicines · doi:10.3390/biomedicines9060636 · Cited by 26 · see citing works

Age-Dependent Alterations of Cognition, Mitochondrial Function, and Beta-Amyloid Deposition in a Murine Model of Alzheimer’s Disease—A Longitudinal Study

Reutzel, M., Grewal, R., Joppe, A., & Eckert, G. P. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.875989 · Cited by 25 · see citing works

Lack of human-like extracellular sortilin neuropathology in transgenic Alzheimer’s disease model mice and macaques

Zhou, F., Jiang, J., Griffith, C. M., Patrylo, P. R., Cai, H., Chu, Y., & Yan, X. (2018) · Alzheimer s Research & Therapy · doi:10.1186/s13195-018-0370-2 · Cited by 25 · see citing works

Affibody-Mediated Sequestration of Amyloid β Demonstrates Preventive Efficacy in a Transgenic Alzheimer’s Disease Mouse Model

Boutajangout, A., Lindberg, H., Awwad, A., Paul, A., Baitalmal, R. M., Almokyad, I. K., Höidén‐Guthenberg, I., Gunneriusson, E., Frejd, F. Y., Härd, T., et al. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00064 · Cited by 25 · see citing works

Pharmacological sequestration of mitochondrial calcium uptake protects against dementia and β-amyloid neurotoxicity

Shevtsova, E. F., Angelova, P. R., Stelmashchuk, O. A., Esteras, N., Васильева, Н. А., Maltsev, A. V., Shevtsov, P. N., Shaposhnikov, A. V., Фисенко, В. П., Бачурин, С. О., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-16817-9 · Cited by 24 · see citing works

Beyond Transgenic Mice: Emerging Models and Translational Strategies in Alzheimer’s Disease

Lopes, P. A., & Guil‐Guerrero, J. L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26125541 · Cited by 23 · see citing works

Age-Related Changes of the Neurovascular Unit in the Cerebral Cortex of Alzheimer Disease Mouse Models: A Neuroanatomical and Molecular Study

Giuliani, A., Sivilia, S., Baldassarro, V. A., Gusciglio, M., Lorenzini, L., Sannia, M., Calzà, L., & Giardino, L. (2019) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nly125 · Cited by 22 · see citing works

Age and sex differences in motivation and spatial working memory in 3xTg-AD mice in the Hebb–Williams maze

Fertan, E., Wong, A. A., Vienneau, N. A., & Brown, R. E. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.111937 · Cited by 22 · see citing works

Does Diet Have a Role in the Treatment of Alzheimer's Disease?

Thelen, M., & Brown‐Borg, H. M. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.617071 · Cited by 23 · see citing works

Inborn errors of metabolism: Lessons from iPSC models

Escribá, R., Ferrer‐Lorente, R., & Raya, Á. (2021) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-021-09671-z · Cited by 21 · see citing works

Alzheimer Combination Therapies: Overview and Scenarios

Cummings, J. L., Burstein, A. H., & Fillit, H. M. (2025) · The Journal of Prevention of Alzheimer s Disease · doi:10.1016/j.tjpad.2025.100328 · Cited by 20 · see citing works

Molecular Pathophysiology of Insulin Depletion, Mitochondrial Dysfunction, and Oxidative Stress in Alzheimer’s Disease Brain

Nakabeppu, Y. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-3540-2_3 · Cited by 20 · see citing works

Neurotoxicity of Pyrethroids in neurodegenerative diseases: From animals' models to humans’ studies

Arsuffi-Marcon, R., Souza, L. G., Santos‐Miranda, A., & Joviano‐Santos, J. V. (2024) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2024.110911 · Cited by 20 · see citing works

Memory Enhancers for Alzheimer’s Dementia: Focus on cGMP

Fedele, E., & Ricciarelli, R. (2021) · Pharmaceuticals · doi:10.3390/ph14010061 · Cited by 20 · see citing works

Whisker exploration behaviours in the 5xFAD mouse are affected by sex and retinal degeneration

Grant, R. A., Wong, A. A., Fertan, E., & Brown, R. E. (2018) · Genes Brain & Behavior · doi:10.1111/gbb.12532 · Cited by 19 · see citing works

The behavioral, pathological and therapeutic features of the triple transgenic Alzheimer's disease (3 × Tg-AD) mouse model strain

Tian, S. L., Ye, T., & Cheng, X. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114505 · Cited by 19 · see citing works

Establishment of a Valuable Mimic of Alzheimer's Disease in Rat Animal Model by Intracerebroventricular Injection of Composited Amyloid Beta Protein

Wu, X.-G., Jianjun, C., Cao, Q., Zhang, H., Lukun, Y., & Yazhen, S. (2018) · Journal of Visualized Experiments · doi:10.3791/56157 · Cited by 19 · see citing works

Overview of Transgenic Mouse Models for Alzheimer's Disease

Myers, A., & McGonigle, P. (2019) · Current Protocols in Neuroscience · doi:10.1002/cpns.81 · Cited by 140 · see citing works

Transgenic mouse models of Alzheimer's disease: phenotype and application.

(2003) · PubMed · doi:10.1097/01.fbp.0000088420.18414.ff · Cited by 147 · see citing works

Use of rodent models in drug discovery for Alzheimer’s disease

Barrett, J. E., Mathiasen, J. R., & McGonigle, P. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-30008-0.00018-1

Transgenic models of Alzheimer’s disease: Learning from animals

Spires‐Jones, T. L., & Hyman, B. T. (2005) · NeuroRx · doi:10.1602/neurorx.2.3.423 · Cited by 209 · see citing works

Potential Animal Models of Alzheimer Disease and Their Importance in Investigating the Pathogenesis of Alzheimer Disease

Farooqui, A. A. (2016) · Springer eBooks · doi:10.1007/978-3-319-15889-1_2