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Cited by 38Exercise and Physiological ResponsesAntioxidant Activity and Oxidative StressPhysical Activity and Health

Moderate exercise training and chronic caloric restriction modulate redox status in rat hippocampus

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Santin, Katiane, da Rocha, Ricardo Fagundes, Cechetti, Fernanda, Quincozes-Santos, André, de Souza, Daniela Fraga, Nardin, Patrícia, Rodrigues, Letícia, Leite, Marina Concli +3 more·2011·Brain Research
DOI 10.1016/j.brainres.2011.08.003
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Abstract

Physical activity has been related to antioxidant adaptations, which is associated with health benefits, including those to the nervous system. Additionally, available data suggest exercise and a caloric restriction regimen may reduce both the incidence and severity of neurological disorders. Therefore, our aim was to compare hippocampal redox status and glial parameters among sedentary, trained, caloric-restricted sedentary and caloric-restricted trained rats. Forty male adult rats were divided into 4 groups: ad libitum-fed sedentary (AS), ad libitum-fed exercise training (AE), calorie-restricted sedentary (RS) and calorie-restricted exercise training (RE). The caloric restriction (decrease of 30% in food intake) and exercise training (moderate in a treadmill) were carried out for 3 months. Thereafter hippocampus was surgically removed, and then redox and glial parameters were assessed. Increases in reduced glutathione (GSH) levels and total antioxidant reactivity (TAR) were observed in AE, RS and RE. The nitrite/nitrate levels decreased only in RE. We found a decrease in carbonyl content in AE, RS and RE, while no modifications were detected in thiobarbituric acid reactive substances (TBARS). Total reactive antioxidant potential (TRAP), superoxide dismutase (SOD) activity, S100B and glial fibrilary acid protein (GFAP) content did not change, but caloric restriction was able to increase glutamine synthetase (GS) activity in RS and glutamate uptake in RS and RE. Exercise training, caloric restriction and both combined can decrease oxidative damage in the hippocampus, possibly involving modulation of astroglial function, and could be used as a strategy for the prevention of neurodegenerative diseases.

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  • Dietary restriction reduces oxidative stress in senescent astrocytes as well as in aged brains, as evidenced by reduction in ROS and protein oxidation.

    “It is evident that DR reduces oxidative stress in senescent astrocytes as well as in aged brains, as evidenced by reduction in ROS and protein oxidation [16,151,152,153,154].”

    From Dietary Restriction and Neuroinflammation: A Potential Mechanistic Link (2019) · cites this paper as [151]

    The Discussion (page unavailable in our copy) reports that caloric restriction reduced protein carbonyl content, a measure of protein oxidation, in rat hippocampus. But the Animals section describes rats that were 60 days old at the start of the experiment, not aged brains; the paper does not establish reduced ROS or reduced oxidative stress specifically in senescent astrocytes. (LLM, conf=0.90)

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Authors
Santin, K., da Rocha, R. F., Cechetti, F., Quincozes-Santos, A., de Souza, D. F., Nardin, P., Rodrigues, L., Leite, M. C., Moreira, J. C. F., Salbego, C. G., & Gonçalves, C. A.
Affiliations
Universidade Federal do Rio Grande do Sul (BR)
Corresponding author
Santin, Katiane
ORCID
Venue
Brain Research
Publisher
Elsevier BV
Published
2011-11
Volume
1421
Pages
1-10
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/j.brainres.2011.08.003
OpenAlex
W1992383112
Cited by
38
References
78
Citations by year
2026: 1 · 2025: 3 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 5 · 2013: 2 · 2012: 7
FWCI
4.54
Type
journal article
Language
en
Open access
Licence
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Counsel of Technological and Scientific Development
  • Improvement Management of Higher Degree Personel
  • Brazilian Institute of Neuroscience Net (01.06.0842-00)
Topics
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
Keywords
moderate exercise training, caloric restriction, hippocampus, redox state, oxidative stress, antioxidant capacity, reduced glutathione, nitrite/nitrate, protein carbonylation, lipid peroxidation, glial fibrillary acidic protein, S100B, glutamine synthetase, glutamate uptake, neurodegenerative disease prevention
MeSH terms
Animals, Astrocytes, Hippocampus, Male, Oxidation-Reduction, Physical Conditioning, Animal, Rats, Wistar, Caloric Restriction, Rats

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