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A review of effects of calorie restriction and fasting with potential relevance to depression

Igwe, O., Sone, M., Matveychuk, D., Baker, G. B., & Dursun, S. M. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110206 · Cited by 39 · see citing works

Long-Term Caloric Restriction Attenuates β-Amyloid Neuropathology and Is Accompanied by Autophagy in APPswe/PS1delta9 Mice

Müller, L., Guerra, N. P., Stenzel, J., Rühlmann, C., Lindner, T., Krause, B. J., Vollmar, B., Teipel, S. J., & Kuhla, A. (2021) · Nutrients · doi:10.3390/nu13030985 · Cited by 40 · see citing works

Autophagy Balances Neuroinflammation in Alzheimer’s Disease

Cheng, X., Wei, Y. Q., Qian, Z., & Han, L. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01269-6 · Cited by 38 · see citing works

Bridging the brain and gut: neuroimmune mechanisms of neuroinflammation and therapeutic insights

Müller, L., & Benedetto, S. D. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1590002 · Cited by 35 · see citing works

Partial Inhibition of Mitochondrial Complex I Reduces Tau Pathology and Improves Energy Homeostasis and Synaptic Function in 3xTg-AD Mice

Stojakovic, A., Chang, S.-Y., Nesbitt, J. J., Pichurin, N. P., Ostroot, M., Aikawa, T., Kanekiyo, T., & Trushina, E. V. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-201015 · Cited by 31 · see citing works

The pharmacological basis of the curcumin nutraceutical uses: an update

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Endogenous Mechanisms of Neuroprotection: To Boost or Not to Be

Marmolejo-Martínez-Artesero, S., Casas, C., & Romeo-Guitart, D. (2021) · Cells · doi:10.3390/cells10020370 · Cited by 27 · see citing works

Partial Inhibition of Complex I Restores Mitochondrial Morphology and Mitochondria-ER Communication in Hippocampus of APP/PS1 Mice

Panes-Fernández, J., Nguyen, T. K. O., Gao, H., Christensen, T. A., Stojakovic, A., Trushin, S., Salisbury, J. L., Fuentealba, J., & Trushina, E. V. (2023) · Cells · doi:10.3390/cells12081111 · Cited by 28 · see citing works

Beneficial Effects on Brain Micro-Environment by Caloric Restriction in Alleviating Neurodegenerative Diseases and Brain Aging

Zhang, L., Xu, H., Ding, N., Li, X., Chen, X., & Chen, Z. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.715443 · Cited by 28 · see citing works

Targeting Mitophagy in Alzheimer’s Disease

Jayatunga, D. P. W., Hone, E., Bharadwaj, P., Garg, M. L., Verdile, G., Guillemin, G. J., & Martins, R. N. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191258 · Cited by 24 · see citing works

The untapped potential of spermidine alkaloids: Sources, structures, bioactivities and syntheses

Shi, Y., Zhang, J., Wang, Y., Ding, K., Yu, Y., Xia, C., Li, X.-X., He, J., Zhang, W., & Xu, J. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114600 · Cited by 22 · see citing works

Caloric restriction ameliorates high-fat diet induced cognitive deficits through attenuating neuroinflammation via the TREM2-PI3K/AKT signaling pathway

Wang, R., Zhou, Z., Wang, D., Zhao, Q., Zhang, C., Liu, C., Zhao, H., Yuan, C., Yuan, D., & Wang, T. (2021) · Food & Function · doi:10.1039/d0fo02946g · Cited by 21 · see citing works

Neuroprotective mitochondria targeted small molecule restores synapses and the distribution of synaptic mitochondria in the hippocampus of APP/PS1 mice

Keller, N., Christensen, T. A., Wanberg, E. J., Salisbury, J. L., & Trushina, E. V. (2025) · Scientific Reports · doi:10.1038/s41598-025-90925-0 · Cited by 19 · see citing works

Effects of lifespan-extending interventions on cognitive healthspan

Čulig, L., Sahbaz, B. D., & Bohr, V. A. (2022) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2022.36 · Cited by 14 · see citing works

Curcumin inhibits liquid–liquid phase separation of fused in sarcoma and attenuates the sequestration of pyruvate kinase to restore cellular metabolism

Shi, W., Lin, W.-J., Ge, W., Chen, L., Zhang, T., Guo, W., Liu, J., & Yin, D. (2023) · Food & Function · doi:10.1039/d2fo03224d · Cited by 12 · see citing works

Fasting, a Potential Intervention in Alzheimer's Disease

Zeng, Z., Zhang, H., Wang, X., Shen, J., & Chen, D. (2024) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2303050 · Cited by 12 · see citing works

Nicotinamide enhances myelin production after demyelination through reduction of astrogliosis and microgliosis

Kaplanis, S.-I., Kaffe, D., Ktena, N., Lygeraki, A., Kolliniati, O., Savvaki, M., & Karagogeos, D. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1201317 · Cited by 11 · see citing works

Caloric restriction leading to attenuation of experimental Alzheimer's disease results from alterations in gut microbiome

Chen, J., Zou, C., Guan, H., Zhou, X., Hou, L., Cui, Y., Xu, J., Luan, P., & Dong, Z. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14823 · Cited by 11 · see citing works

A description of the relationship in healthy longevity and aging-related disease: from gene to protein

Ni, X., Wang, Z., Gao, D., Yuan, H., Sun, L., Zhu, X., Zhou, Q., & Yang, Z. (2021) · Immunity & Ageing · doi:10.1186/s12979-021-00241-0 · Cited by 11 · see citing works

A comparative study of acetyl- l -carnitine and caloric restriction impact on hippocampal autophagy, apoptosis, neurogenesis, and astroglial function in AlCl3-induced Alzheimer’s in rats

Wadie, C. M., Ali, R. H., Mohamed, A. E.-H. A., Labib, J. M. W., Sabaa, A. R., Awad, H. E. A., & Abou-Bakr, D. A. (2023) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2022-0304 · Cited by 10 · see citing works

Caloric Restriction Alleviates CFA-Induced Inflammatory Pain via Elevating β-Hydroxybutyric Acid Expression and Restoring Autophagic Flux in the Spinal Cord

Liu, C., Zheng, X., Liu, L., Hu, Y., Zhu, Q., Zhang, J., Wang, H., Gu, E., Yang, Z., & Xu, G. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.828278 · Cited by 10 · see citing works

Biological Effects of Dietary Restriction on Alzheimer's Disease: Experimental and Clinical Investigations

Liu, Z., Zhang, J., Jiang, F., Liu, C., Shao, Y., & Le, W. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70392 · Cited by 8 · see citing works

Caloric Restriction Can Ameliorate Postoperative Cognitive Dysfunction by Upregulating the Expression of Sirt1, MeCP2 and BDNF in the Hippocampal CA1 Region of Aged C57BL/6 Mice

Wei, L., Tao, Q., Yao, M., Zhao, Z., & Ge, S. (2023) · Brain Sciences · doi:10.3390/brainsci13030462 · Cited by 7 · see citing works

Catch‐up fat in male adults induces low testosterone and consequently promotes metabolic abnormalities and cognitive impairment

Liu, X., He, Y., Zhang, Q., Zeng, T., Zhang, J., Min, J., Tian, S., Huang, H., Wang, W., Dong, F., et al. (2022) · Andrology · doi:10.1111/andr.13177 · Cited by 5 · see citing works

Microglial Autophagic Dysregulation in Traumatic Brain Injury: Molecular Insights and Therapeutic Avenues

Bano, N., Khan, S., Ahamad, S., Dar, N. J., Alanazi, H. H., Nazir, A., & Bhat, S. A. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00617 · Cited by 6 · see citing works

The ratio versus difference optimization and its implications for optimality theory

Shinde, S., Patwardhan, A. A., & Watve, M. (2022) · Evolution · doi:10.1111/evo.14605 · Cited by 5 · see citing works

Regulation of autophagy‐mediated pathways by diet, physical activity, and sleep in Alzheimer's disease

Ariyath, A., Mputhia, Z., Dougherty, C., Rahuman, B. K., Fernando, W. M. A. D. B., Brown, B. M., Gardener, S. L., Rainey‐Smith, S. R., Martins, R. N., & Bharadwaj, P. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71191 · Cited by 4 · see citing works

Comprehensive Bioinformatics Analysis Reveals Molecular Signatures and Potential Caloric Restriction Mimetics with Neuroprotective Effects: Validation in an In Vitro Stroke Model

Krishna, N., Ramalakshmi, N. A., & Krishnamurthy, R. G. (2025) · Journal of Molecular Neuroscience · doi:10.1007/s12031-025-02328-5 · Cited by 2 · see citing works

The Ubiquitin–Proteasome System in Brain Disorders: Pathogenic Pathways, Post-Translational Tweaks, and Therapeutic Frontiers

Gupta, R. V., Begum, M. Y., Kumar, R., Gupta, J., Nagraik, R., Panda, S. P., Abomughaid, M. M., Lakhanpal, S., Avinash, D., Osmani, R. A. M., et al. (2025) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-025-10258-7 · Cited by 4 · see citing works

The Role of Curcumin as an Anti-Aging Compound

Karthika, C., Akter, R., Rahman, M. H., Zehravi, M., Ramproshad, S., Mondal, B., & Sweilam, S. H. (2023) · Springer eBooks · doi:10.1007/978-981-19-7443-4_11 · Cited by 2 · see citing works

Deciphering the anti-senescent effects of Clioquinol: Lifespan prolongation, metabolic homeostasis, and phenotypic rehabilitation in Drosophila melanogaster

Liu, X., Liu, X., Zhang, Y., Liu, Y., Lv, L.-W., Wang, M., Ren, Q., Liu, Y., Wu, M.-Z., Shi, Y., et al. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.06.046 · Cited by 2 · see citing works

阿尔茨海默病脑健康营养干预专家共识

Shi, H., & Xu, J. (2021) · Scientia Sinica Vitae · doi:10.1360/ssv-2021-0196 · Cited by 2 · see citing works

Nutrition as a systems regulator of brain aging trajectories

Müller, L., Benedetto, S. D., & Müller, V. (2026) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2026.1825800 · Cited by 1 · see citing works

Targeting neuroinflammation and neurodegeneration in Parkinson’s disease: Emerging natural and synthetic therapeutic strategies

Arbab, S., Ullah, H., Han, Y., Zhou, J., & Li, K. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103263 · Cited by 1 · see citing works

Crosstalk Between Autophagy and Nutrigenomics in Neurodegenerative Diseases

Russell, A. E., Badr, A., Rai, A., Carafice, C., Rai, A., Daily, K. P., Whitham, O. D., Amer, A. O., Brown, C. M., & Dakhlallah, D. A. (2022) · Nutritional neurosciences · doi:10.1007/978-981-16-9205-5_13 · Cited by 1 · see citing works

Rilmenidine mimics caloric restriction via the nischarin I1-imidazoline receptor to extend lifespan in C. elegansPreprint

Bennett, D. F., Goyala, A., Statzer, C., Beckett, C. W., Tyshkovskiy, A., Gladyshev, V. N., Ewald, C. Y., & de Magalhães, J. P. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.10.13.464294

Natural products as potential therapeutic agents against microplastic-induced neurodegenerative disease

Küçükkarapınar, M., & Reuter, H. (2025) · Studies in natural products chemistry · doi:10.1016/b978-0-443-23752-2.00010-4

The Role of Diet in Supporting Neuroplasticity and Promoting Brain Resilience

Lashin, B. I., Aldalil, S. S., Hefnawy, M. T., Elattar, M., Ghahremanpour, G. K., Mahmoud, A., & Hammad, Y. (2025) · Nutritional neurosciences · doi:10.1007/978-981-95-1983-5_7

Metabolic health and intermittent fasting: implications for age-related disorders

Ghosh, S., Singh, D. K. K., Raghunath, M., & Sinha, J. K. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-30060-8.00007-8

Caloric Restriction Mimetics as Drugs for Healthy Longevity

Tamatta, R., Pai, V., & Singh, A. K. (2026) · Healthy ageing and longevity · doi:10.1007/978-3-032-11608-6_19

Role of Ageing in Alzheimer's Therapeutics

Abdel-Sater, K. A. (2026) · Russian neurological Journal · doi:10.30629/2658-7947-2025-30-6-11-20

Systemic association between aging and Alzheimer′s disease: From shared mechanisms to multi-target interventions

Jiang, Q., & Yan-Jiang, W. A. N. G. (2026) · Shengming kexue · doi:10.3724/cbls.2026100

Caloric restriction mimetics rewire the AMPK–mTOR–ULK1 signaling nexus to restore autophagic proteostasis in the aging brain

Al-Jehani, H., Al‐kuraishy, H. M., Abdelaziz, A. M., Mohamed, A. A., Mamdoh, A. M., Musa, A., Mursy, O. M. A., & Batiha, G. E. (2026) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2026.104128

BindingDB Entry 50015909: The untapped potential of spermidine alkaloids: Sources, structures, bioactivities and syntheses.

BindingDB (2023) · UC San Diego · doi:10.7270/q2db85v3

Caloric restriction attenuates β‐amyloid neuropathology in a mouse model of Alzheimer's disease

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Caloric restriction: Beneficial effects on brain aging and Alzheimer’s disease

Van Cauwenberghe, C., Vandendriessche, C., Libert, C., & Vandenbroucke, R. E. (2016) · Mammalian Genome · doi:10.1007/s00335-016-9647-6 · Cited by 121 · see citing works

Long-Term Caloric Restriction Attenuates β-Amyloid Neuropathology and Is Accompanied by Autophagy in APPswe/PS1delta9 Mice

Müller, L., Guerra, N. P., Stenzel, J., Rühlmann, C., Lindner, T., Krause, B. J., Vollmar, B., Teipel, S. J., & Kuhla, A. (2021) · Nutrients · doi:10.3390/nu13030985 · Cited by 40 · see citing works

Metformin, a calorie restriction mimetic for the treatment of Alzheimer’s disease: A preclinical investigation

Benade, V. S., Jayarajan, P., Nandakumar, K., Kamuju, V., Gandipudi, S., & Nirogi, R. V. S. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.051635 · Cited by 3 · see citing works

Caloric restriction attenuates Aβ-deposition in Alzheimer transgenic models

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