Heterogeneous organization of the locus coeruleus projections to prefrontal and motor cortices
Open accessAbstract
Significance: The locus coeruleus projection system in the brain is thought to exert uniform and synchronous modulatory effects on cells and circuits throughout the CNS by widespread release of its transmitter, norepinephrine. We challenge this notion by demonstrating that neurons in the locus coeruleus maintain segregated connections to brain regions with distinctly different functions. Specifically, cells that communicate with the prefrontal cortex, a region involved in cognition and executive function, are characterized by properties that allow for independent and asynchronous modulation of operations in this area, compared with those that project to the motor cortex and regulate movement generation. These findings have important implications for understanding the role of this system in normal brain physiology and pathologic neuropsychiatric conditions.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A subset of locus coeruleus neurons project selectively to PFC, which may accentuate the stress response in this region.
“Indeed, a subset of locus coeruleus neurons project selectively to PFC50, which may accentuate the stress response in this region.”
From Stress weakens prefrontal networks: molecular insults to higher cognition (2015) · cites this paper as [50]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Davies, D. L., & Bouldin, D. W. (1979) · IEEE Transactions on Pattern Analysis and Machine Intelligence · doi:10.1109/tpami.1979.4766909 · Cited by 9,145 · see citing works
Stress signalling pathways that impair prefrontal cortex structure and function
Arnsten, A. F. T. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2648 · Cited by 3,299 · see citing works
Berridge, C. W., & Waterhouse, B. D. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(03)00143-7 · Cited by 2,529 · see citing works
Self-citationThe locus coeruleus and noradrenergic modulation of cognition
Sara, S. J. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2573 · Cited by 1,848 · see citing works
Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates
Dalley, J. W., Cardinal, R. N., & Robbins, T. W. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.09.006 · Cited by 1,329 · see citing works
Input-specific control of reward and aversion in the ventral tegmental area
Lammel, S., Lim, B. K., Ran, C., Huang, K. W., Betley, M. J., Tye, K. M., Deisseroth, K., & Malenka, R. C. (2012) · Nature · doi:10.1038/nature11527 · Cited by 1,300 · see citing works
Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system
Lammel, S., Hetzel, A., Häckel, O., Jones, I., Liss, B., & Roeper, J. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.022 · Cited by 976 · see citing works
Action potential generation requires a high sodium channel density in the axon initial segment
Kole, M. H. P., Ilschner, S. U., Kampa, B. M., Williams, S. R., Ruben, P. C., & Stuart, G. J. (2008) · Nature Neuroscience · doi:10.1038/nn2040 · Cited by 703 · see citing works
Adrenergic pharmacology and cognition: Focus on the prefrontal cortex
Ramos, B. P., & Arnsten, A. F. T. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.11.006 · Cited by 641 · see citing works
Adaptive gain and the role of the locus coeruleus–norepinephrine system in optimal performance
Aston‐Jones, G., & Cohen, J. D. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20723 · Cited by 630 · see citing works
Berridge, C. W., Devilbiss, D. M., Andrzejewski, M. E., Arnsten, A. F. T., Kelley, A. E., Schmeichel, B., Hamilton, C., & Spencer, R. C. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.04.022 · Cited by 617 · see citing works
Sagvolden, T. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00058-5 · Cited by 525 · see citing works
The locus coeruleus: neurobiology of a central noradrenergic nucleus
Amaral, D. G., & Sinnamon, H. M. (1977) · Progress in Neurobiology · doi:10.1016/0301-0082(77)90016-8 · Cited by 495 · see citing works
Rodent Models of Attention-Deficit/Hyperactivity Disorder
Sagvolden, T., Russell, V. A., Aase, H., Johansen, E. B., & Farshbaf, M. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.02.002 · Cited by 448 · see citing works
Loughlin, S. E., Foote, S. L., & Grzanna, R. (1986) · Neuroscience · doi:10.1016/0306-4522(86)90156-9 · Cited by 437 · see citing works
Arnsten, A. F. T. (2009) · CNS Drugs · doi:10.2165/00023210-200923000-00005 · Cited by 371 · see citing works
Loughlin, S. E., Foote, S. L., & Bloom, F. E. (1986) · Neuroscience · doi:10.1016/0306-4522(86)90155-7 · Cited by 364 · see citing works
Membrane properties of rat locus coeruleus neurones
Williams, J. T., North, R. A., Shefner, S. A., Nishi, S., & Egan, T. M. (1984) · Neuroscience · doi:10.1016/0306-4522(84)90265-3 · Cited by 341 · see citing works
Bluhm, M. D. L., & Morilak, D. A. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.09.031 · Cited by 325 · see citing works
Mehta, M. A., Goodyer, I. M., & Sahakian, B. J. (2004) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2004.00221.x · Cited by 257 · see citing works
Developmental origins of central norepinephrine neuron diversity
Robertson, S. D., Plummer, N. W., de Marchena, J., & Jensen, P. (2013) · Nature Neuroscience · doi:10.1038/nn.3458 · Cited by 249 · see citing works
Through the looking glass: Differential noradenergic modulation of prefrontal cortical function
Arnsten, A. F. T. (2000) · Neural Plasticity · doi:10.1155/np.2000.133 · Cited by 229 · see citing works
McGaughy, J., Ross, R. S., & Eichenbaum, H. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.01.064 · Cited by 226 · see citing works
Locus coeruleus projections to cortex: Topography, morphology and collateralization
Loughlin, S. E., Foote, S. L., & Fallon, J. H. (1982) · Brain Research Bulletin · doi:10.1016/0361-9230(82)90142-3 · Cited by 212 · see citing works
Synchronous Activity in Locus Coeruleus Results from Dendritic Interactions in Pericoerulear Regions
Ishimatsu, M., & Williams, J. T. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-16-05196.1996 · Cited by 201 · see citing works
The distribution of neocortical projection neurons in the locus coeruleus
Waterhouse, B. D., Lin, C.-S., Burne, R. A., & Woodward, D. J. (1983) · The Journal of Comparative Neurology · doi:10.1002/cne.902170406 · Cited by 180 · see citing works
Self-citationChandler, D. J., Lamperski, C. S., & Waterhouse, B. D. (2013) · Brain Research · doi:10.1016/j.brainres.2013.04.057 · Cited by 173 · see citing works
Self-citationBerridge, C. W., & Abercrombie, E. D. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00276-6 · Cited by 171 · see citing works
Monoamine innervation of the forebrain: Collateralization
Fallon, J. H., & Loughlin, S. E. (1982) · Brain Research Bulletin · doi:10.1016/0361-9230(82)90143-5 · Cited by 170 · see citing works
Russell, V. A. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00425-9 · Cited by 167 · see citing works
Devilbiss, D. M., & Waterhouse, B. D. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1573-04.2004 · Cited by 162 · see citing works
Self-citationRussell, V. A., de Villiers, A. S., Sagvolden, T., Lamm, M. C. L., & Taljaard, J. J. F. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00177-0 · Cited by 147 · see citing works
Newman, L. A., Darling, J., & McGaughy, J. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1097-8 · Cited by 137 · see citing works
Locus Ceruleus Regulates Sensory Encoding by Neurons and Networks in Waking Animals
Devilbiss, D. M., Page, M. E., & Waterhouse, B. D. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1776-06.2006 · Cited by 121 · see citing works
Self-citationInhibition of the norepinephrine transporter improves behavioral flexibility in rats and monkeys
Seu, E., Lang, A., Rivera, R. J., & Jentsch, J. D. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1250-4 · Cited by 121 · see citing works
Nagai, T., Satoh, K., Imamoto, K., & Maeda, T. (1981) · Neuroscience Letters · doi:10.1016/0304-3940(81)90027-6 · Cited by 118 · see citing works
Devilbiss, D. M., & Berridge, C. W. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.04.037 · Cited by 117 · see citing works
Waterhouse, B. D., Border, B. G., Wahl, L., & Mihailoff, G. A. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903360304 · Cited by 111 · see citing works
Self-citationChandler, D. J., & Waterhouse, B. D. (2012) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2012.00020 · Cited by 99 · see citing works
Self-citationBerridge, C. W., Shumsky, J. S., Andrzejewski, M. E., McGaughy, J. A., Spencer, R. C., Devilbiss, D. M., & Waterhouse, B. D. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.07.022 · Cited by 94 · see citing works
Self-citationCortical inputs to m2-immunoreactive striatal interneurons in rat and monkey
Thomas, T. M., Smith, Y., Levey, A. I., & Hersch, S. M. (2000) · Synapse · doi:10.1002/1098-2396(20000915)37:4 · Cited by 81 · see citing works
Low-dose methylphenidate actions on tonic and phasic locus coeruleus discharge
Devilbiss, D. M., & Berridge, C. W. (2006) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.110015 · Cited by 67 · see citing works
Moxon, K. A., Devilbiss, D. M., Chapin, J. K., & Waterhouse, B. D. (2007) · Brain Research · doi:10.1016/j.brainres.2007.02.006 · Cited by 56 · see citing works
Self-citationAtomoxetine facilitates attentional set shifting in adolescent rats
Cain, R. E., Wasserman, M. C., Waterhouse, B. D., & McGaughy, J. A. (2011) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2011.04.003 · Cited by 55 · see citing works
Self-citationPoyurovsky, M., Faragian, S., Fuchs, C., & Pashinian, A. (2009) · PubMed · Cited by 23 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Devilbiss DM, Waterhouse BD (2000) Norepinephrine exhibits two distinct profiles of action on sensory cortical neuron responses to excitatory synaptic stimuli. Synapse 37(4):273-282.
Cited by
Sorted by citations
Joshi, S., Li, Y., Kalwani, R. M., & Gold, J. I. (2016) · Neuron · doi:10.1016/j.neuron.2015.11.028 · Cited by 1,387 · see citing works
Stress weakens prefrontal networks: molecular insults to higher cognition
Arnsten, A. F. T. (2015) · Nature Neuroscience · doi:10.1038/nn.4087 · Cited by 752 · see citing works
Viral-genetic tracing of the input-output organization of a central noradrenaline circuit
Schwarz, L. A., Miyamichi, K., Gao, X. J., Beier, K. T., Weissbourd, B., DeLoach, K. E., Ren, J., Ibanes, S., Malenka, R. C., Kremer, E. J., et al. (2015) · Nature · doi:10.1038/nature14600 · Cited by 744 · see citing works
Locus coeruleus: a new look at the blue spot
Poe, G. R., Foote, S., Eschenko, O., Johansen, J. P., Bouret, S., Aston-Jones, G., Harley, C. W., Manahan-Vaughan, D., Weinshenker, D., Valentino, R., et al. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-0360-9 · Cited by 720 · see citing works
Self-citationMather, M., Clewett, D., Sakaki, M., & Harley, C. W. (2016) · Behavioral and Brain Sciences · doi:10.1017/s0140525x15000667 · Cited by 695 · see citing works
Organization of the Locus Coeruleus-Norepinephrine System
Schwarz, L. A., & Luo, L. (2015) · Current Biology · doi:10.1016/j.cub.2015.09.039 · Cited by 578 · see citing works
High-throughput mapping of single-neuron projections by sequencing of barcoded RNA
Kebschull, J. M., Garcia da Silva, P., Reid, A. P., Peikon, I. D., Albeanu, D. F., & Zador, A. M. (2016) · Neuron · doi:10.1016/j.neuron.2016.07.036 · Cited by 376 · see citing works
Development of prefrontal cortex
Kolk, S. M., & Rakic, P. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01137-9 · Cited by 378 · see citing works
Arnsten, A. F. T., Raskind, M. A., Taylor, F. B., & Connor, D. F. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2014.10.002 · Cited by 381 · see citing works
Thiele, A., & Bellgrove, M. A. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.008 · Cited by 350 · see citing works
Neuromodulation of brain state and behavior
McCormick, D. A., Nestvogel, D. B., & He, B. J. (2020) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-100219-105424 · Cited by 303 · see citing works
Modular organization of the brainstem noradrenaline system coordinates opposing learning states
Uematsu, A., Tan, B. Z., Ycu, E. A., Cuevas, J. N. S., Koivumaa, J., Junyent, F., Kremer, E. J., Witten, I. B., Deisseroth, K. A., & Johansen, J. P. (2017) · Nature Neuroscience · doi:10.1038/nn.4642 · Cited by 331 · see citing works
Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine
Kjaerby, C., Andersen, M., Hauglund, N., Untiet, V., Dall, C., Sigurdsson, B., Ding, F., Feng, J., Li, Y., Weikop, P., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01102-9 · Cited by 306 · see citing works
Locus coeruleus: From global projection system to adaptive regulation of behavior
Aston‐Jones, G., & Waterhouse, B. D. (2016) · Brain Research · doi:10.1016/j.brainres.2016.03.001 · Cited by 268 · see citing works
Self-citationHirschberg, S., Li, Y., Randall, A. D., Kremer, E. J., & Pickering, A. E. (2017) · eLife · doi:10.7554/elife.29808 · Cited by 252 · see citing works
Locus coeruleus norepinephrine activity mediates sensory-evoked awakenings from sleep
Hayat, H., Regev, N., Matosevich, N., Sales, A. C., Paredes-Rodriguez, E., Krom, A. J., Bergman, L., Li, Y., Lavigne, M., Kremer, E. J., et al. (2020) · Science Advances · doi:10.1126/sciadv.aaz4232 · Cited by 255 · see citing works
Chandler, D. J., Jensen, P., McCall, J. G., Pickering, A. E., Schwarz, L. A., & Totah, N. K. B. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1164-19.2019 · Cited by 215 · see citing works
Self-citationThe role of the locus coeruleus in the generation of pathological anxiety
Morris, L. S., McCall, J. G., Charney, D. S., & Murrough, J. W. (2020) · Brain and Neuroscience Advances · doi:10.1177/2398212820930321 · Cited by 224 · see citing works
Noradrenergic Locus Coeruleus pathways in pain modulation
Llorca-Torralba, M., Borges, G., Neto, F. L. M., Micó, J. A., & Berrocoso, E. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.05.057 · Cited by 230 · see citing works
Ross, J. A., & Bockstaele, E. J. V. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.601519 · Cited by 223 · see citing works
The role of noradrenaline in cognition and cognitive disorders
Holland, N., Robbins, T. W., & Rowe, J. B. (2021) · Brain · doi:10.1093/brain/awab111 · Cited by 201 · see citing works
Noradrenergic Modulation of Cognition in Health and Disease
Borodovitsyna, O., Flamini, M. D., & Chandler, D. J. (2017) · Neural Plasticity · doi:10.1155/2017/6031478 · Cited by 210 · see citing works
Self-citationNeurotransmitter deficits from frontotemporal lobar degeneration
Murley, A. G., & Rowe, J. B. (2017) · Brain · doi:10.1093/brain/awx327 · Cited by 199 · see citing works
Cools, R., & Arnsten, A. F. T. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01100-8 · Cited by 206 · see citing works
Xing, B., Li, Y.-C., & Gao, W.-J. (2016) · Brain Research · doi:10.1016/j.brainres.2016.01.005 · Cited by 196 · see citing works
Self-citationNoradrenergic Modulation of Fear Conditioning and Extinction
Giustino, T. F., & Maren, S. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00043 · Cited by 189 · see citing works
The Locus Coeruleus Is a Complex and Differentiated Neuromodulatory System
Totah, N. K., Neves, R. M., Panzeri, S., Logothetis, N. K., & Eschenko, O. (2018) · Neuron · doi:10.1016/j.neuron.2018.07.037 · Cited by 179 · see citing works
Neuromodulation in circuits of aversive emotional learning
Likhtik, E., & Johansen, J. P. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0503-3 · Cited by 165 · see citing works
Oe, Y., Wang, X., Patriarchi, T., Konno, A., Ozawa, K., Yahagi, K., Hirai, H., Tsuboi, T., Kitaguchi, T., Tian, L., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14378-x · Cited by 166 · see citing works
The Noradrenergic System in Parkinson’s Disease
Paredes-Rodriguez, E., Vegas‐Suárez, S., Morera‐Herreras, T., Deurwaerdère, P. D., & Miguélez, C. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00435 · Cited by 165 · see citing works
Noradrenergic modulation of rhythmic neural activity shapes selective attention
Dahl, M. J., Mather, M., & Werkle‐Bergner, M. (2021) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2021.10.009 · Cited by 158 · see citing works
Locus Coeruleus in time with the making of memories
Sara, S. J. (2015) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2015.07.004 · Cited by 156 · see citing works
Recent advances in the neurobiology and neuropharmacology of Alzheimer’s disease
Kumar, K., Kumar, A., Keegan, R. M., & Deshmukh, R. R. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.12.053 · Cited by 153 · see citing works
Monoaminergic Neuromodulation of Sensory Processing
Jacob, S. N., & Nienborg, H. (2018) · Frontiers in Neural Circuits · doi:10.3389/fncir.2018.00051 · Cited by 143 · see citing works
Sales, A. C., Friston, K. J., Jones, M. W., Pickering, A. E., & Moran, R. (2019) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1006267 · Cited by 146 · see citing works
Locus Ceruleus Norepinephrine Release: A Central Regulator of CNS Spatio-Temporal Activation?
Atzori, M., Cuevas‐Olguin, R., Esquivel‐Rendon, E., García‐Oscos, F., Salgado‐Delgado, R., Saderi, N., Miranda‐Morales, M., Treviño, M., Pineda, J. C., & Salgado, H. (2016) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2016.00025 · Cited by 144 · see citing works
Locus coeruleus-norepinephrine modulation of sensory processing and perception: A focused review
McBurney-Lin, J., Lu, J., Zuo, Y., & Yang, H. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.06.009 · Cited by 137 · see citing works
Spatiotemporal dynamics of noradrenaline during learned behaviour
Breton‐Provencher, V., Drummond, G. T., Feng, J., Li, Y., & Sur, M. (2022) · Nature · doi:10.1038/s41586-022-04782-2 · Cited by 135 · see citing works
Laminar and Cellular Distribution of Monoamine Receptors in Rat Medial Prefrontal Cortex
Santana, N., & Artigas, F. (2017) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2017.00087 · Cited by 131 · see citing works
The Locus Coeruleus in Aging and Alzheimer’s Disease: A Postmortem and Brain Imaging Review
Beardmore, R., Hou, R. H., Darekar, A., Holmes, C., & Boche, D. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210191 · Cited by 120 · see citing works
Zhang, S., Hu, S., Chao, H. H., & Li, C.-S. R. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv172 · Cited by 119 · see citing works
Volume Transmission in Central Dopamine and Noradrenaline Neurons and Its Astroglial Targets
Fuxé, K., Agnati, L. F., Marcoli, M., & Borroto‐Escuela, D. O. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1574-5 · Cited by 115 · see citing works
Expanding the power of recombinase-based labeling to uncover cellular diversity
Plummer, N. W., Evsyukova, I. Y., Robertson, S. D., de Marchena, J., Tucker, C. J., & Jensen, P. (2015) · Development · doi:10.1242/dev.129981 · Cited by 108 · see citing works
Berridge, C. W., & Spencer, R. C. (2016) · Brain Research · doi:10.1016/j.brainres.2015.11.024 · Cited by 112 · see citing works
Pupil diameter is not an accurate real-time readout of locus coeruleus activity
Megemont, M., McBurney-Lin, J., & Yang, H. (2022) · eLife · doi:10.7554/elife.70510 · Cited by 115 · see citing works
Li, Y., Hickey, L., Perrins, R., Werlen, E., Patel, A. A., Hirschberg, S., Jones, M. W., Salinas, S., Kremer, E. J., & Pickering, A. E. (2016) · Brain Research · doi:10.1016/j.brainres.2016.02.023 · Cited by 97 · see citing works
Waterhouse, B. D., & Navarra, R. L. (2018) · Brain Research · doi:10.1016/j.brainres.2018.08.032 · Cited by 107 · see citing works
Self-citationFernandez, S. P., Cauli, B., Cabezas, C., Muzerelle, A., Poncer, J.-C., & Gaspar, P. (2016) · Brain Structure and Function · doi:10.1007/s00429-015-1142-4 · Cited by 100 · see citing works
The role of norepinephrine in the pathophysiology of schizophrenia
Mäki-Marttunen, V., Andreassen, O. A., & Espeseth, T. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.07.038 · Cited by 97 · see citing works
Persistent Stress-Induced Neuroplastic Changes in the Locus Coeruleus/Norepinephrine System
Borodovitsyna, O., Joshi, N., & Chandler, D. J. (2018) · Neural Plasticity · doi:10.1155/2018/1892570 · Cited by 95 · see citing works
Self-citationUematsu, A., Tan, B. Z., & Johansen, J. P. (2015) · Learning & Memory · doi:10.1101/lm.037283.114 · Cited by 89 · see citing works
Borodovitsyna, O., Flamini, M. D., & Chandler, D. J. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.01.020 · Cited by 94 · see citing works
Self-citationMonoaminergic Modulation of Motor Cortex Function
Vitrac, C., & Benoit‐Marand, M. (2017) · Frontiers in Neural Circuits · doi:10.3389/fncir.2017.00072 · Cited by 84 · see citing works
Metabolic Plasticity of Astrocytes and Aging of the Brain
Morita, M., Ikeshima‐Kataoka, H., Kreft, M., Vardjan, N., Zorec, R., & Noda, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040941 · Cited by 88 · see citing works
Collins, L. N., Francis, J., Emanuel, B., & McCormick, D. A. (2023) · eLife · doi:10.7554/elife.81826 · Cited by 88 · see citing works
Brainstem Modulation of Large-Scale Intrinsic Cortical Activity Correlations
van den Brink, R. L., Pfeffer, T. A., & Donner, T. H. (2019) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2019.00340 · Cited by 83 · see citing works
Role of the locus coeruleus arousal system in cognitive control
Grueschow, M., Kleim, B., & Ruff, C. C. (2020) · Journal of Neuroendocrinology · doi:10.1111/jne.12890 · Cited by 82 · see citing works
Gompf, H. S., Budygin, E. A., Fuller, P. M., & Bass, C. E. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00152 · Cited by 80 · see citing works
Chandler, D. J. (2015) · Brain Research · doi:10.1016/j.brainres.2015.11.022 · Cited by 79 · see citing works
Self-citationCatecholaminergic Neuromodulation Shapes Intrinsic MRI Functional Connectivity in the Human Brain
van den Brink, R. L., Pfeffer, T. A., Warren, C. M., Murphy, P. R., Tona, K., van der Wee, N. J. A., Giltay, E. J., van Noorden, M. S., Rombouts, S. A. R. B., Donner, T. H., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0744-16.2016 · Cited by 80 · see citing works
Noradrenergic and cholinergic systems take centre stage in neuropsychiatric diseases of ageing
Orlando, I. F., Shine, J. M., Robbins, T. W., Rowe, J. B., & O’Callaghan, C. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105167 · Cited by 77 · see citing works
Prefrontal modulation of anxiety through a lens of noradrenergic signaling
Bouras, N. N., Mack, N. R., & Gao, W. (2023) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2023.1173326 · Cited by 81 · see citing works
Self-citationIntegrating brainstem and cortical functional architectures
Hansen, J. Y., Cauzzo, S., Singh, K., García‐Gomar, M. G., Shine, J. M., Bianciardi, M., & Mišić, B. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01787-0 · Cited by 83 · see citing works
Exercise enhances motor skill learning by neurotransmitter switching in the adult midbrain
Li, H.-Q., & Spitzer, N. C. (2020) · Nature Communications · doi:10.1038/s41467-020-16053-7 · Cited by 76 · see citing works
Region-Specific Dissociation between Cortical Noradrenaline Levels and the Sleep/Wake Cycle
Bellesi, M., Tononi, G., Cirelli, C., & Serra, P. A. (2015) · SLEEP · doi:10.5665/sleep.5336 · Cited by 72 · see citing works
Heterogeneous pericoerulear neurons tune arousal and exploratory behaviours
Luskin, A. T., Li, L., Fu, X., Martin, M. M., Barcomb, K., Girven, K. S., Blackburn, T., Wells, B. A., Thai, S., Li, E. M., et al. (2025) · Nature · doi:10.1038/s41586-025-08952-w · Cited by 75 · see citing works
Briand, M., Gosseries, O., Staumont, B., Laureys, S., & Thibaut, A. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00933 · Cited by 74 · see citing works
Azizi, S. A. (2020) · The Neuroscientist · doi:10.1177/1073858420974336 · Cited by 76 · see citing works
Convergent and Divergent Mechanisms of Epileptogenesis in mTORopathies
Nguyen, L. H., & Bordey, A. (2021) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2021.664695 · Cited by 72 · see citing works
Memory Formation Shaped by Astroglia
Zorec, R., Horvat, A., Vardjan, N., & Verkhratsky, A. (2015) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2015.00056 · Cited by 70 · see citing works
Arousal dependent modulation of thalamo-cortical functional interaction
Stitt, I., Zhou, Z. C., Radtke‐Schuller, S., & Frӧhlich, F. (2018) · Nature Communications · doi:10.1038/s41467-018-04785-6 · Cited by 70 · see citing works
Noradrenergic ensemble-based modulation of cognition over multiple timescales
Totah, N. K. B., Logothetis, N. K., & Eschenko, O. (2018) · Brain Research · doi:10.1016/j.brainres.2018.12.031 · Cited by 65 · see citing works
Gilvesy, A., Husén, E., Maglóczky, Z., Mihály, O. S., Hortobágyi, T., Kanatani, S., Heinsen, H., Renier, N., Hökfelt, T. G. M., Mulder, J., et al. (2022) · Acta Neuropathologica · doi:10.1007/s00401-022-02477-6 · Cited by 68 · see citing works
Yamaguchi, H., Hopf, F. W., Li, S., & de Lecea, L. (2018) · Nature Communications · doi:10.1038/s41467-018-07566-3 · Cited by 66 · see citing works
Borodovitsyna, O., Duffy, B. C., Pickering, A. E., & Chandler, D. J. (2020) · Neurobiology of Stress · doi:10.1016/j.ynstr.2020.100284 · Cited by 61 · see citing works
Self-citationLocus coeruleus MRI contrast is associated with cortical thickness in older adults
Bachman, S. L., Dahl, M. J., Werkle‐Bergner, M., Düzel, S., Forlim, C. G., Lindenberger, U., Kühn, S., & Mather, M. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.12.019 · Cited by 64 · see citing works
Distinct ensembles in the noradrenergic locus coeruleus are associated with diverse cortical states
Noei, S., Zouridis, I. S., Logothetis, N. K., Panzeri, S., & Totah, N. K. B. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2116507119 · Cited by 56 · see citing works
Sadacca, B. F., Wikenheiser, A. M., & Schoenbaum, G. M. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.04.017 · Cited by 59 · see citing works
Dual contributions of noradrenaline to behavioural flexibility and motivation
Jahn, C. I., Gilardeau, S., Varazzani, C., Blain, B., Sallet, J., Walton, M. E., & Bouret, S. (2018) · Psychopharmacology · doi:10.1007/s00213-018-4963-z · Cited by 57 · see citing works
Down but Not Out: The Consequences of Pretangle Tau in the Locus Coeruleus
Chalermpalanupap, T., Weinshenker, D., & Rorabaugh, J. M. (2017) · Neural Plasticity · doi:10.1155/2017/7829507 · Cited by 56 · see citing works
Cellular composition and circuit organization of the locus coeruleus of adult mice
McKinney, A., Hu, M., Hoskins, A., Mohammadyar, A., Naeem, N., Jing, J., Patel, S. S., Sheth, B. R., & Jiang, X. (2023) · eLife · doi:10.7554/elife.80100 · Cited by 53 · see citing works
Regulation of neurological and neuropsychiatric phenotypes by locus coeruleus-derived galanin
Weinshenker, D., & Holmes, P. V. (2015) · Brain Research · doi:10.1016/j.brainres.2015.11.025 · Cited by 58 · see citing works
Ectopic HCN4 expression drives mTOR-dependent epilepsy in mice
Hsieh, L. S., Wen, J. H., Nguyen, L. H., Zhang, L., Getz, S. A., Torres-Reveron, J., Wang, Y., Spencer, D. D., & Bordey, A. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.abc1492 · Cited by 51 · see citing works
Plummer, N. W., Chandler, D. J., Powell, J. M., Scappini, E., Waterhouse, B. D., & Jensen, P. (2020) · eNeuro · doi:10.1523/eneuro.0010-20.2020 · Cited by 54 · see citing works
Self-citationArnsten, A. F. T., Joyce, M. K. P., & Roberts, A. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.105000 · Cited by 58 · see citing works
Huber, N., Korhonen, S., Hoffmann, D. B., Leskelä, S., Rostalski, H., Remes, A. M., Honkakoski, P., Solje, E., & Haapasalo, A. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01384-8 · Cited by 55 · see citing works
Noradrenergic Hypothesis Linking Neurodegeneration-Based Cognitive Decline and Astroglia
Leanza, G., Gulino, R., & Zorec, R. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00254 · Cited by 54 · see citing works
Fluid intelligence and the locus coeruleus–norepinephrine system
Tsukahara, J. S., & Engle, R. W. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2110630118 · Cited by 56 · see citing works
Pharmacological evidence for the implication of noradrenaline in effort
Borderies, N., Mattioni, J., Bornert, P., Gilardeau, S., & Bouret, S. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000793 · Cited by 49 · see citing works
The expression of established cognitive brain states stabilizes with working memory development
Montez, D. F., Calabro, F. J., & Luna, B. (2017) · eLife · doi:10.7554/elife.25606 · Cited by 52 · see citing works
Two types of locus coeruleus norepinephrine neurons drive reinforcement learningPreprint
Su, Z., & Cohen, J. Y. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.08.519670 · Cited by 50 · see citing works
Köhler, S., Bär, K., & Wagner, G. (2016) · Human Brain Mapping · doi:10.1002/hbm.23173 · Cited by 52 · see citing works
Sigurdardottir, H. L., Kranz, G. S., Rami‐Mark, C., James, G. M., Vanicek, T., Gryglewski, G., Kautzky, A., Hienert, M., Traub‐Weidinger, T., Mitterhauser, M., et al. (2016) · Human Brain Mapping · doi:10.1002/hbm.23071 · Cited by 51 · see citing works
Slater, C. L., Liu, Y., Weiss, E., Yu, K., & Wang, Q. (2022) · Brain Sciences · doi:10.3390/brainsci12070890 · Cited by 49 · see citing works
Noga, B. R., Turkson, R. P., Xie, S., Taberner, A. M., Pinzón, A., & Hentall, I. D. (2017) · Frontiers in Neural Circuits · doi:10.3389/fncir.2017.00059 · Cited by 50 · see citing works
Janitzky, K. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00371 · Cited by 50 · see citing works
Gong, L., Shi, M., Wang, J., Xu, R., Yu, S., Liu, D., Ding, X., Zhang, B., Zhang, X., & Xi, C. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.678465 · Cited by 49 · see citing works
Kelberman, M. A., Rorabaugh, J. M., Anderson, C. R., Marriott, A., DePuy, S. D., Rasmussen, K., McCann, K. E., Weiss, J. M., & Weinshenker, D. (2022) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2023.01.016 · Cited by 47 · see citing works
Associative memory cells and their working principle in the brain
Wang, J., & Cui, S. (2018) · F1000Research · doi:10.12688/f1000research.13665.1 · Cited by 46 · see citing works
Kelberman, M. A., Keilholz, S. D., & Weinshenker, D. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.583421 · Cited by 43 · see citing works
- Authors
- Chandler, D. J., Gao, W.-J., & Waterhouse, B. D.
- Affiliations
- Drexel University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2014-04-21
- Volume
- 111
- Issue
- 18
- Pages
- 6816-6821
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4020069
- OpenAlex
- W2109682741
- Cited by
- 341
- References
- 45
- Citations by year
- 2026: 41 · 2025: 35 · 2024: 36 · 2023: 28 · 2022: 31 · 2021: 24 · 2020: 32 · 2019: 26 · 2018: 25 · 2017: 23 · 2016: 16 · 2015: 23 · 2014: 1
- FWCI
- 9.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Rowan Digitals Works (Rowan University) (submittedVersion)
- Funders
- National Institute of Mental Health (R01MH085666, R01MH101178)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- locus coeruleus, norepinephrine, prefrontal cortex, motor cortex, efferent projections, neuronal heterogeneity, noradrenaline release, noradrenergic neurons, adaptive and maladaptive behavior
- MeSH terms
- Animals, Behavior, Animal, Efferent Pathways, Locus Coeruleus, Male, Motor Cortex, Norepinephrine, RNA, Messenger, Tyrosine 3-Monooxygenase, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, Prefrontal Cortex, Receptors, AMPA, alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid, Principal Component Analysis, Vesicular Monoamine Transport Proteins, Rats, Voltage-Gated Sodium Channel beta-3 Subunit
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review