Need for speed: Evaluating slopes of OCD recovery in behavior therapy enhanced with d-cycloserine

Chasson, Gregory S.; Buhlmann, Ulrike; Tolin, David F.; Rao, Sowmya R.; Reese, Hannah E.; Rowley, Theresa; Welsh, Kaitlyn S.; Wilhelm, Sabine

doi:10.1016/j.brat.2010.03.007

Cited by 106Obsessive-Compulsive Spectrum DisordersAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychoanalysis and Psychopathology Research

Need for speed: Evaluating slopes of OCD recovery in behavior therapy enhanced with d-cycloserine

Chasson, Gregory S., Buhlmann, Ulrike, Tolin, David F., Rao, Sowmya R., Reese, Hannah E., Rowley, Theresa, Welsh, Kaitlyn S., Wilhelm, Sabine·2010·Behaviour Research and Therapy

DOI 10.1016/j.brat.2010.03.007

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Abstract

Evidence suggests that the antibiotic d-cycloserine (DCS) enhances the treatment effects of exposure and response prevention (ERP) for Obsessive-Compulsive Disorder (OCD). Further, evidence suggests that the effects of DCS diminish partway through treatment, but it is unclear to what extent. In an effort to evaluate these issues, the current study re-analyzes data from a 10-session randomized controlled trial of ERP+DCS versus ERP+placebo in a sample of 22 adults with OCD. We analyzed repeated-measures mixed models with random slopes and intercepts across different intervals: sessions 1-10, 1-5, and 6-10. The results indicate that the course of ERP was 2.3 times faster over the full 10 sessions for the DCS compared to the placebo group, and nearly six times quicker in the first half of ERP. Further interpretation of the results suggests that DCS does not amplify the effects of ERP, but instead initiates treatment effects sooner in treatment. In addition, DCS does not necessarily lose its effect over repeated use, but instead may exhaust its maximum utility after effectively jump-starting ERP. Ultimately, DCS may provide a means for curtailing treatment costs, decreasing treatment dropout and refusal rates, and enhancing access to care.

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Authors: Chasson, G. S., Buhlmann, U., Tolin, D. F., Rao, S. R., Reese, H. E., Rowley, T., Welsh, K. S., & Wilhelm, S.
Affiliations: Harvard University (US)
Humboldt-Universität zu Berlin (DE)
Yale University (US)
Corresponding author: Wilhelm, Sabine
ORCID: Chasson, Gregory S.
Buhlmann, Ulrike
Tolin, David F.
Rao, Sowmya R.
Reese, Hannah E.
Wilhelm, Sabine
Venue: Behaviour Research and Therapy
Publisher: Elsevier BV
Published: 2010-07
Volume: 48
Issue: 7
Pages: 675-679
ISSN: 0005-7967 (ISSN-L)
DOI: 10.1016/j.brat.2010.03.007
OpenAlex: W1990461673
Cited by: 106
References: 20
Citations by year: 2024: 4 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 6 · 2018: 6 · 2017: 8 · 2016: 7 · 2015: 10 · 2014: 19 · 2013: 19 · 2012: 6
FWCI: 12.96
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Behaviour Research and Therapy (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
Keywords: D-cycloserine, obsessive-compulsive disorder, exposure and response prevention, placebo comparison, treatment discontinuation, treatment costs, health care access
MeSH terms: Adult, Behavior Therapy, Combined Modality Therapy, Cycloserine, Female, Humans, Interview, Psychological, Male, Middle Aged, Obsessive-Compulsive Disorder, Psychiatric Status Rating Scales, Psychotropic Drugs, Self-Assessment, Time Factors, Treatment Outcome, Young Adult

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Need for speed: Evaluating slopes of OCD recovery in behavior therapy enhanced with d-cycloserine

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