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Modifying motor learning through gating and homeostatic metaplasticity
Abstract
Synaptic plasticity in the motor cortex is involved at least in some forms of motor learning. Recent evidence showed that the extent of practice-dependent plasticity in the motor cortex can be purposefully enhanced by experimental manipulation. One way of improving motor learning is to transiently increase the excitability of the motor cortex during motor learning. This can be achieved by weakening the excitability of intracortical inhibitory circuits concurrently with practice. This principle is being referred to as "gating." Another strategy to boost learning is to decrease the threshold for induction of synaptic plasticity by lowering neuronal activity in the motor cortex before practice. This approach invokes homeostatic metaplasticity. Here we highlight how transcranial brain stimulation can exploit gating and homeostatic metaplasticity to enhance motor learning in healthy subjects and in patients after stroke.
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“yielding larger and long-lasting functional improvements that modify the impaired system (Cramer et al., 2011).”
From Cognitive Neuroscience of Attention Deficit Hyperactivity Disorder (ADHD) and Its Clinical Translation (2018) · cites this paper as Ziemann and Siebner, 2008
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“…improve task performance (Kuo and Nitsche, 2012), presumably via boosting training-induced plasticity through the addition of stimulation-induced plasticity (Ziemann and Siebner, 2008), yielding larger and long-lasting functional improvements that modify the impaired system (Cramer et al., 2011).”
BackgroundRandom Noise Stimulation Improves Neuroplasticity in Perceptual Learning
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Metadata
- Authors
- Ziemann, U., & Siebner, H. R.
- Affiliations
- Goethe University Frankfurt (DE)
- Christian-Albrechts-Universität zu Kiel (DE)
- Corresponding author
- Ziemann, Ulf
- Venue
- Brain Stimulation
- Publisher
- Elsevier BV
- Published
- 2008-01
- Volume
- 1
- Issue
- 1
- Pages
- 60-66
- ISSN
- 1876-4754 (ISSN-L)
- 1935-861X
- OpenAlex
- W2031034560
- Cited by
- 269
- References
- 73
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 13 · 2023: 12 · 2022: 15 · 2021: 24 · 2020: 19 · 2019: 19 · 2018: 21 · 2017: 12 · 2016: 19 · 2015: 26 · 2014: 16 · 2013: 19 · 2012: 15
- FWCI
- 0.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain stimulation (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- motor learning, motor cortex, synaptic plasticity, gating, intracortical inhibition, cortical excitability, transcranial brain stimulation, stroke rehabilitation
- MeSH terms
- Stroke Rehabilitation, Homeostasis, Humans, Learning, Motor Activity, Motor Cortex, Neuronal Plasticity, Stroke, Transcranial Magnetic Stimulation
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