Cited by 269Transcranial Magnetic Stimulation StudiesMotor Control and AdaptationNeuroscience and Neuropharmacology Research

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Modifying motor learning through gating and homeostatic metaplasticity

Ziemann, Ulf, Siebner, Hartwig R.·2008·Brain Stimulation

DOI 10.1016/j.brs.2007.08.003

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Abstract

Synaptic plasticity in the motor cortex is involved at least in some forms of motor learning. Recent evidence showed that the extent of practice-dependent plasticity in the motor cortex can be purposefully enhanced by experimental manipulation. One way of improving motor learning is to transiently increase the excitability of the motor cortex during motor learning. This can be achieved by weakening the excitability of intracortical inhibitory circuits concurrently with practice. This principle is being referred to as "gating." Another strategy to boost learning is to decrease the threshold for induction of synaptic plasticity by lowering neuronal activity in the motor cortex before practice. This approach invokes homeostatic metaplasticity. Here we highlight how transcranial brain stimulation can exploit gating and homeostatic metaplasticity to enhance motor learning in healthy subjects and in patients after stroke.

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Authors: Ziemann, U., & Siebner, H. R.
Affiliations: Goethe University Frankfurt (DE)
Christian-Albrechts-Universität zu Kiel (DE)
Corresponding author: Ziemann, Ulf
ORCID: Ziemann, Ulf
Siebner, Hartwig R.
Venue: Brain Stimulation
Publisher: Elsevier BV
Published: 2008-01
Volume: 1
Issue: 1
Pages: 60-66
ISSN: 1876-4754 (ISSN-L)
1935-861X
DOI: 10.1016/j.brs.2007.08.003
OpenAlex: W2031034560
Cited by: 269
References: 73
Citations by year: 2026: 5 · 2025: 13 · 2024: 13 · 2023: 12 · 2022: 15 · 2021: 24 · 2020: 19 · 2019: 19 · 2018: 21 · 2017: 12 · 2016: 19 · 2015: 26 · 2014: 16 · 2013: 19 · 2012: 15
FWCI: 0.35
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain stimulation (publishedVersion)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics: Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: motor learning, motor cortex, synaptic plasticity, gating, intracortical inhibition, cortical excitability, transcranial brain stimulation, stroke rehabilitation
MeSH terms: Stroke Rehabilitation, Homeostasis, Humans, Learning, Motor Activity, Motor Cortex, Neuronal Plasticity, Stroke, Transcranial Magnetic Stimulation

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Modifying motor learning through gating and homeostatic metaplasticity

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