Cited by 261Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeural dynamics and brain function

Bidirectional synaptic plasticity: from theory to reality

Open access
Bear, Mark F.·2003·Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences

Abstract

Theories of receptive field plasticity and information storage make specific assumptions for how synapses are modified. I give a personal account of how testing the validity of these assumptions eventually led to a detailed understanding of long-term depression and metaplasticity in hippocampal area CA1 and the visual cortex. The knowledge of these molecular mechanisms now promises to reveal when and how sensory experience modifies synapses in the cerebral cortex.

Integrity signals

Registry

Crossref · 10.1098/rstb.2002.1255

Cites

47 of 48 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Bear, M. F.
Affiliations
Howard Hughes Medical Institute (US)
Corresponding author
Bear, Mark F.
Venue
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences
Published
2003-04-29
Volume
358
Issue
1432
Pages
649-655
ISSN
  • 0962-8436 (ISSN-L)
  • 1471-2970
OpenAlex
W2109372640
Cited by
260
References
47
Citations by year
2026: 2 · 2025: 2 · 2024: 8 · 2023: 7 · 2022: 6 · 2021: 2 · 2020: 12 · 2019: 9 · 2018: 14 · 2017: 5 · 2016: 6 · 2015: 7 · 2014: 14 · 2013: 17 · 2012: 10
FWCI
1.08
Type
journal article
Language
en
Open access
Locations
  • Philosophical Transactions of the Royal Society B Biological Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
bidirectional synaptic plasticity, long-term depression, metaplasticity, receptive field plasticity, information storage, hippocampal CA1, visual cortex
MeSH terms
Animals, Hippocampus, Humans, Models, Biological, Neuronal Plasticity, Synapses, Visual Cortex

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review