Bidirectional synaptic plasticity: from theory to reality
Open accessAbstract
Theories of receptive field plasticity and information storage make specific assumptions for how synapses are modified. I give a personal account of how testing the validity of these assumptions eventually led to a detailed understanding of long-term depression and metaplasticity in hippocampal area CA1 and the visual cortex. The knowledge of these molecular mechanisms now promises to reveal when and how sensory experience modifies synapses in the cerebral cortex.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Cites
A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566 · see citing works
Bliss, T. V. P., & Gardner-Medwin, A. R. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010274 · Cited by 7,460 · see citing works
Morris, R. G. M., Anderson, E., Lynch, G. S., & Baudry, M. (1986) · Nature · doi:10.1038/319774a0 · Cited by 3,640 · see citing works
Bienenstock, E., Cooper, L., & Munro, P. (1982) · The Journal of Neuroscience · doi:10.1523/jneurosci.02-01-00032.1982 · Cited by 2,896 · see citing works
AMPA Receptor Trafficking and Synaptic Plasticity
Malinow, R., & Malenka, R. C. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142758 · Cited by 2,588 · see citing works
Metaplasticity: the plasticity of synaptic plasticity
Abraham, W. C., & Bear, M. F. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)80018-x · Cited by 1,783 · see citing works
Self-citationDudek, S. M., & Bear, M. F. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4363 · Cited by 1,708 · see citing works
Self-citationSynaptic plasticity: LTP and LTD
Bear, M. F., & Malenka, R. C. (1994) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(94)90101-5 · Cited by 1,355 · see citing works
Self-citationA mechanism for the Hebb and the anti-Hebb processes underlying learning and memory.
Lisman, J. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.23.9574 · Cited by 1,127 · see citing works
Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity
Lee, H.-K., Barbarosie, M., Kameyama, K., Bear, M. F., & Huganir, R. L. (2000) · Nature · doi:10.1038/35016089 · Cited by 1,116 · see citing works
Self-citationReinsertion or Degradation of AMPA Receptors Determined by Activity-Dependent Endocytic Sorting
Ehlers, M. D. (2000) · Neuron · doi:10.1016/s0896-6273(00)00129-x · Cited by 1,096 · see citing works
Involvement of a calcineurin/ inhibitor-1 phosphatase cascade in hippocampal long-term depression
Mulkey, R. M., Endo, S., Shenolikar, S., & Malenka, R. C. (1994) · Nature · doi:10.1038/369486a0 · Cited by 1,083 · see citing works
Kaplan, S. J. (1950) · PubMed Central · Cited by 1,054 · see citing works
Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation
Barria, A., Muller, D., Derkach, V., Griffith, L. C., & Soderling, T. R. (1997) · Science · doi:10.1126/science.276.5321.2042 · Cited by 1,049 · see citing works
Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression.
Huber, K., Kayser, M., & Bear, M. (2000) · Science · doi:10.1126/science.288.5469.1254 · Cited by 1,015 · see citing works
Self-citationPostnatal development of the visual cortex and the influence of environment
Wiesel, T. N. (1982) · Nature · doi:10.1038/299583a0 · Cited by 978 · see citing works
Blockade of "NMDA" Receptors Disrupts Experience-Dependent Plasticity of Kitten Striate Cortex
Kleinschmidt, A. K., Bear, M. F., & Singer, W. (1987) · Science · doi:10.1126/science.2443978 · Cited by 906 · see citing works
Self-citationA Physiological Mechanism for Hebb's Postulate of Learning
Stent, G. S. (1973) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.70.4.997 · Cited by 710 · see citing works
Lee, H.-K., Kameyama, K., Huganir, R. L., & Bear, M. F. (1998) · Neuron · doi:10.1016/s0896-6273(00)80632-7 · Cited by 668 · see citing works
Self-citationExperience-dependent modification of synaptic plasticity in visual cortex
Kirkwood, A., Rioult, M., & Bear, M. (1996) · Nature · doi:10.1038/381526a0 · Cited by 666 · see citing works
Self-citationRapid, experience-dependent expression of synaptic NMDA receptors in visual cortex in vivo
Quinlan, E., Philpot, B. D., Huganir, R., & Bear, M. (1999) · Nature Neuroscience · doi:10.1038/7263 · Cited by 614 · see citing works
Self-citationA unified model of NMDA receptor-dependent bidirectional synaptic plasticity
Shouval, H. Z., Bear, M. F., & Cooper, L. N. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152343099 · Cited by 608 · see citing works
Self-citationBidirectional long-term modification of synaptic effectiveness in the adult and immature hippocampus
Dudek, S. M., & Bear, M. F. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-07-02910.1993 · Cited by 595 · see citing works
Self-citationThe neurosciences : fourth study program
Schmitt, F. O., Worden, F. G., Adelman, G., Smith, B. H., & Bloom, F. E. (1979) · Medical Entomology and Zoology · Cited by 535 · see citing works
A Physiological Basis for a Theory of Synapse Modification
Bear, M. F., Cooper, L. N., & Ebner, F. F. (1987) · Science · doi:10.1126/science.3037696 · Cited by 528 · see citing works
Self-citationN-methyl-D-aspartate receptor antagonist desegregates eye-specific stripes.
Cline, H. T., Debski, E. A., & Constantine‐Paton, M. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.12.4342 · Cited by 523 · see citing works
Common Forms of Synaptic Plasticity in the Hippocampus and Neocortex in Vitro
Kirkwood, A., Dudek, S. M., Gold, J. T., Aizenman, C. D., & Bear, M. F. (1993) · Science · doi:10.1126/science.8502997 · Cited by 483 · see citing works
Self-citationPhilpot, B. D., Sekhar, A. K., Shouval, H., & Bear, M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00187-8 · Cited by 440 · see citing works
Self-citationHebbian synapses in visual cortex
Kirkwood, A., & Bear, M. F. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-03-01634.1994 · Cited by 412 · see citing works
Self-citationQuinlan, E. M., Olstein, D. H., & Bear, M. F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12876 · Cited by 382 · see citing works
Self-citationFujii, S., Saito, K., Miyakawa, H., Ito, K., & Kato, H. (1991) · Brain Research · doi:10.1016/0006-8993(91)90867-u · Cited by 375 · see citing works
Barrionuevo, G., Schottler, F., & Lynch, G. (1980) · Life Sciences · doi:10.1016/0024-3205(80)90509-3 · Cited by 321 · see citing works
A synaptic basis for memory storage in the cerebral cortex
Bear, M. F. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13453 · Cited by 315 · see citing works
Self-citationMolecular mechanism for loss of visual cortical responsiveness following brief monocular deprivation
Heynen, A. J., Yoon, B.-J., Liu, C.-H., Chung, H. J., Huganir, R. L., & Bear, M. F. (2003) · Nature Neuroscience · doi:10.1038/nn1100 · Cited by 305 · see citing works
Self-citationStable depression of potentiated synaptic responses in the hippocampus with 1–5 Hz stimulation
Staubli, U. V., & LYNCH, G. S. (1990) · Brain Research · doi:10.1016/0006-8993(90)91096-y · Cited by 301 · see citing works
Homosynaptic long-term depression in the visual cortex
Kirkwood, A., & Bear, M. F. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-05-03404.1994 · Cited by 286 · see citing works
Self-citationKameyama, K., Lee, H.-K., Bear, M. F., & Huganir, R. L. (1998) · Neuron · doi:10.1016/s0896-6273(00)80633-9 · Cited by 283 · see citing works
Self-citationHeynen, A., Quinlan, E., Bae, D. C., & Bear, M. (2000) · Neuron · doi:10.1016/s0896-6273(00)00130-6 · Cited by 237 · see citing works
Self-citationMonocular deprivation induces homosynaptic long-term depression in visual cortex
Rittenhouse, C. D., Shouval, H. Z., Paradiso, M. A., & Bear, M. F. (1999) · Nature · doi:10.1038/16922 · Cited by 228 · see citing works
Self-citationAbraham, W. C., & Goddard, G. V. (1983) · Nature · doi:10.1038/305717a0 · Cited by 194 · see citing works
A Biochemical Correlate of the Critical Period for Synaptic Modification in the Visual Cortex
Dudek, S. M., & Bear, M. F. (1989) · Science · doi:10.1126/science.2573152 · Cited by 160 · see citing works
Self-citationA theory for the acquisition and loss of neuron specificity in visual cortex
Cooper, L. N., Liberman, F. Z., & Erkki Oja, A. (1979) · Biological Cybernetics · doi:10.1007/bf00337414 · Cited by 145 · see citing works
The effects of adenosine on the development of long-term potentiation
Arai, A., Kessler, M., & LYNCH, G. S. (1990) · Neuroscience Letters · doi:10.1016/0304-3940(90)90750-4 · Cited by 139 · see citing works
Bliss, T. V. P., & Lømo, T. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010273 · Cited by 135 · see citing works
Anoxia reveals a vulnerable period in the development of long-term potentiation
Arai, A., Larson, J., & LYNCH, G. S. (1990) · Brain Research · doi:10.1016/0006-8993(90)90184-d · Cited by 93 · see citing works
Reversible loss of hippocampal long term potentiation following electroconvulsive seizures
Hesse, G. W., & Teyler, T. J. (1976) · Nature · doi:10.1038/264562a0 · Cited by 84 · see citing works
Mechanistic relationships between development and learning
Carew, T. J., Shatz, C. J., & Menzel, R. (1998) · Cited by 67 · see citing works
The induction of N -methyl-D-aspartate receptor-dependent long-term potentiation
Collingridge, G. L. (2003) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2002.1241 · Cited by 46 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Rossi, S., Hallett, M., Rossini, P. M., & Pascual-Leone, A. (2009) · Clinical Neurophysiology · doi:10.1016/j.clinph.2009.08.016 · Cited by 5,367 · see citing works
Malenka, R. C., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.012 · Cited by 3,968 · see citing works
Self-citationNeuron-glia metabolic coupling and plasticity
Magistretti, P. J. (2006) · Experimental Physiology · doi:10.1113/expphysiol.2010.053157 · Cited by 739 · see citing works
Consensus: Motor cortex plasticity protocols
Ziemann, U., Paulus, W., Nitsche, M. A., Pascual-Leone, A., Byblow, W. D., Berardelli, A., Siebner, H. R., Classen, J., Cohen, L. G., & Rothwell, J. C. (2008) · Brain Stimulation · doi:10.1016/j.brs.2008.06.006 · Cited by 639 · see citing works
Regulation of NMDA receptor subunit expression and its implications for LTD, LTP, and metaplasticity
Yashiro, K., & Philpot, B. D. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.046 · Cited by 649 · see citing works
The Hippocampal Formation in Schizophrenia
Tamminga, C. A., Stan, A. D., & Wagner, A. D. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09081187 · Cited by 583 · see citing works
Aggleton, J. P., O’Mara, S. M., Vann, S. D., Wright, N. F., Tsanov, M., & Erichsen, J. T. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07251.x · Cited by 468 · see citing works
A role for synaptic plasticity in the adolescent development of executive function
Selemon, L. D. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.7 · Cited by 439 · see citing works
“may trigger LTP and resulting synapse maturation and stabilization; conversely, asynchronous activity may diminish synaptic strength via LTD and predispose the synapse to elimination.(97)”
BackgroundCocaine Experience Controls Bidirectional Synaptic Plasticity in the Nucleus Accumbens
Kourrich, S., Rothwell, P. E., Klug, J. R., & Thomas, M. J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1859-07.2007 · Cited by 429 · see citing works
How Monocular Deprivation Shifts Ocular Dominance in Visual Cortex of Young Mice
Frenkel, M. Y., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.12.003 · Cited by 412 · see citing works
Self-citationElectric and Thermal Field Effects in Tissue Around Radiofrequency Electrodes
Cosman, E. R., & Cosman, E. R. (2005) · Pain Medicine · doi:10.1111/j.1526-4637.2005.00076.x · Cited by 406 · see citing works
The BCM theory of synapse modification at 30: interaction of theory with experiment
Cooper, L. N., & Bear, M. F. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3353 · Cited by 395 · see citing works
Self-citationHomeostatic Regulation of Eye-Specific Responses in Visual Cortex during Ocular Dominance Plasticity
Mrsic-Flogel, T. D., Hofer, S. B., Ohki, K., Reid, R. C., Bonhoeffer, T., & Hübener, M. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.028 · Cited by 330 · see citing works
Transcranial magnetic stimulation and synaptic plasticity: Experimental framework and human models
Thickbroom, G. W. (2007) · Experimental Brain Research · doi:10.1007/s00221-007-0991-3 · Cited by 326 · see citing works
Supervised learning in spiking neural networks: A review of algorithms and evaluations
Wang, X., Lin, X., & Dang, X. (2020) · Neural Networks · doi:10.1016/j.neunet.2020.02.011 · Cited by 276 · see citing works
Modifying motor learning through gating and homeostatic metaplasticity
Ziemann, U., & Siebner, H. R. (2008) · Brain Stimulation · doi:10.1016/j.brs.2007.08.003 · Cited by 269 · see citing works
Cocaine‐induced neuroadaptations in glutamate transmission
Schmidt, H. D., & Pierce, R. C. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05144.x · Cited by 254 · see citing works
Groc, L., Choquet, D., Stephenson, F. A., Verrier, D., Manzoni, O. J., & Chavis, P. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1772-07.2007 · Cited by 225 · see citing works
Karabanov, A. N., Ziemann, U., Hamada, M., George, M. S., Quartarone, A., Claßen, J., Massimini, M., Rothwell, J. C., & Siebner, H. R. (2015) · Brain stimulation · doi:10.1016/j.brs.2015.01.404 · Cited by 224 · see citing works
Obligatory Role of NR2A for Metaplasticity in Visual Cortex
Philpot, B. D., Cho, K. K. A., & Bear, M. F. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.027 · Cited by 207 · see citing works
Self-citationTatti, R., Haley, M. S., Swanson, O. K., Tselha, T., & Maffei, A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.09.017 · Cited by 211 · see citing works
Synaptic plasticity in animal models of early Alzheimer's disease
Rowan, M. J., Klyubin, I. V., Cullen, W. K., & Anwyl, R. (2003) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2002.1240 · Cited by 202 · see citing works
Homeostatic plasticity and STDP: keeping a neuron's cool in a fluctuating world
Watt, A. J. (2010) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2010.00005 · Cited by 189 · see citing works
Müller, J. F. M., Orekhov, Y., Liu, Y., & Ziemann, U. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05603.x · Cited by 175 · see citing works
Bidirectional synaptic mechanisms of ocular dominance plasticity in visual cortex
Smith, G. B., Heynen, A. J., & Bear, M. F. (2008) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2008.0198 · Cited by 175 · see citing works
Self-citationExpression of Long-Term Depression Underlies Visual Recognition Memory
Griffiths, S., Scott, H. L., Glover, C. P. J., Bienemann, A. S., Ghorbel, M. T., Uney, J. B., Brown, M. W., Warburton, E. C., & Bashir, Z. I. (2008) · Neuron · doi:10.1016/j.neuron.2008.02.022 · Cited by 163 · see citing works
Crozier, R. A., Wang, Y., Liu, C.-H., & Bear, M. F. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609596104 · Cited by 163 · see citing works
Self-citationAntistress Effect of TRPV1 Channel on Synaptic Plasticity and Spatial Memory
Li, H.-B., Mao, R., Zhang, J., Yang, Y., Cao, J., & Xu, L. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.02.020 · Cited by 160 · see citing works
Karabanov, A. N., Ziemann, U., Hamada, M., George, M. S., Quartarone, A., Claßen, J., Massimini, M., Rothwell, J. C., & Siebner, H. R. (2015) · Brain stimulation · doi:10.1016/j.brs.2015.06.017 · Cited by 159 · see citing works
Slutsky, I., Sadeghpour, S., Li, B., & Liu, G. (2004) · Neuron · doi:10.1016/j.neuron.2004.11.013 · Cited by 151 · see citing works
Glutamate Dysfunction in Hippocampus: Relevance of Dentate Gyrus and CA3 Signaling
Tamminga, C. A., Southcott, S. A., Sacco, C., Wagner, A. D., & Ghose, S. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs062 · Cited by 144 · see citing works
Nonmonotonic Plasticity: How Memory Retrieval Drives Learning
Ritvo, V. J. H., Turk‐Browne, N. B., & Norman, K. A. (2019) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2019.06.007 · Cited by 146 · see citing works
Lifelong learning: ocular dominance plasticity in mouse visual cortex
Hofer, S. B., Mrsic‐Flogel, T. D., Bonhoeffer, T., & Hübener, M. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.06.007 · Cited by 138 · see citing works
Dow-Edwards, D. L., MacMaster, F. P., Peterson, B. S., Niesink, R. J. M., Andersen, S. L., & Braams, B. R. (2019) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2019.106834 · Cited by 146 · see citing works
Skucas, V. A., Mathews, I. B., Yang, J., Cheng, Q., Treister, A. K., Duffy, Á., Verkman, A. S., Hempstead, B. L., Wood, M. A., Binder, D. K., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6249-10.2011 · Cited by 138 · see citing works
Ranson, A., Cheetham, C. E. J., Fox, K. D., & Sengpiel, F. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112204109 · Cited by 133 · see citing works
Activity-Dependent Acceleration of Endocytosis at a Central Synapse
Wu, W., Xu, J., Wu, X.-S., & Wu, L.-G. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2972-05.2005 · Cited by 134 · see citing works
Agboada, D., Mosayebi-Samani, M., Kuo, M., & Nitsche, M. A. (2020) · Brain stimulation · doi:10.1016/j.brs.2020.04.009 · Cited by 131 · see citing works
Using theoretical models to analyse neural development
Arjen Van Ooyen, B. (2011) · Nature reviews. Neuroscience · doi:10.1038/nrn3031 · Cited by 122 · see citing works
Cellular and System Biology of Memory: Timing, Molecules, and Beyond
Körte, M., & Schmitz, D. (2016) · Physiological Reviews · doi:10.1152/physrev.00010.2015 · Cited by 123 · see citing works
Moderate levels of activation lead to forgetting in the think/no-think paradigm
Detre, G. J., Natarajan, A., Gershman, S. J., & Norman, K. A. (2013) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2013.02.017 · Cited by 120 · see citing works
Yao, N., Skiteva, O., Zhang, X., Svenningsson, P., & Chergui, K. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.239 · Cited by 118 · see citing works
Cooke, S. F., & Bear, M. F. (2013) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0284 · Cited by 114 · see citing works
Self-citationXu, Z., Chen, R., Gu, Q.-H., Yan, J.-Z., Wang, S., Liu, S., & Lü, W. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1014-09.2009 · Cited by 115 · see citing works
Cho, K. K. A., Khibnik, L. A., Philpot, B. D., & Bear, M. F. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808104106 · Cited by 114 · see citing works
Self-citationArleo, A., & Rondi‐Reig, L. (2007) · Journal of Integrative Neuroscience · doi:10.1142/s0219635207001593 · Cited by 108 · see citing works
Ismailov, I. I., Kalikulov, D., Inoue, T., & Friedlander, M. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0738-04.2004 · Cited by 111 · see citing works
Liu, C.-H., Heynen, A. J., Shuler, M. G. H., & Bear, M. F. (2008) · Neuron · doi:10.1016/j.neuron.2008.02.020 · Cited by 108 · see citing works
Self-citationAbnormal Changes of Synaptic Excitability in Migraine with Aura
Siniatchkin, M., Sendacki, M., Moeller, F., Wolff, S., Jansen, O., Siebner, H. R., & Stephani, U. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr248 · Cited by 110 · see citing works
Chen, W. S., & Bear, M. F. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.07.003 · Cited by 105 · see citing works
Self-citationSeeburg, D. P., & Sheng, M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1853-08.2008 · Cited by 106 · see citing works
Increased NR2A:NR2B ratio compresses long-term depression range and constrains long-term memory
Cui, Z., Feng, R., Jacobs, S., Duan, Y., Wang, H., Cao, X., & Tsien, J. Z. (2013) · Scientific Reports · doi:10.1038/srep01036 · Cited by 108 · see citing works
Neocortex Network Activation and Deactivation States Controlled by the Thalamus
Hirata, A., & Castro‐Alamancos, M. A. (2010) · Journal of Neurophysiology · doi:10.1152/jn.00955.2009 · Cited by 108 · see citing works
Moult, P. R., Corrêa, S. A. L., Collingridge, G. L., Fitzjohn, S. M., & Bashir, Z. I. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.153122 · Cited by 107 · see citing works
Bliss, T., Collingridge, G. L., & Morris, R. (2003) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2003.1282 · Cited by 105 · see citing works
Bartels, C., Kunert, H. J., Stawicki, S., Kröner‐Herwig, B., Ehrenreich, H., & Krampe, H. (2006) · Alcohol and Alcoholism · doi:10.1093/alcalc/agl104 · Cited by 101 · see citing works
Competition between items in working memory leads to forgetting
Lewis‐Peacock, J. A., & Norman, K. A. (2014) · Nature Communications · doi:10.1038/ncomms6768 · Cited by 98 · see citing works
Improved Binocular Outcomes Following Binocular Treatment for Childhood Amblyopia
Kelly, K. R., Jost, R. M., Wang, Y., Dao, L. M., Beauchamp, C. L., Leffler, J. N., & Birch, E. E. (2018) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.17-23235 · Cited by 98 · see citing works
Roles of NR2A and NR2B in the Development of Dendritic Arbor MorphologyIn Vivo
Ewald, R. C., Keuren‐Jensen, K. R. V., Aizenman, C. D., & Cline, H. T. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5078-07.2008 · Cited by 95 · see citing works
Essential role for a long-term depression mechanism in ocular dominance plasticity
Yoon, B.-J., Smith, G. B., Heynen, A. J., Neve, R. L., & Bear, M. F. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901305106 · Cited by 94 · see citing works
Self-citationFragile X: translation in action
Bear, M. F., Dölen, G., Osterweil, E., & Nagarajan, N. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301610 · Cited by 94 · see citing works
Self-citationKeck, T., Hübener, M., & Bonhoeffer, T. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.02.003 · Cited by 93 · see citing works
Kameyama, K., Sohya, K., Ebina, T., Fukuda, A., Yanagawa, Y., & Tsumoto, T. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5025-09.2010 · Cited by 88 · see citing works
GTP-independent rapid and slow endocytosis at a central synapse
Xu, J., McNeil, B. D., Wu, W., Nees, D. W., Bai, L., & Wu, L. (2007) · Nature Neuroscience · doi:10.1038/nn2021 · Cited by 87 · see citing works
Narayanan, R., & Johnston, D. (2010) · Journal of Neurophysiology · doi:10.1152/jn.01129.2009 · Cited by 85 · see citing works
Endocannabinoids in brain plasticity: Cortical maturation, HPA axis function and behavior
Dow-Edwards, D. L., & Silva, L. (2016) · Brain Research · doi:10.1016/j.brainres.2016.08.037 · Cited by 84 · see citing works
Plasticity and specificity of cortical processing networks
Majewska, A. K., & Sur, M. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.04.002 · Cited by 83 · see citing works
Aquaporin-4 water channels and synaptic plasticity in the hippocampus
Scharfman, H. E., & Binder, D. K. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2013.05.003 · Cited by 83 · see citing works
Zemmar, A., Weinmann, O., Kellner, Y., Yu, X., Vicente, R., Gullo, M., Kasper, H., Lussi, K., Ristic, Z., Luft, A. R., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3817-13.2014 · Cited by 78 · see citing works
Brain-derived neurotrophic factor
Laske, C., & Eschweiler, G. W. (2005) · Der Nervenarzt · doi:10.1007/s00115-005-1971-0 · Cited by 76 · see citing works
Degeneracy in hippocampal physiology and plasticity
Rathour, R. K., & Narayanan, R. (2019) · Hippocampus · doi:10.1002/hipo.23139 · Cited by 75 · see citing works
Guyonneau, R., VanRullen, R., & Thorpe, S. J. (2004) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2005.09.004 · Cited by 69 · see citing works
Pelkey, K. A., Topolnik, L., Yuan, X.-Q., Lacaille, J.-C., & McBain, C. J. (2008) · Neuron · doi:10.1016/j.neuron.2008.11.018 · Cited by 69 · see citing works
Sarihi, A., Jiang, B., Komaki, A., Sohya, K., Yanagawa, Y., & Tsumoto, T. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4928-07.2008 · Cited by 68 · see citing works
Experience-dependent changes in NMDA receptor composition at mature central synapses
Kopp, C., Longordo, F., & Lüthi, A. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.03.014 · Cited by 69 · see citing works
Delvendahl, I., Jung, N. H., Mainberger, F., Kuhnke, N. G., Cronjaeger, M., & Mall, V. (2010) · Clinical Neurophysiology · doi:10.1016/j.clinph.2009.09.034 · Cited by 67 · see citing works
Neuroplasticity of the visual cortex: in sickness and in health
Baroncelli, L., & Lunghi, C. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113515 · Cited by 70 · see citing works
Schimanski, L. A., & Nguyen, P. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.04.002 · Cited by 65 · see citing works
Acute opioid dependence: characterizing the early adaptations underlying drug withdrawal
Harris, A. C., & Gewirtz, J. C. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2155-0 · Cited by 63 · see citing works
Grau, J. W., Huie, J. R., Lee, K. H., Hoy, K. C., Huang, Y.-J., Turtle, J. D., Strain, M. M., Baumbauer, K. M., Miranda, R. M., Hook, M. A., et al. (2014) · Frontiers in Neural Circuits · doi:10.3389/fncir.2014.00100 · Cited by 61 · see citing works
Huang, Y.-Y., Yasuda, H., Sarihi, A., & Tsumoto, T. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0899-08.2008 · Cited by 64 · see citing works
Presynaptically expressed long-term depression at cerebellar parallel fiber synapses
Qiu, D., & Knöpfel, T. (2008) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-008-0555-9 · Cited by 60 · see citing works
Multiple forms of activity‐dependent intrinsic plasticity in layer V cortical neurones in vivo
Paz, J. T., Mahon, S., Tiret, P., Genet, S., Delord, B., & Charpier, S. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.169334 · Cited by 60 · see citing works
Neural mechanisms of recovery following early visual deprivation
Mitchell, D. E., & Sengpiel, F. (2008) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2008.0192 · Cited by 58 · see citing works
NMDA Receptors and Brain Development
Ewald, R. C., & Cline, H. T. (2008) · Frontiers in neuroscience · doi:10.1201/9781420044157.ch1 · Cited by 57 · see citing works
Grau, J. W., Huang, Y.-J., Turtle, J. D., Strain, M. M., Miranda, R. C., Garraway, S. M., & Hook, M. A. (2016) · Journal of Neurotrauma · doi:10.1089/neu.2016.4626 · Cited by 55 · see citing works
Miska, N. J., Richter, L. M. A., Cary, B. A., Gjorgjieva, J., & Turrigiano, G. G. (2018) · eLife · doi:10.7554/elife.38846 · Cited by 52 · see citing works
Speechley, W. J., Hogsden, J. L., & Dringenberg, H. C. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05857.x · Cited by 55 · see citing works
Rubio, F. J., Ampuero, E., Sandoval, R., Toledo, J., Pancetti, F., & Wyneken, U. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00066 · Cited by 54 · see citing works
Beazely, M. A., Lim, A., Li, H., Trepanier, C. H., Chen, X., Sidhu, B., & MacDonald, J. F. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805384200 · Cited by 54 · see citing works
Revisiting the flip side: Long-term depression of synaptic efficacy in the hippocampus
Pinar, C., Fontaine, C. J., Triviño-Paredes, J., Lottenberg, C. P., Gil‐Mohapel, J., & Christie, B. R. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.06.001 · Cited by 56 · see citing works
Glial Tumor Necrosis Factor Alpha (TNFα) Generates Metaplastic Inhibition of Spinal Learning
Huie, J. R., Baumbauer, K. M., Lee, K. H., Bresnahan, J. C., Beattie, M. S., Ferguson, A. R., & Grau, J. W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039751 · Cited by 53 · see citing works
D1/D5Modulation of Synaptic NMDA Receptor Currents
Varela, J. A., Hirsch, S. J., Chapman, D. E., Leverich, L. S., & Greene, R. W. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4746-08.2009 · Cited by 52 · see citing works
Increasing stimulus similarity drives nonmonotonic representational change in hippocampus
Wammes, J. D., Norman, K. A., & Turk-Browne, N. B. (2022) · eLife · doi:10.7554/elife.68344 · Cited by 49 · see citing works
Activity-dependent plasticity of developing climbing fiber–Purkinje cell synapses
Bosman, L. W. J., & Konnerth, A. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.01.032 · Cited by 52 · see citing works
More is less: increased processing of unwanted memories facilitates forgetting
Wang, T. H., Placek, K., & Lewis‐Peacock, J. A. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2033-18.2019 · Cited by 51 · see citing works
Origlia, N., Kuczewski, N., Aztiria, E., Gautam, D., Wess, J., & Domenici, L. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.117119 · Cited by 51 · see citing works
Chapter 1 Theoretical Models of Neural Circuit Development
Simpson, H. D., Mortimer, D., & Goodhill, G. J. (2009) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(09)01201-0 · Cited by 48 · see citing works
Stoneham, E. T., Sanders, E. M., Sanyal, M., & Dumas, T. C. (2010) · Biological Bulletin · doi:10.1086/bblv219n2p81 · Cited by 47 · see citing works
Synaptic and Molecular Mechanisms Regulating Plasticity during Early Learning
Nordeen, K. W., & Nordeen, E. J. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1298.018 · Cited by 46 · see citing works
- Authors
- Bear, M. F.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Bear, Mark F.
- ORCID
- Bear, Mark F.
- Venue
- Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences
- Publisher
- The Royal Society
- Published
- 2003-04-29
- Volume
- 358
- Issue
- 1432
- Pages
- 649-655
- ISSN
- 0962-8436 (ISSN-L)
- 1471-2970
- PMC
- PMC1693164
- OpenAlex
- W2109372640
- Cited by
- 260
- References
- 47
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 8 · 2023: 7 · 2022: 6 · 2021: 2 · 2020: 12 · 2019: 9 · 2018: 14 · 2017: 5 · 2016: 6 · 2015: 7 · 2014: 14 · 2013: 17 · 2012: 10
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Philosophical Transactions of the Royal Society B Biological Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- bidirectional synaptic plasticity, long-term depression, metaplasticity, receptive field plasticity, information storage, hippocampal CA1, visual cortex
- MeSH terms
- Animals, Hippocampus, Humans, Models, Biological, Neuronal Plasticity, Synapses, Visual Cortex
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review