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Cancer related inflammation: The macrophage connection
Abstract
Tumor-associated macrophages (TAM) are key regulators of the link between inflammation and cancer. In the tumor microenvironment neoplastic cells shape the differentiation and functional orientation of TAM which, in turn, express several protumoral functions, including secretion of growth factors and matrix-proteases, promotion of angiogenesis and suppression of adaptive immunity. This review analyzes our current knowledge of TAM and their involvement in tumor development and progression. The interplay between TAM and neoplastic cells represents a promising target of future therapeutic approaches.
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Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111
Inflammation and cancer: back to Virchow?
Balkwill, F., & Mantovani, A. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04046-0 · Cited by 7,746
Self-citationAngiogenesis in cancer, vascular, rheumatoid and other disease
Folkman, J. (1995) · Nature Medicine · doi:10.1038/nm0195-27 · Cited by 7,627
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
Hanahan, D., & Folkman, J. (1996) · Cell · doi:10.1016/s0092-8674(00)80108-7 · Cited by 6,885
Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
Galon, J., Costes, A., Sanchez-Cabo, F., Kirilovsky, A., Mlecnik, B., Lagorce-Pagès, C., Tosolini, M., Camus, M., Berger, A., Wind, P., et al. (2006) · Science · doi:10.1126/science.1129139 · Cited by 6,516
A Multigene Assay to Predict Recurrence of Tamoxifen-Treated, Node-Negative Breast Cancer
Paik, S., Shak, S., Tang, G., Kim, C., Baker, J. B., Cronin, M. T., Baehner, F. L., Walker, M. G., Watson, D., Park, T., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa041588 · Cited by 6,321
MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528
Self-citationInvolvement of chemokine receptors in breast cancer metastasis
Müller, A., Homey, B., Soto, H., Ge, N., Catron, D., Buchanan, M. E., McClanahan, T., Murphy, E., Yuan, W., Wagner, S. N., et al. (2001) · Nature · doi:10.1038/35065016 · Cited by 5,340
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180
Haine, M. M.-L., & Meeùs, N. (1986) · Cited by 3,464
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Grivennikov, S. I., Greten, F. R., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.025 · Cited by 10,755
Macrophage plasticity, polarization, and function in health and disease
Shapouri‐Moghaddam, A., Mohammadian, S., Vazini, H., Taghadosi, M., Esmaeili, S., Mardani, F., Seifi, B., Mohammadi, A., Afshari, J. T., & Sahebkar, A. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26429 · Cited by 4,930
Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications
Dadfar, S. M., Roemhild, K., Drude, N. I., von Stillfried, S., Knüchel, R., Kiessling, F., & Lammers, T. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.005 · Cited by 1,181
Tackling the cancer stem cells — what challenges do they pose?
Pattabiraman, D. R., & Weinberg, R. A. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4253 · Cited by 1,013
Targeting tumor-associated macrophages to synergize tumor immunotherapy
Xiang, X., Wang, J., Lu, D., & Xu, X. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00484-9 · Cited by 1,014
Macrophage polarization in pathology
Sica, A., Erreni, M., Allavena, P., & Porta, C. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1995-y · Cited by 673
Self-citationThe inflammatory chemokines CCL2 and CCL5 in breast cancer
Soria, G., & Ben‐Baruch, A. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.03.018 · Cited by 591
Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554
Rivollier, A., He, J., Kole, A., Valatas, V., & Kelsall, B. L. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20101387 · Cited by 548
Immune Cell Membrane‐Coated Biomimetic Nanoparticles for Targeted Cancer Therapy
Oroojalian, F., Beygi, M., Baradaran, B., Mokhtarzadeh, A., & Shahbazi, M. (2021) · Small · doi:10.1002/smll.202006484 · Cited by 528
Edin, S., Wikberg, M. L., Dahlin, A. M., Rutegård, M., Öberg, Å., Oldenborg, P., & Palmqvist, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047045 · Cited by 507
VEGF and angiopoietin signaling in tumor angiogenesis and metastasis
Saharinen, P., Eklund, L., Pulkki, K. H., Bono, P., & Alitalo, K. K. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.01.015 · Cited by 489
Inflammation and oncogenesis: a vicious connection
Grivennikov, S. I., & Karin, M. (2009) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2009.11.004 · Cited by 474
Chemokine-Induced Macrophage Polarization in Inflammatory Conditions
Ruytinx, P., Proost, P., Damme, J. V., & Struyf, S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01930 · Cited by 465
Liao, D., Luo, Y., Markowitz, D., Xiang, R., & Reisfeld, R. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007965 · Cited by 437
Cell membrane-based nanoparticles: a new biomimetic platform for tumor diagnosis and treatment
Li, R., He, Y., Zhang, S., Qin, J., & Wang, J. (2017) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2017.11.009 · Cited by 435
Capece, D., Fischietti, M., Verzella, D., Gaggiano, A., Cicciarelli, G., Tessitore, A., Zazzeroni, F., & Alesse, E. (2012) · BioMed Research International · doi:10.1155/2013/187204 · Cited by 414
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Haibe, Y., Kreidieh, M., Hajj, H. E., Khalifeh, I. M., Mukherji, D., Temraz, S. N., & Shamseddine, A. I. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00221 · Cited by 430
Maycotte, P., & Thorburn, A. M. (2011) · Cancer Biology & Therapy · doi:10.4161/cbt.11.2.14627 · Cited by 397
On the dual roles and polarized phenotypes of neutrophils in tumor development and progression
Piccard, H., Muschel, R. J., & Opdenakker, G. (2011) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2011.06.004 · Cited by 369
Harnessing tumor‐associated macrophages as aids for cancer immunotherapy
Li, X., Liu, R., Su, X., Pan, Y., Han, X., Shao, C., & Shi, Y. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1102-3 · Cited by 364
Wang, J., Li, D., Cang, H., & Guo, B. (2019) · Cancer Medicine · doi:10.1002/cam4.2327 · Cited by 363
Chow, A. Y., Zhou, W., Liu, L., Fong, M., Champer, J., Haute, D. V., Chin, A. R., Ren, X., Gugiu, B. G., Meng, Z., et al. (2014) · Scientific Reports · doi:10.1038/srep05750 · Cited by 345
RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis
Turovskaya, O., Foell, D., Sinha, P., Vogl, T., Newlin, R., Nayak, J., Nguyen, M. T. X., Olsson, A., Nawroth, P. P., Bierhaus, A., et al. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn188 · Cited by 300
Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors
Bonde, A.-K., Tischler, V., Kumar, S., Soltermann, A., & Schwendener, R. A. (2012) · BMC Cancer · doi:10.1186/1471-2407-12-35 · Cited by 292
Srikrishna, G., & Freeze, H. H. (2009) · Neoplasia · doi:10.1593/neo.09284 · Cited by 281
Significance of alternatively activated macrophages in patients with intrahepatic cholangiocarcinoma
Horlad, H., Komohara, Y., Okabe, H., Masuda, T., Ohnishi, K., Lei, X., Beppu, T., Baba, H., & Takeya, M. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2010.01614.x · Cited by 280
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Kadomoto, S., Izumi, K., & Mizokami, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155186 · Cited by 272
Macrophage infiltration and its prognostic relevance in clear cell renal cell carcinoma
Komohara, Y., Horlad, H., Ohnishi, K., Fujiwara, Y., Suzu, S., Eto, M., & Takeya, M. (2011) · Cancer Science · doi:10.1111/j.1349-7006.2011.01945.x · Cited by 269
Munn, L. L. (2016) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1370 · Cited by 273
Shirota, Y., Shirota, H., & Klinman, D. M. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1101304 · Cited by 256
Chemokines at the crossroads of tumor-fibroblast interactions that promote malignancy
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Peddareddigari, V. G. R., Wang, D., & DuBois, R. N. (2010) · Cancer Microenvironment · doi:10.1007/s12307-010-0038-3 · Cited by 252
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Guarino, V., Castellone, M. D., Avilla, E., & Melillo, R. M. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.10.003 · Cited by 233
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Rebelo, S. P., Pinto, C., Martins, T. R., Harrer, N., Estrada, M. F., Loza-Alvarez, P., Cabeçadas, J., Alves, P. M., Gualda, E. J., Sommergruber, W., et al. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.02.030 · Cited by 227
Daniela, M., Luca, C. M., Onu, I., Paula, M., Iordan, D. A., & Buculei, I. (2022) · Antioxidants · doi:10.3390/antiox11020350 · Cited by 264
Mizutani, K., Sud, S., McGregor, N., Martinovski, G., Rice, B. T., Craig, M. J., Varsos, Z. S., Roca, H., & Pienta, K. J. (2009) · Neoplasia · doi:10.1593/neo.09988 · Cited by 219
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Keibel, A., Singh, V., & Sharma, M. C. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788453167 · Cited by 225
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Lohr, M., Edlund, K., Botling, J., Hammad, S., Hellwig, B., Othman, A., Berglund, A., Lambe, M. P., Holmberg, L., Ekman, S., et al. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.01.036 · Cited by 210
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Capparuccia, L., & Tamagnone, L. (2009) · Journal of Cell Science · doi:10.1242/jcs.030197 · Cited by 215
Evaluation of the association of chronic inflammation and cancer: Insights and implications
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Audrito, V., Serra, S., Brusa, D., Mazzola, F., Arruga, F., Vaisitti, T., Coscia, M., Maffei, R., Rossi, D., Wang, T., et al. (2014) · Blood · doi:10.1182/blood-2014-07-589069 · Cited by 199
Analysis of the intricate relationship between chronic inflammation and cancer
Chai, E. Z. P., Siveen, K. S., Shanmugam, M. K., Arfuso, F., & Sethi, G. (2015) · Biochemical Journal · doi:10.1042/bj20141337 · Cited by 202
Blockade of a Chemokine, CCL2, Reduces Chronic Colitis-Associated Carcinogenesis in Mice
Popivanova, B. K., Kostadinova, F. I., Furuichi, K., Shamekh, M. M., Kondo, T., Wada, T., Egashira, K., & Mukaida, N. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1451 · Cited by 201
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Achyut, B. R., & Yang, H. H. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.07.048 · Cited by 203
Yang, Y., Li, S., To, K. K. W., Zhu, S., Wang, F., & Fu, L. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03377-9 · Cited by 221
Radiation, inflammation and the immune response in cancer
McKelvey, K. J., Hudson, A. L., Back, M., Eade, T., & Diakos, C. I. (2018) · Mammalian Genome · doi:10.1007/s00335-018-9777-0 · Cited by 203
Binnemars‐Postma, K., Bansal, R., Storm, G., & Prakash, J. (2017) · The FASEB Journal · doi:10.1096/fj.201700629r · Cited by 188
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Goff, S. L., & Danforth, D. N. (2020) · Clinical Breast Cancer · doi:10.1016/j.clbc.2020.06.011 · Cited by 188
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Curtale, G., Rubino, M., & Locati, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00799 · Cited by 192
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Su, Y., Xie, Z., Kim, G. B., Dong, C., & Yang, J. Y. (2015) · ACS Biomaterials Science & Engineering · doi:10.1021/ab500179h · Cited by 180
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Schneider, J. G., Amend, S. R., & Weilbaecher, K. N. (2010) · Bone · doi:10.1016/j.bone.2010.09.016 · Cited by 176
Ålgars, A., Irjala, H., Vaittinen, S., Huhtinen, H., Sundström, J. T. T., Salmi, M., Ristamäki, R., & Jalkanen, S. (2011) · International Journal of Cancer · doi:10.1002/ijc.26457 · Cited by 174
Pienta, K. J., McGregor, N., Axelrod, R., & Axelrod, D. E. (2008) · Translational Oncology · doi:10.1593/tlo.08178 · Cited by 165
Zhou, Q., Xian, M., Xiang, S., Xiang, D., Shao, X., Wang, J., Cao, J., Yang, X., Yang, B., Ying, M., et al. (2017) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-16-0259 · Cited by 168
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Szkandera, J., Gerger, A., Liegl‐Atzwanger, B., Absenger, G., Stotz, M., Friesenbichler, J., Trajanoski, S., Stojaković, T., Eberhard, K., Leithner, A., et al. (2013) · International Journal of Cancer · doi:10.1002/ijc.28677 · Cited by 160
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Hu, J. M., Liu, K., Liu, J. H., Jiang, X. L., Wang, X. L., Chen, Y. Z., Li, S. G., Zou, H., Pang, L. J., Liu, C. X., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.15630 · Cited by 159
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Sasso, J. M., Tenchov, R., Bird, R. E., Iyer, K. A., Ralhan, K., Rodríguez, Y., & Zhou, Q. A. (2023) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.3c00374 · Cited by 162
Nasser, M. W., Wani, N. A., Ahirwar, D. K., Powell, C. A., Ravi, J., Elbaz, M., Zhao, H., Padilla, L., Zhang, X., Shilo, K., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-2161 · Cited by 156
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Zhang, C., & Zhang, F. (2014) · Protein & Cell · doi:10.1007/s13238-014-0119-z · Cited by 149
Domínguez‐Soto, Á., Sierra‐Filardi, E., Puig‐Kröger, A., Pérez-Maceda, B. T., Gómez, F., Corcuera, M. T., Sánchez‐Mateos, P., & Corbí, A. L. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1000475 · Cited by 152
Inflammatory signaling and cellular senescence
Ren, J., Pan, J., Lu, Y.-P., Sun, P., & Han, J. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2008.10.011 · Cited by 153
Jin, G., Kawsar, H. I., Hirsch, S. A., Zeng, C., Jia, X., Feng, Z., Ghosh, S. K., Zheng, Q. Y., Zhou, A., McIntyre, T. M., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010993 · Cited by 152
Fueling inflammation at tumor microenvironment: the role of multiligand/rage axis
Armando Rojas, R., Figueroa, H., & Morales, E. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp322 · Cited by 147
VanSaun, M. N., Lee, I. K., Washington, M. K., Matrisian, L. M., & Gorden, D. L. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080703 · Cited by 145
Role of tumor vascular architecture in drug delivery
Narang, A. S., & Varia, S. A. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.04.002 · Cited by 147
Mylonas, K. J., Nair, M. G., Prieto-Lafuente, L., Paape, D., & Allen, J. E. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803463 · Cited by 140
Zhang, Y., Sime, W., Juhas, M., & Sjölander, A. (2013) · European Journal of Cancer · doi:10.1016/j.ejca.2013.06.005 · Cited by 146
Role of estrogen in hepatocellular carcinoma: is inflammation the key?
Shi, L., Feng, Y.-L., Lin, H. M., Ma, R., & Cai, X. (2014) · Journal of Translational Medicine · doi:10.1186/1479-5876-12-93 · Cited by 140
Green, C. E., Liu, T., Montel, V., Hsiao, G., Lester, R. D., Subramaniam, S., Gonias, S. L., & Klemke, R. L. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006713 · Cited by 133
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Vasto, S., Carruba, G., Lio, D., Colonna‐Romano, G., Bona, D. D., Candore, G., & Caruso, C. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.06.003 · Cited by 134
Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers
Wang, I., Zhang, B., Yang, X., Zhu, J., Stepaniants, S., Zhang, C., Meng, Q., Peters, M. A., He, Y. D., Ni, C., et al. (2012) · Molecular Systems Biology · doi:10.1038/msb.2012.24 · Cited by 130
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Nasser, M. W., Qamri, Z., Deol, Y. S., Ravi, J., Powell, C. A., Trikha, P., Schwendener, R. A., Bai, X., Shilo, K., Zou, X., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-0669 · Cited by 134
Moraes, L. A., Kar, S., Foo, S. L., Gu, T., Toh, Y. Q., Ampomah, P. B., Sachaphibulkij, K., Yap, G. L. R., Zharkova, O., Lukman, H. M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-17622-5 · Cited by 133
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Kim, J., Denu, R. A., Dollar, B. A., Escalante, L. E., Kuether, J. P., Callander, N. S., Asimakopoulos, F. A., & Hematti, P. (2012) · British Journal of Haematology · doi:10.1111/j.1365-2141.2012.09154.x · Cited by 123
Mukaida, N., Sasaki, S., & Baba, T. (2014) · Mediators of Inflammation · doi:10.1155/2014/170381 · Cited by 127
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Nasry, W. H. S., Rodriguez-Lecompte, J. C., & Martin, C. K. (2018) · Cancers · doi:10.3390/cancers10100348 · Cited by 123
Liao, Q., Zeng, Z., Guo, X., Li, X., Wei, F., Zhang, W., Li, X., Chen, P., Liang, F., Xiang, B., et al. (2013) · Oncogene · doi:10.1038/onc.2013.161 · Cited by 118
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Subimerb, C., Pinlaor, S., Lulitanond, V, Khuntikeo, N., Okada, S., McGrath, M. S., & Wongkham, S. (2010) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2010.04200.x · Cited by 113
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Metadata
- Authors
- Sica, A., Allavena, P., & Mantovani, A.
- Affiliations
- Fondazione Humanitas per la Ricerca (IT)
- University of Milan (IT)
- Corresponding author
- Allavena, Paola
- Venue
- Cancer Letters
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 267
- Issue
- 2
- Pages
- 204-215
- ISSN
- 0304-3835 (ISSN-L)
- OpenAlex
- W2141487097
- Cited by
- 601
- References
- 96
- Citations by year
- 2026: 10 · 2025: 17 · 2024: 22 · 2023: 36 · 2022: 30 · 2021: 36 · 2020: 36 · 2019: 30 · 2018: 29 · 2017: 39 · 2016: 32 · 2015: 35 · 2014: 47 · 2013: 35 · 2012: 37
- FWCI
- 3.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
- Keywords
- tumor-associated macrophages, tumor inflammation, tumor microenvironment, macrophage polarization, tumor progression, angiogenesis, immunosuppression, growth factors, carcinogenesis, therapeutic target
- MeSH terms
- Animals, Humans, Inflammation, Macrophage Activation, Macrophages, Neoplasms, NF-kappa B, Cell Polarity, Disease Progression, STAT3 Transcription Factor, Hypoxia-Inducible Factor 1, alpha Subunit
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