Cancer related inflammation: The macrophage connection

Inflammation and cancer

Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111

Inflammation and cancer: back to Virchow?

Balkwill, F., & Mantovani, A. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04046-0 · Cited by 7,746

Angiogenesis in cancer, vascular, rheumatoid and other disease

Folkman, J. (1995) · Nature Medicine · doi:10.1038/nm0195-27 · Cited by 7,627

Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

Hanahan, D., & Folkman, J. (1996) · Cell · doi:10.1016/s0092-8674(00)80108-7 · Cited by 6,885

Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome

Galon, J., Costes, A., Sanchez-Cabo, F., Kirilovsky, A., Mlecnik, B., Lagorce-Pagès, C., Tosolini, M., Camus, M., Berger, A., Wind, P., et al. (2006) · Science · doi:10.1126/science.1129139 · Cited by 6,516

A Multigene Assay to Predict Recurrence of Tamoxifen-Treated, Node-Negative Breast Cancer

Paik, S., Shak, S., Tang, G., Kim, C., Baker, J. B., Cronin, M. T., Baehner, F. L., Walker, M. G., Watson, D., Park, T., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa041588 · Cited by 6,321

Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528

Involvement of chemokine receptors in breast cancer metastasis

Müller, A., Homey, B., Soto, H., Ge, N., Catron, D., Buchanan, M. E., McClanahan, T., Murphy, E., Yuan, W., Wagner, S. N., et al. (2001) · Nature · doi:10.1038/35065016 · Cited by 5,340

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180

Van Damme A.

Haine, M. M.-L., & Meeùs, N. (1986) · Cited by 3,464

Tumour-educated macrophages promote tumour progression and metastasis

Pollard, J. W. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1256 · Cited by 3,413

Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer

Zhang, L., Conejo-Garcia, J. R., Katsaros, D., Gimotty, P. A., Massobrio, M., Regnani, G., Makrigiannakis, A., Gray, H., Schlienger, K., Liebman, M. N., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa020177 · Cited by 3,397

Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

Apetoh, L., Ghiringhelli, F., Tesniere, A., Obeid, M., Ortiz, C., Criollo, A., Mignot, G., Maiuri, M. C., Ullrich, E., Saulnier, P., et al. (2007) · Nature Medicine · doi:10.1038/nm1622 · Cited by 3,056

Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis

Condeelis, J. S., & Pollard, J. W. (2006) · Cell · doi:10.1016/j.cell.2006.01.007 · Cited by 2,677

Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1

Ceradini, D. J., Kulkarni, A. R., Callaghan, M. J., Tepper, O. M., Bastidas, N., Kleinman, M. E., Capla, J. M., Galiano, R. D., Levine, J. P., & Gurtner, G. C. (2004) · Nature Medicine · doi:10.1038/nm1075 · Cited by 2,600

NF-κB in cancer: from innocent bystander to major culprit

Karin, M., Cao, Y., Greten, F. R., & Li, Z. (2002) · Nature reviews. Cancer · doi:10.1038/nrc780 · Cited by 2,476

IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer

Greten, F. R., Eckmann, L., Greten, T. F., Park, J. M., Li, Z.-W., Egan, L. J., Kagnoff, M. F., & Karin, M. (2004) · Cell · doi:10.1016/j.cell.2004.07.013 · Cited by 2,433

NF-κB functions as a tumour promoter in inflammation-associated cancer

Pikarsky, E., Porat, R. M., Stein, I., Abramovitch, R., Amit, S., Kasem, S., Gutkovich-Pyest, E., Urieli-Shoval, S., Galun, E., & Ben‐Neriah, Y. (2004) · Nature · doi:10.1038/nature02924 · Cited by 2,423

Cancer and the chemokine network

Balkwill, F. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1388 · Cited by 2,343

Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase

Uyttenhove, C., Pilotte, L., Théate, I., Stroobant, V., Colau, D., Parmentier, N., Boon, T., & Van den Eynde, B. J. (2003) · Nature Medicine · doi:10.1038/nm934 · Cited by 2,305

Paradoxical roles of the immune system during cancer development

de Visser, K. E., Eichten, A., & Coussens, L. M. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1782 · Cited by 2,299

HIF-1α is essential for myeloid cell-mediated inflammation

Cramer, T., Yamanishi, Y., Clausen, B. E., Förster, I., Pawlinski, R., Mackman, N., Haase, V. H., Jaenisch, R., Corr, M., Nizet, V., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00154-5 · Cited by 2,046

The role of tumour‐associated macrophages in tumour progression: implications for new anticancer therapies

Bingle, L., Brown, N. J., & Lewis, C. E. (2002) · The Journal of Pathology · doi:10.1002/path.1027 · Cited by 2,022

Smoldering and polarized inflammation in the initiation and promotion of malignant disease

Balkwill, F., Charles, K. A., & Mantovani, A. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.02.013 · Cited by 1,769

Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications

van Rooijen, N., & Sanders, A. (1994) · Journal of Immunological Methods · doi:10.1016/0022-1759(94)90012-4 · Cited by 1,763

Colony-Stimulating Factor 1 Promotes Progression of Mammary Tumors to Malignancy

Lin, E. Y., Nguyen, A. V., Russell, R. G., & Pollard, J. W. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.6.727 · Cited by 1,594

Angiogenesis in cancer

Nishida, N., Yano, H., Nishida, T., Kamura, T., & Kojiro, M. (2006) · Vascular Health and Risk Management · doi:10.2147/vhrm.2006.2.3.213 · Cited by 1,509

Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: Potential targets of anti-cancer therapy

Sica, A., Schioppa, T., Mantovani, A., & Allavena, P. (2006) · European Journal of Cancer · doi:10.1016/j.ejca.2006.01.003 · Cited by 1,483

Prediction of Survival in Follicular Lymphoma Based on Molecular Features of Tumor-Infiltrating Immune Cells

Davé, S. S., Wright, G. W., Tan, B. K., Rosenwald, A., Gascoyne, R. D., Chan, W. C., Fisher, R. I., Braziel, R. M., Rimsza, L. M., Grogan, T. M., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa041869 · Cited by 1,417

The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

Talks, K. L., Turley, H., Gatter, K. C., Maxwell, P. H., Pugh, C. W., Ratcliffe, P. J., & Harris, A. L. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64554-3 · Cited by 1,312

Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors

De Palma, M., Venneri, M. A., Galli, R., Sergi, L. S., Politi, L. S., Sampaolesi, M., & Naldini, L. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.08.002 · Cited by 1,311

MMP-9 Supplied by Bone Marrow–Derived Cells Contributes to Skin Carcinogenesis

Coussens, L. M., Tinkle, C. L., Hanahan, D., & Werb, Z. (2000) · Cell · doi:10.1016/s0092-8674(00)00139-2 · Cited by 1,306

Macrophage Polarization Comes of Age

Mantovani, Sica, & Locati, M. (2005) · Immunity · doi:10.1016/j.immuni.2005.10.001 · Cited by 1,259 · cited 2×

Altered macrophage differentiation and immune dysfunction in tumor development

Sica, A., & Bronte, V. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31422 · Cited by 1,258

The role of STATs in transcriptional control and their impact on cellular function

Bromberg, J., & Darnell, J. E. (2000) · Oncogene · doi:10.1038/sj.onc.1203476 · Cited by 1,201

Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma

Clemente, C. G., Mihm, M. C., Bufalino, R., Zurrida, S., Collini, P., & Cascinelli, N. (1996) · Cancer · doi:10.1002/(sici)1097-0142(19960401)77:7 · Cited by 1,194

Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells

Wang, T., Niu, G., Kortylewski, M., Burdelya, L. G., Shain, K. H., Zhang, S., Bhattacharya, R., Gabrilovich, D. I., Heller, R. F., Coppola, D., et al. (2003) · Nature Medicine · doi:10.1038/nm976 · Cited by 1,182

The origin and function of tumor-associated macrophages

Mantovani, A., Bottazzi, B., Colotta, F., Sozzani, S., & Ruco, L. P. (1992) · Immunology Today · doi:10.1016/0167-5699(92)90008-u · Cited by 1,088

Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy

Muller, A. J., DuHadaway, J. B., Donover, P. S., Sutanto-Ward, E., & Prendergast, G. C. (2005) · Nature Medicine · doi:10.1038/nm1196 · Cited by 1,064

The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages.

Allavena, P., Sica, A., Solinas, G., Porta, C., & Mantovani, A. (2008) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2007.07.004 · Cited by 1,044

IL-1 is required for tumor invasiveness and angiogenesis

Voronov, E., Shouval, D. S., Krelin, Y., Cagnano, E., Benharroch, D., Iwakura, Y., Dinarello, C. A., & Apte, R. N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0437939100 · Cited by 1,033

Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity

Kortylewski, M., Kujawski, M., Wang, T., Sheng, W., Zhang, S., Pilon‐Thomas, S., Niu, G., Kay, H. D., Mulé, J. J., Kerr, W. G., et al. (2005) · Nature Medicine · doi:10.1038/nm1325 · Cited by 1,026

IL-6 switches the differentiation of monocytes from dendritic cells to macrophages

Chomarat, P., Banchereau, J., Davoust, J. M., & Palucka, K. (2000) · Nature Immunology · doi:10.1038/82763 · Cited by 906

Role of tumor-associated macrophages in tumor progression and invasion

Mantovani, A., Schioppa, T., Porta, C., Allavena, P., & Sica, A. (2006) · Cancer and Metastasis Reviews · doi:10.1007/s10555-006-9001-7 · Cited by 901

Regulation of the Chemokine Receptor CXCR4 by Hypoxia

Schioppa, T., Uranchimeg, B., Saccani, A., Biswas, S. K., Doni, A., Rapisarda, A., Bernasconi, S., Saccani, S., Nebuloni, M., Vago, L., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030267 · Cited by 841

Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment

Budhu, A., Forgues, M., Ye, Q.-H., Jia, H.-L., He, P., Zanetti, K. A., Kammula, U. S., Chen, Y., Qin, L., Tang, Z., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.06.016 · Cited by 838

Tumor-Associated Macrophages Express Lymphatic Endothelial Growth Factors and Are Related to Peritumoral Lymphangiogenesis

Schoppmann, S. F., Birner, P., Stöckl, J., Kalt, R., Ullrich, R., Caucig, C., Kriehuber, E., Nagy, K., Alitalo, K., & Kerjaschki, D. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64255-1 · Cited by 794

IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland

Sansone, P., Storci, G., Tavolari, S., Guarnieri, T., Giovannini, C., Taffurelli, M., Ceccarelli, C., Santini, D., Paterini, P., Marcu, K. B., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32533 · Cited by 779

Macrophages Promote the Invasion of Breast Carcinoma Cells via a Colony-Stimulating Factor-1/Epidermal Growth Factor Paracrine Loop

Goswami, S. K., Sahai, E. A., Wyckoff, J. B., Cammer, M., Cox, D., Pixley, F. J., Stanley, E. R., Segall, J. E., & Condeelis, J. S. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-1853 · Cited by 758

B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma

Kryczek, I., Zou, L., Rodriguez, P., Zhu, G., Wei, S., Mottram, P., Brumlik, M., Cheng, P., Curiel, T., Myers, L., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20050930 · Cited by 748

An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis.

Giraudo, E., Inoue, M., & Hanahan, D. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422087 · Cited by 700

A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF- B and enhanced IRF-3/STAT1 activation)

Biswas, S. K. (2005) · Blood · doi:10.1182/blood-2005-01-0428 · Cited by 691

Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas

Gao, S. P., Mark, K. G., Leslie, K., Pao, W., Motoi, N., Gerald, W. L., Travis, W. D., Bornmann, W., Veach, D., Clarkson, B., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31871 · Cited by 666

HIF-1 as a target for drug development

Giaccia, A., Siim, B. G., & Johnson, R. S. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1199 · Cited by 631

Clodronate-liposome-mediated depletion of tumour-associated macrophages: a new and highly effective antiangiogenic therapy approach

Zeisberger, S. M., Odermatt, B., Marty, C., Zehnder-Fjällman, A. H. M., Ballmer‐Hofer, K., & Schwendener, R. A. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603240 · Cited by 622

L-arginine metabolism in myeloid cells controls T-lymphocyte functions

Bronte, V., Serafini, P., Mazzoni, A., Segal, D. M., & Zanovello, P. (2003) · Trends in Immunology · doi:10.1016/s1471-4906(03)00132-7 · Cited by 599

The involvement of IL-1 in tumorigenesis, tumor invasiveness, metastasis and tumor-host interactions

Apte, R. N., Dotan, S., Elkabets, M., White, M. R., Reich, E., Carmi, Y., Song, X., Dvozkin, T., Krelin, Y., & Voronov, E. (2006) · Cancer and Metastasis Reviews · doi:10.1007/s10555-006-9004-4 · Cited by 589

Redirecting In vivo Elicited Tumor Infiltrating Macrophages and Dendritic Cells towards Tumor Rejection

Guiducci, C., Vicari, A. P., Sangaletti, S., Trinchieri, G., & Colombo, M. P. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4262 · Cited by 549

Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells

Palma, M. D., Venneri, M. A., Roca, C., & Naldini, L. (2003) · Nature Medicine · doi:10.1038/nm871 · Cited by 546

Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer

Venneri, M. A., Palma, M. D., Ponzoni, M., Pucci, F., Scielzo, C., Zonari, E., Mazzieri, R., Doglioni, C., & Naldini, L. (2007) · Blood · doi:10.1182/blood-2006-10-053504 · Cited by 519

Reduction of Myeloid-Derived Suppressor Cells and Induction of M1 Macrophages Facilitate the Rejection of Established Metastatic Disease

Sinha, P., Clements, V. K., & Ostrand‐Rosenberg, S. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.2.636 · Cited by 461

p50 Nuclear Factor-κB Overexpression in Tumor-Associated Macrophages Inhibits M1 Inflammatory Responses and Antitumor Resistance

Saccani, A., Schioppa, T., Porta, C., Biswas, S. K., Nebuloni, M., Vago, L., Bottazzi, B., Colombo, M. P., Mantovani, A., & Sica, A. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1867 · Cited by 450

Autocrine Production of IL-10 Mediates Defective IL-12 Production and NF-κB Activation in Tumor-Associated Macrophages

Sica, A., Saccani, A., Bottazzi, B., Polentarutti, N., Vecchi, A., Damme, J. V., & Mantovani, A. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.2.762 · Cited by 423

Macrophage Responses to Hypoxia

Lewis, C., & Murdoch, C. (2005) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)62038-x · Cited by 413

Boosting antitumor responses of T lymphocytes infiltrating human prostate cancers

Bronte, V., Kasic, T., Gri, G., Gallana, K., Borsellino, G., Marigo, I., Battistini, L., Iafrate, M., Prayer‐Galetti, T., Pagano, F. C., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20042028 · Cited by 408

Induction of interleukin-8 preserves the angiogenic response in HIF-1α–deficient colon cancer cells

Mizukami, Y., Jo, W., Duerr, E., Gala, M. K., Li, J., Zhang, X., Zimmer, M. A., Iliopoulos, O., Zukerberg, L. R., Kohgo, Y., et al. (2005) · Nature Medicine · doi:10.1038/nm1294 · Cited by 407

The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activityPreprint

Lisztwan, J. H., Imbert, G., Wirbelauer, C., Gstaiger, M., & Krek, W. (1999) · Genes & Development · doi:10.1101/gad.13.14.1822 · Cited by 380

Autocrine IL-6 Signaling: A Key Event in Tumorigenesis?

Grivennikov, S. I., & Karin, M. (2008) · Cancer Cell · doi:10.1016/j.ccr.2007.12.020 · Cited by 373

Macrophage infiltration and its prognostic implications in breast cancer: The relationship with VEGF expression and microvessel density

Tsutsui, S., Yasuda, K., Suzuki, K., Tahara, K., Higashi, H., & Era, S. (2005) · Oncology Reports · doi:10.3892/or.14.2.425 · Cited by 368

Regulation of the Macrophage Content of Neoplasms by Chemoattractants

Bottazzi, B., Polentarutti, N., Acero, R., Balsari, A., Boraschi, D., Ghezzi, P., Salmona, M., & Mantovani, A. (1983) · Science · doi:10.1126/science.6828888 · Cited by 352

Tumour-associated macrophages as a prototypic type II polarised phagocyte population: role in tumour progression

Mantovani, A., Allavena, P., & Sica, A. (2004) · European Journal of Cancer · doi:10.1016/j.ejca.2004.03.016 · Cited by 322

RSUME, a Small RWD-Containing Protein, Enhances SUMO Conjugation and Stabilizes HIF-1α during Hypoxia

Carbia-Nagashima, A., Gerez, J., Perez-Castro, C., Paez-Pereda, M., Silberstein, S., Stalla, G. K., Holsboer, F., & Arzt, E. (2007) · Cell · doi:10.1016/j.cell.2007.07.044 · Cited by 318

SHIP Represses the Generation of Alternatively Activated Macrophages

Rauh, M. J., Ho, V. W., Pereira, C. C., Sham, A. P., Sly, L. M., Lam, V., Huxham, L. A., Minchinton, A. I., Mui, A., & Krystal, G. (2005) · Immunity · doi:10.1016/j.immuni.2005.09.003 · Cited by 301

Tumor-Infiltrating Lymphocytes Predict Sentinel Lymph Node Positivity in Patients With Cutaneous Melanoma

Taylor, R. C., Patel, A. B., Panageas, K. S., BUSAM, K. J., & Brady, M. S. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2006.08.9755 · Cited by 299

Anti-inflammatory Properties of the Novel Antitumor Agent Yondelis (Trabectedin): Inhibition of Macrophage Differentiation and Cytokine Production

Allavena, P., Signorelli, M., Chieppa, M., Erba, E., Bianchi, G., Marchesi, F., Olimpio, C. O., Bonardi, C., Garbi, A., Lissoni, A. A., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4037 · Cited by 287

Cytokine regulation of angiogenesis in breast cancer: the role of tumor-associated macrophages

Lewis, C. E., Leek, R., Harris, A. L., & McGee, J. O. (1995) · Journal of Leukocyte Biology · doi:10.1002/jlb.57.5.747 · Cited by 285

Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors

Mantovani, A., Allavena, P., Sozzani, S., Vecchi, A., Locati, M., & Sica, A. (2004) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2003.10.001 · Cited by 210

Identification of Biologically Active Chemokine Isoforms from Ascitic Fluid and Elevated Levels of CCL18/Pulmonary and Activation-regulated Chemokine in Ovarian Carcinoma

Schutyser, E., Struyf, S., Proost, P., Opdenakker, G., Laureys, G., Verhasselt, B., Peperstraete, L., de Putte, I. V., Saccani, A., Allavena, P., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112275200 · Cited by 207

Analysis of the Gene Expression Profile Activated by the CC Chemokine Ligand 5/RANTES and by Lipopolysaccharide in Human Monocytes

Locati, M., Deuschle, U., Massardi, M. L., Martínez, F. O., Sironi, M., Sozzani, S., Bartfai, T., & Mantovani, A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.7.3557 · Cited by 181

92 kDa type IV collagenase (MMP-9) is expressed in neutrophils and macrophages but not in malignant epithelial cells in human colon cancer

Nielsen, B. S., Timshel, S., Kjeldsen, L., Sehested, M., Pyke, C., Borregaard, N., & Danø, K. (1996) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19960103)65:1 · Cited by 173

Tumor infiltrating lymphocytes and macrophages have a potential dual role in lung cancer by supporting both host-defense and tumor progression.

Kataki, A., Scheid, P., Piet, M., Marie, B., Martinet, N., Martinet, Y., & Vignaud, J. (2002) · Journal of Laboratory and Clinical Medicine · doi:10.1067/mlc.2002.128317 · Cited by 168

Trabectedin for Women With Ovarian Carcinoma After Treatment With Platinum and Taxanes Fails

Sessa, C., de Braud, F., Perotti, A., Bauer, J. A., Curigliano, G., Noberasco, C., Zanaboni, F., Gianni, L., Marsoni, S., Jimeno, J. M., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.09.032 · Cited by 162

Melanoma-specific tumor-infiltrating lymphocytes but not circulating melanoma-specific T cells may predict survival in resected advanced-stage melanoma patients

Haanen, J. B. A. G., Baars, A., Gomez, R., Weder, P., Smits, M., de Gruijl, T. D., Blomberg, B. M. E. V., Bloemena, E., Scheper, R. J., van Ham, S. M., et al. (2005) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-005-0018-5 · Cited by 152

Tie2 identifies a hematopoietic monocytes required for tumor lineage of proangiogenic vessel formation and a mesenchymal population of pericyte progenitors

Palma, M. D., Venneri, M. A., Galli, R., Sergi, L., Politi, L., Sampaolesi, M., & Naldini, L. (2005) · Lirias · doi:10.1016/j.ccr.2005.08.0052 · Cited by 151

Leukocyte, Rather than Tumor-produced SPARC, Determines Stroma and Collagen Type IV Deposition in Mammary Carcinoma

Sangaletti, S., Stoppacciaro, A., Guiducci, C., Torrisi, M. R., & Colombo, M. P. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030202 · Cited by 132

Macrophage Role in the Anti-Prostate Cancer Response to One Class of Antiangiogenic Agents

Joseph, I. B. J., & Isaacs, J. T. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.21.1648 · Cited by 119

Mechanisms by which tumor cells and monocytes expressing the angiogenic factor thymidine phosphorylase mediate human endothelial cell migration.

Hotchkiss, K. A., Ashton, A. W., Klein, R. S., Lenzi, M. L., Zhu, G. H., & Schwartz, E. L. (2003) · PubMed · Cited by 115

GFP expression in the mammary gland for imaging of mammary tumor cells in transgenic mice.

Ahmed, F., Wyckoff, J. B., Lin, E. Y., Wang, W., Wang, Y., Hennighausen, L. G., Miyazaki, J., Jones, J. G., Pollard, J. W., Condeelis, J. S., et al. (2002) · PubMed · Cited by 109

Targeting Myelomonocytic Cells to Revert Inflammation-Dependent Cancer Promotion

Colombo, M. P., & Mantovani, A. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-2714 · Cited by 103

Stat3 is required for the development of skin cancer

Pedranzini, L., Leitch, A., & Bromberg, J. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22800 · Cited by 78

Infiltration of tumours by macrophages and dendritic cells: tumour-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes.

Mantovani, A., Sozzani, S., Locati, M., Schioppa, T., Saccani, A., Allavena, P., & Sica, A. (2004) · Novartis Foundation symposium · doi:10.1002/0470856734.ch10 · Cited by 75

Macrophages and the hypoxic tumour microenvironment

Knowles, H. J. (2007) · Frontiers in bioscience · doi:10.2741/2389 · Cited by 71

Macrophage Infiltration and Angiogenesis in Human Malignancy

Knowles, H. J., Leek, R., & Harris, A. L. (2004) · Novartis Foundation symposium · doi:10.1002/0470856734.ch14 · Cited by 69

In situ quantitation of inflammatory mononuclear cells in ductal infiltrating breast carcinoma. Relation to prognostic parameters.

An, T., Sood, U., Pietruk, T., Cummings, G., Hashimoto, K., & Crissman, J. D. (1987) · PubMed Central · Cited by 59

Engineering of Macrophages to Produce IFN-γ in Response to Hypoxia

Carta, L., Pastorino, S., Melillo, G., Bosco, M. C., Massazza, S., & Varesio, L. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.9.5374 · Cited by 54

Diminished Expression of Transcription Factors Nuclear Factor κB and CCAAT/Enhancer Binding Protein Underlies a Novel Tumor Evasion Mechanism Affecting Macrophages of Mammary Tumor–Bearing Mice

Torroella‐Kouri, M., Ma, X., Perry, G. M., Ivanova, M., Cejas, P. J., Owen, J. L., Iragavarapu‐Charyulu, V., & Lopez, D. M. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0365 · Cited by 41

Immunity, Inflammation, and Cancer

Grivennikov, S. I., Greten, F. R., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.025 · Cited by 10,755

Macrophage plasticity, polarization, and function in health and disease

Shapouri‐Moghaddam, A., Mohammadian, S., Vazini, H., Taghadosi, M., Esmaeili, S., Mardani, F., Seifi, B., Mohammadi, A., Afshari, J. T., & Sahebkar, A. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26429 · Cited by 4,930

Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications

Dadfar, S. M., Roemhild, K., Drude, N. I., von Stillfried, S., Knüchel, R., Kiessling, F., & Lammers, T. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.005 · Cited by 1,181

Tackling the cancer stem cells — what challenges do they pose?

Pattabiraman, D. R., & Weinberg, R. A. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4253 · Cited by 1,013

Targeting tumor-associated macrophages to synergize tumor immunotherapy

Xiang, X., Wang, J., Lu, D., & Xu, X. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00484-9 · Cited by 1,014

The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages.

Allavena, P., Sica, A., Solinas, G., Porta, C., & Mantovani, A. (2008) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2007.07.004 · Cited by 1,044

Tumor-associated Macrophages in Cancer Growth and Progression

Mantovani, A., Galdiero, M. R., Allavena, P., & Sica, A. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-394296-8.00027-0 · Cited by 1

Tumor-associated macrophages: role in tumorigenesis and immunotherapy implications

Zhu, S., Luo, Z., Li, X., Han, X., Shi, S., & Zhang, T. (2020) · Journal of Cancer · doi:10.7150/jca.49692 · Cited by 85

Role of tumour-associated macrophages in cancer-related inflammation.

Sica, A. (2010) · PubMed · Cited by 117

Tumor-Associated Macrophages

Allavena, P., & Belgiovine, C. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-374279-7.17013-4 · Cited by 2